RU2707752C2 - Композиции, включающие трамадол и целекоксиб, для лечения боли - Google Patents

Композиции, включающие трамадол и целекоксиб, для лечения боли Download PDF

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RU2707752C2
RU2707752C2 RU2016125895A RU2016125895A RU2707752C2 RU 2707752 C2 RU2707752 C2 RU 2707752C2 RU 2016125895 A RU2016125895 A RU 2016125895A RU 2016125895 A RU2016125895 A RU 2016125895A RU 2707752 C2 RU2707752 C2 RU 2707752C2
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pain
celecoxib
tramadol
pharmaceutical composition
rac
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RU2016125895A
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Russian (ru)
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RU2016125895A3 (enExample
RU2016125895A (ru
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Энрике ПОРТИЛЬО САЛИДО
Себастия ВИДЕЛА СЕС
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Эстеве Фармасьютикалз, С.А.
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Application filed by Эстеве Фармасьютикалз, С.А. filed Critical Эстеве Фармасьютикалз, С.А.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/01Hydrocarbons
    • A61K31/015Hydrocarbons carbocyclic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • A61K31/085Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/63Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2016125895A 2009-10-16 2010-10-15 Композиции, включающие трамадол и целекоксиб, для лечения боли RU2707752C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09384004A EP2311446A1 (en) 2009-10-16 2009-10-16 Compositions comprising Tramadol and Celecoxib in the treatment of pain
EP09384004.9 2009-10-16

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2012120087/15A Division RU2012120087A (ru) 2009-10-16 2010-10-15 Композиции, включающие трамадол и целекоксиб для лечения боли

Publications (3)

Publication Number Publication Date
RU2016125895A3 RU2016125895A3 (enExample) 2018-12-05
RU2016125895A RU2016125895A (ru) 2018-12-05
RU2707752C2 true RU2707752C2 (ru) 2019-11-29

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ID=41566149

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2016125895A RU2707752C2 (ru) 2009-10-16 2010-10-15 Композиции, включающие трамадол и целекоксиб, для лечения боли
RU2012120087/15A RU2012120087A (ru) 2009-10-16 2010-10-15 Композиции, включающие трамадол и целекоксиб для лечения боли

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Application Number Title Priority Date Filing Date
RU2012120087/15A RU2012120087A (ru) 2009-10-16 2010-10-15 Композиции, включающие трамадол и целекоксиб для лечения боли

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Country Link
US (3) US8569271B2 (enExample)
EP (3) EP2311446A1 (enExample)
JP (2) JP5579858B2 (enExample)
KR (1) KR101688996B1 (enExample)
CN (2) CN107050006A (enExample)
AR (1) AR078653A1 (enExample)
AU (1) AU2010306114B2 (enExample)
BR (1) BR112012005044B8 (enExample)
CA (1) CA2771651C (enExample)
CO (1) CO6511249A2 (enExample)
CY (1) CY1114960T1 (enExample)
DK (1) DK2488170T3 (enExample)
EC (1) ECSP12011735A (enExample)
ES (1) ES2450615T3 (enExample)
HR (1) HRP20140157T1 (enExample)
IL (1) IL218096A (enExample)
IN (1) IN2012DN01434A (enExample)
MA (1) MA33743B1 (enExample)
MX (1) MX2012003051A (enExample)
MY (1) MY156275A (enExample)
NZ (1) NZ598361A (enExample)
PL (1) PL2488170T3 (enExample)
PT (1) PT2488170E (enExample)
RS (1) RS53202B (enExample)
RU (2) RU2707752C2 (enExample)
SG (1) SG178833A1 (enExample)
SI (1) SI2488170T1 (enExample)
SM (1) SMT201400035B (enExample)
TN (1) TN2012000059A1 (enExample)
TW (1) TWI466668B (enExample)
UA (1) UA108213C2 (enExample)
WO (1) WO2011045075A1 (enExample)
ZA (1) ZA201202151B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2177215A1 (en) 2008-10-17 2010-04-21 Laboratorios Del. Dr. Esteve, S.A. Co-crystals of tramadol and NSAIDs
US8746719B2 (en) 2010-08-03 2014-06-10 Polaris Industries Inc. Side-by-side vehicle
MX346312B (es) * 2011-04-05 2017-03-15 Optosolve Res & Dev Ltd Tratamientos oftalmicos.
ES2551427T3 (es) 2012-02-06 2015-11-19 William L. Pridgen Combinación de famciclovir y celecoxib para síndromes somáticos funcionales
WO2016116942A1 (en) 2015-01-20 2016-07-28 Anlon Chemical Research Organization Novel pharmaceutical compounds comprising ticagrelor with salts of aspirin
WO2016191744A1 (en) * 2015-05-28 2016-12-01 Dr. Reddy's Laboratories Ltd. Oral composition of celecoxib for treatment of pain
KR101710792B1 (ko) * 2015-07-14 2017-02-28 주식회사 유영제약 세레콕시브 및 트라마돌을 함유하는 약제학적 조성물
MX2016006464A (es) * 2016-05-18 2017-11-17 Laboratorios Liomont S A De C V Composicion farmaceutica de una combinacion de clorhidrato de tramadol-etoricoxib para el tratamiento del dolor.
US10722456B2 (en) * 2016-05-27 2020-07-28 Dr. Reddy's Laboratories Ltd Oral composition of celecoxib for treatment of pain
WO2018186650A2 (ko) * 2017-04-03 2018-10-11 주식회사 킴스헬스케어 트라마돌과 셀레콕시브를 포함한 경구투여용 이중 복합정제
KR102033716B1 (ko) 2017-04-03 2019-10-17 주식회사 킴스헬스케어 트라마돌과 셀레콕시브를 포함한 경구투여용 이중 복합정제
KR102631399B1 (ko) 2018-03-30 2024-02-01 씨지인바이츠 주식회사 폴마콕시브 및 프레가발린을 포함하는 통증 치료용 약제학적 조성물
BR112021020893A2 (pt) * 2019-05-14 2022-04-19 Esteve Pharmaceuticals Sa Uso de cocristais de tramadol e celecoxib para o tratamento de dor, ao mesmo tempo que reduzindo a suscetibilidade a abuso do tramadol
CN112007024A (zh) * 2019-05-28 2020-12-01 江苏恒瑞医药股份有限公司 艾瑞昔布与曲马多联合在制备治疗疼痛的药物中的用途
EP4267132A1 (en) 2020-12-28 2023-11-01 Dr. Reddy's Laboratories Ltd. Celecoxib for treating pain
WO2025125888A1 (en) * 2023-12-15 2025-06-19 Centro De Investigación Y De Estudios Avanzados Del I.P.N. Aripiprazole and tramadol compositions with potentiation effects and high analgesic efficacy useful for the treatment of neuropathic pain

Citations (3)

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Publication number Priority date Publication date Assignee Title
US5516803A (en) * 1991-10-30 1996-05-14 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
WO2000051685A1 (en) * 1999-03-01 2000-09-08 Ortho-Mcneil Pharmaceutical, Inc. Composition comprising a tramadol material and a selective cox-2 inhibitor drug
US20070015841A1 (en) * 2002-02-15 2007-01-18 Transform Pharmaceuticals, Inc. Pharmaceutical propylene glycol solvate compositions

Family Cites Families (7)

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AU661723B2 (en) 1991-10-30 1995-08-03 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
RS49982B (sr) * 1997-09-17 2008-09-29 Euro-Celtique S.A., Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
DE19927688A1 (de) 1999-06-17 2000-12-21 Gruenenthal Gmbh Mehrschichttablette zur Verabreichung einer fixen Kombination von Tramadol und Diclofenac
ATE524186T1 (de) * 2002-02-19 2011-09-15 Adcock Ingram Ltd Pharmazeutische kombinationen bestehend aus meloxicam, tramadol und paracetamol
US20080031950A1 (en) * 2007-04-27 2008-02-07 Nectid Inc. Novel anelgesic combination
HRP20130316T1 (en) 2009-10-16 2013-05-31 Laboratorios Del Dr. Esteve, S.A. Co-crystals of tramadol and coxibs
EP2392319A1 (en) 2010-06-04 2011-12-07 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical compositions of co-crystals of tramadol and coxibs

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516803A (en) * 1991-10-30 1996-05-14 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
WO2000051685A1 (en) * 1999-03-01 2000-09-08 Ortho-Mcneil Pharmaceutical, Inc. Composition comprising a tramadol material and a selective cox-2 inhibitor drug
US20070015841A1 (en) * 2002-02-15 2007-01-18 Transform Pharmaceuticals, Inc. Pharmaceutical propylene glycol solvate compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Осипова Н.А. Трамадол (Трамал) в лечении острых и хронических болевых синдромов // Русский медицинский журнал.-2003. -N4. *

Also Published As

Publication number Publication date
CO6511249A2 (es) 2012-08-31
KR20120089287A (ko) 2012-08-09
MA33743B1 (fr) 2012-11-01
RU2016125895A3 (enExample) 2018-12-05
ZA201202151B (en) 2012-11-28
BR112012005044B8 (pt) 2021-05-25
US20150150889A1 (en) 2015-06-04
DK2488170T3 (en) 2014-03-03
CN107050006A (zh) 2017-08-18
HK1173379A1 (en) 2013-05-16
IN2012DN01434A (enExample) 2015-06-05
BR112012005044A2 (pt) 2016-05-03
CY1114960T1 (el) 2016-12-14
PT2488170E (pt) 2014-03-11
UA108213C2 (uk) 2015-04-10
AU2010306114A1 (en) 2012-03-15
US20120172341A1 (en) 2012-07-05
KR101688996B1 (ko) 2016-12-22
IL218096A0 (en) 2012-04-30
PL2488170T3 (pl) 2014-05-30
SI2488170T1 (sl) 2014-04-30
TWI466668B (zh) 2015-01-01
RS53202B (sr) 2014-06-30
NZ598361A (en) 2014-01-31
SG178833A1 (en) 2012-05-30
US20140024622A1 (en) 2014-01-23
RU2012120087A (ru) 2013-11-27
IL218096A (en) 2015-02-26
US8569271B2 (en) 2013-10-29
ECSP12011735A (es) 2012-05-30
EP2488170B1 (en) 2014-01-22
BR112012005044B1 (pt) 2020-12-15
SMT201400035B (it) 2014-05-07
ES2450615T3 (es) 2014-03-25
JP2013507408A (ja) 2013-03-04
EP2311446A1 (en) 2011-04-20
JP2014221797A (ja) 2014-11-27
WO2011045075A1 (en) 2011-04-21
EP2488170A1 (en) 2012-08-22
TW201114418A (en) 2011-05-01
TN2012000059A1 (en) 2013-09-19
MX2012003051A (es) 2012-05-29
CN102573824A (zh) 2012-07-11
CA2771651A1 (en) 2011-04-11
AR078653A1 (es) 2011-11-23
CA2771651C (en) 2016-08-23
MY156275A (en) 2016-01-29
EP2737898A1 (en) 2014-06-04
AU2010306114B2 (en) 2015-07-23
RU2016125895A (ru) 2018-12-05
JP5579858B2 (ja) 2014-08-27
HRP20140157T1 (hr) 2014-03-28

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