RU99123047A - Производное 2-аминопропан-1,3-диола, его фармацевтическое применение и промежуточные продукты для их синтеза - Google Patents
Производное 2-аминопропан-1,3-диола, его фармацевтическое применение и промежуточные продукты для их синтезаInfo
- Publication number
- RU99123047A RU99123047A RU99123047/04A RU99123047A RU99123047A RU 99123047 A RU99123047 A RU 99123047A RU 99123047/04 A RU99123047/04 A RU 99123047/04A RU 99123047 A RU99123047 A RU 99123047A RU 99123047 A RU99123047 A RU 99123047A
- Authority
- RU
- Russia
- Prior art keywords
- derivative
- diol
- pharmaceutical composition
- protected
- amino
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 230000002194 synthesizing Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000011780 sodium chloride Substances 0.000 claims 5
- KJJPLEZQSCZCKE-UHFFFAOYSA-N 2-aminopropane-1,3-diol Chemical compound OCC(N)CO KJJPLEZQSCZCKE-UHFFFAOYSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- FLBPTSOAFRMSPF-UHFFFAOYSA-N 1-[4-[3-amino-4-hydroxy-3-(hydroxymethyl)butyl]phenyl]-5-phenylpentan-1-one Chemical compound C1=CC(CCC(CO)(CO)N)=CC=C1C(=O)CCCCC1=CC=CC=C1 FLBPTSOAFRMSPF-UHFFFAOYSA-N 0.000 claims 1
- PWHWQOHDEMCBQY-UHFFFAOYSA-N 2-amino-2-[2-[4-(1-hydroxy-5-phenylpentyl)phenyl]ethyl]propane-1,3-diol Chemical compound C1=CC(CCC(CO)(CO)N)=CC=C1C(O)CCCCC1=CC=CC=C1 PWHWQOHDEMCBQY-UHFFFAOYSA-N 0.000 claims 1
- ORIXTHOKZDJHBB-UHFFFAOYSA-N 4-[3-amino-4-hydroxy-3-(hydroxymethyl)butyl]benzaldehyde Chemical compound OCC(N)(CO)CCC1=CC=C(C=O)C=C1 ORIXTHOKZDJHBB-UHFFFAOYSA-N 0.000 claims 1
- 206010003816 Autoimmune disease Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 201000005794 allergic hypersensitivity disease Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 230000001861 immunosuppresant Effects 0.000 claims 1
- 230000001506 immunosuppresive Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
Claims (9)
1. Производное 2-аминопропан-1,3-диола общей формулы
где R1, R2, R3 и R4 одинаковы или различны, и каждый обозначает водород или ацил; его фармацевтически приемлемая соль добавления кислоты или гидрат.
где R1, R2, R3 и R4 одинаковы или различны, и каждый обозначает водород или ацил; его фармацевтически приемлемая соль добавления кислоты или гидрат.
2. Производное 2-аминопропан-1,3-диола по п. 1, которое представляет собой 2-амино-2-(2-(4-(1-оксo-5-фенилпентил)-фенил)этил)пропан-1,3-диол, его фармацевтически приемлемую соль добавления кислоты или гидрат.
3. Фармацевтическая композиция, обладающая иммуносупрессивной активностью, содержащая в качестве активного ингредиента производное 2-аминопропан-1,3-диола по п.1 или 2, его фармацевтически приемлемую соль добавления кислоты или гидрат и фармацевтически приемлемый разбавитель или носитель.
4. Фармацевтическая композиция по п.3, являющаяся иммуносупрессантом.
5. Фармацевтическая композиция по п.3, являющаяся суппресантом отторжения.
6. Фармацевтическая композиция по п.3, являющаяся средством для профилактики или лечения заболеваний "трансплантат против хозяина".
7. Фармацевтическая композиция по п.3, являющаяся средством для профилактики или лечения аутоиммунных заболеваний или аллергических заболеваний.
8. 2-Амино-2-(2-(4-(1-гидрокси-5-фенилпентил)фенил)-этил)пропан-1,3-диол, его производное, где аминогруппа и/или гидроксигруппа защищены/защищена, или их соль.
9. 2-Амино-2-(2-(4-формилфенил)этил)пропан-1,3-диол, его производное, где аминогруппа и/или гидроксигруппа защищены/защищена, или их соль.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9/86255 | 1997-04-04 | ||
| JP8625597 | 1997-04-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU99123047A true RU99123047A (ru) | 2001-09-27 |
| RU2198162C2 RU2198162C2 (ru) | 2003-02-10 |
Family
ID=13881722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU99123047/04A RU2198162C2 (ru) | 1997-04-04 | 1998-04-03 | Производное 2-аминопропан-1,3-диола, его фармацевтическое применение и промежуточные продукты для их синтеза |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6214873B1 (ru) |
| EP (2) | EP1002792B1 (ru) |
| JP (1) | JP4045364B2 (ru) |
| KR (1) | KR100551931B1 (ru) |
| CN (2) | CN1137086C (ru) |
| AT (2) | ATE271028T1 (ru) |
| AU (1) | AU735853B2 (ru) |
| BR (1) | BR9808481A (ru) |
| CA (1) | CA2286315C (ru) |
| DE (2) | DE69825056T2 (ru) |
| DK (2) | DK1002792T3 (ru) |
| ES (2) | ES2240868T3 (ru) |
| IL (3) | IL155066A (ru) |
| NZ (1) | NZ500713A (ru) |
| PT (2) | PT1002792E (ru) |
| RU (1) | RU2198162C2 (ru) |
| SI (2) | SI1002792T1 (ru) |
| WO (1) | WO1998045249A1 (ru) |
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| AU2011205050B2 (en) * | 2003-04-08 | 2014-01-30 | Mitsubishi Tanabe Pharma Corporation | Solid pharmaceutical compositions comprising a S1P receptor agonist and a sugar alcohol |
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| KR101339976B1 (ko) * | 2006-08-08 | 2013-12-10 | 교린 세이야꾸 가부시키 가이샤 | 아미노인산에스테르 유도체 및 그들을 유효성분으로 하는 ｓ1ｐ 수용체 조절제 |
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| CN110862409B (zh) * | 2019-12-04 | 2021-08-20 | 江南大学 | 一种制备含二元醇结构的硅烷类化合物及其改性水性聚氨酯的方法 |
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| US3660488A (en) | 1965-07-16 | 1972-05-02 | Phillips Petroleum Co | 2-halo-alkylene- and -cyclopentylene-2-amino-propane 1 3-diols |
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1998
- 1998-04-03 AU AU65230/98A patent/AU735853B2/en not_active Ceased
- 1998-04-03 RU RU99123047/04A patent/RU2198162C2/ru not_active IP Right Cessation
- 1998-04-03 SI SI9830698T patent/SI1002792T1/xx unknown
- 1998-04-03 WO PCT/JP1998/001571 patent/WO1998045249A1/ja active IP Right Grant
- 1998-04-03 IL IL15506698A patent/IL155066A/en not_active IP Right Cessation
- 1998-04-03 BR BR9808481-0A patent/BR9808481A/pt active Search and Examination
- 1998-04-03 DE DE69825056T patent/DE69825056T2/de not_active Expired - Lifetime
- 1998-04-03 US US09/402,375 patent/US6214873B1/en not_active Ceased
- 1998-04-03 EP EP98911211A patent/EP1002792B1/en not_active Expired - Lifetime
- 1998-04-03 KR KR1019997009082A patent/KR100551931B1/ko not_active IP Right Cessation
- 1998-04-03 IL IL13220898A patent/IL132208A/xx not_active IP Right Cessation
- 1998-04-03 CA CA002286315A patent/CA2286315C/en not_active Expired - Fee Related
- 1998-04-03 DK DK98911211T patent/DK1002792T3/da active
- 1998-04-03 AT AT98911211T patent/ATE271028T1/de active
- 1998-04-03 US US10/410,387 patent/USRE39072E1/en not_active Expired - Lifetime
- 1998-04-03 ES ES03003623T patent/ES2240868T3/es not_active Expired - Lifetime
- 1998-04-03 SI SI9830785T patent/SI1319651T1/xx unknown
- 1998-04-03 DK DK03003623T patent/DK1319651T3/da active
- 1998-04-03 IL IL15506598A patent/IL155065A/en not_active IP Right Cessation
- 1998-04-03 ES ES98911211T patent/ES2226110T3/es not_active Expired - Lifetime
- 1998-04-03 JP JP54259298A patent/JP4045364B2/ja not_active Expired - Fee Related
- 1998-04-03 NZ NZ500713A patent/NZ500713A/xx not_active IP Right Cessation
- 1998-04-03 PT PT98911211T patent/PT1002792E/pt unknown
- 1998-04-03 DE DE69830756T patent/DE69830756T2/de not_active Expired - Lifetime
- 1998-04-03 AT AT03003623T patent/ATE298740T1/de active
- 1998-04-03 CN CNB988058804A patent/CN1137086C/zh not_active Expired - Fee Related
- 1998-04-03 EP EP03003623A patent/EP1319651B1/en not_active Expired - Lifetime
- 1998-04-03 PT PT03003623T patent/PT1319651E/pt unknown
- 1998-04-03 CN CNB03136893XA patent/CN1290819C/zh not_active Expired - Fee Related
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