SE0002320D0 - Malignant tumors - Google Patents

Malignant tumors

Info

Publication number
SE0002320D0
SE0002320D0 SE0002320A SE0002320A SE0002320D0 SE 0002320 D0 SE0002320 D0 SE 0002320D0 SE 0002320 A SE0002320 A SE 0002320A SE 0002320 A SE0002320 A SE 0002320A SE 0002320 D0 SE0002320 D0 SE 0002320D0
Authority
SE
Sweden
Prior art keywords
malignant tumors
compounds
formula
racemate
tautomer
Prior art date
Application number
SE0002320A
Other languages
English (en)
Swedish (sv)
Inventor
Anders Bjoerk
Gunnar Hedlund
Original Assignee
Active Biotech Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9903838A external-priority patent/SE9903838D0/xx
Application filed by Active Biotech Ab filed Critical Active Biotech Ab
Priority to SE0002320A priority Critical patent/SE0002320D0/xx
Publication of SE0002320D0 publication Critical patent/SE0002320D0/xx
Priority to CA002386775A priority patent/CA2386775C/en
Priority to CZ20021293A priority patent/CZ298534B6/cs
Priority to UA2002032524A priority patent/UA73748C2/uk
Priority to CNB008147574A priority patent/CN100390148C/zh
Priority to PCT/SE2000/002055 priority patent/WO2001030758A1/en
Priority to IL14878200A priority patent/IL148782A0/xx
Priority to DE60034240T priority patent/DE60034240T2/de
Priority to ES00973329T priority patent/ES2280258T3/es
Priority to AU11851/01A priority patent/AU775057B2/en
Priority to HU0203238A priority patent/HU229072B1/hu
Priority to HR20020353A priority patent/HRP20020353A2/hr
Priority to HK03100644.7A priority patent/HK1049830A1/zh
Priority to US09/694,757 priority patent/US6395750B1/en
Priority to KR1020027005077A priority patent/KR100597938B1/ko
Priority to DK00973329T priority patent/DK1224172T3/da
Priority to YUP-232/02A priority patent/RS51019B/sr
Priority to NZ518296A priority patent/NZ518296A/xx
Priority to JP2001533112A priority patent/JP3950337B2/ja
Priority to EEP200200207A priority patent/EE200200207A/xx
Priority to PL354540A priority patent/PL199781B1/pl
Priority to AT00973329T priority patent/ATE358668T1/de
Priority to EP00973329A priority patent/EP1224172B1/en
Priority to KR1020067008739A priority patent/KR100674160B1/ko
Priority to IL148782A priority patent/IL148782A/en
Priority to IS6329A priority patent/IS2750B/is
Priority to NO20021932A priority patent/NO323320B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SE0002320A 1999-10-25 2000-06-21 Malignant tumors SE0002320D0 (sv)

Priority Applications (27)

Application Number Priority Date Filing Date Title
SE0002320A SE0002320D0 (sv) 1999-10-25 2000-06-21 Malignant tumors
EP00973329A EP1224172B1 (en) 1999-10-25 2000-10-24 Drugs for the treatment of malignant tumours
KR1020067008739A KR100674160B1 (ko) 1999-10-25 2000-10-24 악성 종양의 치료용 약제
HR20020353A HRP20020353A2 (en) 1999-10-25 2000-10-24 Drugs for the treatment of malignant tumours
KR1020027005077A KR100597938B1 (ko) 1999-10-25 2000-10-24 악성 종양의 치료용 약제
UA2002032524A UA73748C2 (en) 1999-10-25 2000-10-24 Medicaments for the treatment of cancer
CNB008147574A CN100390148C (zh) 1999-10-25 2000-10-24 用于治疗恶性肿瘤的药物
PCT/SE2000/002055 WO2001030758A1 (en) 1999-10-25 2000-10-24 Drugs for the treatment of malignant tumours
IL14878200A IL148782A0 (en) 1999-10-25 2000-10-24 Drugs for the treatment of malignant tumours
DE60034240T DE60034240T2 (de) 1999-10-25 2000-10-24 Drogen zur behandlung maligner tumoren
ES00973329T ES2280258T3 (es) 1999-10-25 2000-10-24 Farmacos para el tratamiento de tumores malignos.
AU11851/01A AU775057B2 (en) 1999-10-25 2000-10-24 Drugs for the treatment of malignant tumours
HU0203238A HU229072B1 (en) 1999-10-25 2000-10-24 Drugs for the treatment of malignant tumours
CA002386775A CA2386775C (en) 1999-10-25 2000-10-24 Drugs for the treatment of malignant tumours
HK03100644.7A HK1049830A1 (zh) 1999-10-25 2000-10-24 用於治療惡性腫瘤的藥物
US09/694,757 US6395750B1 (en) 1999-10-25 2000-10-24 Drugs for the treatment of malignant tumors
CZ20021293A CZ298534B6 (cs) 1999-10-25 2000-10-24 Lécivo k lécbe maligních nádoru
DK00973329T DK1224172T3 (da) 1999-10-25 2000-10-24 Medikamenter til behandling af ondartede tumorer
YUP-232/02A RS51019B (sr) 1999-10-25 2000-10-24 Lekovi za lečenje malignih tumora
NZ518296A NZ518296A (en) 1999-10-25 2000-10-24 N-phenyl-1,2-dihydro-2-oxo-quinoline-3-carboxamide derivatives and their use in the treatment of breast and prostatic cancer
JP2001533112A JP3950337B2 (ja) 1999-10-25 2000-10-24 悪性腫瘍治療薬
EEP200200207A EE200200207A (et) 1999-10-25 2000-10-24 Kinoliiniderivaatide kasutamine vähivastase ravimi valmistamiseks, ühendite saamine ning neid sisaldavad farmatseutilised kompositsioonid
PL354540A PL199781B1 (pl) 1999-10-25 2000-10-24 Nowe związki pochodne chinoliny, zastosowanie związków pochodnych chinoliny, zawierające je kompozycje farmaceutyczne i sposób ich wytwarzania
AT00973329T ATE358668T1 (de) 1999-10-25 2000-10-24 Drogen zur behandlung maligner tumoren
IL148782A IL148782A (en) 1999-10-25 2002-03-20 Drugs for the treatment of malignant tissues
IS6329A IS2750B (is) 1999-10-25 2002-04-02 Leiðarafesting
NO20021932A NO323320B1 (no) 1999-10-25 2002-04-24 Medikament egnet til behandling av ondartede tumorer

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16140799P 1999-10-25 1999-10-25
SE9903838A SE9903838D0 (sv) 1999-10-25 1999-10-25 Novel compounds
US21281600P 2000-06-21 2000-06-21
SE0002320A SE0002320D0 (sv) 1999-10-25 2000-06-21 Malignant tumors
PCT/SE2000/002055 WO2001030758A1 (en) 1999-10-25 2000-10-24 Drugs for the treatment of malignant tumours

Publications (1)

Publication Number Publication Date
SE0002320D0 true SE0002320D0 (sv) 2000-06-21

Family

ID=27484521

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0002320A SE0002320D0 (sv) 1999-10-25 2000-06-21 Malignant tumors

Country Status (21)

Country Link
EP (1) EP1224172B1 (cs)
JP (1) JP3950337B2 (cs)
KR (2) KR100597938B1 (cs)
AT (1) ATE358668T1 (cs)
AU (1) AU775057B2 (cs)
CA (1) CA2386775C (cs)
CZ (1) CZ298534B6 (cs)
DE (1) DE60034240T2 (cs)
DK (1) DK1224172T3 (cs)
EE (1) EE200200207A (cs)
ES (1) ES2280258T3 (cs)
HK (1) HK1049830A1 (cs)
HR (1) HRP20020353A2 (cs)
HU (1) HU229072B1 (cs)
IL (2) IL148782A0 (cs)
IS (1) IS2750B (cs)
NO (1) NO323320B1 (cs)
NZ (1) NZ518296A (cs)
SE (1) SE0002320D0 (cs)
UA (1) UA73748C2 (cs)
WO (1) WO2001030758A1 (cs)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
SE0400235D0 (sv) 2004-02-06 2004-02-06 Active Biotech Ab New composition containing quinoline compounds
US8314124B2 (en) 2004-02-06 2012-11-20 Active Biotech Ab Crystalline salts of quinoline compounds and methods for preparing them
SE0401578D0 (sv) * 2004-06-18 2004-06-18 Active Biotech Ab Novel compounds
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
SI2489659T1 (en) 2004-06-24 2018-04-30 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
RS53666B1 (en) 2005-10-19 2015-04-30 Teva Pharmaceutical Industries Ltd CRYSTALS OF SODIUM LAKVINIMOD AND THE PROCESS FOR OBTAINING THEM
LT1993360T (lt) 2005-12-28 2017-06-12 Vertex Pharmaceuticals Incorporated N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma
AR061348A1 (es) 2006-06-12 2008-08-20 Teva Pharma Preparados estables de laquinimod
KR100916160B1 (ko) * 2007-02-21 2009-09-08 (주)바이오버드 약제학적 항암 조성물
EP2065380A1 (en) * 2007-08-22 2009-06-03 F.Hoffmann-La Roche Ag Pyridoneamide derivatives as focal adhesion kinase (FAK) inhibitors and their use for the treatment of cancer
EP2977049A1 (en) 2007-12-20 2016-01-27 Teva Pharmaceutical Industries, Ltd. Stable laquinimod preparations
KR20110048571A (ko) 2008-09-03 2011-05-11 테바 파마슈티컬 인더스트리즈 리미티드 면역 기능을 지닌 ２―옥소―１,２―다이하이드로―퀴놀린 조절제
SG10201504084QA (en) 2009-03-20 2015-06-29 Vertex Pharma Process for making modulators of cystic fibrosis transmembrane conductance regulator
EP2627638B1 (en) * 2010-10-14 2017-07-12 Immunahr AB 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides as ahr activators.
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
EP2537517A1 (en) * 2011-06-22 2012-12-26 Active Biotech AB Deuterium-enriched 4-hydroxy-5-methoxy-n,1-dimethyl-2-oxo-n-[(4-trifluoro-methyl)phenyl]-1,2-dihydroquinoline-3-carboxamide
AU2013226076B2 (en) 2012-02-27 2017-11-16 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administration thereof
EA201590788A1 (ru) * 2012-11-07 2015-12-30 Тева Фармасьютикал Индастриз Лтд. Аминные соли лахинимода
PE20151935A1 (es) 2013-03-14 2016-01-15 Teva Pharma Cristales de laquinimod sodico y proceso mejorado para la elaboracion de los mismos
EA030948B1 (ru) * 2014-09-23 2018-10-31 Эктив Байотек Аб Хинолинкарбоксамиды для применения в лечении множественной миеломы
MX370450B (es) 2014-10-07 2019-12-13 Vertex Pharma Co-cristales de moduladores de regulador de conductancia de transmembrana en fibrosis quistica.
CA2967112C (en) * 2014-11-19 2023-05-16 Active Biotech Ab Quinoline carboxamides for use in the treatment of leukemia
EP3695839A4 (en) 2017-10-13 2021-07-14 ONO Pharmaceutical Co., Ltd. THERAPEUTIC AGENT FOR SOLID CANCERS, WHICH CONTAINS AN AXL INHIBITOR AS AN ACTIVE SUBSTANCE
CN119523983A (zh) * 2019-11-28 2025-02-28 拜耳公司 作为免疫活化的DGKα抑制剂的取代的氨基喹诺酮
CN115209881A (zh) 2020-03-03 2022-10-18 活跃生物技术有限公司 用于组合疗法的他喹莫德或其药学上可接受的盐
BR112022023448A2 (pt) * 2020-05-21 2023-01-31 Stemsynergy Therapeutics Inc Inibidores de notch e usos dos mesmos
US20240091215A1 (en) 2021-01-18 2024-03-21 Active Biotech Ab Tasquinimod or a pharmaceutically acceptable salt thereof for use in the treatment of myelodysplastic syndrome
BR112023023715A2 (pt) 2021-05-25 2024-02-20 Active Biotech Ab Pluralidade de partículas compreendendo tasquinimod, composição farmacêutica, unidade de dosagem farmacêutica, uso da pluralidade de partículas ou da composição farmacêutica, e, método para o tratamento do câncer
AU2022303084A1 (en) 2021-07-02 2024-01-25 Active Biotech Ab A pharmaceutical product containing tasquinimod and a method for assessing the purity of said product
AR126963A1 (es) 2021-09-13 2023-12-06 Lilly Co Eli Agonistas de ahr
TWI838849B (zh) * 2021-09-13 2024-04-11 美商美國禮來大藥廠 Ahr促效劑

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52670B1 (en) * 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
GB9108547D0 (en) * 1991-04-22 1991-06-05 Fujisawa Pharmaceutical Co Quinoline derivatives
GB9404378D0 (en) * 1994-03-07 1994-04-20 Fujisawa Pharmaceutical Co Quinoline derivatives
GB2290786A (en) * 1994-06-30 1996-01-10 Fujisawa Pharmaceutical Co Quinoline derivatives
SE9801474D0 (sv) * 1998-04-27 1998-04-27 Active Biotech Ab Quinoline Derivatives
SE9802550D0 (sv) * 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
SE9802549D0 (sv) * 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
US6121287A (en) * 1998-07-15 2000-09-19 Active Biotech Ab Quinoline derivatives

Also Published As

Publication number Publication date
EP1224172B1 (en) 2007-04-04
AU1185101A (en) 2001-05-08
JP2003512454A (ja) 2003-04-02
IL148782A (en) 2007-05-15
AU775057B2 (en) 2004-07-15
WO2001030758A1 (en) 2001-05-03
HUP0203238A2 (hu) 2003-01-28
DK1224172T3 (da) 2007-08-13
KR100597938B1 (ko) 2006-07-06
EP1224172A1 (en) 2002-07-24
KR20020043646A (ko) 2002-06-10
ES2280258T3 (es) 2007-09-16
DE60034240T2 (de) 2007-12-20
NO20021932D0 (no) 2002-04-24
CA2386775A1 (en) 2001-05-03
NZ518296A (en) 2003-06-30
IL148782A0 (en) 2002-09-12
ATE358668T1 (de) 2007-04-15
HRP20020353A2 (en) 2005-10-31
CZ298534B6 (cs) 2007-10-31
HUP0203238A3 (en) 2003-05-28
HU229072B1 (en) 2013-07-29
KR100674160B1 (ko) 2007-01-24
IS6329A (is) 2002-04-02
CA2386775C (en) 2004-07-13
IS2750B (is) 2011-08-15
CZ20021293A3 (cs) 2002-07-17
UA73748C2 (en) 2005-09-15
NO20021932L (no) 2002-06-21
JP3950337B2 (ja) 2007-08-01
HK1049830A1 (zh) 2003-05-30
EE200200207A (et) 2003-06-16
DE60034240D1 (de) 2007-05-16
KR20060054496A (ko) 2006-05-22
NO323320B1 (no) 2007-03-12

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