SA519410598B1 - طريقة علاج أو تخفيف الاضطرابات الأيضية باستخدام بروتينات الربط لمستقبل ببتيد التثبيط المعوي في توليفة مع مساعدات بولي بيبتيدات شبيه بالجلوكاجون-1 - Google Patents
طريقة علاج أو تخفيف الاضطرابات الأيضية باستخدام بروتينات الربط لمستقبل ببتيد التثبيط المعوي في توليفة مع مساعدات بولي بيبتيدات شبيه بالجلوكاجون-1 Download PDFInfo
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- SA519410598B1 SA519410598B1 SA519410598A SA519410598A SA519410598B1 SA 519410598 B1 SA519410598 B1 SA 519410598B1 SA 519410598 A SA519410598 A SA 519410598A SA 519410598 A SA519410598 A SA 519410598A SA 519410598 B1 SA519410598 B1 SA 519410598B1
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- antibody
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- binding protein
- glp
- antigen binding
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
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| US201762522559P | 2017-06-20 | 2017-06-20 | |
| PCT/US2018/038638 WO2018237097A1 (en) | 2017-06-20 | 2018-06-20 | METHOD OF TREATING OR REDUCING METABOLIC DISORDERS USING GASTRIC INHIBITING PEPTIDE RECEPTOR BINDING PROTEINS (GIPR) IN ASSOCIATION WITH GLP-1 AGONISTS |
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| MY197023A (en) | 2015-12-23 | 2023-05-22 | Amgen Inc | Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists |
| JOP20190177A1 (ar) | 2017-01-17 | 2019-07-16 | Amgen Inc | طريقة لعلاج أو تحسين اضطرابات أيضية باستخدام مساعدات مستقبل glp-1 مقترنة بمناهضات لمستقبل ببتيد مثبط معوي (gipr) |
| MX2019013919A (es) | 2017-06-20 | 2020-01-21 | Amgen Inc | Metodo para tratar o mejorar trastornos metabolicos con proteinas de union para el receptor peptidico inhibidor gastrico (gipr) en combinacion con agonistas de glp-1. |
| EP3642238A1 (en) | 2017-06-21 | 2020-04-29 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using antagonistic binding proteins for gastric inhibitory peptide receptor (gipr)/glp-1 receptor agonist fusion proteins |
| CN112521501A (zh) * | 2019-09-18 | 2021-03-19 | 鸿运华宁(杭州)生物医药有限公司 | Gipr抗体及其与glp-1的融合蛋白质,以及其药物组合物和应用 |
| WO2021202013A1 (en) * | 2020-03-30 | 2021-10-07 | Crystal Bioscience Inc. | Anti-gipr antibody and methods of use thereof |
| JP2024522376A (ja) * | 2021-06-09 | 2024-06-18 | スウィフトノボ セラピューティックス インコーポレイテッド | 代謝障害を治療又は改善するための治療薬及び方法 |
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2018
- 2018-06-20 MX MX2019013919A patent/MX2019013919A/es unknown
- 2018-06-20 WO PCT/US2018/038638 patent/WO2018237097A1/en not_active Ceased
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- 2018-06-20 BR BR112019024410-7A patent/BR112019024410A2/pt unknown
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- 2018-06-20 EA EA201992502A patent/EA201992502A1/ru unknown
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2024
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| JP2025060834A (ja) | 2025-04-10 |
| JP2023071835A (ja) | 2023-05-23 |
| CN110831969B (zh) | 2024-06-21 |
| WO2018237097A1 (en) | 2018-12-27 |
| CN110831969A (zh) | 2020-02-21 |
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| CR20190532A (es) | 2020-01-10 |
| AU2018288854B2 (en) | 2025-06-26 |
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| AU2018288854A1 (en) | 2019-11-21 |
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| US20210087286A1 (en) | 2021-03-25 |
| KR20200019122A (ko) | 2020-02-21 |
| JP7237853B2 (ja) | 2023-03-13 |
| PE20200013A1 (es) | 2020-01-06 |
| PH12019502603A1 (en) | 2020-07-13 |
| ZA201907259B (en) | 2021-08-25 |
| CO2019013008A2 (es) | 2020-01-17 |
| CL2019003332A1 (es) | 2020-03-20 |
| US12435149B2 (en) | 2025-10-07 |
| BR112019024410A2 (pt) | 2020-07-14 |
| CA3062194A1 (en) | 2018-12-27 |
| EP3642239A1 (en) | 2020-04-29 |
| MA49460A (fr) | 2020-04-29 |
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