RU2712166C2 - Лечение боли - Google Patents

Лечение боли Download PDF

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Publication number
RU2712166C2
RU2712166C2 RU2016102346A RU2016102346A RU2712166C2 RU 2712166 C2 RU2712166 C2 RU 2712166C2 RU 2016102346 A RU2016102346 A RU 2016102346A RU 2016102346 A RU2016102346 A RU 2016102346A RU 2712166 C2 RU2712166 C2 RU 2712166C2
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RU
Russia
Prior art keywords
pain
csf
seq
antibody
ser
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Application number
RU2016102346A
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English (en)
Russian (ru)
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RU2016102346A3 (enExample
RU2016102346A (ru
Inventor
Джон Аллан ХЭМИЛЬТОН
Эндрю Дэвид КУК
Original Assignee
Де Юниверсити Оф Мельбурн
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Publication of RU2016102346A publication Critical patent/RU2016102346A/ru
Publication of RU2016102346A3 publication Critical patent/RU2016102346A3/ru
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243Colony Stimulating Factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
RU2016102346A 2008-12-22 2009-12-21 Лечение боли RU2712166C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13968708P 2008-12-22 2008-12-22
US61/139,687 2008-12-22
US16449109P 2009-03-30 2009-03-30
US61/164,491 2009-03-30

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2011127333A Division RU2630969C2 (ru) 2008-12-22 2009-12-21 Лечение боли

Publications (3)

Publication Number Publication Date
RU2016102346A RU2016102346A (ru) 2018-11-20
RU2016102346A3 RU2016102346A3 (enExample) 2019-07-29
RU2712166C2 true RU2712166C2 (ru) 2020-01-24

Family

ID=42286785

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2016102346A RU2712166C2 (ru) 2008-12-22 2009-12-21 Лечение боли
RU2011127333A RU2630969C2 (ru) 2008-12-22 2009-12-21 Лечение боли

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2011127333A RU2630969C2 (ru) 2008-12-22 2009-12-21 Лечение боли

Country Status (12)

Country Link
US (3) US8475796B2 (enExample)
EP (2) EP2387418B1 (enExample)
JP (3) JP5674677B2 (enExample)
KR (1) KR101761324B1 (enExample)
CN (2) CN102256621B (enExample)
AU (2) AU2009329811B2 (enExample)
BR (1) BRPI0918103A2 (enExample)
CA (1) CA2747206C (enExample)
ES (2) ES2685895T3 (enExample)
HK (2) HK1255046A1 (enExample)
RU (2) RU2712166C2 (enExample)
WO (1) WO2010071923A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010071923A1 (en) * 2008-12-22 2010-07-01 The University Of Melbourne Pain treatment
AU2009329814B2 (en) 2008-12-22 2015-06-18 The University Of Melbourne Osteoarthritis treatment
KR20210021153A (ko) * 2012-09-20 2021-02-24 모르포시스 아게 류마티스 관절염에 대한 치료
CN109999195A (zh) * 2012-09-20 2019-07-12 莫弗系统股份公司 类风湿关节炎的治疗
JP6339578B2 (ja) * 2012-10-31 2018-06-06 タケダ・ゲー・エム・ベー・ハーTakeda GmbH Gm−csf中和化合物を含む凍結乾燥製剤
AR093297A1 (es) 2012-10-31 2015-05-27 Amgen Res Munich Gmbh Formulacion liquida que comprende un compuesto neutralizante de gm-csf
WO2014138862A1 (en) * 2013-03-14 2014-09-18 John Schrader Human monoclonal antibodies that neutralize bioactivity of granulocyte macrophage colony-stimulating factor and methods and uses thereof
CN105705518A (zh) 2013-08-30 2016-06-22 塔科达有限责任公司 用于治疗类风湿性关节炎或作为镇痛药的中和gm-csf的抗体
JP7256116B2 (ja) 2016-09-19 2023-04-11 アイ-エムエービー バイオファーマ (ハンジョウ) カンパニー リミテッド 抗gm-csf抗体およびその使用
CN107840885B (zh) * 2016-09-19 2020-11-10 天境生物科技(上海)有限公司 Gm-csf抗体及其用途
CN120093288B (zh) * 2025-05-08 2025-07-11 中国农业大学烟台研究院 一种牲畜生理行为监测方法及系统

Citations (5)

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WO2006122797A2 (en) * 2005-05-18 2006-11-23 Morphosys Ag Anti-gm-csf antibodies and uses therefor
WO2007092939A2 (en) * 2006-02-08 2007-08-16 Morphotek, Inc. Antigenic gm-csf peptides and antibodies to gm-csf
US20070243225A1 (en) * 2006-04-13 2007-10-18 Mckay William F Drug depot implant designs and methods of implantation
WO2008064321A2 (en) * 2006-11-21 2008-05-29 Kalobios Pharmaceuticals, Inc. Methods of treating chronic inflammatory diseases using a gm-csf antagonist

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WO2010071923A1 (en) 2008-12-22 2010-07-01 The University Of Melbourne Pain treatment
AU2009329814B2 (en) 2008-12-22 2015-06-18 The University Of Melbourne Osteoarthritis treatment
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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002100387A1 (en) * 2001-06-11 2002-12-19 A+ Science Invest Ab Prevention of neovascularization of intervertebral discs and/or of tissues with local inflammation
WO2006122797A2 (en) * 2005-05-18 2006-11-23 Morphosys Ag Anti-gm-csf antibodies and uses therefor
WO2007092939A2 (en) * 2006-02-08 2007-08-16 Morphotek, Inc. Antigenic gm-csf peptides and antibodies to gm-csf
US20070243225A1 (en) * 2006-04-13 2007-10-18 Mckay William F Drug depot implant designs and methods of implantation
WO2008064321A2 (en) * 2006-11-21 2008-05-29 Kalobios Pharmaceuticals, Inc. Methods of treating chronic inflammatory diseases using a gm-csf antagonist

Also Published As

Publication number Publication date
EP2387418A4 (en) 2013-07-17
EP2387418B1 (en) 2018-06-13
ES2685895T3 (es) 2018-10-15
AU2016200267B2 (en) 2017-09-07
HK1255227A1 (en) 2019-08-09
EP3381471C0 (en) 2024-03-20
US9834599B2 (en) 2017-12-05
HK1255046A1 (zh) 2019-08-02
CN102256621A (zh) 2011-11-23
US8475796B2 (en) 2013-07-02
US20160311896A1 (en) 2016-10-27
JP2017149740A (ja) 2017-08-31
RU2016102346A3 (enExample) 2019-07-29
US20130243791A1 (en) 2013-09-19
RU2016102346A (ru) 2018-11-20
AU2016200267A1 (en) 2016-02-11
JP6147704B2 (ja) 2017-06-14
RU2630969C2 (ru) 2017-09-15
CN102256621B (zh) 2017-12-12
US9352034B2 (en) 2016-05-31
AU2009329811B2 (en) 2016-02-25
KR20110117659A (ko) 2011-10-27
AU2009329811A1 (en) 2010-07-01
ES2978209T3 (es) 2024-09-09
JP5674677B2 (ja) 2015-02-25
CA2747206C (en) 2018-04-24
US20110287027A1 (en) 2011-11-24
RU2011127333A (ru) 2013-01-27
CA2747206A1 (en) 2010-07-01
EP3381471A1 (en) 2018-10-03
CN108014335A (zh) 2018-05-11
EP3381471B1 (en) 2024-03-20
EP2387418A1 (en) 2011-11-23
JP2012512814A (ja) 2012-06-07
JP2014224123A (ja) 2014-12-04
BRPI0918103A2 (pt) 2016-07-05
KR101761324B1 (ko) 2017-07-25
WO2010071923A1 (en) 2010-07-01

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