BR112018010267A2 - antibióticos macrocíclicos de amplo espectro - Google Patents
antibióticos macrocíclicos de amplo espectroInfo
- Publication number
- BR112018010267A2 BR112018010267A2 BR112018010267A BR112018010267A BR112018010267A2 BR 112018010267 A2 BR112018010267 A2 BR 112018010267A2 BR 112018010267 A BR112018010267 A BR 112018010267A BR 112018010267 A BR112018010267 A BR 112018010267A BR 112018010267 A2 BR112018010267 A2 BR 112018010267A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- broad
- macrocyclic antibiotics
- spectrum
- modalities
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 241000894006 Bacteria Species 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108010087967 type I signal peptidase Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2015/095165 | 2015-11-20 | ||
| CNPCT/CN2016/105043 | 2016-11-08 | ||
| PCT/CN2016/106597 WO2017084629A1 (en) | 2015-11-20 | 2016-11-21 | Macrocyclic broad spectrum antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018010267A2 true BR112018010267A2 (pt) | 2018-11-27 |
Family
ID=58231314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018010267A BR112018010267A2 (pt) | 2015-11-20 | 2016-11-21 | antibióticos macrocíclicos de amplo espectro |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11072635B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3377474B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6873993B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20180109858A (cg-RX-API-DMAC7.html) |
| CN (1) | CN109219596B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016357926B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112018010267A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3005551A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL259429B (cg-RX-API-DMAC7.html) |
| MX (1) | MX387476B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2761476C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017084629A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10501493B2 (en) | 2011-05-27 | 2019-12-10 | Rqx Pharmaceuticals, Inc. | Broad spectrum antibiotics |
| EP3145944B1 (en) | 2014-05-20 | 2021-05-05 | RQX Pharmaceuticals, Inc. | Macrocyclic broad spectrum antibiotics |
| RU2761476C2 (ru) | 2015-11-20 | 2021-12-08 | АрКьюИкс ФАРМАСЬЮТИКЭЛС, ИНК. | Макроциклические антибиотики широкого спектра действия |
| KR102671585B1 (ko) * | 2017-02-15 | 2024-06-04 | 알큐엑스 파마슈티컬스, 인크. | 거대환형 광범위 항생제 |
| MA50664A (fr) * | 2017-09-29 | 2020-08-05 | Genentech Inc | Complexes d'antibiotiques peptidiques et leurs méthodes d'utilisation |
| HRP20231497T8 (hr) * | 2019-05-28 | 2024-08-02 | F. Hoffmann-La Roche Ag | Makrociklični antibiotici širokog spektra |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3128280A (en) | 1959-10-23 | 1964-04-07 | Searle & Co | 1-(alkoxylated/halogenated phenyl)-3-pyridylmethylureas |
| US5204328A (en) | 1990-06-26 | 1993-04-20 | Merck & Co., Inc. | Peptides having atrial natriuretic factor activity |
| JPH11514527A (ja) | 1995-11-03 | 1999-12-14 | イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー | バキルス エスピー（Ｂａｃｉｌｌｕｓ ｓｐ．）用の陽性選択ベクター |
| JP4080541B2 (ja) | 1996-10-18 | 2008-04-23 | バーテックス ファーマシューティカルズ インコーポレイテッド | セリンプロテアーゼ、特にｃ型肝炎ウイルスｎｓ３プロテアーゼの阻害因子 |
| EP0895999A1 (en) | 1997-08-06 | 1999-02-10 | Pfizer Products Inc. | C-4" substituted macrolide antibiotics |
| GB9902399D0 (en) | 1999-02-03 | 1999-03-24 | Smithkline Beecham Plc | Compounds |
| US6660832B1 (en) | 1999-08-20 | 2003-12-09 | Isis Pharmaceuticals, Inc. | Macrocyclic compounds and preparation methods thereof |
| US6951840B2 (en) | 2001-08-31 | 2005-10-04 | Eli Lilly And Company | Lipoglycopeptide antibiotics |
| DE10226921A1 (de) | 2002-06-17 | 2003-12-24 | Bayer Ag | Antibakterielle Amid-Makrozyklen |
| EA010294B1 (ru) | 2003-07-17 | 2008-08-29 | Майджиникс, Инк. | Композиции на основе производных липопептидных антибиотиков и способы их применения |
| DE10358824A1 (de) | 2003-12-16 | 2005-07-21 | Bayer Healthcare Ag | Antibakterielle Makrozyklen mit substituiertem Biphenyl |
| DE102005014247A1 (de) | 2005-03-30 | 2006-10-05 | Aicuris Gmbh & Co. Kg | Antibakterielle Amid-Makrozyklen VI |
| DE102005014245A1 (de) | 2005-03-30 | 2006-10-05 | Aicuris Gmbh & Co. Kg | Antibakterielle Amid-Makrozyklen V |
| CA2791680A1 (en) | 2010-03-01 | 2011-09-09 | Myrexis, Inc. | Compounds and therapeutic uses thereof |
| WO2011112441A1 (en) | 2010-03-09 | 2011-09-15 | Merck Sharp & Dohme Corp. | Bridged lipoglycopeptides that potentiate the activity of beta-lactam antibacterials |
| WO2011120071A1 (en) | 2010-04-01 | 2011-10-06 | The University Of Queensland | Oxytocin peptide analogues |
| WO2012036907A2 (en) | 2010-09-15 | 2012-03-22 | Romesberg Floyd E | Broad spectrum antibiotic arylomycin analogs |
| TWI642684B (zh) | 2011-05-27 | 2018-12-01 | Ｒｑｘ製藥股份有限公司 | 廣效性抗生素 |
| US10501493B2 (en) | 2011-05-27 | 2019-12-10 | Rqx Pharmaceuticals, Inc. | Broad spectrum antibiotics |
| CN103159830B (zh) | 2011-12-15 | 2017-06-20 | 上海来益生物药物研究开发中心有限责任公司 | 脂肽类化合物 |
| FR2986154B1 (fr) | 2012-01-31 | 2017-08-04 | Pierre Fabre Dermo Cosmetique | Nouveau systeme photoprotecteur |
| CN104284664A (zh) * | 2012-03-14 | 2015-01-14 | 斯克里普斯研究所 | 广谱抗生素Arylomycin类似物 |
| CN103788176A (zh) * | 2012-10-31 | 2014-05-14 | 上海来益生物药物研究开发中心有限责任公司 | 一种arylomycin类化合物及其制备方法和应用 |
| BR112015011697A2 (pt) * | 2012-11-21 | 2017-07-11 | Rqx Pharmaceuticals Inc | antibióticos macrocíclicos de amplo espectro |
| EP3145944B1 (en) | 2014-05-20 | 2021-05-05 | RQX Pharmaceuticals, Inc. | Macrocyclic broad spectrum antibiotics |
| ITUB20154591A1 (it) | 2015-10-12 | 2017-04-12 | Crestoptics S R L | Apparato di microscopia confocale e relativo procedimento di acquisizione ed elaborazione di immagini |
| RU2761476C2 (ru) | 2015-11-20 | 2021-12-08 | АрКьюИкс ФАРМАСЬЮТИКЭЛС, ИНК. | Макроциклические антибиотики широкого спектра действия |
| TWI725075B (zh) * | 2015-11-20 | 2021-04-21 | 美商Ｒｑｘ製藥公司 | 巨環廣效抗生素 |
| KR102671585B1 (ko) | 2017-02-15 | 2024-06-04 | 알큐엑스 파마슈티컬스, 인크. | 거대환형 광범위 항생제 |
| ES2892173T3 (es) | 2017-03-27 | 2022-02-02 | Hoffmann La Roche | Procedimiento para fabricar análogos de anillo de arilomicina |
| MA50664A (fr) | 2017-09-29 | 2020-08-05 | Genentech Inc | Complexes d'antibiotiques peptidiques et leurs méthodes d'utilisation |
| HRP20231497T8 (hr) | 2019-05-28 | 2024-08-02 | F. Hoffmann-La Roche Ag | Makrociklični antibiotici širokog spektra |
-
2016
- 2016-11-21 RU RU2018122498A patent/RU2761476C2/ru active
- 2016-11-21 KR KR1020187017097A patent/KR20180109858A/ko not_active Ceased
- 2016-11-21 CN CN201680079520.3A patent/CN109219596B/zh active Active
- 2016-11-21 JP JP2018525573A patent/JP6873993B2/ja active Active
- 2016-11-21 MX MX2018006199A patent/MX387476B/es unknown
- 2016-11-21 EP EP16843251.6A patent/EP3377474B1/en active Active
- 2016-11-21 WO PCT/CN2016/106597 patent/WO2017084629A1/en not_active Ceased
- 2016-11-21 BR BR112018010267A patent/BR112018010267A2/pt not_active Application Discontinuation
- 2016-11-21 CA CA3005551A patent/CA3005551A1/en not_active Abandoned
- 2016-11-21 AU AU2016357926A patent/AU2016357926B2/en not_active Ceased
- 2016-11-21 US US15/777,509 patent/US11072635B2/en active Active
-
2018
- 2018-05-16 IL IL259429A patent/IL259429B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016357926B2 (en) | 2021-05-27 |
| US20200239519A1 (en) | 2020-07-30 |
| US11072635B2 (en) | 2021-07-27 |
| JP2019501123A (ja) | 2019-01-17 |
| EP3377474C0 (en) | 2023-08-16 |
| JP6873993B2 (ja) | 2021-05-19 |
| CN109219596B (zh) | 2022-04-19 |
| KR20180109858A (ko) | 2018-10-08 |
| MX2018006199A (es) | 2019-01-10 |
| MX387476B (es) | 2025-03-18 |
| IL259429A (en) | 2018-07-31 |
| AU2016357926A1 (en) | 2018-06-14 |
| CA3005551A1 (en) | 2017-05-26 |
| RU2018122498A3 (cg-RX-API-DMAC7.html) | 2020-02-28 |
| RU2018122498A (ru) | 2019-12-26 |
| CN109219596A (zh) | 2019-01-15 |
| WO2017084629A1 (en) | 2017-05-26 |
| EP3377474B1 (en) | 2023-08-16 |
| EP3377474A1 (en) | 2018-09-26 |
| RU2761476C2 (ru) | 2021-12-08 |
| IL259429B (en) | 2021-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |