RU2736955C2 - Способ прививки клеток печени субъекту с заболеванием или дисфункцией печени - Google Patents

Способ прививки клеток печени субъекту с заболеванием или дисфункцией печени Download PDF

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RU2736955C2
RU2736955C2 RU2015155133A RU2015155133A RU2736955C2 RU 2736955 C2 RU2736955 C2 RU 2736955C2 RU 2015155133 A RU2015155133 A RU 2015155133A RU 2015155133 A RU2015155133 A RU 2015155133A RU 2736955 C2 RU2736955 C2 RU 2736955C2
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cells
liver
cmha
donor
cell
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RU2015155133A
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RU2015155133A3 (OSRAM
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Рейчел ТЕРНЕР
Дейвид ГЕРБЕР
Освальдо ЛОЗОЙЯ
Лола М. РЕЙД
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Юниверсити Оф Норт Каролина Эт Чепел Хилл
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    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
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RU2015155133A 2010-05-07 2011-05-06 Способ прививки клеток печени субъекту с заболеванием или дисфункцией печени RU2736955C2 (ru)

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US33244110P 2010-05-07 2010-05-07
US61/332,441 2010-05-07

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RU2012152610/14A Division RU2574364C2 (ru) 2010-05-07 2011-05-06 Способ трансплантации клеток из плотных тканей

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RU2020137594A Division RU2020137594A (ru) 2010-05-07 2020-11-17 Способ прививки клеток печени субъекту с заболеванием или дисфункцией печени

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RU2015155133A RU2015155133A (ru) 2019-01-16
RU2015155133A3 RU2015155133A3 (OSRAM) 2019-05-28
RU2736955C2 true RU2736955C2 (ru) 2020-11-23

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US (1) US20110274666A1 (OSRAM)
EP (1) EP2566567A4 (OSRAM)
JP (4) JP6177687B2 (OSRAM)
KR (4) KR102230864B1 (OSRAM)
CN (2) CN102985130A (OSRAM)
AR (1) AR081906A1 (OSRAM)
AU (1) AU2011247984B2 (OSRAM)
BR (1) BR112012028265B1 (OSRAM)
CA (2) CA3146949A1 (OSRAM)
CL (1) CL2012003085A1 (OSRAM)
CR (1) CR20120603A (OSRAM)
IL (3) IL222857A (OSRAM)
MX (3) MX359678B (OSRAM)
NZ (2) NZ603913A (OSRAM)
PH (1) PH12012502176A1 (OSRAM)
RU (1) RU2736955C2 (OSRAM)
SG (2) SG10201503582YA (OSRAM)
TW (3) TW202006136A (OSRAM)
WO (1) WO2011140428A1 (OSRAM)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
US8961617B2 (en) * 2012-03-08 2015-02-24 Liventa Bioscience, Inc. Amnion and chorion constructs and uses thereof in abdominal surgery
US9533013B2 (en) * 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
EP2886644A1 (en) 2013-12-20 2015-06-24 Kallistem Process for implementing in vitro spermatogenesis and associated device
US10765705B2 (en) 2014-11-24 2020-09-08 Prime Merger Sub, Llc Visco-supplement compositions, and methods of use thereof
WO2016118950A1 (en) * 2015-01-23 2016-07-28 Everon Biosciences, Inc. Induction of cellular senescence for tissue therapies
CN106148266A (zh) * 2015-04-20 2016-11-23 烟台赛泽生物技术有限公司 一种免疫细胞用培养基及该培养基的添加剂
JP2016209303A (ja) * 2015-05-08 2016-12-15 レジエンス株式会社 肝組織を再生するための製剤
US20170369849A1 (en) * 2016-05-11 2017-12-28 The University Of North Carolina At Chapel Hill Compositions and methods for bioengineered tissues
WO2018058541A1 (zh) 2016-09-30 2018-04-05 台北荣民总医院 冷冻处理中保护生物组织的防冻剂及其制备方法
AU2018249853A1 (en) * 2017-04-06 2019-10-31 Sapienza Universita Di Roma Cryopreservation method
EP3638310A4 (en) 2017-06-12 2021-04-14 The University Of North Carolina At Chapel Hill PATCH TRANSPLANT COMPOSITIONS FOR CELL TRANSPLANTATION
IL278370B2 (en) 2018-05-03 2024-02-01 Collplant Ltd Dermal fillers and their uses
JP2020050625A (ja) 2018-09-27 2020-04-02 株式会社北里コーポレーション 卵巣組織の移植方法および卵胞活性化方法
JP7350505B2 (ja) * 2019-02-15 2023-09-26 イビデン株式会社 生体試料を含む固化体
US20230039816A1 (en) * 2019-09-27 2023-02-09 Public University Corporation Yokohama City University Method for inducing hepatocyte plasticity
WO2023042875A1 (ja) * 2021-09-16 2023-03-23 富士フイルム株式会社 ゲル形成キット及びその利用
US20250154453A1 (en) * 2021-12-28 2025-05-15 Pormedtec Co., Ltd. Method for producing transplant material, and transplant material
JPWO2024043306A1 (OSRAM) * 2022-08-24 2024-02-29
CN116920263A (zh) * 2023-07-28 2023-10-24 南方医科大学南方医院 一种透皮递送活体干细胞的冷冻微针及其制备方法和应用
CN117426368A (zh) * 2023-10-08 2024-01-23 北京汇智泰康医药技术有限公司 一种肝细胞冻存液及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005021730A2 (en) * 2003-09-02 2005-03-10 University Of North Carolina At Chapel Hill Biodegradable polymer-ligand conjugates and their uses in isolation of cellular subpopulations and in cryopreservation, culture and transplantation of cells
WO2009022339A1 (en) * 2007-08-15 2009-02-19 Ramot At Tel Aviv University Ltd. Polypeptides, matrices, hydrogels and methods of using same for tissue regeneration and repair

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6231881B1 (en) * 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
US20040138329A1 (en) * 1992-04-20 2004-07-15 Board Of Regents Of The University Of Texas System Gels for encapsulation of biological materials
EP0655910A4 (en) * 1992-07-29 1996-02-28 Univ Washington USE OF A BAG FOR IMPLANTING LIVING CELLS.
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5681587A (en) * 1995-10-06 1997-10-28 Desmos, Inc. Growth of adult pancreatic islet cells
US6482231B1 (en) * 1995-11-20 2002-11-19 Giovanni Abatangelo Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative
EP0915967A1 (en) * 1996-05-28 1999-05-19 The Board Of Regents Of The University Of Michigan Engineering oral tissues
US6224893B1 (en) * 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
JP3014343B2 (ja) * 1997-06-06 2000-02-28 科学技術振興事業団 肝細胞の培養方法
IT1293484B1 (it) * 1997-06-11 1999-03-01 Fidia Advanced Biopolymers Srl Materiale biologico comprendente una efficiente coltura di cellule e una matrice tridimensionale biocompatibile e biodegradabile
US6129911A (en) * 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
EP1147179B1 (en) * 1999-01-19 2008-11-12 The University of North Carolina at Chapel Hill Human liver progenitors
US6592623B1 (en) * 1999-08-31 2003-07-15 Virginia Commonwealth University Intellectual Property Foundation Engineered muscle
US6365385B1 (en) * 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
AU772484B2 (en) * 1999-04-30 2004-04-29 Massachusetts General Hospital Fabrication of vascularized tissue using microfabricated two-dimensional molds
AU6092900A (en) * 1999-07-14 2001-02-05 Board Of Trustees Of The Leland Stanford Junior University Animals comprising human hepatocellular tissue
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
RU2165263C1 (ru) * 2000-06-23 2001-04-20 Зыбин Дмитрий Владимирович Способ лечения сахарного диабета
US7291673B2 (en) * 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US6435190B1 (en) * 2000-06-14 2002-08-20 Syde A. Taheri Autogenous cell patch cardio myoplasty and advanced muscle graft implantation system
MY130475A (en) * 2000-08-25 2007-06-29 Contura As Polyacrylamide hydrogel and its use as an endoprosthesis
AU2002219935A1 (en) * 2000-11-28 2002-06-11 Focal, Inc. Polyalkylene glycol viscosity-enhancing polymeric formulations
US20030077566A1 (en) * 2001-09-10 2003-04-24 Palasz Andrzej T. Method for cryopreserving mammalian cells and tissues
JP2005534430A (ja) * 2002-08-06 2005-11-17 ジェンベック, インコーポレイテッド 改良された注射システム
AU2003284875A1 (en) * 2002-10-17 2004-05-04 Vacanti, Joseph P. Biological scaffolding material
CA2524929C (en) * 2003-05-08 2015-01-13 Cellartis Ab Cryopreservation of human blastocyst-derived stem cells by use of a closed straw vitrification method
CA2539002A1 (en) * 2003-09-19 2005-03-31 Newsouth Innovations Pty Limited Method for isolating hepatocytes
WO2005056763A2 (en) * 2003-12-04 2005-06-23 University Of Utah Research Foundation Process and formulation to improve viability of stored cells and tissue
US7884185B2 (en) * 2004-07-28 2011-02-08 University Of Delaware Hydrogels and uses thereof
US8828433B2 (en) * 2005-04-19 2014-09-09 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
RU2008124158A (ru) * 2005-11-16 2010-01-10 Юниверсити Оф Норт Каролина Эт Чепел Хилл (Us) Внеклеточные матриксные компоненты для экспансии и дифференцировки гепатических клеток-предшественников
CA2653905A1 (en) * 2006-05-30 2007-12-06 Julio De La Fuente Martinez Procedure for the preparation of unilamellar vesicles for cryopreservation and the culture of stem cells and embryos
TW200817019A (en) * 2006-07-10 2008-04-16 Univ Columbia De novo formation and regeneration of vascularized tissue from tissue progenitor cells and vascular progenitor cells
AU2007297611B2 (en) * 2006-09-21 2013-02-07 Purdue Research Foundation Collagen preparation and method of isolation
US20080233088A1 (en) * 2007-02-16 2008-09-25 Varian Medical Systems Technologies, Inc. Preparative regimen for engraftment, growth and differentiation of non-hematopoeitic cells in vivo after transplantation
MX2009009582A (es) * 2007-03-06 2009-10-26 Univ North Carolina Complejos de hialuronanos, otros componentes de matriz, hormonas y factores de crecimiento para el mantenimiento, expansion y/o diferenciacion de celulas hepaticas.
US20080299177A1 (en) * 2007-06-06 2008-12-04 Biovaluation & Analysis, Inc. Supramolecular Complexes for Use in Acoustically Mediated Intracellular Drug Delivery in vivo
IN2010KN00157A (OSRAM) * 2007-06-15 2015-08-28 Univ North Carolina
GB0713079D0 (en) * 2007-07-05 2007-08-15 Ucl Business Plc biomaterial scaffolds with defined stiffness
JP2011501686A (ja) * 2007-08-20 2011-01-13 ドゥ−コープ テクノロジーズ リミテッド 富化されたナノ構造組成物
EP2222159B1 (en) * 2007-11-20 2018-02-21 Pioneer Surgical Orthobiologics, Inc. Cryopreservation of cells using cross-linked bioactive hydrogel matrix particles
CN101618235A (zh) * 2008-07-01 2010-01-06 中国人民解放军军事医学科学院基础医学研究所 一种基于opf水凝胶为液态支架的可注射性心肌组织工程产品
EP2341953B1 (en) * 2008-09-04 2018-11-21 The General Hospital Corporation Hydrogels for vocal cord and soft tissue augmentation and repair
US20100092533A1 (en) * 2008-10-15 2010-04-15 Joshua Stopek Bioabsorbable Surgical Composition
EP2221362A1 (en) * 2009-02-19 2010-08-25 Naturin GmbH & Co Method for the cryopreservation of cells, artificial cell constructs or three-dimensional complex tissues assemblies

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005021730A2 (en) * 2003-09-02 2005-03-10 University Of North Carolina At Chapel Hill Biodegradable polymer-ligand conjugates and their uses in isolation of cellular subpopulations and in cryopreservation, culture and transplantation of cells
WO2009022339A1 (en) * 2007-08-15 2009-02-19 Ramot At Tel Aviv University Ltd. Polypeptides, matrices, hydrogels and methods of using same for tissue regeneration and repair

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ЛЮНДУП А.В. и др. "О роли синусоидальных клеток печени и клеток костного мозга в обеспечении регенераторной стратегии здоровой и поврежденной печени" // "Вестник трансплантологии и искусственных органов", том XII, N1-2010, стр.78-85. TURNER WS et al. "Human hepatoblast phenotype maintained by hyaluronan hydrogels". J Biomed Mater Res B Appl Biomater. 2007 Jul;82(1):156-66, Реферат, найдено 23.05.2019 из PubMed PMID: 17183559. *

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