RU2727802C2 - Апилимод для применения в лечении рака почек - Google Patents

Апилимод для применения в лечении рака почек Download PDF

Info

Publication number
RU2727802C2
RU2727802C2 RU2017119065A RU2017119065A RU2727802C2 RU 2727802 C2 RU2727802 C2 RU 2727802C2 RU 2017119065 A RU2017119065 A RU 2017119065A RU 2017119065 A RU2017119065 A RU 2017119065A RU 2727802 C2 RU2727802 C2 RU 2727802C2
Authority
RU
Russia
Prior art keywords
apilimod
use according
inhibitor
cancer
pharmaceutically acceptable
Prior art date
Application number
RU2017119065A
Other languages
English (en)
Russian (ru)
Other versions
RU2017119065A (ru
RU2017119065A3 (enExample
Inventor
Нил БИХАРРИ
София ГЕЙЛ
Шон ЛАНДРЕТТЕ
Пол БЕКЕТТ
Крис КОНРАД
Тянь СЮЙ
Джонатан М. РОТБЕРГ
Хенри ЛИХЕНШТЕЙН
Original Assignee
ЭйАй ТЕРАПЬЮТИКС, ИНК.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ЭйАй ТЕРАПЬЮТИКС, ИНК. filed Critical ЭйАй ТЕРАПЬЮТИКС, ИНК.
Publication of RU2017119065A publication Critical patent/RU2017119065A/ru
Publication of RU2017119065A3 publication Critical patent/RU2017119065A3/ru
Application granted granted Critical
Publication of RU2727802C2 publication Critical patent/RU2727802C2/ru

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
RU2017119065A 2014-11-07 2015-11-06 Апилимод для применения в лечении рака почек RU2727802C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462077127P 2014-11-07 2014-11-07
US62/077,127 2014-11-07
PCT/US2015/059512 WO2016073877A1 (en) 2014-11-07 2015-11-06 Apilimod for use in the treatment of renal cancer

Publications (3)

Publication Number Publication Date
RU2017119065A RU2017119065A (ru) 2018-12-07
RU2017119065A3 RU2017119065A3 (enExample) 2019-06-05
RU2727802C2 true RU2727802C2 (ru) 2020-07-24

Family

ID=54548302

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2017119065A RU2727802C2 (ru) 2014-11-07 2015-11-06 Апилимод для применения в лечении рака почек

Country Status (16)

Country Link
US (3) US10206910B2 (enExample)
EP (2) EP3215158B1 (enExample)
JP (1) JP6705828B2 (enExample)
KR (1) KR20170098812A (enExample)
CN (1) CN107249638B (enExample)
AU (1) AU2015342869A1 (enExample)
BR (1) BR112017008799A2 (enExample)
CA (1) CA2966359A1 (enExample)
ES (1) ES2741399T3 (enExample)
HU (1) HUE044557T2 (enExample)
IL (1) IL251905B (enExample)
MX (1) MX377593B (enExample)
PL (1) PL3215158T3 (enExample)
PT (1) PT3215158T (enExample)
RU (1) RU2727802C2 (enExample)
WO (1) WO2016073877A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10179135B2 (en) 2014-01-24 2019-01-15 Lam Therapeutics, Inc. Apilimod compositions and methods for using same
BR112017008799A2 (pt) 2014-11-07 2017-12-19 Lam Therapeutics Inc composições de apilimod e métodos de uso das mesmas no tratamento de câncer renal
CN107427522B (zh) * 2014-11-07 2021-06-15 人工智能治疗公司 用于治疗黑素瘤的阿吡莫德
EP3405199A1 (en) * 2016-01-21 2018-11-28 LAM Therapeutics, Inc. Biomarkers for treating cancer with apilimod
AU2017316475A1 (en) * 2016-08-25 2019-03-07 AI Therapeutics, Inc. Compositions comprising PIKfyve inhibitors and methods related to inhibition of rank signaling
AU2017342262B2 (en) * 2016-10-12 2023-09-28 Orphai Therapeutics Inc. Apilimod compositions and methods for using same in the treatment of alzheimer's disease
WO2018175906A1 (en) 2017-03-24 2018-09-27 Nanosyn, Inc. Fused triazolo-pyrimidine compounds having useful pharmaceutical application
IL310376B1 (en) 2018-01-26 2025-10-01 Univ California Methods and compositions for treating angiogenic disorders using anti-VEGF factors
RU2020130837A (ru) 2018-02-21 2022-03-21 ЭйАй ТЕРАПЬЮТИКС, ИНК. Комбинационная терапия апилимодом и глутаматергическими агентами
CA3168512A1 (en) 2019-11-25 2021-06-03 Napoleone Ferrara Long-acting vegf inhibitors for intraocular neovascularization
PH12022551623A1 (en) 2020-01-13 2023-11-29 Verge Analytics Inc Substituted pyrazolo-pyrimidines and uses thereof
CN114306370A (zh) * 2021-12-31 2022-04-12 北京悦康科创医药科技股份有限公司 反义寡核苷酸在制备治疗肾癌药物中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006128129A2 (en) * 2005-05-26 2006-11-30 Synta Pharmaceuticals Corp. Method for treating cancer
RU2486183C9 (ru) * 2007-08-01 2014-01-27 Байер Интеллектуэль Проперти Гмбх Дипептидные пролекарства и их применение
RU2013110124A (ru) * 2010-08-17 2014-09-27 Ф.Хоффманн-Ля Рош Аг Комбинированная противораковая терапия

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
EP1921169B1 (en) 1993-11-12 2012-02-15 PHRI Properties, Inc. Hybridization probes for nucleic acid detection, universal stems, methods and kits
US6693097B2 (en) 2001-11-30 2004-02-17 Synta Pharmaceuticals Corp. Pyrimidine compounds
MXPA06008746A (es) 2004-02-06 2007-01-23 Elan Pharm Inc Metodos y composiciones para tratamiento de tumores y enfermedad metastatica.
WO2005112938A2 (en) 2004-04-13 2005-12-01 Synta Pharmaceuticals Corp. Disalt inhibitors of il-12 production
CA2579096C (en) 2004-09-08 2012-11-13 Chelsea Therapeutics, Inc. Quinazoline derivatives as metabolically inert antifolate compounds
WO2006053112A1 (en) 2004-11-10 2006-05-18 Synta Pharmaceuticals Corp. Process for preparing trisubstituted pyrimidine compounds
WO2006124662A1 (en) 2005-05-13 2006-11-23 Synta Pharmaceuticals Corp. Il-12 modulatory compounds
EA015463B1 (ru) 2005-11-17 2011-08-30 Оси Фармасьютикалз, Инк. КОНДЕНСИРОВАННОЕ БИЦИКЛИЧЕСКОЕ СОЕДИНЕНИЕ - ИНГИБИТОР mTOR, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ЕГО СОДЕРЖАЩАЯ, И СПОСОБ ЛЕЧЕНИЯ РАКА
AR057960A1 (es) 2005-12-02 2007-12-26 Osi Pharm Inc Inhibidores de proteina quinasa biciclicos
JP5156644B2 (ja) 2006-01-25 2013-03-06 オーエスアイ・フアーマシユーテイカルズ・エル・エル・シー 不飽和mTOR阻害剤
EA031888B1 (ru) 2006-07-12 2019-03-29 Юниверсити Оф Теннесси Рисерч Фаундейшн Способы применения замещенных ациланилидов
MX2009008341A (es) 2007-02-06 2009-08-12 Novartis Ag Inhibidores de cinasa de pi3 y metodos para su uso.
RU2438664C2 (ru) 2007-05-15 2012-01-10 Пирамал Лайф Сайнсиз Лимитед Синергическая фармацевтическая комбинация для лечения рака
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
JP5258331B2 (ja) 2008-03-03 2013-08-07 ロート製薬株式会社 光安定性が改善されたニューキノロン系抗菌剤含有医薬組成物
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
WO2010006438A1 (en) 2008-07-17 2010-01-21 Critical Outcome Technologies Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
EP3338770B1 (en) 2010-03-08 2023-06-07 Sloan-Kettering Institute For Cancer Research Cdc7 kinase inhibitors and uses thereof
CN102905707A (zh) * 2010-03-29 2013-01-30 味之素株式会社 含有苯基丙氨酸衍生物的医药制剂
US8402515B2 (en) 2010-05-06 2013-03-19 Jonathan Weizman Apparatus and method for establishing a peer-to-peer communication session with a client device
US20110287018A1 (en) 2010-05-19 2011-11-24 Philip Bosch Methods of Treating Interstitial Cystitis
JP6061346B2 (ja) 2010-11-19 2017-01-18 エコール ポリテクニーク フェデラル ドゥ ローザンヌ (イーピーエフエル) 2−ピペラジン−1−イル−4h−1,3−ベンゾチアジン−4−オン誘導体、および哺乳類の感染症治療へのその使用
WO2013152342A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Anti-cancer mtor inhibitor and anti-androgen combination
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CA3213528A1 (en) 2012-05-15 2013-11-21 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
EP2903644A4 (en) 2012-10-05 2016-03-09 Cerulean Pharma Inc TREATMENT OF CANCER
US9295731B2 (en) 2013-04-01 2016-03-29 Mark Quang Nguyen Cleavable drug conjugates, compositions thereof and methods of use
US10179135B2 (en) 2014-01-24 2019-01-15 Lam Therapeutics, Inc. Apilimod compositions and methods for using same
CN107427522B (zh) 2014-11-07 2021-06-15 人工智能治疗公司 用于治疗黑素瘤的阿吡莫德
BR112017008799A2 (pt) 2014-11-07 2017-12-19 Lam Therapeutics Inc composições de apilimod e métodos de uso das mesmas no tratamento de câncer renal
KR101761573B1 (ko) 2014-12-29 2017-07-26 주식회사 인트론바이오테크놀로지 신규한 장출혈성 대장균 박테리오파지 Esc-CHP-1 및 이의 장출혈성 대장균 증식 억제 용도
WO2016126707A1 (en) 2015-02-03 2016-08-11 Lam Therapeutics, Inc. Apilimod compositions and methods for using same
WO2016160102A1 (en) 2015-03-31 2016-10-06 Lam Therapeutics, Inc. Active metabolites of apilimod and uses thereof
TWI746449B (zh) 2015-07-20 2021-11-21 美商Ai治療公司 使用阿吡莫德治療癌症之方法
AU2019299234A1 (en) 2018-07-05 2021-01-14 Mayo Foundation For Medical Education And Research PIKfyve inhibitors
US20210077500A1 (en) 2019-09-12 2021-03-18 Al Therapeutics, Inc. Pikfyve inhibitors for cancer therapy

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006128129A2 (en) * 2005-05-26 2006-11-30 Synta Pharmaceuticals Corp. Method for treating cancer
RU2486183C9 (ru) * 2007-08-01 2014-01-27 Байер Интеллектуэль Проперти Гмбх Дипептидные пролекарства и их применение
RU2013110124A (ru) * 2010-08-17 2014-09-27 Ф.Хоффманн-Ля Рош Аг Комбинированная противораковая терапия

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Cai X et al. PIKfyve, a class III PI kinase, isthe target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-likereceptor signaling // Chem Biol.- 2013 Jul 25; 20(7):912-21. *
Cai X, et al. PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling // Chem Biol.- 2013.- Jul 25; 20(7):912-21. *
George K. Philips, et al. Therapeutic uses of anti-PD-1 and anti-PD-L1 antibodies // International Immunology. - 16.10.2014. - Volume 27, Issue 1.- Pages 39-46. Cai X et al. PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling // Chem Biol.- 2013 Jul 25; 20(7):912-21. *
George K. Philips, et al. Therapeutic usesof anti-PD-1 and anti-PD-L1 antibodies // International Immunology. - 16.10.2014. - Volume 27, Issue 1.- Pages 39-46. *

Also Published As

Publication number Publication date
CN107249638B (zh) 2021-05-14
MX377593B (es) 2025-03-10
US20170333408A1 (en) 2017-11-23
WO2016073877A1 (en) 2016-05-12
PL3215158T3 (pl) 2019-11-29
EP3215158B1 (en) 2019-05-08
IL251905B (en) 2021-03-25
JP2017535601A (ja) 2017-11-30
RU2017119065A (ru) 2018-12-07
MX2017006015A (es) 2017-11-17
AU2015342869A1 (en) 2017-06-15
CA2966359A1 (en) 2016-05-12
US11166944B2 (en) 2021-11-09
KR20170098812A (ko) 2017-08-30
JP6705828B2 (ja) 2020-06-03
BR112017008799A2 (pt) 2017-12-19
HUE044557T2 (hu) 2019-11-28
RU2017119065A3 (enExample) 2019-06-05
EP3581184A1 (en) 2019-12-18
US10206910B2 (en) 2019-02-19
IL251905A0 (en) 2017-06-29
US20190201385A1 (en) 2019-07-04
ES2741399T3 (es) 2020-02-10
PT3215158T (pt) 2019-08-23
CN107249638A (zh) 2017-10-13
US20200297706A1 (en) 2020-09-24
EP3581184B1 (en) 2021-02-24
EP3215158A1 (en) 2017-09-13

Similar Documents

Publication Publication Date Title
US11166944B2 (en) Apilimod compositions and methods for using same in the treatment of renal cancer
US11266654B2 (en) Apilimod compositions and methods for using same
RU2739992C2 (ru) Композиции апилимода и способы их применения в лечении колоректального рака
HK40018267B (en) Apilimod for use in the treatment of renal cancer
HK40018267A (en) Apilimod for use in the treatment of renal cancer
HK1242205B (en) Apilimod for use in the treatment of renal cancer
HK1242205A1 (en) Apilimod for use in the treatment of renal cancer
HK1226329B (en) Apilimod compositions for treating non-hodgkin's b cell lymphoma
NZ722491B2 (en) Apilimod compositions and methods for using same
HK1242965B (en) Apilimod for use in the treatment of colorectal cancer

Legal Events

Date Code Title Description
HZ9A Changing address for correspondence with an applicant