HUP9901138A3 - Neuroactive steroids of the androstane and pregnane series - Google Patents
Neuroactive steroids of the androstane and pregnane seriesInfo
- Publication number
- HUP9901138A3 HUP9901138A3 HU9901138A HUP9901138A HUP9901138A3 HU P9901138 A3 HUP9901138 A3 HU P9901138A3 HU 9901138 A HU9901138 A HU 9901138A HU P9901138 A HUP9901138 A HU P9901138A HU P9901138 A3 HUP9901138 A3 HU P9901138A3
- Authority
- HU
- Hungary
- Prior art keywords
- androstane
- neuroactive steroids
- pregnane series
- pregnane
- series
- Prior art date
Links
- QZLYKIGBANMMBK-UGCZWRCOSA-N 5α-Androstane Chemical compound C([C@@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CCC[C@@]2(C)CC1 QZLYKIGBANMMBK-UGCZWRCOSA-N 0.000 title 1
- 150000003128 pregnanes Chemical class 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0007—Androstane derivatives not substituted in position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0029—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0055—Estrane derivatives not substituted in position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0077—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46740495A | 1995-06-06 | 1995-06-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9901138A2 HUP9901138A2 (hu) | 1999-07-28 |
| HUP9901138A3 true HUP9901138A3 (en) | 1999-11-29 |
Family
ID=23855552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9901138A HUP9901138A3 (en) | 1995-06-06 | 1996-06-06 | Neuroactive steroids of the androstane and pregnane series |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5925630A (hu) |
| EP (2) | EP0837874B1 (hu) |
| JP (1) | JP4145350B2 (hu) |
| KR (1) | KR19990022323A (hu) |
| CN (1) | CN1190404A (hu) |
| AT (1) | ATE284895T1 (hu) |
| AU (1) | AU725214B2 (hu) |
| BR (1) | BR9608592A (hu) |
| CA (1) | CA2223996A1 (hu) |
| CZ (1) | CZ394197A3 (hu) |
| DE (1) | DE69634039T2 (hu) |
| ES (1) | ES2235187T3 (hu) |
| FI (1) | FI974448A (hu) |
| GE (1) | GEP20012530B (hu) |
| HU (1) | HUP9901138A3 (hu) |
| IL (1) | IL122348A0 (hu) |
| NO (1) | NO311805B1 (hu) |
| NZ (1) | NZ310850A (hu) |
| PL (1) | PL185523B1 (hu) |
| PT (1) | PT837874E (hu) |
| RU (1) | RU2194712C2 (hu) |
| UA (1) | UA57706C2 (hu) |
| WO (1) | WO1996040043A2 (hu) |
Families Citing this family (95)
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| WO2000066614A1 (en) * | 1999-04-29 | 2000-11-09 | Purdue Pharma Ltd. | 3α-HYDROXY-3β METHOXYMETHYL-21-HETEROCYCLE SUBSTITUTED STEROIDS WITH ANESTHETIC ACTIVITY |
| AU7736300A (en) | 1999-09-30 | 2001-04-30 | Hollis-Eden Pharmaceuticals, Inc. | Therapeutic treatment of androgen receptor driven conditions |
| GB2363983A (en) * | 2000-06-29 | 2002-01-16 | Hunter Fleming Ltd | Protection against neuronal damage using 7-hydroxyepiandrosterone |
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| EP4430056A1 (en) | 2021-11-10 | 2024-09-18 | Umecrine AB | 3.beta.-hydroxy, 3.alpha.-ethyl steroids for modulation of the alpha-3 subtype of the gaba-a receptor |
| EP4430057A1 (en) | 2021-11-10 | 2024-09-18 | Umecrine AB | 3.alpha.-substituted 3.beta.-hydroxy 17-oximated androstane compound for modulation of the alpha-3 subtype of the gaba-a receptor |
| WO2023083980A1 (en) | 2021-11-10 | 2023-05-19 | Umecrine Ab | Steroid as a modulator of gabaa receptor |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1050765B (de) * | 1959-02-19 | Les Laboratoires Fran?ais de Chimiotherapie, Paris | Verfahren zur Herstellung von Testan-3a-ol-ll-on und seinen Estern | |
| GB839911A (en) * | 1957-01-29 | 1960-06-29 | Chimiotherapie Lab Franc | Derivatives of etiocholane and the preparation thereof |
| US3135744A (en) * | 1961-04-12 | 1964-06-02 | Vismara Francesco Spa | Cycloalkenyl ethers of 17 beta-hydroxy androstanes |
| FR1437361A (fr) * | 1962-06-28 | 1966-05-06 | Vismara Francesco Spa | Procédé de préparation de nouveaux éthers alcényliques de 17beta-hydroxy-androstanes |
| US3316146A (en) * | 1964-03-30 | 1967-04-25 | Upjohn Co | Method of inducing sedation and muscle relaxation |
| GB1376892A (en) * | 1970-11-12 | 1974-12-11 | Glaxo Lab Ltd | 2beta-substituted-3alpha-hydroxysteroids and their esters |
| US3953429A (en) * | 1970-12-17 | 1976-04-27 | Glaxo Laboratories Limited | Anaesthetic steroids of the androstance and pregnane series |
| GB1377608A (en) * | 1970-12-17 | 1974-12-18 | Glaxo Lab Ltd | 3alpha-hydroxy or acyloxy pregnene-21-ethers |
| US3943124A (en) * | 1970-12-17 | 1976-03-09 | Gordon Hanley Phillipps | Chemical compounds |
| US3969345A (en) * | 1970-12-17 | 1976-07-13 | Glaxo Laboratories Limited | 20β,21-Epoxy-3α-hydroxy-5α-pregnanes and derivatives thereof |
| GB1380248A (en) * | 1970-12-17 | 1975-01-08 | Glaxo Lab Ltd | 3alpha-hydroxy steroids and esters thereof |
| GB1409239A (en) * | 1971-11-11 | 1975-10-08 | Glaxo Lab Ltd | Process for the preparation of 3alpha-hydroxy-5alpha-steroids |
| US3959260A (en) * | 1972-05-05 | 1976-05-25 | Glaxo Laboratories Limited | Anaesthetic steroids of the pregnane and 19-norpregnane series having a sulfur-containing group at the 21-position |
| GB1432135A (en) * | 1972-05-05 | 1976-04-14 | Glaxo Lab Ltd | 21-substituted pregnanes |
| GB1436324A (en) * | 1972-05-12 | 1976-05-19 | Glaxo Lab Ltd | Anaesthetic 3alpha-hydroxy pregnanes |
| US4192871A (en) * | 1976-01-06 | 1980-03-11 | Glaxo Laboratories Limited | Chemical compounds |
| US4197296A (en) * | 1977-03-23 | 1980-04-08 | Glaxo Group Limited | Androstanes |
| GB1581235A (en) * | 1977-04-04 | 1980-12-10 | Glaxo Operations Ltd | 11a-amino-3a-hydroxy-steroids |
| US4297350A (en) * | 1978-10-10 | 1981-10-27 | The Upjohn Company | Male contraceptive steroids and methods of use |
| US5232917A (en) * | 1987-08-25 | 1993-08-03 | University Of Southern California | Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series |
| US5319115A (en) * | 1987-08-25 | 1994-06-07 | Cocensys Inc. | Method for making 3α-hydroxy, 3β-substituted-pregnanes |
| US5208227A (en) * | 1987-08-25 | 1993-05-04 | University Of Southern California | Method, compositions, and compounds for modulating brain excitability |
| US5120723A (en) * | 1987-08-25 | 1992-06-09 | University Of Southern California | Method, compositions, and compounds for modulating brain excitability |
| AU698834B2 (en) * | 1993-05-24 | 1998-11-12 | Purdue Pharma Ltd. | Methods and compositions for inducing sleep |
| IL112638A (en) * | 1994-02-14 | 2003-10-31 | Cocensys Inc | 3alpha-HYDROXYLATED PREGNANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
| CN1171114A (zh) * | 1994-11-23 | 1998-01-21 | 科斯赛斯公司 | 用于γ-氨基丁酸受体的变构调节的雄甾烷和孕甾烷组系 |
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1996
- 1996-06-06 CZ CZ973941A patent/CZ394197A3/cs unknown
- 1996-06-06 NZ NZ310850A patent/NZ310850A/xx not_active IP Right Cessation
- 1996-06-06 WO PCT/US1996/010115 patent/WO1996040043A2/en active IP Right Grant
- 1996-06-06 BR BR9608592A patent/BR9608592A/pt not_active IP Right Cessation
- 1996-06-06 KR KR1019970708803A patent/KR19990022323A/ko not_active Application Discontinuation
- 1996-06-06 EP EP96919372A patent/EP0837874B1/en not_active Expired - Lifetime
- 1996-06-06 DE DE69634039T patent/DE69634039T2/de not_active Expired - Lifetime
- 1996-06-06 AT AT96919372T patent/ATE284895T1/de active
- 1996-06-06 UA UA98010025A patent/UA57706C2/uk unknown
- 1996-06-06 PL PL96323718A patent/PL185523B1/pl unknown
- 1996-06-06 EP EP02025321A patent/EP1288220A3/en not_active Ceased
- 1996-06-06 GE GEAP19964051A patent/GEP20012530B/en unknown
- 1996-06-06 JP JP50221097A patent/JP4145350B2/ja not_active Expired - Fee Related
- 1996-06-06 ES ES96919372T patent/ES2235187T3/es not_active Expired - Lifetime
- 1996-06-06 RU RU98100755/04A patent/RU2194712C2/ru not_active IP Right Cessation
- 1996-06-06 PT PT96919372T patent/PT837874E/pt unknown
- 1996-06-06 AU AU61725/96A patent/AU725214B2/en not_active Ceased
- 1996-06-06 HU HU9901138A patent/HUP9901138A3/hu unknown
- 1996-06-06 CN CN96195360A patent/CN1190404A/zh active Pending
- 1996-06-06 US US08/659,192 patent/US5925630A/en not_active Expired - Lifetime
- 1996-06-06 IL IL12234896A patent/IL122348A0/xx not_active IP Right Cessation
- 1996-06-06 CA CA002223996A patent/CA2223996A1/en not_active Abandoned
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1997
- 1997-12-04 NO NO19975608A patent/NO311805B1/no not_active IP Right Cessation
- 1997-12-05 FI FI974448A patent/FI974448A/fi unknown
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