RU2727802C2 - Апилимод для применения в лечении рака почек - Google Patents

Апилимод для применения в лечении рака почек Download PDF

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Publication number
RU2727802C2
RU2727802C2 RU2017119065A RU2017119065A RU2727802C2 RU 2727802 C2 RU2727802 C2 RU 2727802C2 RU 2017119065 A RU2017119065 A RU 2017119065A RU 2017119065 A RU2017119065 A RU 2017119065A RU 2727802 C2 RU2727802 C2 RU 2727802C2
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apilimod
use according
inhibitor
cancer
pharmaceutically acceptable
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RU2017119065A
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Russian (ru)
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RU2017119065A3 (enExample
RU2017119065A (ru
Inventor
Нил БИХАРРИ
София ГЕЙЛ
Шон ЛАНДРЕТТЕ
Пол БЕКЕТТ
Крис КОНРАД
Тянь СЮЙ
Джонатан М. РОТБЕРГ
Хенри ЛИХЕНШТЕЙН
Original Assignee
ЭйАй ТЕРАПЬЮТИКС, ИНК.
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Publication of RU2017119065A3 publication Critical patent/RU2017119065A3/ru
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
RU2017119065A 2014-11-07 2015-11-06 Апилимод для применения в лечении рака почек RU2727802C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462077127P 2014-11-07 2014-11-07
US62/077,127 2014-11-07
PCT/US2015/059512 WO2016073877A1 (en) 2014-11-07 2015-11-06 Apilimod for use in the treatment of renal cancer

Publications (3)

Publication Number Publication Date
RU2017119065A RU2017119065A (ru) 2018-12-07
RU2017119065A3 RU2017119065A3 (enExample) 2019-06-05
RU2727802C2 true RU2727802C2 (ru) 2020-07-24

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RU2017119065A RU2727802C2 (ru) 2014-11-07 2015-11-06 Апилимод для применения в лечении рака почек

Country Status (16)

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US (3) US10206910B2 (enExample)
EP (2) EP3215158B1 (enExample)
JP (1) JP6705828B2 (enExample)
KR (1) KR20170098812A (enExample)
CN (1) CN107249638B (enExample)
AU (1) AU2015342869A1 (enExample)
BR (1) BR112017008799A2 (enExample)
CA (1) CA2966359A1 (enExample)
ES (1) ES2741399T3 (enExample)
HU (1) HUE044557T2 (enExample)
IL (1) IL251905B (enExample)
MX (1) MX377593B (enExample)
PL (1) PL3215158T3 (enExample)
PT (1) PT3215158T (enExample)
RU (1) RU2727802C2 (enExample)
WO (1) WO2016073877A1 (enExample)

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ES2741399T3 (es) 2014-11-07 2020-02-10 Ai Therapeutics Inc Apilimod para el uso en el tratamiento de cáncer renal
RU2018130070A (ru) * 2016-01-21 2020-02-21 Лэм Терапьютикс, Инк. Биомаркеры для лечения рака при помощи апилимода
CA3034453A1 (en) * 2016-08-25 2018-03-01 AI Therapeutics, Inc. Compositions comprising pikfyve inhibitors and methods related to inhibition of rank signaling
JP7199349B2 (ja) * 2016-10-12 2023-01-05 エイアイ・セラピューティクス・インコーポレーテッド アピリモド組成物およびそれをアルツハイマー病の処置に使用するための方法
US11066410B2 (en) 2017-03-24 2021-07-20 3100 Central Expressway Llc Fused triazolo-pyrimidine compounds having useful pharmaceutical application
JP7517988B2 (ja) 2018-01-26 2024-07-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 抗vegf剤を使用した血管新生障害の治療のための方法および組成物
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CA3168512A1 (en) 2019-11-25 2021-06-03 Napoleone Ferrara Long-acting vegf inhibitors for intraocular neovascularization
TWI885039B (zh) 2020-01-13 2025-06-01 美商邊際分析公司 經取代吡唑并嘧啶及其用途
CN114306370A (zh) * 2021-12-31 2022-04-12 北京悦康科创医药科技股份有限公司 反义寡核苷酸在制备治疗肾癌药物中的应用

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Publication number Publication date
CA2966359A1 (en) 2016-05-12
IL251905A0 (en) 2017-06-29
US20190201385A1 (en) 2019-07-04
CN107249638A (zh) 2017-10-13
EP3215158B1 (en) 2019-05-08
JP2017535601A (ja) 2017-11-30
KR20170098812A (ko) 2017-08-30
EP3581184B1 (en) 2021-02-24
US11166944B2 (en) 2021-11-09
ES2741399T3 (es) 2020-02-10
EP3215158A1 (en) 2017-09-13
PT3215158T (pt) 2019-08-23
US20170333408A1 (en) 2017-11-23
JP6705828B2 (ja) 2020-06-03
HUE044557T2 (hu) 2019-11-28
AU2015342869A1 (en) 2017-06-15
RU2017119065A3 (enExample) 2019-06-05
US20200297706A1 (en) 2020-09-24
CN107249638B (zh) 2021-05-14
MX377593B (es) 2025-03-10
WO2016073877A1 (en) 2016-05-12
RU2017119065A (ru) 2018-12-07
PL3215158T3 (pl) 2019-11-29
IL251905B (en) 2021-03-25
MX2017006015A (es) 2017-11-17
EP3581184A1 (en) 2019-12-18
US10206910B2 (en) 2019-02-19
BR112017008799A2 (pt) 2017-12-19

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