RU2761476C2 - Макроциклические антибиотики широкого спектра действия - Google Patents

Макроциклические антибиотики широкого спектра действия Download PDF

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Publication number
RU2761476C2
RU2761476C2 RU2018122498A RU2018122498A RU2761476C2 RU 2761476 C2 RU2761476 C2 RU 2761476C2 RU 2018122498 A RU2018122498 A RU 2018122498A RU 2018122498 A RU2018122498 A RU 2018122498A RU 2761476 C2 RU2761476 C2 RU 2761476C2
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RU
Russia
Prior art keywords
alkyl
compound
formula
another embodiment
optionally substituted
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RU2018122498A
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English (en)
Russian (ru)
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RU2018122498A3 (cg-RX-API-DMAC7.html
RU2018122498A (ru
Inventor
Юньшэнь ЧЭНЬ
Петер Эндрю Смит
Такер Карран Робертс
Роберт И. Хигучи
Прасуна Параселли
Майкл Ф.Т. КЕЛЕР
Джейкоб Бредли ШВАРЦ
Джеймс Джон Кроуфорд
Куонг Ц. ЛЮ
Хуайонг ХУ
Чжиоюн ЮЙ
Original Assignee
АрКьюИкс ФАРМАСЬЮТИКЭЛС, ИНК.
Дженетек, Инк.
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Publication of RU2018122498A publication Critical patent/RU2018122498A/ru
Publication of RU2018122498A3 publication Critical patent/RU2018122498A3/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
RU2018122498A 2015-11-20 2016-11-21 Макроциклические антибиотики широкого спектра действия RU2761476C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2015/095165 2015-11-20
CNPCT/CN2015/095165 2015-11-20
CNPCT/CN2016/105043 2016-11-08
CNPCT/CN2016/105043 2016-11-08
PCT/CN2016/106597 WO2017084629A1 (en) 2015-11-20 2016-11-21 Macrocyclic broad spectrum antibiotics

Publications (3)

Publication Number Publication Date
RU2018122498A RU2018122498A (ru) 2019-12-26
RU2018122498A3 RU2018122498A3 (cg-RX-API-DMAC7.html) 2020-02-28
RU2761476C2 true RU2761476C2 (ru) 2021-12-08

Family

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Family Applications (1)

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RU2018122498A RU2761476C2 (ru) 2015-11-20 2016-11-21 Макроциклические антибиотики широкого спектра действия

Country Status (12)

Country Link
US (1) US11072635B2 (cg-RX-API-DMAC7.html)
EP (1) EP3377474B1 (cg-RX-API-DMAC7.html)
JP (1) JP6873993B2 (cg-RX-API-DMAC7.html)
KR (1) KR20180109858A (cg-RX-API-DMAC7.html)
CN (1) CN109219596B (cg-RX-API-DMAC7.html)
AU (1) AU2016357926B2 (cg-RX-API-DMAC7.html)
BR (1) BR112018010267A2 (cg-RX-API-DMAC7.html)
CA (1) CA3005551A1 (cg-RX-API-DMAC7.html)
IL (1) IL259429B (cg-RX-API-DMAC7.html)
MX (1) MX387476B (cg-RX-API-DMAC7.html)
RU (1) RU2761476C2 (cg-RX-API-DMAC7.html)
WO (1) WO2017084629A1 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
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US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
EP3145944B1 (en) 2014-05-20 2021-05-05 RQX Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
RU2761476C2 (ru) 2015-11-20 2021-12-08 АрКьюИкс ФАРМАСЬЮТИКЭЛС, ИНК. Макроциклические антибиотики широкого спектра действия
KR102671585B1 (ko) * 2017-02-15 2024-06-04 알큐엑스 파마슈티컬스, 인크. 거대환형 광범위 항생제
MA50664A (fr) * 2017-09-29 2020-08-05 Genentech Inc Complexes d'antibiotiques peptidiques et leurs méthodes d'utilisation
HRP20231497T8 (hr) * 2019-05-28 2024-08-02 F. Hoffmann-La Roche Ag Makrociklični antibiotici širokog spektra

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WO2012166665A2 (en) * 2011-05-27 2012-12-06 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
WO2013138187A1 (en) * 2012-03-14 2013-09-19 The Scripps Research Institute Broad spectrum antibiotic arylomycin analogs
RU2012142832A (ru) * 2010-03-09 2014-04-20 Мерк Шарп Энд Домэ Корп. Мостиковые липогликопептиды, усиливающие активность бета-лактамных антибактериальных агентов
WO2014081886A1 (en) * 2012-11-21 2014-05-30 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics

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TWI725075B (zh) * 2015-11-20 2021-04-21 美商Ｒｑｘ製藥公司 巨環廣效抗生素
KR102671585B1 (ko) 2017-02-15 2024-06-04 알큐엑스 파마슈티컬스, 인크. 거대환형 광범위 항생제
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MA50664A (fr) 2017-09-29 2020-08-05 Genentech Inc Complexes d'antibiotiques peptidiques et leurs méthodes d'utilisation
HRP20231497T8 (hr) 2019-05-28 2024-08-02 F. Hoffmann-La Roche Ag Makrociklični antibiotici širokog spektra

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RU2012142832A (ru) * 2010-03-09 2014-04-20 Мерк Шарп Энд Домэ Корп. Мостиковые липогликопептиды, усиливающие активность бета-лактамных антибактериальных агентов
WO2012166665A2 (en) * 2011-05-27 2012-12-06 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
WO2013138187A1 (en) * 2012-03-14 2013-09-19 The Scripps Research Institute Broad spectrum antibiotic arylomycin analogs
WO2014081886A1 (en) * 2012-11-21 2014-05-30 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics

Also Published As

Publication number Publication date
AU2016357926B2 (en) 2021-05-27
US20200239519A1 (en) 2020-07-30
US11072635B2 (en) 2021-07-27
JP2019501123A (ja) 2019-01-17
EP3377474C0 (en) 2023-08-16
JP6873993B2 (ja) 2021-05-19
CN109219596B (zh) 2022-04-19
KR20180109858A (ko) 2018-10-08
MX2018006199A (es) 2019-01-10
MX387476B (es) 2025-03-18
IL259429A (en) 2018-07-31
BR112018010267A2 (pt) 2018-11-27
AU2016357926A1 (en) 2018-06-14
CA3005551A1 (en) 2017-05-26
RU2018122498A3 (cg-RX-API-DMAC7.html) 2020-02-28
RU2018122498A (ru) 2019-12-26
CN109219596A (zh) 2019-01-15
WO2017084629A1 (en) 2017-05-26
EP3377474B1 (en) 2023-08-16
EP3377474A1 (en) 2018-09-26
IL259429B (en) 2021-12-01

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