DK1002792T3 - 2-aminopropan-1,3-diolforbindelser, medicinsk anvendelse deraf og mellemprodukter til syntese af disse - Google Patents
2-aminopropan-1,3-diolforbindelser, medicinsk anvendelse deraf og mellemprodukter til syntese af disseInfo
- Publication number
- DK1002792T3 DK1002792T3 DK98911211T DK98911211T DK1002792T3 DK 1002792 T3 DK1002792 T3 DK 1002792T3 DK 98911211 T DK98911211 T DK 98911211T DK 98911211 T DK98911211 T DK 98911211T DK 1002792 T3 DK1002792 T3 DK 1002792T3
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- aminopropane
- intermediates
- synthesis
- drug
- Prior art date
Links
- KJJPLEZQSCZCKE-UHFFFAOYSA-N 2-aminopropane-1,3-diol Chemical class OCC(N)CO KJJPLEZQSCZCKE-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 238000010322 bone marrow transplantation Methods 0.000 abstract 1
- 239000003937 drug carrier Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/16—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same carbon atom of an acyclic carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/34—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton and at least one hydroxy group bound to another carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C223/00—Compounds containing amino and —CHO groups bound to the same carbon skeleton
- C07C223/02—Compounds containing amino and —CHO groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8625597 | 1997-04-04 | ||
| PCT/JP1998/001571 WO1998045249A1 (fr) | 1997-04-04 | 1998-04-03 | Composes 2-aminopropane-1,3-diol, leur utilisation pharmaceutique, et intermediaires servant a leur synthese |
| EP98911211A EP1002792B1 (en) | 1997-04-04 | 1998-04-03 | 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1002792T3 true DK1002792T3 (da) | 2004-11-22 |
Family
ID=13881722
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03003623T DK1319651T3 (da) | 1997-04-04 | 1998-04-03 | 2-aminopropan-1,3-diolforbindelser, medicinsk anvendelse deraf og mellemprodukter til syntese af disse |
| DK98911211T DK1002792T3 (da) | 1997-04-04 | 1998-04-03 | 2-aminopropan-1,3-diolforbindelser, medicinsk anvendelse deraf og mellemprodukter til syntese af disse |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03003623T DK1319651T3 (da) | 1997-04-04 | 1998-04-03 | 2-aminopropan-1,3-diolforbindelser, medicinsk anvendelse deraf og mellemprodukter til syntese af disse |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | USRE39072E1 (da) |
| EP (2) | EP1319651B1 (da) |
| JP (1) | JP4045364B2 (da) |
| KR (1) | KR100551931B1 (da) |
| CN (2) | CN1137086C (da) |
| AT (2) | ATE271028T1 (da) |
| AU (1) | AU735853B2 (da) |
| BR (1) | BR9808481A (da) |
| CA (1) | CA2286315C (da) |
| DE (2) | DE69830756T2 (da) |
| DK (2) | DK1319651T3 (da) |
| ES (2) | ES2240868T3 (da) |
| IL (3) | IL155065A (da) |
| NZ (1) | NZ500713A (da) |
| PT (2) | PT1002792E (da) |
| RU (1) | RU2198162C2 (da) |
| SI (2) | SI1002792T1 (da) |
| WO (1) | WO1998045249A1 (da) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6861442B1 (en) * | 1998-12-30 | 2005-03-01 | Sugen, Inc. | PYK2 and inflammation |
| US6515117B2 (en) * | 1999-10-12 | 2003-02-04 | Bristol-Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
| EP1300405B1 (en) | 2000-07-13 | 2007-04-18 | Sankyo Company, Limited | Amino alcohol derivatives |
| US7169818B2 (en) | 2000-10-03 | 2007-01-30 | University Of Virginia Patent Foundation | Lysophosphatidic acid receptor agonists and antagonists |
| US6534693B2 (en) * | 2000-11-06 | 2003-03-18 | Afmedica, Inc. | Surgically implanted devices having reduced scar tissue formation |
| US20040241211A9 (en) * | 2000-11-06 | 2004-12-02 | Fischell Robert E. | Devices and methods for reducing scar tissue formation |
| WO2002064616A2 (en) | 2001-01-30 | 2002-08-22 | University Of Virgina Patent Foundation | Agonists and antagonists of sphingosine-1-phosphate receptors |
| US20040087662A1 (en) * | 2001-02-22 | 2004-05-06 | Marc Bigaud | Use of accelerated lymphocyte homing agents for the manufacture of a medicament for the treatment of delayed graft function |
| US20030072717A1 (en) * | 2001-02-23 | 2003-04-17 | Vapotronics, Inc. | Inhalation device having an optimized air flow path |
| ATE314383T1 (de) * | 2001-03-26 | 2006-01-15 | Novartis Pharma Gmbh | 2-amino-propanol derivate |
| ES2268044T3 (es) * | 2001-05-21 | 2007-03-16 | Injet Digital Aerosols Limited | Composiciones para la administracion de proteinas por la via pulmonar. |
| GB0117921D0 (en) * | 2001-07-23 | 2001-09-12 | Novartis Ag | Organic compounds |
| DE60223699T2 (de) | 2001-09-27 | 2008-10-30 | Kyorin Pharmaceutical Co., Ltd. | Diarylsulfidderivat, dessen additionssalz und immunsuppressivum |
| US6963012B2 (en) | 2001-09-27 | 2005-11-08 | Kyorin Pharmaceutical Co., Ltd. | Diaryl ether derivative, addition salt thereof, and immunosuppressant |
| GB0125443D0 (en) | 2001-10-23 | 2001-12-12 | Novartis Ag | Organic Compounds |
| BR0306811A (pt) | 2002-01-11 | 2004-10-26 | Sankyo Co | Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero |
| US6797722B2 (en) * | 2002-05-03 | 2004-09-28 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases |
| CA2483594C (en) * | 2002-05-16 | 2011-02-15 | Novartis Ag | Use of edg receptor binding agents in cancer |
| GB0217152D0 (en) | 2002-07-24 | 2002-09-04 | Novartis Ag | Organic compounds |
| EP1539674A1 (en) * | 2002-09-13 | 2005-06-15 | Novartis AG | Amino-propanol derivatives |
| US20060046979A1 (en) * | 2002-09-24 | 2006-03-02 | Foster Carolyn A | Organic compounds |
| PL2316431T3 (pl) * | 2003-04-08 | 2016-09-30 | Kompozycja w postaci stałego preparatu do stosowania doustnego obejmująca agonistę receptora S1P i alkohol cukrowy | |
| AU2011205050B2 (en) * | 2003-04-08 | 2014-01-30 | Mitsubishi Tanabe Pharma Corporation | Solid pharmaceutical compositions comprising a S1P receptor agonist and a sugar alcohol |
| AU2008200368B2 (en) * | 2003-04-08 | 2011-04-28 | Mitsubishi Tanabe Pharma Corporation | Solid pharmaceutical compositions comprising a S1P receptor agonist and a sugar alcohol |
| BRPI0410025A (pt) | 2003-04-30 | 2006-04-25 | Novartis Ag | derivados de amino-propanol como modulador do receptor de esfingosina-1-fosfato |
| MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
| EP1484057A1 (en) * | 2003-06-06 | 2004-12-08 | Aventis Pharma Deutschland GmbH | Use of 2-amino-1-3-propanediol derivatives for the manufacture of a medicament for the treatment of various types of pain |
| US7524887B2 (en) | 2003-06-06 | 2009-04-28 | Sanofi-Aventis Deutschland Gmbh | 2-amino-1,3-propanediol compounds for the treatment of acute pain |
| US20040265238A1 (en) * | 2003-06-27 | 2004-12-30 | Imtiaz Chaudry | Inhalable formulations for treating pulmonary hypertension and methods of using same |
| GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
| GB0324210D0 (en) | 2003-10-15 | 2003-11-19 | Novartis Ag | Organic compounds |
| GB0329498D0 (en) | 2003-12-19 | 2004-01-28 | Novartis Ag | Organic compounds |
| GB0500020D0 (en) | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
| AU2005215320B2 (en) | 2004-02-24 | 2008-04-17 | Sankyo Company, Limited | Amino alcohol compound |
| CA2563569A1 (en) * | 2004-05-03 | 2005-11-10 | Novartis Ag | Combinations comprising a s1p receptor agonist and a jak3 kinase inhibitor |
| EP1750722A4 (en) | 2004-05-06 | 2010-03-10 | Univ Virginia | NEW LYSOPHOSPHIC ACID RECEPTORSELECTIVE ANTAGONISTS |
| GB0411929D0 (en) * | 2004-05-27 | 2004-06-30 | Novartis Ag | Organic compounds |
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| EP1772145B1 (en) | 2004-07-16 | 2011-03-23 | Kyorin Pharmaceutical Co., Ltd. | Method of effectively using medicine and method concerning prevention of side effect |
| JP4919374B2 (ja) * | 2004-07-29 | 2012-04-18 | 第一三共株式会社 | 免疫抑制剤としての医薬組成物 |
| TW200611687A (en) * | 2004-07-29 | 2006-04-16 | Sankyo Co | Pharmaceutical compositions used for immunosuppressant |
| MX2007001236A (es) | 2004-07-30 | 2007-03-23 | Novartis Ag | Formulaciones de compuestos de 2-amino-1, 3-propanodiol. |
| US7241812B2 (en) * | 2004-08-13 | 2007-07-10 | Praecis Pharmaceuticals, Inc. | Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity |
| US20060223866A1 (en) * | 2004-08-13 | 2006-10-05 | Praecis Pharmaceuticals, Inc. | Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity |
| JP4792400B2 (ja) * | 2004-10-12 | 2011-10-12 | 杏林製薬株式会社 | ２−アミノ−２−［２−［４−（３−ベンジルオキシフェニルチオ）−２−クロロフェニル］エチル］−１，３−プロパンジオール塩酸塩又はその水和物の製造方法及びその製造中間体 |
| EP2384749A1 (en) | 2004-11-29 | 2011-11-09 | Novartis AG | Dosage regimen of an S1P receptor agonist |
| WO2006086361A2 (en) * | 2005-02-08 | 2006-08-17 | Novartis Ag | ANTILYMPHOCYTE ANTIBODY INDUCTION BY COMBINATION OF AN SlP RECEPTOR AGONIST/MODULATOR AND OF IMMUNOSUPPRESSIVE DRUGS |
| GB0504544D0 (en) | 2005-03-04 | 2005-04-13 | Novartis Ag | Organic compounds |
| TW200702326A (en) * | 2005-05-31 | 2007-01-16 | Mitsubishi Pharma Corp | 2-aminobutanol compound and its pharmaceutical use |
| TWI418350B (zh) * | 2005-06-24 | 2013-12-11 | Sankyo Co | 含有ｐｐａｒ調節劑之醫藥組成物的用途 |
| GT200600350A (es) * | 2005-08-09 | 2007-03-28 | Formulaciones líquidas | |
| WO2007043433A1 (ja) * | 2005-10-07 | 2007-04-19 | Kyorin Pharmaceutical Co., Ltd. | ２－アミノ－１，３－プロパンジオール誘導体を有効成分とする肝臓疾患治療剤および肝臓疾患治療方法 |
| TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| KR101059593B1 (ko) | 2006-04-11 | 2011-08-25 | 노파르티스 아게 | Ｈｃｖ/ｈｉｖ 억제제 및 이들의 용도 |
| GB0612721D0 (en) | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
| TW200815600A (en) | 2006-08-04 | 2008-04-01 | Daiichi Sankyo Co Ltd | An enzyme for phosphorizing a medicine |
| TWI396677B (zh) * | 2006-08-08 | 2013-05-21 | Kyorin Seiyaku Kk | An amine alcohol derivative and an immunosuppressive agent for use as an active ingredient |
| DK2058317T3 (da) * | 2006-08-08 | 2014-01-06 | Kyorin Seiyaku Kk | Aminophosphorsyreesterderivat og S1P receptormodulator indeholdende samme som aktiv ingrediens |
| AU2007302296A1 (en) | 2006-09-26 | 2008-04-03 | Novartis Ag | Pharmaceutical compositions comprising an S1P modulator |
| US20080261986A1 (en) * | 2007-03-30 | 2008-10-23 | Friden Phillip M | Pharmaceutical formulations for iontophoretic delivery of an anti-fungal drug |
| TWI439263B (zh) | 2007-06-14 | 2014-06-01 | Mitsubishi Tanabe Pharma Corp | 胺化合物及其醫藥用途 |
| DE102007039954A1 (de) * | 2007-08-23 | 2009-02-26 | Henkel Ag & Co. Kgaa | Reduktive Entfärbung keratinhaltiger Fasern |
| CA2699788C (en) | 2007-10-12 | 2016-06-14 | Novartis Ag | Compositions comprising sphingosine 1 phosphate (s1p) receptor modulators |
| US8476305B2 (en) | 2008-02-07 | 2013-07-02 | Kyorin Pharmaceutical Co., Ltd. | Therapeutic agent or prophylactic agent for inflammatory bowel disease comprising amino alcohol derivative as active ingredient |
| US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
| US20110182850A1 (en) | 2009-04-10 | 2011-07-28 | Trixi Brandl | Organic compounds and their uses |
| BR112013008510A2 (pt) | 2010-10-08 | 2016-07-05 | Novartis Ag | vitamina e formulações de inibidores de sulfamida ns3 |
| AR085749A1 (es) | 2011-04-01 | 2013-10-23 | Novartis Ag | Formulaciones |
| ES2665336T3 (es) | 2012-04-23 | 2018-04-25 | Mitsubishi Tanabe Pharma Corporation | Compuesto amina y su uso para propósitos médicos |
| CN110862409B (zh) * | 2019-12-04 | 2021-08-20 | 江南大学 | 一种制备含二元醇结构的硅烷类化合物及其改性水性聚氨酯的方法 |
| US20220153684A1 (en) * | 2020-11-13 | 2022-05-19 | Shivalik Rasayan Limited | Process for preparation of fingolimod hydrochloride |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3660488A (en) | 1965-07-16 | 1972-05-02 | Phillips Petroleum Co | 2-halo-alkylene- and -cyclopentylene-2-amino-propane 1 3-diols |
| ES2126658T3 (es) | 1992-10-21 | 1999-04-01 | Yoshitomi Pharmaceutical | Compuesto de 2-amino-1,3-propanodiol e inmunosupresor. |
| PT778263E (pt) * | 1994-08-22 | 2002-06-28 | Mitsubishi Pharma Corp | Composto de benzeno e sua utilizacao farmaceutica |
-
1998
- 1998-04-03 EP EP03003623A patent/EP1319651B1/en not_active Expired - Lifetime
- 1998-04-03 DE DE69830756T patent/DE69830756T2/de not_active Expired - Lifetime
- 1998-04-03 IL IL15506598A patent/IL155065A/en not_active IP Right Cessation
- 1998-04-03 EP EP98911211A patent/EP1002792B1/en not_active Expired - Lifetime
- 1998-04-03 PT PT98911211T patent/PT1002792E/pt unknown
- 1998-04-03 JP JP54259298A patent/JP4045364B2/ja not_active Expired - Fee Related
- 1998-04-03 DK DK03003623T patent/DK1319651T3/da active
- 1998-04-03 IL IL15506698A patent/IL155066A/en not_active IP Right Cessation
- 1998-04-03 SI SI9830698T patent/SI1002792T1/xx unknown
- 1998-04-03 PT PT03003623T patent/PT1319651E/pt unknown
- 1998-04-03 US US10/410,387 patent/USRE39072E1/en not_active Expired - Lifetime
- 1998-04-03 WO PCT/JP1998/001571 patent/WO1998045249A1/ja active IP Right Grant
- 1998-04-03 IL IL13220898A patent/IL132208A/xx not_active IP Right Cessation
- 1998-04-03 CN CNB988058804A patent/CN1137086C/zh not_active Expired - Fee Related
- 1998-04-03 CA CA002286315A patent/CA2286315C/en not_active Expired - Fee Related
- 1998-04-03 ES ES03003623T patent/ES2240868T3/es not_active Expired - Lifetime
- 1998-04-03 ES ES98911211T patent/ES2226110T3/es not_active Expired - Lifetime
- 1998-04-03 SI SI9830785T patent/SI1319651T1/xx unknown
- 1998-04-03 BR BR9808481-0A patent/BR9808481A/pt active Search and Examination
- 1998-04-03 CN CNB03136893XA patent/CN1290819C/zh not_active Expired - Fee Related
- 1998-04-03 DE DE69825056T patent/DE69825056T2/de not_active Expired - Lifetime
- 1998-04-03 AU AU65230/98A patent/AU735853B2/en not_active Ceased
- 1998-04-03 KR KR1019997009082A patent/KR100551931B1/ko not_active IP Right Cessation
- 1998-04-03 AT AT98911211T patent/ATE271028T1/de active
- 1998-04-03 RU RU99123047/04A patent/RU2198162C2/ru not_active IP Right Cessation
- 1998-04-03 AT AT03003623T patent/ATE298740T1/de active
- 1998-04-03 US US09/402,375 patent/US6214873B1/en not_active Ceased
- 1998-04-03 NZ NZ500713A patent/NZ500713A/xx not_active IP Right Cessation
- 1998-04-03 DK DK98911211T patent/DK1002792T3/da active
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