RU2769470C2 - Рекомбинантные связывающие белки и их применение - Google Patents

Рекомбинантные связывающие белки и их применение Download PDF

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RU2769470C2
RU2769470C2 RU2017134456A RU2017134456A RU2769470C2 RU 2769470 C2 RU2769470 C2 RU 2769470C2 RU 2017134456 A RU2017134456 A RU 2017134456A RU 2017134456 A RU2017134456 A RU 2017134456A RU 2769470 C2 RU2769470 C2 RU 2769470C2
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ala
leu
asp
gly
amino acid
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RU2017134456A3 (cg-RX-API-DMAC7.html
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Талита БАККЕР
Михель Т. ШТУМП
Ханс Каспар БИНЦ
Дуглас ФИЛЛИПС
Игнасио ДОЛАДО
Патрик ФОРРЕР
Фридер В. МЕРЦ
Иво ЗОНДЕРЕГГЕР
Даниль ШТАЙНЕР
Майя ГУЛОТТИ-ДЖОРДЖИЕВА
САЛИБА Йохан АБРАМ
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Молекьюлар Партнерс Аг
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    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Gastroenterology & Hepatology (AREA)
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RU2017134456A 2015-04-02 2016-04-01 Рекомбинантные связывающие белки и их применение RU2769470C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15162502 2015-04-02
EP15162511 2015-04-02
EP15162511.8 2015-04-02
EP15162502.7 2015-04-02
PCT/EP2016/057272 WO2016156596A1 (en) 2015-04-02 2016-04-01 Designed ankyrin repeat domains with binding specificity for serum albumin

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RU2017134456A RU2017134456A (ru) 2019-04-03
RU2017134456A3 RU2017134456A3 (cg-RX-API-DMAC7.html) 2019-10-08
RU2769470C2 true RU2769470C2 (ru) 2022-04-01

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MX393655B (es) 2025-03-24
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US20160362453A1 (en) 2016-12-15
SA517390092B1 (ar) 2022-03-03
IL254788A0 (en) 2017-12-31
AU2021286418A1 (en) 2022-01-20
EP3277711A1 (en) 2018-02-07
AU2016240220A1 (en) 2017-10-19
EP3277711C0 (en) 2023-06-07
JP2018511327A (ja) 2018-04-26
AU2021286418B2 (en) 2024-01-04
US11332501B2 (en) 2022-05-17
KR20170131515A (ko) 2017-11-29
AU2020201264A1 (en) 2020-03-12
ES2953482T3 (es) 2023-11-13
RU2017134456A (ru) 2019-04-03
EP3277711B9 (en) 2023-08-16
PH12017501792B1 (en) 2022-07-20
KR20220109488A (ko) 2022-08-04
MX2017012485A (es) 2018-04-11
MY179505A (en) 2020-11-09
RU2017134456A3 (cg-RX-API-DMAC7.html) 2019-10-08
BR112017020986A2 (pt) 2018-08-14
SG11201707606RA (en) 2017-10-30
IL254788B (en) 2020-09-30
CL2017002454A1 (es) 2018-05-25
US20190263869A1 (en) 2019-08-29
IL276944B (en) 2022-07-01
NZ735803A (en) 2021-12-24
US20160289285A1 (en) 2016-10-06
AU2016240220B2 (en) 2019-11-21
CO2017009954A2 (es) 2018-02-20
US9458211B1 (en) 2016-10-04
MX2022008302A (es) 2023-02-28
IL276944A (en) 2020-10-29
PH12017501792A1 (en) 2019-01-21
JP6552636B2 (ja) 2019-07-31
CA2979602A1 (en) 2016-10-06
HK1244009A1 (en) 2018-07-27
CN107454904A (zh) 2017-12-08
US10155791B2 (en) 2018-12-18
WO2016156596A1 (en) 2016-10-06
KR102427117B1 (ko) 2022-07-29
EP4272838A3 (en) 2024-01-10

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