ES2685895T3 - Tratamiento del dolor - Google Patents
Tratamiento del dolor Download PDFInfo
- Publication number
- ES2685895T3 ES2685895T3 ES09833923.7T ES09833923T ES2685895T3 ES 2685895 T3 ES2685895 T3 ES 2685895T3 ES 09833923 T ES09833923 T ES 09833923T ES 2685895 T3 ES2685895 T3 ES 2685895T3
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- csf
- pain
- antagonist
- seq
- antibody
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US139687P | 1999-06-16 | ||
| US164491P | 1999-11-09 | ||
| US13968708P | 2008-12-22 | 2008-12-22 | |
| US16449109P | 2009-03-30 | 2009-03-30 | |
| PCT/AU2009/001671 WO2010071923A1 (en) | 2008-12-22 | 2009-12-21 | Pain treatment |
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|---|---|
| ES2685895T3 true ES2685895T3 (es) | 2018-10-15 |
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| ES18170226T Active ES2978209T3 (es) | 2008-12-22 | 2009-12-21 | Tratamiento del dolor |
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| ES18170226T Active ES2978209T3 (es) | 2008-12-22 | 2009-12-21 | Tratamiento del dolor |
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| EP (2) | EP2387418B1 (enExample) |
| JP (3) | JP5674677B2 (enExample) |
| KR (1) | KR101761324B1 (enExample) |
| CN (2) | CN102256621B (enExample) |
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| WO (1) | WO2010071923A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2010071923A1 (en) * | 2008-12-22 | 2010-07-01 | The University Of Melbourne | Pain treatment |
| AU2009329814B2 (en) | 2008-12-22 | 2015-06-18 | The University Of Melbourne | Osteoarthritis treatment |
| KR20210021153A (ko) * | 2012-09-20 | 2021-02-24 | 모르포시스 아게 | 류마티스 관절염에 대한 치료 |
| CN109999195A (zh) * | 2012-09-20 | 2019-07-12 | 莫弗系统股份公司 | 类风湿关节炎的治疗 |
| JP6339578B2 (ja) * | 2012-10-31 | 2018-06-06 | タケダ・ゲー・エム・ベー・ハーＴａｋｅｄａ ＧｍｂＨ | Ｇｍ−ｃｓｆ中和化合物を含む凍結乾燥製剤 |
| AR093297A1 (es) | 2012-10-31 | 2015-05-27 | Amgen Res Munich Gmbh | Formulacion liquida que comprende un compuesto neutralizante de gm-csf |
| WO2014138862A1 (en) * | 2013-03-14 | 2014-09-18 | John Schrader | Human monoclonal antibodies that neutralize bioactivity of granulocyte macrophage colony-stimulating factor and methods and uses thereof |
| CN105705518A (zh) | 2013-08-30 | 2016-06-22 | 塔科达有限责任公司 | 用于治疗类风湿性关节炎或作为镇痛药的中和gm-csf的抗体 |
| JP7256116B2 (ja) | 2016-09-19 | 2023-04-11 | アイ－エムエービー バイオファーマ （ハンジョウ） カンパニー リミテッド | 抗ｇｍ－ｃｓｆ抗体およびその使用 |
| CN107840885B (zh) * | 2016-09-19 | 2020-11-10 | 天境生物科技(上海)有限公司 | Gm-csf抗体及其用途 |
| CN120093288B (zh) * | 2025-05-08 | 2025-07-11 | 中国农业大学烟台研究院 | 一种牲畜生理行为监测方法及系统 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH27534A (en) * | 1989-07-14 | 1993-08-18 | Schering Corp | Antoganists of gm-csf derived from the carboxyl terminus |
| JP3267966B2 (ja) | 1989-08-11 | 2002-03-25 | アムラド・コーポレイション・リミテッド | 顆粒球―マクロファージコロニー刺激因子受容体およびその誘導体における改良 |
| US5747032A (en) | 1990-08-10 | 1998-05-05 | Amrad Corporation Limited | Monoclonal antibody to human granulocyte macrophage colony stimulating factor |
| EP0673389A1 (en) * | 1992-11-19 | 1995-09-27 | Dana Farber Cancer Institute | Antibodies for gm-csf receptor and uses thereof |
| ES2176484T3 (es) | 1995-08-18 | 2002-12-01 | Morphosys Ag | Bancos de proteinas/(poli)peptidos. |
| AUPP525198A0 (en) | 1998-08-13 | 1998-09-03 | Medvet Science Pty. Ltd. | Monoclonal antibody inhibitor of GM-CSF, IL-3 and IL-5 and other cytokines and uses thereof |
| US7108852B2 (en) | 2000-03-20 | 2006-09-19 | Warner-Lambert Company Llc | Methods of treating inflammation using antibodies to M-CSF |
| US7455836B2 (en) | 2000-05-08 | 2008-11-25 | The University Of Melbourne | Method of treatment and agents useful for same |
| SE0102067D0 (sv) * | 2001-06-11 | 2001-06-11 | A & Science Invest Ab | Prevention of neovascularization of intervertebral discs and/or of tissues with local inflammation |
| JP2005507915A (ja) | 2001-10-26 | 2005-03-24 | ノバルティス アクチエンゲゼルシャフト | 変形性関節症の処置方法およびその組成物 |
| US7381801B2 (en) | 2002-02-13 | 2008-06-03 | Ludwig Institute For Cancer Research | Chimerized GM-CSF antibodies |
| AU2002950957A0 (en) * | 2002-08-23 | 2002-09-12 | The Walter And Eliza Hall Institute Of Medical Research | A method of treatment and prophylaxis |
| US7569364B2 (en) | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
| US20040241755A1 (en) | 2003-06-02 | 2004-12-02 | Pfizer Inc. | Human cell assay to determine effect of sample compounds on Col2 enhancer expression |
| JP4825667B2 (ja) | 2004-03-31 | 2011-11-30 | 一和 中尾 | 関節炎症治療剤又は予防剤 |
| DE602004021773D1 (de) | 2004-05-05 | 2009-08-13 | Micromet Ag | Herstellung eines einkettigen fv Antikörperfragments |
| UA94403C2 (ru) | 2005-04-18 | 2011-05-10 | Микромет Аг | Человеческое моноклональное антитело, которое нейтрализует gm-csf |
| SI3620171T1 (sl) | 2005-05-18 | 2022-09-30 | Morphosys Ag | Protitelesa proti GM-CSF in uporabe zanje |
| JP4736037B2 (ja) | 2005-10-26 | 2011-07-27 | 株式会社イーベック | ヒトｇｍ−ｃｓｆに結合するヒトのモノクローナル抗体並びにその抗原結合部分 |
| EA200801166A1 (ru) | 2005-12-01 | 2008-12-30 | Домантис Лимитед | Форматы конкурентного доменного антитела, которые связываются с рецептором интерлейкина 1 первого типа |
| WO2007092939A2 (en) * | 2006-02-08 | 2007-08-16 | Morphotek, Inc. | Antigenic gm-csf peptides and antibodies to gm-csf |
| CA2647449C (en) | 2006-03-27 | 2017-05-16 | Medimmune Limited | Binding member for gm-csf receptor |
| US7741273B2 (en) | 2006-04-13 | 2010-06-22 | Warsaw Orthopedic, Inc. | Drug depot implant designs |
| EP2402013A1 (en) | 2006-11-21 | 2012-01-04 | Kalobios Pharmaceuticals, Inc. | Methods of Treating Chronic Inflammatory Diseases using a GM-CSF Antagonist |
| WO2008080134A2 (en) | 2006-12-22 | 2008-07-03 | Rigel Pharmaceuticals, Inc. | 4-amin0-2- (hetero) arylamino-5- (hetero) arylthiazoles useful as axl inhibitors |
| WO2008141391A1 (en) | 2007-05-23 | 2008-11-27 | Crc For Asthma And Airways Ltd | Neutralizing antibodies |
| TW200918553A (en) | 2007-09-18 | 2009-05-01 | Amgen Inc | Human GM-CSF antigen binding proteins |
| WO2009062238A1 (en) | 2007-11-12 | 2009-05-22 | Crc For Asthma And Airways Ltd | Epitope for neutralizing antibodies |
| CN104072613A (zh) | 2007-11-13 | 2014-10-01 | Evec股份有限公司 | 与hGM-CSF结合的单克隆抗体及包含它的药物组合物 |
| EA201001691A1 (ru) | 2008-04-28 | 2011-10-31 | Калобайос Фармасьютикалз, Инк. | Антитела к гранулоцитарно-макрофагальному колониестимулирующему фактору |
| WO2010071923A1 (en) | 2008-12-22 | 2010-07-01 | The University Of Melbourne | Pain treatment |
| AU2009329814B2 (en) | 2008-12-22 | 2015-06-18 | The University Of Melbourne | Osteoarthritis treatment |
| SG175305A1 (en) | 2009-04-23 | 2011-11-28 | Theraclone Sciences Inc | Granulocyte-macrophage colony-stimulating factor (gm-csf) neutralizing antibodies |
-
2009
- 2009-12-21 WO PCT/AU2009/001671 patent/WO2010071923A1/en not_active Ceased
- 2009-12-21 JP JP2011541029A patent/JP5674677B2/ja active Active
- 2009-12-21 EP EP09833923.7A patent/EP2387418B1/en active Active
- 2009-12-21 AU AU2009329811A patent/AU2009329811B2/en active Active
- 2009-12-21 CA CA2747206A patent/CA2747206C/en active Active
- 2009-12-21 KR KR1020117017019A patent/KR101761324B1/ko active Active
- 2009-12-21 CN CN200980151639.7A patent/CN102256621B/zh active Active
- 2009-12-21 BR BRPI0918103A patent/BRPI0918103A2/pt not_active Application Discontinuation
- 2009-12-21 EP EP18170226.7A patent/EP3381471B1/en active Active
- 2009-12-21 ES ES09833923.7T patent/ES2685895T3/es active Active
- 2009-12-21 RU RU2016102346A patent/RU2712166C2/ru active
- 2009-12-21 US US13/140,839 patent/US8475796B2/en active Active
- 2009-12-21 RU RU2011127333A patent/RU2630969C2/ru active
- 2009-12-21 CN CN201711112956.0A patent/CN108014335A/zh active Pending
- 2009-12-21 ES ES18170226T patent/ES2978209T3/es active Active
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2013
- 2013-05-28 US US13/903,009 patent/US9352034B2/en active Active
-
2014
- 2014-07-04 JP JP2014138170A patent/JP6147704B2/ja active Active
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2016
- 2016-01-18 AU AU2016200267A patent/AU2016200267B2/en active Active
- 2016-04-29 US US15/142,746 patent/US9834599B2/en active Active
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2017
- 2017-04-05 JP JP2017074868A patent/JP2017149740A/ja active Pending
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2018
- 2018-11-07 HK HK18114170.3A patent/HK1255046A1/zh unknown
- 2018-11-09 HK HK18114356.9A patent/HK1255227A1/en unknown
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