PT3215158T - Apilimod para utilização no tratamento de cancro renal - Google Patents

Apilimod para utilização no tratamento de cancro renal

Info

Publication number
PT3215158T
PT3215158T PT15795318T PT15795318T PT3215158T PT 3215158 T PT3215158 T PT 3215158T PT 15795318 T PT15795318 T PT 15795318T PT 15795318 T PT15795318 T PT 15795318T PT 3215158 T PT3215158 T PT 3215158T
Authority
PT
Portugal
Prior art keywords
apilimod
treatment
renal cancer
renal
cancer
Prior art date
Application number
PT15795318T
Other languages
English (en)
Portuguese (pt)
Inventor
BEEHARRY Neil
Gayle Sophia
LANDRETTE Sean
Beckett Paul
Conrad Chris
Xu Tian
M Rothberg Jonathan
Lichenstein Henri
Original Assignee
Ai Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ai Therapeutics Inc filed Critical Ai Therapeutics Inc
Publication of PT3215158T publication Critical patent/PT3215158T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
PT15795318T 2014-11-07 2015-11-06 Apilimod para utilização no tratamento de cancro renal PT3215158T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462077127P 2014-11-07 2014-11-07

Publications (1)

Publication Number Publication Date
PT3215158T true PT3215158T (pt) 2019-08-23

Family

ID=54548302

Family Applications (1)

Application Number Title Priority Date Filing Date
PT15795318T PT3215158T (pt) 2014-11-07 2015-11-06 Apilimod para utilização no tratamento de cancro renal

Country Status (16)

Country Link
US (3) US10206910B2 (enExample)
EP (2) EP3215158B1 (enExample)
JP (1) JP6705828B2 (enExample)
KR (1) KR20170098812A (enExample)
CN (1) CN107249638B (enExample)
AU (1) AU2015342869A1 (enExample)
BR (1) BR112017008799A2 (enExample)
CA (1) CA2966359A1 (enExample)
ES (1) ES2741399T3 (enExample)
HU (1) HUE044557T2 (enExample)
IL (1) IL251905B (enExample)
MX (1) MX377593B (enExample)
PL (1) PL3215158T3 (enExample)
PT (1) PT3215158T (enExample)
RU (1) RU2727802C2 (enExample)
WO (1) WO2016073877A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10179135B2 (en) 2014-01-24 2019-01-15 Lam Therapeutics, Inc. Apilimod compositions and methods for using same
BR112017008799A2 (pt) 2014-11-07 2017-12-19 Lam Therapeutics Inc composições de apilimod e métodos de uso das mesmas no tratamento de câncer renal
CN107427522B (zh) * 2014-11-07 2021-06-15 人工智能治疗公司 用于治疗黑素瘤的阿吡莫德
EP3405199A1 (en) * 2016-01-21 2018-11-28 LAM Therapeutics, Inc. Biomarkers for treating cancer with apilimod
AU2017316475A1 (en) * 2016-08-25 2019-03-07 AI Therapeutics, Inc. Compositions comprising PIKfyve inhibitors and methods related to inhibition of rank signaling
AU2017342262B2 (en) * 2016-10-12 2023-09-28 Orphai Therapeutics Inc. Apilimod compositions and methods for using same in the treatment of alzheimer's disease
WO2018175906A1 (en) 2017-03-24 2018-09-27 Nanosyn, Inc. Fused triazolo-pyrimidine compounds having useful pharmaceutical application
IL310376B1 (en) 2018-01-26 2025-10-01 Univ California Methods and compositions for treating angiogenic disorders using anti-VEGF factors
RU2020130837A (ru) 2018-02-21 2022-03-21 ЭйАй ТЕРАПЬЮТИКС, ИНК. Комбинационная терапия апилимодом и глутаматергическими агентами
CA3168512A1 (en) 2019-11-25 2021-06-03 Napoleone Ferrara Long-acting vegf inhibitors for intraocular neovascularization
PH12022551623A1 (en) 2020-01-13 2023-11-29 Verge Analytics Inc Substituted pyrazolo-pyrimidines and uses thereof
CN114306370A (zh) * 2021-12-31 2022-04-12 北京悦康科创医药科技股份有限公司 反义寡核苷酸在制备治疗肾癌药物中的应用

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
EP1921169B1 (en) 1993-11-12 2012-02-15 PHRI Properties, Inc. Hybridization probes for nucleic acid detection, universal stems, methods and kits
US6693097B2 (en) 2001-11-30 2004-02-17 Synta Pharmaceuticals Corp. Pyrimidine compounds
MXPA06008746A (es) 2004-02-06 2007-01-23 Elan Pharm Inc Metodos y composiciones para tratamiento de tumores y enfermedad metastatica.
WO2005112938A2 (en) 2004-04-13 2005-12-01 Synta Pharmaceuticals Corp. Disalt inhibitors of il-12 production
CA2579096C (en) 2004-09-08 2012-11-13 Chelsea Therapeutics, Inc. Quinazoline derivatives as metabolically inert antifolate compounds
WO2006053112A1 (en) 2004-11-10 2006-05-18 Synta Pharmaceuticals Corp. Process for preparing trisubstituted pyrimidine compounds
WO2006124662A1 (en) 2005-05-13 2006-11-23 Synta Pharmaceuticals Corp. Il-12 modulatory compounds
WO2006128129A2 (en) * 2005-05-26 2006-11-30 Synta Pharmaceuticals Corp. Method for treating cancer
EA015463B1 (ru) 2005-11-17 2011-08-30 Оси Фармасьютикалз, Инк. КОНДЕНСИРОВАННОЕ БИЦИКЛИЧЕСКОЕ СОЕДИНЕНИЕ - ИНГИБИТОР mTOR, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ЕГО СОДЕРЖАЩАЯ, И СПОСОБ ЛЕЧЕНИЯ РАКА
AR057960A1 (es) 2005-12-02 2007-12-26 Osi Pharm Inc Inhibidores de proteina quinasa biciclicos
JP5156644B2 (ja) 2006-01-25 2013-03-06 オーエスアイ・フアーマシユーテイカルズ・エル・エル・シー 不飽和ｍＴＯＲ阻害剤
EA031888B1 (ru) 2006-07-12 2019-03-29 Юниверсити Оф Теннесси Рисерч Фаундейшн Способы применения замещенных ациланилидов
MX2009008341A (es) 2007-02-06 2009-08-12 Novartis Ag Inhibidores de cinasa de pi3 y metodos para su uso.
RU2438664C2 (ru) 2007-05-15 2012-01-10 Пирамал Лайф Сайнсиз Лимитед Синергическая фармацевтическая комбинация для лечения рака
DE102007036076A1 (de) * 2007-08-01 2009-02-05 Bayer Healthcare Aktiengesellschaft Dipeptoid-Produgs und ihre Verwendung
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
JP5258331B2 (ja) 2008-03-03 2013-08-07 ロート製薬株式会社 光安定性が改善されたニューキノロン系抗菌剤含有医薬組成物
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
WO2010006438A1 (en) 2008-07-17 2010-01-21 Critical Outcome Technologies Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
EP3338770B1 (en) 2010-03-08 2023-06-07 Sloan-Kettering Institute For Cancer Research Cdc7 kinase inhibitors and uses thereof
CN102905707A (zh) * 2010-03-29 2013-01-30 味之素株式会社 含有苯基丙氨酸衍生物的医药制剂
US8402515B2 (en) 2010-05-06 2013-03-19 Jonathan Weizman Apparatus and method for establishing a peer-to-peer communication session with a client device
US20110287018A1 (en) 2010-05-19 2011-11-24 Philip Bosch Methods of Treating Interstitial Cystitis
US8709419B2 (en) * 2010-08-17 2014-04-29 Hoffmann-La Roche, Inc. Combination therapy
JP6061346B2 (ja) 2010-11-19 2017-01-18 エコール ポリテクニーク フェデラル ドゥ ローザンヌ （イーピーエフエル） ２−ピペラジン−１−イル−４ｈ−１，３−ベンゾチアジン−４−オン誘導体、および哺乳類の感染症治療へのその使用
WO2013152342A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Anti-cancer mtor inhibitor and anti-androgen combination
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CA3213528A1 (en) 2012-05-15 2013-11-21 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
EP2903644A4 (en) 2012-10-05 2016-03-09 Cerulean Pharma Inc TREATMENT OF CANCER
US9295731B2 (en) 2013-04-01 2016-03-29 Mark Quang Nguyen Cleavable drug conjugates, compositions thereof and methods of use
US10179135B2 (en) 2014-01-24 2019-01-15 Lam Therapeutics, Inc. Apilimod compositions and methods for using same
CN107427522B (zh) 2014-11-07 2021-06-15 人工智能治疗公司 用于治疗黑素瘤的阿吡莫德
BR112017008799A2 (pt) 2014-11-07 2017-12-19 Lam Therapeutics Inc composições de apilimod e métodos de uso das mesmas no tratamento de câncer renal
KR101761573B1 (ko) 2014-12-29 2017-07-26 주식회사 인트론바이오테크놀로지 신규한 장출혈성 대장균 박테리오파지 Ｅｓｃ-ＣＨＰ-1 및 이의 장출혈성 대장균 증식 억제 용도
WO2016126707A1 (en) 2015-02-03 2016-08-11 Lam Therapeutics, Inc. Apilimod compositions and methods for using same
WO2016160102A1 (en) 2015-03-31 2016-10-06 Lam Therapeutics, Inc. Active metabolites of apilimod and uses thereof
TWI746449B (zh) 2015-07-20 2021-11-21 美商Ａｉ治療公司 使用阿吡莫德治療癌症之方法
AU2019299234A1 (en) 2018-07-05 2021-01-14 Mayo Foundation For Medical Education And Research PIKfyve inhibitors
US20210077500A1 (en) 2019-09-12 2021-03-18 Al Therapeutics, Inc. Pikfyve inhibitors for cancer therapy

Also Published As

Publication number Publication date
CN107249638B (zh) 2021-05-14
MX377593B (es) 2025-03-10
US20170333408A1 (en) 2017-11-23
WO2016073877A1 (en) 2016-05-12
PL3215158T3 (pl) 2019-11-29
EP3215158B1 (en) 2019-05-08
IL251905B (en) 2021-03-25
JP2017535601A (ja) 2017-11-30
RU2017119065A (ru) 2018-12-07
MX2017006015A (es) 2017-11-17
RU2727802C2 (ru) 2020-07-24
AU2015342869A1 (en) 2017-06-15
CA2966359A1 (en) 2016-05-12
US11166944B2 (en) 2021-11-09
KR20170098812A (ko) 2017-08-30
JP6705828B2 (ja) 2020-06-03
BR112017008799A2 (pt) 2017-12-19
HUE044557T2 (hu) 2019-11-28
RU2017119065A3 (enExample) 2019-06-05
EP3581184A1 (en) 2019-12-18
US10206910B2 (en) 2019-02-19
IL251905A0 (en) 2017-06-29
US20190201385A1 (en) 2019-07-04
ES2741399T3 (es) 2020-02-10
CN107249638A (zh) 2017-10-13
US20200297706A1 (en) 2020-09-24
EP3581184B1 (en) 2021-02-24
EP3215158A1 (en) 2017-09-13

Similar Documents

Publication Publication Date Title
ZA201607415B (en) Antibody-drug-conjugate and its use for the treatment of cancer
IL248455A0 (en) igf-1r antibody-drug conjugate and its use for cancer treatment
IL251630A0 (en) Combined therapy for use in cancer treatment
IL258953A (en) Dihydroimidazopyrazinone derivatives are useful for the treatment of cancer
IL251905B (en) Epilimod for use in the treatment of kidney cancer
IL276733A (en) Use of Aribolin in cancer treatment
PL3122358T3 (pl) Połączenia inhibitorów fgfr i cmet w leczeniu nowotworu
IL251371A0 (en) Cortexolone 17alpha-benzoate for use in the treatment of tumors
IL248767B (en) Trimethoxyphenyl-benzaimidazole compounds for cancer treatment
IL251903A0 (en) Epilimod for use in the treatment of colon cancer
IL247859A0 (en) Cancer treatment
IL250507A0 (en) Anti-ck8 antibodies for use in cancer therapy
PL3253208T3 (pl) Terapie kombinowane do zastosowania w leczeniu nowotworu piersi
IL252493A0 (en) Compounds for use in the prevention or treatment of cancer
GB201410695D0 (en) Uses of oligouronates in cancer treatment
GB201411111D0 (en) bis-Pyridazine compounds and their use in treating cancer
HK1237824A1 (en) Combination therapy for use in cancer therapy
ZA201403006B (en) Composition for use in treatment of cancer
EP3125903A4 (en) Method for use of homopiperazinium compounds in the treatment of cancer
GB201417819D0 (en) Agents for cancer therapy
GB201411884D0 (en) Cancer therapy