CN107124889A - 人工核酸分子 - Google Patents

人工核酸分子 Download PDF

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Publication number
CN107124889A
CN107124889A CN201580070984.3A CN201580070984A CN107124889A CN 107124889 A CN107124889 A CN 107124889A CN 201580070984 A CN201580070984 A CN 201580070984A CN 107124889 A CN107124889 A CN 107124889A
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utr
nucleic acid
acid molecule
gene
protein
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CN201580070984.3A
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Chinese (zh)
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斯缔芬尼·格朗德
托马斯·施拉克
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Curevac SE
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Curevac AG
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/67—General methods for enhancing the expression
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
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    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
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    • C12N2840/00—Vectors comprising a special translation-regulating system
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CN201580070984.3A 2014-12-30 2015-12-29 人工核酸分子 Pending CN107124889A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2014003479 2014-12-30
EPPCT/EP2014/003479 2014-12-30
PCT/EP2015/081366 WO2016107877A1 (en) 2014-12-30 2015-12-29 Artificial nucleic acid molecules

Publications (1)

Publication Number Publication Date
CN107124889A true CN107124889A (zh) 2017-09-01

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CN201580070984.3A Pending CN107124889A (zh) 2014-12-30 2015-12-29 人工核酸分子

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US (3) US20180148727A1 (enExample)
EP (2) EP3240558A1 (enExample)
JP (2) JP6907116B2 (enExample)
KR (1) KR102580696B1 (enExample)
CN (1) CN107124889A (enExample)
AU (1) AU2015373404B2 (enExample)
BR (1) BR112017009835A2 (enExample)
CA (1) CA2966092A1 (enExample)
MX (1) MX2017008670A (enExample)
RU (1) RU2757675C2 (enExample)
SG (2) SG11201704681QA (enExample)
WO (1) WO2016107877A1 (enExample)

Cited By (11)

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Publication number Priority date Publication date Assignee Title
CN108026537A (zh) * 2015-08-28 2018-05-11 库瑞瓦格股份公司 人工核酸分子
CN109985230A (zh) * 2018-01-02 2019-07-09 上海清流生物医药科技有限公司 一种蛋白在制备预防和治疗肾病药物中的应用
CN110699367A (zh) * 2018-07-09 2020-01-17 武汉纽福斯生物科技有限公司 编码人nadh脱氢酶亚单位4蛋白的核酸及其应用
CN111630173A (zh) * 2017-10-19 2020-09-04 库瑞瓦格股份公司 新型人工核酸分子
CN112368382A (zh) * 2018-05-25 2021-02-12 柏业公司 用于预防和治疗纤维化相关疾病和呼吸系统疾病的双调蛋白基因特异性双链寡核苷酸和包含其的组合物
CN112673106A (zh) * 2017-12-21 2021-04-16 贝瑟克里科有限公司 点击修饰的mRNA
CN113302290A (zh) * 2018-11-16 2021-08-24 编码治疗公司 治疗威尔逊氏病的组合物和方法
CN115448982A (zh) * 2021-06-07 2022-12-09 中国农业科学院作物科学研究所 TaRomo1蛋白在调控小麦雄性育性中的应用
WO2024098361A1 (zh) * 2022-11-11 2024-05-16 斯微(上海)生物科技股份有限公司 人工核酸分子
WO2024098360A1 (zh) * 2022-11-11 2024-05-16 斯微(上海)生物科技股份有限公司 人工核酸分子
WO2024213137A1 (zh) * 2023-04-14 2024-10-17 深圳瑞吉生物科技有限公司 提高mRNA翻译蛋白的输出量的核酸及其应用

Families Citing this family (131)

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JP6456305B2 (ja) 2013-02-22 2019-01-23 キュアバック アーゲー ワクチン接種とｐｄ−１経路の阻害との組み合わせ
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CA2984125A1 (en) 2015-04-27 2016-11-03 The Trustees Of The University Of Pennsylvania Nucleoside-modified rna for inducing an adaptive immune response
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