RU98100755A - Соединения нейроактивных стероидов из рядов андростана и прегнана, фармацевтический препарат, содержащий указанное соединение, способ модулирования комплекса рецептор гамка - хлоридный ионофор на животном объекте, способы лечения или профилактики стресса или состояния тревоги, судорожной активности, бессонницы, предменструального синдрома или послеродовой депрессии, нарушений настроения у животного объекта, способ индукции сна и поддержания значительно уровня rem-сна, способ индукции анестезии у животного объекта - Google Patents
Соединения нейроактивных стероидов из рядов андростана и прегнана, фармацевтический препарат, содержащий указанное соединение, способ модулирования комплекса рецептор гамка - хлоридный ионофор на животном объекте, способы лечения или профилактики стресса или состояния тревоги, судорожной активности, бессонницы, предменструального синдрома или послеродовой депрессии, нарушений настроения у животного объекта, способ индукции сна и поддержания значительно уровня rem-сна, способ индукции анестезии у животного объектаInfo
- Publication number
- RU98100755A RU98100755A RU98100755/04A RU98100755A RU98100755A RU 98100755 A RU98100755 A RU 98100755A RU 98100755/04 A RU98100755/04 A RU 98100755/04A RU 98100755 A RU98100755 A RU 98100755A RU 98100755 A RU98100755 A RU 98100755A
- Authority
- RU
- Russia
- Prior art keywords
- sleep
- induction
- animal object
- methods
- pregnane
- Prior art date
Links
- 230000001939 inductive effect Effects 0.000 title 2
- QZLYKIGBANMMBK-UGCZWRCOSA-N 5α-Androstane Chemical compound C([C@@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CCC[C@@]2(C)CC1 QZLYKIGBANMMBK-UGCZWRCOSA-N 0.000 title 1
- JWMFYGXQPXQEEM-NUNROCCHSA-N 5β-pregnane Chemical compound C([C@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](CC)[C@@]2(C)CC1 JWMFYGXQPXQEEM-NUNROCCHSA-N 0.000 title 1
- 206010002091 Anaesthesia Diseases 0.000 title 1
- 206010002855 Anxiety Diseases 0.000 title 1
- 206010057666 Anxiety disease Diseases 0.000 title 1
- 206010010904 Convulsion Diseases 0.000 title 1
- 206010022437 Insomnia Diseases 0.000 title 1
- 241001465754 Metazoa Species 0.000 title 1
- 206010036618 Premenstrual syndrome Diseases 0.000 title 1
- 206010039911 Seizure Diseases 0.000 title 1
- 230000037005 anaesthesia Effects 0.000 title 1
- 230000036506 anxiety Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000002555 ionophore Substances 0.000 title 1
- 230000000236 ionophoric Effects 0.000 title 1
- 230000000051 modifying Effects 0.000 title 1
- 201000008895 mood disease Diseases 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 201000009916 postpartum depression Diseases 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
Claims (1)
- nnnnnnnnn
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46740495A | 1995-06-06 | 1995-06-06 | |
US08/467,404 | 1995-06-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU98100755A true RU98100755A (ru) | 1999-09-20 |
RU2194712C2 RU2194712C2 (ru) | 2002-12-20 |
Family
ID=23855552
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU98100755/04A RU2194712C2 (ru) | 1995-06-06 | 1996-06-06 | НЕЙРОАКТИВНЫЕ СТЕРОИДЫ, ФАРМАЦЕВТИЧЕСКИЙ ПРЕПАРАТ, СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ РАЗЛИЧНЫХ НАРУШЕНИЙ, СПОСОБ ИНДУКЦИИ СНА И СПОСОБ ИНДУКЦИИ АНЕСТЕЗИИ С ИХ ИСПОЛЬЗОВАНИЕМ, СПОСОБ МОДУЛИРОВАНИЯ КОМПЛЕКСА РЕЦЕПТОР ГАМКa-ХЛОРИДНЫЙ ИОНОФОР |
Country Status (23)
Country | Link |
---|---|
US (1) | US5925630A (ru) |
EP (2) | EP1288220A3 (ru) |
JP (1) | JP4145350B2 (ru) |
KR (1) | KR19990022323A (ru) |
CN (1) | CN1190404A (ru) |
AT (1) | ATE284895T1 (ru) |
AU (1) | AU725214B2 (ru) |
BR (1) | BR9608592A (ru) |
CA (1) | CA2223996A1 (ru) |
CZ (1) | CZ394197A3 (ru) |
DE (1) | DE69634039T2 (ru) |
ES (1) | ES2235187T3 (ru) |
FI (1) | FI974448A (ru) |
GE (1) | GEP20012530B (ru) |
HU (1) | HUP9901138A3 (ru) |
IL (1) | IL122348A0 (ru) |
NO (1) | NO311805B1 (ru) |
NZ (1) | NZ310850A (ru) |
PL (1) | PL185523B1 (ru) |
PT (1) | PT837874E (ru) |
RU (1) | RU2194712C2 (ru) |
UA (1) | UA57706C2 (ru) |
WO (1) | WO1996040043A2 (ru) |
Families Citing this family (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070129282A1 (en) * | 1998-11-24 | 2007-06-07 | Ahlem Clarence N | Pharmaceutical treatments and compositions |
WO2000050034A1 (en) * | 1999-02-24 | 2000-08-31 | The Regents Of The University Of California | Gaba receptors mediate inhibition of t cell responses |
WO2000066614A1 (en) * | 1999-04-29 | 2000-11-09 | Purdue Pharma Ltd. | 3α-HYDROXY-3β METHOXYMETHYL-21-HETEROCYCLE SUBSTITUTED STEROIDS WITH ANESTHETIC ACTIVITY |
EP1449846A1 (en) * | 1999-04-29 | 2004-08-25 | Euro-Celtique S.A. | 3-alpha Hydroxy-3-beta methoxymethyl-21-heterocycle substituted steriods with anaesthetic activity |
CA2670236C (en) * | 1999-09-30 | 2012-06-05 | Hollis-Eden Pharmaceuticals, Inc. | Therapeutic treatment of androgen receptor driven conditions |
GB2363984A (en) * | 2000-06-29 | 2002-01-16 | Hunter Fleming Ltd | Protection against neuronal damage using 3-hydroxy-7 -hydroxy steroids and 3-oxo-7 -hydroxy steroids |
GB2363983A (en) | 2000-06-29 | 2002-01-16 | Hunter Fleming Ltd | Protection against neuronal damage using 7-hydroxyepiandrosterone |
US20020072509A1 (en) * | 2000-10-11 | 2002-06-13 | Stein Donald Gerald | Methods for the treatment of a traumatic central nervous system injury |
AR031473A1 (es) * | 2000-11-20 | 2003-09-24 | Lundbeck & Co As H | Intensificadores de gaba en el tratamiento de enfermedades relacionadas con una reducida actividad neuroesteroide |
GR1003861B (el) * | 2000-12-29 | 2002-04-11 | Νεα νευροστεροειδη που αλληλεπιδρουν με τον υποδοχεα gabaa. | |
EP2135611A1 (en) | 2001-03-01 | 2009-12-23 | Hollis-Eden Pharmaceuticals Inc. | Pregn-5-en-20-yne-3,7,17-triol derivatives for use in therapy |
US8569275B2 (en) | 2002-08-28 | 2013-10-29 | Harbor Therapeutics, Inc. | Steroids having 7-oxgen and 17-heteroaryl substitution |
EP1615944A4 (en) * | 2003-04-01 | 2010-08-11 | Harbor Biosciences Inc | ANTI-ORANGE PROBLEMS WITH MARGINAL AGONIST EFFECT AND METHOD OF USE |
US7795266B2 (en) * | 2003-09-25 | 2010-09-14 | Helton David R | Tetrahydroindolone derivatives for treament of neurological conditions |
US20050107439A1 (en) * | 2003-11-10 | 2005-05-19 | Helton David R. | Composition and method for treating emesis |
WO2006012563A2 (en) * | 2004-07-23 | 2006-02-02 | The Regents Of The University Of California | Method for the treatment and diagnosis of certain psychiatric disorders related to the menstrual cycle |
CA2582231A1 (en) | 2004-09-29 | 2006-10-19 | Hollis-Eden Pharmaceuticals, Inc. | Steroid analogs and uses |
US20060211667A1 (en) * | 2005-03-21 | 2006-09-21 | Eric Marchewitz | Use of pregnane steroid derivatives for enhancing physical performance |
EP1868614B1 (en) * | 2005-03-24 | 2012-08-08 | Emory University | Dosage regimen for the treatment of a traumatic brain injury with progesterone |
US7473687B2 (en) * | 2005-03-24 | 2009-01-06 | Emory University | Methods for the treatment of a traumatic central nervous system injury |
EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
CA2625210A1 (en) * | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
MX2009002496A (es) | 2006-09-08 | 2009-07-10 | Braincells Inc | Combinaciones que contienen un derivado de 4-acilaminopiridina. |
PL2097437T3 (pl) * | 2006-11-21 | 2015-12-31 | Umecrine Cognition Ab | Zastosowanie steroidów pregnanowych i androstanowych do wytwarzania kompozycji farmaceutycznej do leczenia zaburzeń OUN |
US20100204192A1 (en) | 2007-06-11 | 2010-08-12 | University Of Sourthern California | Agents, compositions and methods for enhancing neurological function |
WO2008154579A1 (en) * | 2007-06-11 | 2008-12-18 | University Of Southern California | Allopregnanolone in a method for enhancing neurological function (alzheimer disease) |
WO2009062134A1 (en) * | 2007-11-09 | 2009-05-14 | Cenomed Biosciences, Llc | Treatment of post-traumatic stress disorder with tetrahydroindolone arylpiperazine compounds |
US20090264443A1 (en) * | 2008-04-18 | 2009-10-22 | David Helton | Treatment of organophosphate exposure with tetrahydroindolone arylpiperazine compounds |
CN101585862B (zh) * | 2008-05-20 | 2014-12-17 | 梅克芳股份公司 | 甾族化合物 |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
WO2012050907A2 (en) | 2010-09-28 | 2012-04-19 | The Regents Of The University Of California | Gaba agonists in the treatment of disorders associated with metabolic syndrome and gaba combinations in treatment or prophylaxis of type i diabetes |
WO2012116290A2 (en) | 2011-02-25 | 2012-08-30 | Washington University | Neuroactive 17(20)-z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same |
WO2013019711A2 (en) * | 2011-07-29 | 2013-02-07 | The Regents Of The University Of California | NOVEL 17β-HETEROARYL-SUBSTITUTED STEROIDS AS MODULATORS OF GABAA RECEPTORS |
CN107936076B (zh) * | 2011-09-08 | 2021-10-15 | 萨奇治疗股份有限公司 | 神经活性类固醇、组合物、及其用途 |
CA3152410A1 (en) * | 2011-10-14 | 2013-04-18 | Sage Therapeutics, Inc. | 3,3-disubstituted 19-nor pregnane compounds, compositions, and uses thereof for the treatment of cns related disorders |
LT2806877T (lt) | 2012-01-23 | 2019-12-10 | Sage Therapeutics Inc | Neuroaktyvios steroidų kompozicijos, apimančios alopregnanolono ir sulfobutilo eterio beta-ciklodekstrino kompleksą |
US20130281418A1 (en) * | 2012-04-23 | 2013-10-24 | Eric D. Marchewitz | Use of hydroxypregnenolone derivatives for enhancing health and physical performance |
CN102816198A (zh) * | 2012-09-08 | 2012-12-12 | 广西师范学院 | 具有氨衍生物支链结构的3-羟基-5-烯甾体化合物制备方法及其在抗肿瘤药物中的应用 |
CN102924554B (zh) * | 2012-10-29 | 2015-07-22 | 中国科学院昆明植物研究所 | C-3,11,12,20-四取代c-21甾体类衍生物及其药物组合物和其在医药中的应用 |
EP2925327B1 (en) | 2012-11-30 | 2024-01-10 | The Regents of The University of California | Allopregnanolone for treating, reducing or mitigating symptoms of post-partum depression |
MX365644B (es) * | 2012-12-18 | 2019-06-10 | Univ Washington | Esteroides neuroactivos sustituidos con 19-alcoxi-17, profarmacos de los mismos, y metodos de tratamiento usando los mismos. |
US10202413B2 (en) | 2013-02-15 | 2019-02-12 | Washington University | Neuroactive enantiomeric 15-, 16- and 17-substituted steroids as modulators for GABA type-A receptors |
US9512170B2 (en) | 2013-03-01 | 2016-12-06 | Washington University | Neuroactive 13, 17-substituted steroids as modulators for GABA type-A receptors |
US9365502B2 (en) | 2013-03-11 | 2016-06-14 | Washington University | Neuroactive substituted cyclopenta[b]phenanthrenes as modulators for GABA type-A receptors |
WO2014160480A1 (en) | 2013-03-13 | 2014-10-02 | Sage Therapeutics, Inc. | Neuroactive steroids and methods of use thereof |
US9562026B2 (en) | 2013-03-14 | 2017-02-07 | Washington University | Neuroactive substituted cyclopent[a]anthracenes as modulators for GABA type-A receptors |
CN112110976B (zh) | 2013-04-17 | 2023-08-29 | 萨奇治疗股份有限公司 | 刺激神经活性的19-去甲类固醇及其使用方法 |
US9725481B2 (en) | 2013-04-17 | 2017-08-08 | Sage Therapeutics, Inc. | 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof |
CN113527400A (zh) | 2013-04-17 | 2021-10-22 | 萨奇治疗股份有限公司 | 19-去甲c3,3-二取代的c21-n-吡唑基类固醇及其使用方法 |
US20160068563A1 (en) | 2013-04-17 | 2016-03-10 | Boyd L. Harrison | 19-nor neuroactive steroids and methods of use thereof |
LT3021852T (lt) | 2013-07-19 | 2021-04-12 | Sage Therapeutics, Inc. | Neuroaktyvūs steroidai, jų kompozicijos ir panaudojimas |
DK3488852T3 (da) | 2013-08-23 | 2021-02-01 | Sage Therapeutics Inc | Neuroaktive steroider, sammensætninger og anvendelser deraf |
WO2015195962A1 (en) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
EP4306114A1 (en) | 2014-06-18 | 2024-01-17 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
WO2016036724A1 (en) | 2014-09-02 | 2016-03-10 | The Texas A&M University System | Method of treating organophosphate intoxication |
ES2808855T3 (es) | 2014-10-16 | 2021-03-02 | Sage Therapeutics Inc | Composiciones y métodos para tratar trastornos del SNC |
TW202235090A (zh) | 2014-10-16 | 2022-09-16 | 美商賽吉醫療公司 | 用於治療中樞神經系統(cns)病症之組合物及方法 |
WO2016082789A1 (en) | 2014-11-27 | 2016-06-02 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
TWI748936B (zh) | 2015-01-12 | 2021-12-11 | 瑞典商優鎂奎認知Ab公司 | 新穎化合物 |
HUE054092T2 (hu) | 2015-01-26 | 2021-08-30 | Sage Therapeutics Inc | Központi idegrendszeri zavarok kezelésére szolgáló kompozíciók és eljárások |
ES2935476T3 (es) | 2015-02-20 | 2023-03-07 | Sage Therapeutics Inc | Esteroides neuroactivos, composiciones y usos de los mismos |
IL305404A (en) | 2015-07-06 | 2023-10-01 | Sage Therapeutics Inc | Oxysterols and methods of using them |
EP4316591A3 (en) | 2015-07-06 | 2024-04-24 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
US11117924B2 (en) | 2015-07-06 | 2021-09-14 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
WO2017156103A1 (en) | 2016-03-08 | 2017-09-14 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
BR112018070123A2 (pt) | 2016-04-01 | 2019-02-05 | Sage Therapeutics Inc | oxiesterós e métodos de uso dos mesmos |
WO2017193046A1 (en) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
CA3029900A1 (en) | 2016-07-07 | 2018-01-11 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
CA3030420A1 (en) | 2016-07-11 | 2018-01-18 | Sage Therapeutics, Inc. | C7, c12, and c16 substituted neuroactive steroids and their methods of use |
IL264129B2 (en) * | 2016-07-11 | 2024-05-01 | Sage Therapeutics Inc | C20, C17 and C21 converted neuroactive steroids and methods of using them |
CN106265685A (zh) * | 2016-09-18 | 2017-01-04 | 南通大学 | 没药甾酮z在制备抗抑郁症药物中的应用 |
EP3519422B1 (en) | 2016-09-30 | 2022-08-31 | Sage Therapeutics, Inc. | C7 substituted oxysterols and these compounds for use as nmda modulators |
CN115181153A (zh) | 2016-10-18 | 2022-10-14 | 萨奇治疗股份有限公司 | 氧甾醇及其使用方法 |
AU2017345399B2 (en) | 2016-10-18 | 2022-02-24 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
WO2019075362A1 (en) * | 2017-10-12 | 2019-04-18 | Sage Therapeutics, Inc. | METHOD OF TREATING CENTRAL NERVOUS SYSTEM DISORDERS WITH NEUROSTEROIDS AND GABAERGIC COMPOUNDS |
MA51568A (fr) | 2018-01-12 | 2021-04-21 | Sage Therapeutics Inc | Composés aza-, oxa et thia-pregnan-20-one-3.alpha.-ol s'utilisant dans le traitement de troubles du système nerveux central |
CN114805462A (zh) * | 2018-02-11 | 2022-07-29 | 江苏豪森药业集团有限公司 | 一种甾族类衍生物调节剂及其制备方法和应用 |
CN110366555B (zh) * | 2018-02-11 | 2021-11-05 | 江苏豪森药业集团有限公司 | 甾族类衍生物调节剂、其制备方法和应用 |
US10562930B1 (en) | 2018-08-31 | 2020-02-18 | Praxis Precision Medicines, Inc. | Salts and crystal forms of GABAA positive allosteric modulator |
WO2020143640A1 (zh) * | 2019-01-08 | 2020-07-16 | 成都康弘药业集团股份有限公司 | 甾体类化合物、用途及其制备方法 |
BR112021024033A2 (pt) * | 2019-05-31 | 2022-02-08 | Sage Therapeutics Inc | Esteroides neuroativos e suas composições |
JP2023518411A (ja) * | 2020-03-18 | 2023-05-01 | セージ セラピューティクス, インコーポレイテッド | 神経刺激性ステロイド及びその使用方法 |
CA3178758A1 (en) * | 2020-05-18 | 2021-11-25 | Shawn K. SINGH | Treatment of adjustment disorders |
RU2739247C1 (ru) * | 2020-09-14 | 2020-12-22 | Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" | Способ получения лекарственного препарата для парентерального применения |
WO2023060067A1 (en) | 2021-10-04 | 2023-04-13 | Marinus Pharmaceuticals, Inc. | Amorphous solid dispersion ganaxolone formulation |
CA3237550A1 (en) | 2021-11-10 | 2023-05-19 | Umecrine Ab | 3.alpha.-substituted 3.beta.-hydroxy 17-oximated androstane compound for modulation of the alpha-3 subtype of the gaba-a receptor |
WO2023083980A1 (en) | 2021-11-10 | 2023-05-19 | Umecrine Ab | Steroid as a modulator of gabaa receptor |
WO2023083979A1 (en) | 2021-11-10 | 2023-05-19 | Umecrine Ab | 3.beta.-hydroxy, 3.alpha.-ethyl steroids for modulation of the alpha-3 subtype of the gaba-a receptor |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1050765B (de) * | 1959-02-19 | Les Laboratoires Fran?ais de Chimiotherapie, Paris | Verfahren zur Herstellung von Testan-3a-ol-ll-on und seinen Estern | |
GB839911A (en) * | 1957-01-29 | 1960-06-29 | Chimiotherapie Lab Franc | Derivatives of etiocholane and the preparation thereof |
US3135744A (en) * | 1961-04-12 | 1964-06-02 | Vismara Francesco Spa | Cycloalkenyl ethers of 17 beta-hydroxy androstanes |
FR1437361A (fr) * | 1962-06-28 | 1966-05-06 | Vismara Francesco Spa | Procédé de préparation de nouveaux éthers alcényliques de 17beta-hydroxy-androstanes |
US3316146A (en) * | 1964-03-30 | 1967-04-25 | Upjohn Co | Method of inducing sedation and muscle relaxation |
GB1376892A (en) * | 1970-11-12 | 1974-12-11 | Glaxo Lab Ltd | 2beta-substituted-3alpha-hydroxysteroids and their esters |
US3943124A (en) * | 1970-12-17 | 1976-03-09 | Gordon Hanley Phillipps | Chemical compounds |
US3953429A (en) * | 1970-12-17 | 1976-04-27 | Glaxo Laboratories Limited | Anaesthetic steroids of the androstance and pregnane series |
US3969345A (en) * | 1970-12-17 | 1976-07-13 | Glaxo Laboratories Limited | 20β,21-Epoxy-3α-hydroxy-5α-pregnanes and derivatives thereof |
GB1380248A (en) * | 1970-12-17 | 1975-01-08 | Glaxo Lab Ltd | 3alpha-hydroxy steroids and esters thereof |
GB1377608A (en) * | 1970-12-17 | 1974-12-18 | Glaxo Lab Ltd | 3alpha-hydroxy or acyloxy pregnene-21-ethers |
GB1409239A (en) * | 1971-11-11 | 1975-10-08 | Glaxo Lab Ltd | Process for the preparation of 3alpha-hydroxy-5alpha-steroids |
GB1432135A (en) * | 1972-05-05 | 1976-04-14 | Glaxo Lab Ltd | 21-substituted pregnanes |
US3959260A (en) * | 1972-05-05 | 1976-05-25 | Glaxo Laboratories Limited | Anaesthetic steroids of the pregnane and 19-norpregnane series having a sulfur-containing group at the 21-position |
GB1436324A (en) * | 1972-05-12 | 1976-05-19 | Glaxo Lab Ltd | Anaesthetic 3alpha-hydroxy pregnanes |
US4192871A (en) * | 1976-01-06 | 1980-03-11 | Glaxo Laboratories Limited | Chemical compounds |
US4197296A (en) * | 1977-03-23 | 1980-04-08 | Glaxo Group Limited | Androstanes |
GB1581235A (en) * | 1977-04-04 | 1980-12-10 | Glaxo Operations Ltd | 11a-amino-3a-hydroxy-steroids |
US4297350A (en) * | 1978-10-10 | 1981-10-27 | The Upjohn Company | Male contraceptive steroids and methods of use |
US5120723A (en) * | 1987-08-25 | 1992-06-09 | University Of Southern California | Method, compositions, and compounds for modulating brain excitability |
US5208227A (en) * | 1987-08-25 | 1993-05-04 | University Of Southern California | Method, compositions, and compounds for modulating brain excitability |
US5319115A (en) * | 1987-08-25 | 1994-06-07 | Cocensys Inc. | Method for making 3α-hydroxy, 3β-substituted-pregnanes |
US5232917A (en) * | 1987-08-25 | 1993-08-03 | University Of Southern California | Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series |
AU698834B2 (en) * | 1993-05-24 | 1998-11-12 | Purdue Pharma Ltd. | Methods and compositions for inducing sleep |
IL112638A (en) * | 1994-02-14 | 2003-10-31 | Cocensys Inc | 3alpha-HYDROXYLATED PREGNANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
CN1171114A (zh) * | 1994-11-23 | 1998-01-21 | 科斯赛斯公司 | 用于γ-氨基丁酸受体的变构调节的雄甾烷和孕甾烷组系 |
-
1996
- 1996-06-06 ES ES96919372T patent/ES2235187T3/es not_active Expired - Lifetime
- 1996-06-06 NZ NZ310850A patent/NZ310850A/xx not_active IP Right Cessation
- 1996-06-06 AT AT96919372T patent/ATE284895T1/de active
- 1996-06-06 JP JP50221097A patent/JP4145350B2/ja not_active Expired - Fee Related
- 1996-06-06 AU AU61725/96A patent/AU725214B2/en not_active Ceased
- 1996-06-06 HU HU9901138A patent/HUP9901138A3/hu unknown
- 1996-06-06 RU RU98100755/04A patent/RU2194712C2/ru not_active IP Right Cessation
- 1996-06-06 US US08/659,192 patent/US5925630A/en not_active Expired - Lifetime
- 1996-06-06 UA UA98010025A patent/UA57706C2/ru unknown
- 1996-06-06 CZ CZ973941A patent/CZ394197A3/cs unknown
- 1996-06-06 EP EP02025321A patent/EP1288220A3/en not_active Ceased
- 1996-06-06 CA CA002223996A patent/CA2223996A1/en not_active Abandoned
- 1996-06-06 DE DE69634039T patent/DE69634039T2/de not_active Expired - Lifetime
- 1996-06-06 PL PL96323718A patent/PL185523B1/pl unknown
- 1996-06-06 WO PCT/US1996/010115 patent/WO1996040043A2/en active IP Right Grant
- 1996-06-06 IL IL12234896A patent/IL122348A0/xx not_active IP Right Cessation
- 1996-06-06 PT PT96919372T patent/PT837874E/pt unknown
- 1996-06-06 KR KR1019970708803A patent/KR19990022323A/ko not_active Application Discontinuation
- 1996-06-06 GE GEAP19964051A patent/GEP20012530B/en unknown
- 1996-06-06 CN CN96195360A patent/CN1190404A/zh active Pending
- 1996-06-06 BR BR9608592A patent/BR9608592A/pt not_active IP Right Cessation
- 1996-06-06 EP EP96919372A patent/EP0837874B1/en not_active Expired - Lifetime
-
1997
- 1997-12-04 NO NO19975608A patent/NO311805B1/no not_active IP Right Cessation
- 1997-12-05 FI FI974448A patent/FI974448A/fi unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU98100755A (ru) | Соединения нейроактивных стероидов из рядов андростана и прегнана, фармацевтический препарат, содержащий указанное соединение, способ модулирования комплекса рецептор гамка - хлоридный ионофор на животном объекте, способы лечения или профилактики стресса или состояния тревоги, судорожной активности, бессонницы, предменструального синдрома или послеродовой депрессии, нарушений настроения у животного объекта, способ индукции сна и поддержания значительно уровня rem-сна, способ индукции анестезии у животного объекта | |
DE69529951D1 (de) | Vorrichtung zur Erkennung und Behandlung obstruktiver Atemwegserkrankungen | |
DE69532740D1 (de) | Vorrichtung zur Erkennung und Behandlung obstruktiver Atemwegserkrankungen | |
DE69636883D1 (de) | Vorrichtung zur Behandlung von Schlafapnoe durch elektrische Stimulation | |
DE69324625D1 (de) | Vorrichtung zur Behandlung von Fettleibigkeit und motorischen Störungen des Magens | |
FR2654286B1 (fr) | Procede de validation instantanee d'actions dans le cadre d'emissions televisees et dispositif de mise en óoeuvre. | |
ATE275383T1 (de) | Oxadisäuren und verwandte verbindungen zur behandlung von hautstörungen | |
DE69829625D1 (de) | Verfahren und Vorrichtung zur Behandlung von Perfluorokohlenstoff | |
DE69526767T2 (de) | Apparat zur synchronen Behandlung von obstruktiver Schlaf-Apnoe | |
DE69312624D1 (de) | Vorrichtung zur unterscheidung von tachykardien und fibrillationen und zur entsprechenden behandlung | |
DE58906894D1 (de) | Einrichtung zur diagnostik und behandlung von nasenerkrankungen. | |
DE69124293D1 (de) | Vorrichtung zur Behandlung von Wirbelsäulenerkrankungen | |
DE69602461T2 (de) | Verfahren und server-rechner zum lastausgleich zwischen den prozessoren des server-rechners | |
NO901326D0 (no) | Distraksjonsinnretning for osteosyntese av korte roerformede ben. | |
DE59602414D1 (de) | MR-Verfahren und MR-Gerät zur Durchführung des Verfahrens | |
DE69726830D1 (de) | Verfahren und Vorrichtung zur plasmachemischen Behandlung von Gasen | |
ZA965938B (en) | Use of MP52 of MP121 for the treatment and prevention of diseases of the nervous system. | |
NO973413D0 (no) | Fremgangsmåte og anordning til styring av et innåndingsapparat for terapi av sövnapnè | |
DE9305147U1 (de) | Trainingsgerät zur Behandlung von an Wahrnehmungsstörungen leidenden Patienten | |
DE69735417D1 (de) | 2,5-dihydroxybenzylsulfonderivate zur behandlung von sexuellen störungen | |
IL119354A0 (en) | Method and device for treatment of the brainstem | |
NO20010390L (no) | Behandling av angstsykdommer | |
NO972655D0 (no) | Emulsjonsdrivstoff og apparat til forbrenning av samme | |
ATE348885T1 (de) | Peptide zur behandlung des systemischen lupus erythematosus | |
DE69507691T2 (de) | Medizinisches entscheidungsunterstützungssystem und vorrichtung zur verabreichung mindestens eines heilmittels |