RU2761667C2 - КОМПОЗИЦИИ НА ОСНОВЕ iRNA SERPINA1 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ - Google Patents

КОМПОЗИЦИИ НА ОСНОВЕ iRNA SERPINA1 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ Download PDF

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RU2761667C2
RU2761667C2 RU2019119242A RU2019119242A RU2761667C2 RU 2761667 C2 RU2761667 C2 RU 2761667C2 RU 2019119242 A RU2019119242 A RU 2019119242A RU 2019119242 A RU2019119242 A RU 2019119242A RU 2761667 C2 RU2761667 C2 RU 2761667C2
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dsrna
antisense strand
nucleotides
serpina1
strand
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RU2019119242A
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Russian (ru)
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RU2019119242A3 (enExample
RU2019119242A (ru
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Марк К. ШЛЕГЕЛЬ
Майя Джанас
Васант Р. ДЖАДХАВ
Дональд Фостер
Мутхиах Манохаран
Каллантхоттатхил Г. РАДЖИВ
Александер В. КЕЛ'ИН
Клаус Хариссе
Джаяпракаш К. НАИР
Мартин А. МАЙЕР
Шигео Мацуда
Мутхусами Джаяраман
Алфика Сехгал
Кристофер Браун
Кевин ФИЦДЖЕРАЛЬД
Стюарт Милстейн
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Элнилэм Фармасьютикалз, Инк.
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RU2019119242A 2016-11-23 2017-11-21 КОМПОЗИЦИИ НА ОСНОВЕ iRNA SERPINA1 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ RU2761667C2 (ru)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201662425907P 2016-11-23 2016-11-23
US62/425,907 2016-11-23
US201762548589P 2017-08-22 2017-08-22
US62/548,589 2017-08-22
US201762549099P 2017-08-23 2017-08-23
US62/549,099 2017-08-23
US201762561514P 2017-09-21 2017-09-21
US62/561,514 2017-09-21
PCT/US2017/062701 WO2018098117A1 (en) 2016-11-23 2017-11-21 SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF

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RU2019119242A3 RU2019119242A3 (enExample) 2021-02-24
RU2761667C2 true RU2761667C2 (ru) 2021-12-13

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RU2021126115A RU2021126115A (ru) 2016-11-23 2017-11-21 КОМПОЗИЦИИ НА ОСНОВЕ iRNA SERPINA1 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ

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TW202313978A (zh) 2016-11-23 2023-04-01 美商阿尼拉製藥公司 絲胺酸蛋白酶抑制因子Ａ１ ｉＲＮＡ組成物及其使用方法
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MX2020009812A (es) * 2018-03-21 2021-01-08 Regeneron Pharma COMPOSICIONES DE ARNI DE 17ß-HIDROXIESTEROIDE DESHIDROGENASA TIPO 13 (HSD17B13) Y MÉTODOS DE USO DE LAS MISMAS.
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WO2021022109A1 (en) * 2019-08-01 2021-02-04 Alnylam Pharmaceuticals, Inc. SERPIN FAMILY F MEMBER 2 (SERPINF2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
KR20230011913A (ko) 2020-03-04 2023-01-25 버브 테라퓨틱스, 인크. 표적화된 rna 전달을 위한 조성물 및 방법
JP2023549505A (ja) * 2020-11-13 2023-11-27 ザ ジョージ ワシントン ユニバーシティ， ア コングレッショナリー チャータード ノット－フォー－プロフィット コーポレイション Ｂ－スペクトリン（ｓｐｔｂｎ１）欠損はマウスを高脂肪食起因性肝疾患及び癌への進展から保護する
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IL315546A (en) * 2022-03-16 2024-11-01 Empirico Inc GALNAC compositions to improve siRNA bioavailability
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AU2023313030A1 (en) * 2022-07-27 2025-01-09 E-Therapeutics Plc Nucleic acid compounds
CN117070583B (zh) * 2023-10-16 2024-05-14 吉林凯莱英制药有限公司 抑制PCSK9基因表达的siRNA的制备方法
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JP7348067B2 (ja) 2023-09-20
JP2020500929A (ja) 2020-01-16
RU2019119242A (ru) 2020-12-25
US11725207B2 (en) 2023-08-15
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