RU2757675C2 - Молекулы новых искусственных нуклеиновых кислот - Google Patents

Молекулы новых искусственных нуклеиновых кислот Download PDF

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RU2757675C2
RU2757675C2 RU2017127203A RU2017127203A RU2757675C2 RU 2757675 C2 RU2757675 C2 RU 2757675C2 RU 2017127203 A RU2017127203 A RU 2017127203A RU 2017127203 A RU2017127203 A RU 2017127203A RU 2757675 C2 RU2757675 C2 RU 2757675C2
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utr
nucleic acid
protein
acid molecule
sequence
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RU2017127203A
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RU2017127203A (ru
RU2017127203A3 (enExample
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Штефани ГРУНД
Томас ШЛАКЕ
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Куревак Аг
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/68—Stabilisation of the vector
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/10—Vectors comprising a special translation-regulating system regulates levels of translation
    • C12N2840/105—Vectors comprising a special translation-regulating system regulates levels of translation enhancing translation

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
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  • Endocrinology (AREA)
  • Obesity (AREA)
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  • Neurology (AREA)
  • Cardiology (AREA)
  • Evolutionary Biology (AREA)
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  • Communicable Diseases (AREA)
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RU2017127203A 2014-12-30 2015-12-29 Молекулы новых искусственных нуклеиновых кислот RU2757675C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2014003479 2014-12-30
EPPCT/EP2014/003479 2014-12-30
PCT/EP2015/081366 WO2016107877A1 (en) 2014-12-30 2015-12-29 Artificial nucleic acid molecules

Publications (3)

Publication Number Publication Date
RU2017127203A RU2017127203A (ru) 2019-02-01
RU2017127203A3 RU2017127203A3 (enExample) 2020-01-10
RU2757675C2 true RU2757675C2 (ru) 2021-10-20

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RU2017127203A RU2757675C2 (ru) 2014-12-30 2015-12-29 Молекулы новых искусственных нуклеиновых кислот

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US (3) US20180148727A1 (enExample)
EP (2) EP3240558A1 (enExample)
JP (2) JP6907116B2 (enExample)
KR (1) KR102580696B1 (enExample)
CN (1) CN107124889A (enExample)
AU (1) AU2015373404B2 (enExample)
BR (1) BR112017009835A2 (enExample)
CA (1) CA2966092A1 (enExample)
MX (1) MX2017008670A (enExample)
RU (1) RU2757675C2 (enExample)
SG (2) SG11201704681QA (enExample)
WO (1) WO2016107877A1 (enExample)

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