RU2754466C2 - Слитый полипептид с противораковой активностью - Google Patents

Слитый полипептид с противораковой активностью Download PDF

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RU2754466C2
RU2754466C2 RU2017135539A RU2017135539A RU2754466C2 RU 2754466 C2 RU2754466 C2 RU 2754466C2 RU 2017135539 A RU2017135539 A RU 2017135539A RU 2017135539 A RU2017135539 A RU 2017135539A RU 2754466 C2 RU2754466 C2 RU 2754466C2
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RU2017135539A
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RU2017135539A (ru
RU2017135539A3 (enExample
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Марлон ХИННЕР
АЙБА Рачида Сихам БЕЛ
Кристине РОТЕ
Шейн ОЛЬВИЛЛЬ
Коринна ШЛОССЕР
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ПИЕРИС ФАРМАСЬЮТИКАЛС ГмбХ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
RU2017135539A 2015-05-18 2016-05-18 Слитый полипептид с противораковой активностью RU2754466C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15167927 2015-05-18
EP15167927.1 2015-05-18
EP16150508 2016-01-08
EP16150508.6 2016-01-08
PCT/EP2016/061071 WO2016184882A1 (en) 2015-05-18 2016-05-18 Anti-cancer fusion polypeptide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2021119777A Division RU2021119777A (ru) 2015-05-18 2016-05-18 Слитый полипептид, способный связывать cd137 и gpc3, молекула нуклеиновой кислоты, содержащая нуклеотидную последовательность, кодирующую такой слитый полипептид, способ его получения и пути применения

Publications (3)

Publication Number Publication Date
RU2017135539A RU2017135539A (ru) 2019-06-18
RU2017135539A3 RU2017135539A3 (enExample) 2019-11-29
RU2754466C2 true RU2754466C2 (ru) 2021-09-02

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RU2017135539A RU2754466C2 (ru) 2015-05-18 2016-05-18 Слитый полипептид с противораковой активностью
RU2021119777A RU2021119777A (ru) 2015-05-18 2016-05-18 Слитый полипептид, способный связывать cd137 и gpc3, молекула нуклеиновой кислоты, содержащая нуклеотидную последовательность, кодирующую такой слитый полипептид, способ его получения и пути применения

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RU2021119777A RU2021119777A (ru) 2015-05-18 2016-05-18 Слитый полипептид, способный связывать cd137 и gpc3, молекула нуклеиновой кислоты, содержащая нуклеотидную последовательность, кодирующую такой слитый полипептид, способ его получения и пути применения

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US (2) US10913778B2 (enExample)
EP (2) EP4219535A1 (enExample)
JP (1) JP6947642B2 (enExample)
KR (1) KR102685748B1 (enExample)
CN (1) CN108112253B (enExample)
AU (1) AU2016262845B2 (enExample)
CA (1) CA2980838A1 (enExample)
DK (1) DK3298030T5 (enExample)
ES (1) ES2938525T3 (enExample)
FI (1) FI3298030T3 (enExample)
HR (1) HRP20230145T1 (enExample)
HU (1) HUE061108T2 (enExample)
LT (1) LT3298030T (enExample)
MX (1) MX390894B (enExample)
PL (1) PL3298030T3 (enExample)
RS (1) RS64002B1 (enExample)
RU (2) RU2754466C2 (enExample)
SG (1) SG11201707426SA (enExample)
SI (1) SI3298030T1 (enExample)
SM (1) SMT202300026T1 (enExample)
WO (1) WO2016184882A1 (enExample)
ZA (1) ZA201706061B (enExample)

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KR20190099527A (ko) * 2017-01-03 2019-08-27 에프. 호프만-라 로슈 아게 항-4-1bb 클론 20h4.9를 포함하는 이중특이성 항원 결합 분자
JP7267921B2 (ja) 2017-01-06 2023-05-02 クレシェンド・バイオロジックス・リミテッド プログラム細胞死（ｐｄ－１）に対するシングルドメイン抗体
WO2018134279A1 (en) * 2017-01-18 2018-07-26 Pieris Pharmaceuticals Gmbh Novel fusion polypeptides specific for lag-3 and pd-1
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LT3830120T (lt) * 2018-07-31 2023-07-10 Pieris Pharmaceuticals Gmbh Naujas sulietas baltymas specifinis cd137 ir pd-l1 atžvilgiu
IL284687B2 (en) * 2019-02-26 2025-11-01 Pieris Pharmaceuticals Gmbh Novel fusion proteins specific for cd137 and gpc3
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AU2020301161B2 (en) 2019-06-25 2023-10-26 Gilead Sciences, Inc. FLT3L-Fc fusion proteins and methods of use
TWI860386B (zh) * 2019-07-30 2024-11-01 英商拜西可泰克斯有限公司 異質雙環肽複合物
WO2023036043A1 (zh) * 2021-09-09 2023-03-16 广东东阳光药业有限公司 抗癌结合分子及其应用
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Publication number Publication date
AU2016262845A1 (en) 2018-01-04
RU2017135539A (ru) 2019-06-18
PL3298030T3 (pl) 2023-05-08
WO2016184882A1 (en) 2016-11-24
US20210403516A1 (en) 2021-12-30
KR102685748B1 (ko) 2024-07-18
LT3298030T (lt) 2023-02-27
KR20180002855A (ko) 2018-01-08
US20180148485A1 (en) 2018-05-31
CN108112253B (zh) 2022-09-23
MX2017014716A (es) 2018-06-28
HRP20230145T1 (hr) 2023-04-28
HUE061108T2 (hu) 2023-05-28
US10913778B2 (en) 2021-02-09
FI3298030T3 (fi) 2023-02-22
SG11201707426SA (en) 2017-10-30
US11919931B2 (en) 2024-03-05
MX390894B (es) 2025-03-21
BR112017020445A2 (pt) 2018-07-03
RU2017135539A3 (enExample) 2019-11-29
JP2018519803A (ja) 2018-07-26
SI3298030T1 (sl) 2023-05-31
ZA201706061B (en) 2022-05-25
EP3298030B1 (en) 2023-01-18
EP4219535A1 (en) 2023-08-02
CA2980838A1 (en) 2016-11-24
ES2938525T3 (es) 2023-04-12
RU2021119777A (ru) 2021-08-16
AU2016262845B2 (en) 2020-07-23
EP3298030A1 (en) 2018-03-28
DK3298030T3 (en) 2023-02-06
SMT202300026T1 (it) 2023-03-17
RS64002B1 (sr) 2023-03-31
DK3298030T5 (en) 2024-10-07
CN108112253A (zh) 2018-06-01
JP6947642B2 (ja) 2021-10-13

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