RU2709742C2 - Гуманизированные антитела к ox40 и способы их применения - Google Patents

Гуманизированные антитела к ox40 и способы их применения Download PDF

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RU2709742C2
RU2709742C2 RU2017115662A RU2017115662A RU2709742C2 RU 2709742 C2 RU2709742 C2 RU 2709742C2 RU 2017115662 A RU2017115662 A RU 2017115662A RU 2017115662 A RU2017115662 A RU 2017115662A RU 2709742 C2 RU2709742 C2 RU 2709742C2
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antibody
seq
cells
fragment
human
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Скотт А. ХАММОНД
Майкл ОБЕРСТ
Цюнь ДУ
Мелисса ДАМШРОДЕР
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МЕДИММЬЮН, ЭлЭлСи
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
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    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07K2317/734Complement-dependent cytotoxicity [CDC]
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Wood Science & Technology (AREA)
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  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
RU2017115662A 2014-10-10 2015-10-07 Гуманизированные антитела к ox40 и способы их применения RU2709742C2 (ru)

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Application Number Priority Date Filing Date Title
US201462062431P 2014-10-10 2014-10-10
US62/062,431 2014-10-10
PCT/US2015/054490 WO2016057667A1 (en) 2014-10-10 2015-10-07 Humanized anti-ox40 antibodies and uses thereof

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RU2017115662A RU2017115662A (ru) 2018-11-13
RU2017115662A3 RU2017115662A3 (OSRAM) 2019-05-20
RU2709742C2 true RU2709742C2 (ru) 2019-12-19

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US (3) US9738723B2 (OSRAM)
EP (1) EP3204422B1 (OSRAM)
JP (2) JP6794348B2 (OSRAM)
KR (1) KR20170064550A (OSRAM)
CN (1) CN107074953A (OSRAM)
AR (1) AR102239A1 (OSRAM)
AU (1) AU2015328090A1 (OSRAM)
BR (1) BR112017007170A2 (OSRAM)
CA (1) CA2963798A1 (OSRAM)
CL (1) CL2017000885A1 (OSRAM)
CO (1) CO2017004516A2 (OSRAM)
ES (1) ES2914177T3 (OSRAM)
GB (1) GB2536324A (OSRAM)
IL (1) IL251537A0 (OSRAM)
MX (1) MX2017004715A (OSRAM)
RU (1) RU2709742C2 (OSRAM)
SG (1) SG11201702826XA (OSRAM)
TW (1) TW201619200A (OSRAM)
WO (1) WO2016057667A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
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RU2826983C2 (ru) * 2020-09-10 2024-09-19 Обласов Михаил Викторович Способ лечения covid-19 с помощью применения агонистов рецептора ox40 (cd134)

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