CA3005551A1 - Macrocyclic broad spectrum antibiotics - Google Patents

Macrocyclic broad spectrum antibiotics Download PDF

Info

Publication number
CA3005551A1
CA3005551A1 CA3005551A CA3005551A CA3005551A1 CA 3005551 A1 CA3005551 A1 CA 3005551A1 CA 3005551 A CA3005551 A CA 3005551A CA 3005551 A CA3005551 A CA 3005551A CA 3005551 A1 CA3005551 A1 CA 3005551A1
Authority
CA
Canada
Prior art keywords
compound
alkyl
formula
another embodiment
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3005551A
Other languages
English (en)
French (fr)
Inventor
Yongsheng Chen
Peter Andrew Smith
Tucker Curran Roberts
Robert I. Higuchi
Prasuna PARASELLI
Michael F. T. Koehler
Jacob Bradley Schwarz
James John CRAWFORD
Cuong Q. Ly
Huiyong Hu
Zhiyong Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
RQx Pharmaceuticals Inc
Original Assignee
Genentech Inc
RQx Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, RQx Pharmaceuticals Inc filed Critical Genentech Inc
Publication of CA3005551A1 publication Critical patent/CA3005551A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA3005551A 2015-11-20 2016-11-21 Macrocyclic broad spectrum antibiotics Abandoned CA3005551A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2015/095165 2015-11-20
CNPCT/CN2015/095165 2015-11-20
CNPCT/CN2016/105043 2016-11-08
CNPCT/CN2016/105043 2016-11-08
PCT/CN2016/106597 WO2017084629A1 (en) 2015-11-20 2016-11-21 Macrocyclic broad spectrum antibiotics

Publications (1)

Publication Number Publication Date
CA3005551A1 true CA3005551A1 (en) 2017-05-26

Family

ID=58231314

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3005551A Abandoned CA3005551A1 (en) 2015-11-20 2016-11-21 Macrocyclic broad spectrum antibiotics

Country Status (12)

Country Link
US (1) US11072635B2 (cg-RX-API-DMAC7.html)
EP (1) EP3377474B1 (cg-RX-API-DMAC7.html)
JP (1) JP6873993B2 (cg-RX-API-DMAC7.html)
KR (1) KR20180109858A (cg-RX-API-DMAC7.html)
CN (1) CN109219596B (cg-RX-API-DMAC7.html)
AU (1) AU2016357926B2 (cg-RX-API-DMAC7.html)
BR (1) BR112018010267A2 (cg-RX-API-DMAC7.html)
CA (1) CA3005551A1 (cg-RX-API-DMAC7.html)
IL (1) IL259429B (cg-RX-API-DMAC7.html)
MX (1) MX387476B (cg-RX-API-DMAC7.html)
RU (1) RU2761476C2 (cg-RX-API-DMAC7.html)
WO (1) WO2017084629A1 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
EP3145944B1 (en) 2014-05-20 2021-05-05 RQX Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
RU2761476C2 (ru) 2015-11-20 2021-12-08 АрКьюИкс ФАРМАСЬЮТИКЭЛС, ИНК. Макроциклические антибиотики широкого спектра действия
KR102671585B1 (ko) * 2017-02-15 2024-06-04 알큐엑스 파마슈티컬스, 인크. 거대환형 광범위 항생제
MA50664A (fr) * 2017-09-29 2020-08-05 Genentech Inc Complexes d'antibiotiques peptidiques et leurs méthodes d'utilisation
HRP20231497T8 (hr) * 2019-05-28 2024-08-02 F. Hoffmann-La Roche Ag Makrociklični antibiotici širokog spektra

Family Cites Families (32)

* Cited by examiner, † Cited by third party
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US3128280A (en) 1959-10-23 1964-04-07 Searle & Co 1-(alkoxylated/halogenated phenyl)-3-pyridylmethylureas
US5204328A (en) 1990-06-26 1993-04-20 Merck & Co., Inc. Peptides having atrial natriuretic factor activity
JPH11514527A (ja) 1995-11-03 1999-12-14 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー バキルス エスピー（Ｂａｃｉｌｌｕｓ ｓｐ．）用の陽性選択ベクター
JP4080541B2 (ja) 1996-10-18 2008-04-23 バーテックス ファーマシューティカルズ インコーポレイテッド セリンプロテアーゼ、特にｃ型肝炎ウイルスｎｓ３プロテアーゼの阻害因子
EP0895999A1 (en) 1997-08-06 1999-02-10 Pfizer Products Inc. C-4" substituted macrolide antibiotics
GB9902399D0 (en) 1999-02-03 1999-03-24 Smithkline Beecham Plc Compounds
US6660832B1 (en) 1999-08-20 2003-12-09 Isis Pharmaceuticals, Inc. Macrocyclic compounds and preparation methods thereof
US6951840B2 (en) 2001-08-31 2005-10-04 Eli Lilly And Company Lipoglycopeptide antibiotics
DE10226921A1 (de) 2002-06-17 2003-12-24 Bayer Ag Antibakterielle Amid-Makrozyklen
EA010294B1 (ru) 2003-07-17 2008-08-29 Майджиникс, Инк. Композиции на основе производных липопептидных антибиотиков и способы их применения
DE10358824A1 (de) 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014247A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen VI
DE102005014245A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
CA2791680A1 (en) 2010-03-01 2011-09-09 Myrexis, Inc. Compounds and therapeutic uses thereof
WO2011112441A1 (en) 2010-03-09 2011-09-15 Merck Sharp & Dohme Corp. Bridged lipoglycopeptides that potentiate the activity of beta-lactam antibacterials
WO2011120071A1 (en) 2010-04-01 2011-10-06 The University Of Queensland Oxytocin peptide analogues
WO2012036907A2 (en) 2010-09-15 2012-03-22 Romesberg Floyd E Broad spectrum antibiotic arylomycin analogs
TWI642684B (zh) 2011-05-27 2018-12-01 Ｒｑｘ製藥股份有限公司 廣效性抗生素
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
CN103159830B (zh) 2011-12-15 2017-06-20 上海来益生物药物研究开发中心有限责任公司 脂肽类化合物
FR2986154B1 (fr) 2012-01-31 2017-08-04 Pierre Fabre Dermo Cosmetique Nouveau systeme photoprotecteur
CN104284664A (zh) * 2012-03-14 2015-01-14 斯克里普斯研究所 广谱抗生素Arylomycin类似物
CN103788176A (zh) * 2012-10-31 2014-05-14 上海来益生物药物研究开发中心有限责任公司 一种arylomycin类化合物及其制备方法和应用
BR112015011697A2 (pt) * 2012-11-21 2017-07-11 Rqx Pharmaceuticals Inc antibióticos macrocíclicos de amplo espectro
EP3145944B1 (en) 2014-05-20 2021-05-05 RQX Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
ITUB20154591A1 (it) 2015-10-12 2017-04-12 Crestoptics S R L Apparato di microscopia confocale e relativo procedimento di acquisizione ed elaborazione di immagini
RU2761476C2 (ru) 2015-11-20 2021-12-08 АрКьюИкс ФАРМАСЬЮТИКЭЛС, ИНК. Макроциклические антибиотики широкого спектра действия
TWI725075B (zh) * 2015-11-20 2021-04-21 美商Ｒｑｘ製藥公司 巨環廣效抗生素
KR102671585B1 (ko) 2017-02-15 2024-06-04 알큐엑스 파마슈티컬스, 인크. 거대환형 광범위 항생제
ES2892173T3 (es) 2017-03-27 2022-02-02 Hoffmann La Roche Procedimiento para fabricar análogos de anillo de arilomicina
MA50664A (fr) 2017-09-29 2020-08-05 Genentech Inc Complexes d'antibiotiques peptidiques et leurs méthodes d'utilisation
HRP20231497T8 (hr) 2019-05-28 2024-08-02 F. Hoffmann-La Roche Ag Makrociklični antibiotici širokog spektra

Also Published As

Publication number Publication date
AU2016357926B2 (en) 2021-05-27
US20200239519A1 (en) 2020-07-30
US11072635B2 (en) 2021-07-27
JP2019501123A (ja) 2019-01-17
EP3377474C0 (en) 2023-08-16
JP6873993B2 (ja) 2021-05-19
CN109219596B (zh) 2022-04-19
KR20180109858A (ko) 2018-10-08
MX2018006199A (es) 2019-01-10
MX387476B (es) 2025-03-18
IL259429A (en) 2018-07-31
BR112018010267A2 (pt) 2018-11-27
AU2016357926A1 (en) 2018-06-14
RU2018122498A3 (cg-RX-API-DMAC7.html) 2020-02-28
RU2018122498A (ru) 2019-12-26
CN109219596A (zh) 2019-01-15
WO2017084629A1 (en) 2017-05-26
EP3377474B1 (en) 2023-08-16
EP3377474A1 (en) 2018-09-26
RU2761476C2 (ru) 2021-12-08
IL259429B (en) 2021-12-01

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EEER Examination request

Effective date: 20211119

EEER Examination request

Effective date: 20211119

EEER Examination request

Effective date: 20211119

EEER Examination request

Effective date: 20211119

FZDE Discontinued

Effective date: 20240415