HRP20230145T1 - Fuzijski polipeptid protiv raka - Google Patents

Fuzijski polipeptid protiv raka Download PDF

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Publication number
HRP20230145T1
HRP20230145T1 HRP20230145TT HRP20230145T HRP20230145T1 HR P20230145 T1 HRP20230145 T1 HR P20230145T1 HR P20230145T T HRP20230145T T HR P20230145TT HR P20230145 T HRP20230145 T HR P20230145T HR P20230145 T1 HRP20230145 T1 HR P20230145T1
Authority
HR
Croatia
Prior art keywords
fusion protein
seq
amino acid
group
acid sequence
Prior art date
Application number
HRP20230145TT
Other languages
English (en)
Croatian (hr)
Inventor
Marlon HINNER
Rachida Siham Bel Aiba
Christine Rothe
Shane Olwill
Corinna SCHLOSSER
Original Assignee
Pieris Pharmaceuticals Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pieris Pharmaceuticals Gmbh filed Critical Pieris Pharmaceuticals Gmbh
Publication of HRP20230145T1 publication Critical patent/HRP20230145T1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HRP20230145TT 2015-05-18 2016-05-18 Fuzijski polipeptid protiv raka HRP20230145T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP15167927 2015-05-18
EP16150508 2016-01-08
EP16729794.4A EP3298030B1 (en) 2015-05-18 2016-05-18 Anti-cancer fusion polypeptide
PCT/EP2016/061071 WO2016184882A1 (en) 2015-05-18 2016-05-18 Anti-cancer fusion polypeptide

Publications (1)

Publication Number Publication Date
HRP20230145T1 true HRP20230145T1 (hr) 2023-04-28

Family

ID=56134305

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20230145TT HRP20230145T1 (hr) 2015-05-18 2016-05-18 Fuzijski polipeptid protiv raka

Country Status (22)

Country Link
US (2) US10913778B2 (enExample)
EP (2) EP3298030B1 (enExample)
JP (1) JP6947642B2 (enExample)
KR (1) KR102685748B1 (enExample)
CN (1) CN108112253B (enExample)
AU (1) AU2016262845B2 (enExample)
CA (1) CA2980838A1 (enExample)
DK (1) DK3298030T5 (enExample)
ES (1) ES2938525T3 (enExample)
FI (1) FI3298030T3 (enExample)
HR (1) HRP20230145T1 (enExample)
HU (1) HUE061108T2 (enExample)
LT (1) LT3298030T (enExample)
MX (1) MX390894B (enExample)
PL (1) PL3298030T3 (enExample)
RS (1) RS64002B1 (enExample)
RU (2) RU2754466C2 (enExample)
SG (1) SG11201707426SA (enExample)
SI (1) SI3298030T1 (enExample)
SM (1) SMT202300026T1 (enExample)
WO (1) WO2016184882A1 (enExample)
ZA (1) ZA201706061B (enExample)

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KR20180029238A (ko) 2015-07-15 2018-03-20 피어이스 파마슈티컬즈 게엠베하 Lag-3에 특이적인 신규 단백질
AR106188A1 (es) 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización
EP3565843A1 (en) * 2017-01-03 2019-11-13 H. Hoffnabb-La Roche Ag Bispecific antigen binding molecules comprising anti-4-1bb clone 20h4.9
EP3565842A1 (en) 2017-01-06 2019-11-13 Crescendo Biologics Limited Single domain antibodies to programmed cell death (pd-1)
WO2018134279A1 (en) * 2017-01-18 2018-07-26 Pieris Pharmaceuticals Gmbh Novel fusion polypeptides specific for lag-3 and pd-1
WO2018134274A1 (en) 2017-01-18 2018-07-26 Pieris Pharmaceuticals Gmbh Lipocalin muteins with binding affinity for lag-3
JP7312168B2 (ja) * 2017-11-13 2023-07-20 クレッシェンド、バイオロジックス、リミテッド Ｃｄ１３７に結合するシングルドメイン抗体
GB201802573D0 (en) 2018-02-16 2018-04-04 Crescendo Biologics Ltd Therapeutic molecules that bind to LAG3
TW202003462A (zh) 2018-03-26 2020-01-16 德商４Ｓｃ製藥公司 用於癌症療法的包括ｈｄａｃ抑制劑和ｃｄ１３７激動劑之組合
HRP20230590T2 (hr) * 2018-07-31 2024-02-16 Pieris Pharmaceuticals Gmbh Novi fuzijski protein specifičan za cd137 i pd-l1
JP7476219B2 (ja) * 2019-02-26 2024-04-30 ピエリス ファーマシューティカルズ ゲーエムベーハー Ｃｄ１３７およびｇｐｃ３に特異的な新規融合タンパク質
KR20210146999A (ko) * 2019-03-29 2021-12-06 피어이스 파마슈티컬즈 게엠베하 리포칼린 뮤테인의 흡입 투여
EP3952996A1 (en) * 2019-04-12 2022-02-16 F. Hoffmann-La Roche AG Bispecific antigen binding molecules comprising lipocalin muteins
KR20200124176A (ko) * 2019-04-23 2020-11-02 주식회사 엘지화학 면역글로불린의 Fc 영역 및 GDF15를 포함하는 융합 폴리펩타이드
MX2021015452A (es) 2019-06-25 2022-02-11 Gilead Sciences Inc Proteinas de fusion flt3l-fc y metodos de uso.
TWI862640B (zh) * 2019-07-30 2024-11-21 英商拜西可泰克斯有限公司 異質雙環肽複合物
CN115960242B (zh) * 2021-09-09 2023-10-17 广东东阳光药业股份有限公司 抗癌结合分子及其应用
TW202428603A (zh) * 2022-09-21 2024-07-16 美商思進公司 新穎的cd137及cd228特異性融合蛋白

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Also Published As

Publication number Publication date
CN108112253B (zh) 2022-09-23
SI3298030T1 (sl) 2023-05-31
RU2021119777A (ru) 2021-08-16
AU2016262845A1 (en) 2018-01-04
RS64002B1 (sr) 2023-03-31
RU2017135539A3 (enExample) 2019-11-29
EP3298030A1 (en) 2018-03-28
FI3298030T3 (fi) 2023-02-22
US20180148485A1 (en) 2018-05-31
SMT202300026T1 (it) 2023-03-17
ES2938525T3 (es) 2023-04-12
MX2017014716A (es) 2018-06-28
RU2017135539A (ru) 2019-06-18
AU2016262845B2 (en) 2020-07-23
WO2016184882A1 (en) 2016-11-24
MX390894B (es) 2025-03-21
DK3298030T5 (en) 2024-10-07
RU2754466C2 (ru) 2021-09-02
PL3298030T3 (pl) 2023-05-08
JP2018519803A (ja) 2018-07-26
US20210403516A1 (en) 2021-12-30
SG11201707426SA (en) 2017-10-30
CA2980838A1 (en) 2016-11-24
KR102685748B1 (ko) 2024-07-18
KR20180002855A (ko) 2018-01-08
LT3298030T (lt) 2023-02-27
ZA201706061B (en) 2022-05-25
JP6947642B2 (ja) 2021-10-13
US10913778B2 (en) 2021-02-09
CN108112253A (zh) 2018-06-01
US11919931B2 (en) 2024-03-05
EP4219535A1 (en) 2023-08-02
DK3298030T3 (en) 2023-02-06
BR112017020445A2 (pt) 2018-07-03
HUE061108T2 (hu) 2023-05-28
EP3298030B1 (en) 2023-01-18

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