HK1255046A1 - 粒細胞巨噬細胞集落刺激因子的拮抗劑的用途 - Google Patents

粒細胞巨噬細胞集落刺激因子的拮抗劑的用途

Info

Publication number
HK1255046A1
HK1255046A1 HK18114170.3A HK18114170A HK1255046A1 HK 1255046 A1 HK1255046 A1 HK 1255046A1 HK 18114170 A HK18114170 A HK 18114170A HK 1255046 A1 HK1255046 A1 HK 1255046A1
Authority
HK
Hong Kong
Prior art keywords
antagonist
stimulating factor
macrophage colony
granulocyte macrophage
granulocyte
Prior art date
Application number
HK18114170.3A
Other languages
English (en)
Inventor
約翰‧艾倫‧漢密爾頓
安德魯‧大衛‧庫克
Original Assignee
墨爾本大學
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 墨爾本大學 filed Critical 墨爾本大學
Publication of HK1255046A1 publication Critical patent/HK1255046A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
HK18114170.3A 2008-12-22 2018-11-07 粒細胞巨噬細胞集落刺激因子的拮抗劑的用途 HK1255046A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13968708P 2008-12-22 2008-12-22
US16449109P 2009-03-30 2009-03-30

Publications (1)

Publication Number Publication Date
HK1255046A1 true HK1255046A1 (zh) 2019-08-02

Family

ID=42286785

Family Applications (2)

Application Number Title Priority Date Filing Date
HK18114170.3A HK1255046A1 (zh) 2008-12-22 2018-11-07 粒細胞巨噬細胞集落刺激因子的拮抗劑的用途
HK18114356.9A HK1255227A1 (zh) 2008-12-22 2018-11-09 疼痛治療

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK18114356.9A HK1255227A1 (zh) 2008-12-22 2018-11-09 疼痛治療

Country Status (12)

Country Link
US (3) US8475796B2 (zh)
EP (2) EP3381471B1 (zh)
JP (3) JP5674677B2 (zh)
KR (1) KR101761324B1 (zh)
CN (2) CN102256621B (zh)
AU (2) AU2009329811B2 (zh)
BR (1) BRPI0918103A2 (zh)
CA (1) CA2747206C (zh)
ES (2) ES2685895T3 (zh)
HK (2) HK1255046A1 (zh)
RU (2) RU2630969C2 (zh)
WO (1) WO2010071923A1 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2376121T1 (sl) 2008-12-22 2016-07-29 The University Of Melbourne Zdravljenje osteoartritisa
ES2685895T3 (es) 2008-12-22 2018-10-15 The University Of Melbourne Tratamiento del dolor
KR20210021153A (ko) * 2012-09-20 2021-02-24 모르포시스 아게 류마티스 관절염에 대한 치료
JP2015533806A (ja) * 2012-09-20 2015-11-26 モルフォシス・アー・ゲー 関節リウマチの治療
AR093297A1 (es) 2012-10-31 2015-05-27 Amgen Res (Munich) Gmbh Formulacion liquida que comprende un compuesto neutralizante de gm-csf
JP6339578B2 (ja) 2012-10-31 2018-06-06 タケダ・ゲー・エム・ベー・ハーＴａｋｅｄａ ＧｍｂＨ Ｇｍ−ｃｓｆ中和化合物を含む凍結乾燥製剤
WO2014138862A1 (en) * 2013-03-14 2014-09-18 John Schrader Human monoclonal antibodies that neutralize bioactivity of granulocyte macrophage colony-stimulating factor and methods and uses thereof
AU2014314053C1 (en) 2013-08-30 2023-11-02 Takeda Pharmaceutical Company Limited Antibodies neutralizing GM-CSF for use in the treatment of rheumatoid arthritis or as analgesics
CN107840885B (zh) * 2016-09-19 2020-11-10 天境生物科技(上海)有限公司 Gm-csf抗体及其用途
CN109219616B (zh) * 2016-09-19 2022-10-21 天境生物科技(杭州)有限公司 Gm-csf抗体及其用途

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04503815A (ja) * 1989-07-14 1992-07-09 シェリング・コーポレーション カルボキシル末端から誘導されたｇｍ―ｃｓｆのアンタゴニスト
EP0486572B1 (en) 1989-08-11 1998-01-07 Amrad Corporation Limited Improvements in granulocyte-macrophage colony-stimulating factor receptor and derivatives thereof
US5747032A (en) 1990-08-10 1998-05-05 Amrad Corporation Limited Monoclonal antibody to human granulocyte macrophage colony stimulating factor
AU5611394A (en) * 1992-11-19 1994-06-08 Dana-Farber Cancer Institute Antibodies for gm-csf receptor and uses thereof
CA2229043C (en) 1995-08-18 2016-06-07 Morphosys Gesellschaft Fur Proteinoptimierung Mbh Protein/(poly)peptide libraries
AUPP525198A0 (en) 1998-08-13 1998-09-03 Medvet Science Pty. Ltd. Monoclonal antibody inhibitor of GM-CSF, IL-3 and IL-5 and other cytokines and uses thereof
US7108852B2 (en) 2000-03-20 2006-09-19 Warner-Lambert Company Llc Methods of treating inflammation using antibodies to M-CSF
US7455836B2 (en) 2000-05-08 2008-11-25 The University Of Melbourne Method of treatment and agents useful for same
SE0102067D0 (sv) * 2001-06-11 2001-06-11 A & Science Invest Ab Prevention of neovascularization of intervertebral discs and/or of tissues with local inflammation
US20060067938A1 (en) 2001-10-26 2006-03-30 Sherif Daouti Methods for the treatment of osteoarthritis and compositions thereof
ATE444308T1 (de) 2002-02-13 2009-10-15 Ludwig Inst Cancer Res Fusionsproteine humanisierter g250-spezifischer antikörper sowie verwendungen davon
AU2002950957A0 (en) * 2002-08-23 2002-09-12 The Walter And Eliza Hall Institute Of Medical Research A method of treatment and prophylaxis
US7569364B2 (en) 2002-12-24 2009-08-04 Pfizer Inc. Anti-NGF antibodies and methods using same
US20040241755A1 (en) 2003-06-02 2004-12-02 Pfizer Inc. Human cell assay to determine effect of sample compounds on Col2 enhancer expression
CN1960758B (zh) 2004-03-31 2014-10-22 中外制药株式会社 关节炎的治疗剂或预防剂
ATE435238T1 (de) 2004-05-05 2009-07-15 Micromet Ag Herstellung eines einkettigen fv antikörperfragments
CN103342751B (zh) 2005-04-18 2015-12-23 安进研发（慕尼黑）股份有限公司 人粒细胞巨噬细胞集落刺激因子的抗体中和剂
HUE058876T2 (hu) * 2005-05-18 2022-09-28 Morphosys Ag Anti-GM-CSF antitestek és felhasználásuk
JP4736037B2 (ja) 2005-10-26 2011-07-27 株式会社イーベック ヒトｇｍ−ｃｓｆに結合するヒトのモノクローナル抗体並びにその抗原結合部分
KR20080077237A (ko) 2005-12-01 2008-08-21 도만티스 리미티드 인터루킨 1 수용체 타입 1에 결합하는 경쟁적 도메인 항체포맷
PT1981909T (pt) 2006-02-08 2017-01-18 Morphotek Inc Péptidos antigénicos do gm-csf e anticorpos contra o gm-csf
PT2423230E (pt) 2006-03-27 2013-08-26 Medimmune Ltd Membro de ligação para o recetor de gm-csf
US7741273B2 (en) * 2006-04-13 2010-06-22 Warsaw Orthopedic, Inc. Drug depot implant designs
SG176503A1 (en) 2006-11-21 2011-12-29 Kalobios Pharmaceuticals Inc Methods of treating chronic inflammatory diseases using a gm-csf antagonist
US7879856B2 (en) 2006-12-22 2011-02-01 Rigel Pharmaceuticals, Inc. Diaminothiazoles useful as Axl inhibitors
US20110044996A1 (en) 2007-05-23 2011-02-24 Charles Mackay Neutralizing antibodies
TW200918553A (en) 2007-09-18 2009-05-01 Amgen Inc Human GM-CSF antigen binding proteins
WO2009062238A1 (en) 2007-11-12 2009-05-22 Crc For Asthma And Airways Ltd Epitope for neutralizing antibodies
PT2215119E (pt) 2007-11-13 2013-02-11 Boehringer Ingelheim Int Anticorpos monoclonais que se ligam a hgm-csf e composições médicas que os compreendem
AU2009243184B2 (en) 2008-04-28 2015-06-04 Humanigen, Inc. Antibodies to granulocyte-macrophage colony-stimulating factor
SI2376121T1 (sl) 2008-12-22 2016-07-29 The University Of Melbourne Zdravljenje osteoartritisa
ES2685895T3 (es) * 2008-12-22 2018-10-15 The University Of Melbourne Tratamiento del dolor
CN102459340A (zh) 2009-04-23 2012-05-16 特罗科隆科学有限公司 粒性白血细胞-巨噬细胞菌落-刺激因子(gm-csf)中和抗体

Also Published As

Publication number Publication date
CN102256621A (zh) 2011-11-23
US8475796B2 (en) 2013-07-02
EP2387418A4 (en) 2013-07-17
ES2978209T3 (es) 2024-09-09
RU2016102346A (ru) 2018-11-20
AU2016200267A1 (en) 2016-02-11
RU2712166C2 (ru) 2020-01-24
EP2387418B1 (en) 2018-06-13
US20110287027A1 (en) 2011-11-24
EP3381471C0 (en) 2024-03-20
RU2630969C2 (ru) 2017-09-15
EP2387418A1 (en) 2011-11-23
US9834599B2 (en) 2017-12-05
BRPI0918103A2 (pt) 2016-07-05
AU2016200267B2 (en) 2017-09-07
AU2009329811B2 (en) 2016-02-25
AU2009329811A1 (en) 2010-07-01
ES2685895T3 (es) 2018-10-15
US9352034B2 (en) 2016-05-31
WO2010071923A1 (en) 2010-07-01
CA2747206C (en) 2018-04-24
US20130243791A1 (en) 2013-09-19
JP6147704B2 (ja) 2017-06-14
JP5674677B2 (ja) 2015-02-25
KR101761324B1 (ko) 2017-07-25
EP3381471A1 (en) 2018-10-03
EP3381471B1 (en) 2024-03-20
JP2017149740A (ja) 2017-08-31
RU2016102346A3 (zh) 2019-07-29
JP2012512814A (ja) 2012-06-07
CN108014335A (zh) 2018-05-11
HK1255227A1 (zh) 2019-08-09
US20160311896A1 (en) 2016-10-27
KR20110117659A (ko) 2011-10-27
CA2747206A1 (en) 2010-07-01
JP2014224123A (ja) 2014-12-04
RU2011127333A (ru) 2013-01-27
CN102256621B (zh) 2017-12-12

Similar Documents

Publication Publication Date Title
HK1255046A1 (zh) 粒細胞巨噬細胞集落刺激因子的拮抗劑的用途
HK1163770A1 (en) Adjustable ladders
IL219390A0 (en) Il-17a antagonists
PT2513058T (pt) Métodos de síntese de inibidores do fator xa
IL210207A0 (en) Compounds having antiviral properties
PL2328545T3 (pl) Zastosowanie glukozyloglicerolu
AU327287S (en) Table skirting panel
ZA201008076B (en) Calibration of dtonators
ZA201105056B (en) 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2
HK1160925A1 (zh) 組織蛋白酶 的用途
GB0916609D0 (en) Coated insulation board
EP2328873A4 (en) PREPARATION OF RANOLAZINE
EP2391895A4 (en) PRECISION MEASUREMENT OF WAVEFORMS
PL2237782T3 (pl) Zastosowanie tetrahydropirymidyn
EP2370476A4 (en) IONIC COMONOMER SYNTHESIS SOLUBLE IN STYRENE
PL388186A1 (pl) Listwa przypodłogowa
EP2257303A4 (en) USES OF MODIFIED ELR-CXC G31P CHEMOKINE
PL2358570T3 (pl) Izolacja akustyczna
EP2369920A4 (en) IONIC COMONOMER SYNTHESIS SOLUBLE IN STYRENE
TWM371466U (en) Hidden-type extension table
GB0724013D0 (en) Granulocyte colony stimulating factor
GB0715133D0 (en) Granulocyte colony stimulating factor
PL384708A1 (pl) Stół pomiarowy
PL118323U1 (pl) Listwa przypodłogowa
IL207069A0 (en) An extendable table