HRP20140157T1 - Pripravci koji sadrže tramadol i celekoksib za lijeäśenje bola - Google Patents

Pripravci koji sadrže tramadol i celekoksib za lijeäśenje bola Download PDF

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Publication number
HRP20140157T1
HRP20140157T1 HRP20140157AT HRP20140157T HRP20140157T1 HR P20140157 T1 HRP20140157 T1 HR P20140157T1 HR P20140157A T HRP20140157A T HR P20140157AT HR P20140157 T HRP20140157 T HR P20140157T HR P20140157 T1 HRP20140157 T1 HR P20140157T1
Authority
HR
Croatia
Prior art keywords
pain
celecoxib
tramadol
pharmaceutical preparation
rac
Prior art date
Application number
HRP20140157AT
Other languages
English (en)
Inventor
Enrique Portillo Salido
Sebastia Videla Ces
Original Assignee
Laboratorios Del Dr. Esteve, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41566149&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20140157(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Laboratorios Del Dr. Esteve, S.A. filed Critical Laboratorios Del Dr. Esteve, S.A.
Publication of HRP20140157T1 publication Critical patent/HRP20140157T1/hr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Claims (4)

1. Farmaceutski pripravak koji sadrži kombinaciju (rac)-tramadol·HCl i celekoksiba ili farmaceutski prihvatljivu sol ili hidrat, naznačen time da molekularni omjer (rac)-tramadol·HCl prema celekoksibu je molarni omjer od 1:1 do 1:5 ili od 1:1 do 5:1.
2. Farmaceutski pripravak prema zahtjevu 1 naznačen time da je celekoksib u neutralnom obliku.
3. Farmaceutski pripravak prema zahtjevu 1 naznačen time da molekularni omjer (rac)-tramadol·HCl prema celekoksibu je molarni omjer od 1:1.
4. Farmaceutski pripravak prema bilo kojem od zahtjeva 1 ili 3 naznačen time da je za uporabu kao analgetik ili uporabu kod liječenja bola, poželjno akutnog bola, kroničnog bola, neuropatskog bola, nociceptivnog bola, blagog, srednjeg i teškog bola, hiperalgezije, bola u vezi sa središnjom senzibilizacijom, alodinije ili bola zbog karcinoma, uključivši dijabetičku neuropatiju ili dijabetičku perifernu neuropatiju i osteoartritis, fibromialgiju, reumatoidni artritis, ankilozirajući spondilitis, smrznuto rame ili išijas.
HRP20140157AT 2009-10-16 2014-02-19 Pripravci koji sadrže tramadol i celekoksib za lijeäśenje bola HRP20140157T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09384004A EP2311446A1 (en) 2009-10-16 2009-10-16 Compositions comprising Tramadol and Celecoxib in the treatment of pain
PCT/EP2010/006317 WO2011045075A1 (en) 2009-10-16 2010-10-15 Compositions comprising tramadol and celecoxib in the treatment of pain

Publications (1)

Publication Number Publication Date
HRP20140157T1 true HRP20140157T1 (hr) 2014-03-28

Family

ID=41566149

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20140157AT HRP20140157T1 (hr) 2009-10-16 2014-02-19 Pripravci koji sadrže tramadol i celekoksib za lijeäśenje bola

Country Status (34)

Country Link
US (3) US8569271B2 (hr)
EP (3) EP2311446A1 (hr)
JP (2) JP5579858B2 (hr)
KR (1) KR101688996B1 (hr)
CN (2) CN102573824A (hr)
AR (1) AR078653A1 (hr)
AU (1) AU2010306114B2 (hr)
BR (1) BR112012005044B8 (hr)
CA (1) CA2771651C (hr)
CO (1) CO6511249A2 (hr)
CY (1) CY1114960T1 (hr)
DK (1) DK2488170T3 (hr)
EC (1) ECSP12011735A (hr)
ES (1) ES2450615T3 (hr)
HK (1) HK1173379A1 (hr)
HR (1) HRP20140157T1 (hr)
IL (1) IL218096A (hr)
IN (1) IN2012DN01434A (hr)
MA (1) MA33743B1 (hr)
MX (1) MX2012003051A (hr)
MY (1) MY156275A (hr)
NZ (1) NZ598361A (hr)
PL (1) PL2488170T3 (hr)
PT (1) PT2488170E (hr)
RS (1) RS53202B (hr)
RU (2) RU2707752C2 (hr)
SG (1) SG178833A1 (hr)
SI (1) SI2488170T1 (hr)
SM (1) SMT201400035B (hr)
TN (1) TN2012000059A1 (hr)
TW (1) TWI466668B (hr)
UA (1) UA108213C2 (hr)
WO (1) WO2011045075A1 (hr)
ZA (1) ZA201202151B (hr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2177215A1 (en) 2008-10-17 2010-04-21 Laboratorios Del. Dr. Esteve, S.A. Co-crystals of tramadol and NSAIDs
US8746719B2 (en) * 2010-08-03 2014-06-10 Polaris Industries Inc. Side-by-side vehicle
EP2694048B1 (en) * 2011-04-05 2020-10-07 Optosolve Research & Development Ltd Ophthalmic treatments
US9642824B2 (en) 2012-02-06 2017-05-09 Innovative Med Concepts, LLC Valaciclovir and diclofenac combination therapy for functional somatic syndromes
WO2016116942A1 (en) 2015-01-20 2016-07-28 Anlon Chemical Research Organization Novel pharmaceutical compounds comprising ticagrelor with salts of aspirin
EA038013B1 (ru) * 2015-05-28 2021-06-23 Др. Редди'С Лабораториз Лтд. Пероральная композиция целекоксиба для лечения боли
KR101710792B1 (ko) * 2015-07-14 2017-02-28 주식회사 유영제약 세레콕시브 및 트라마돌을 함유하는 약제학적 조성물
MX2016006464A (es) * 2016-05-18 2017-11-17 Laboratorios Liomont S A De C V Composicion farmaceutica de una combinacion de clorhidrato de tramadol-etoricoxib para el tratamiento del dolor.
EP3463340A2 (en) * 2016-05-27 2019-04-10 Dr. Reddy's Laboratories Ltd. Oral composition of celecoxib for treatment of pain
US20200323780A1 (en) 2017-04-03 2020-10-15 Kims Healthcare Co., Ltd. Bilayer combination tablet for oral administration containing tramadol and celecoxib
WO2018186650A2 (ko) * 2017-04-03 2018-10-11 주식회사 킴스헬스케어 트라마돌과 셀레콕시브를 포함한 경구투여용 이중 복합정제
KR102631399B1 (ko) 2018-03-30 2024-02-01 씨지인바이츠 주식회사 폴마콕시브 및 프레가발린을 포함하는 통증 치료용 약제학적 조성물
CA3137381A1 (en) * 2019-05-14 2020-11-19 Esteve Pharmaceuticals, S.A. Use of co-crystals of tramadol and celecoxib for treating pain while reducing the abuse liability of tramadol
CN112007024A (zh) * 2019-05-28 2020-12-01 江苏恒瑞医药股份有限公司 艾瑞昔布与曲马多联合在制备治疗疼痛的药物中的用途

Family Cites Families (10)

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AU661723B2 (en) 1991-10-30 1995-08-03 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
US5516803A (en) 1991-10-30 1996-05-14 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
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EP2392319A1 (en) 2010-06-04 2011-12-07 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical compositions of co-crystals of tramadol and coxibs

Also Published As

Publication number Publication date
IL218096A0 (en) 2012-04-30
CA2771651C (en) 2016-08-23
CO6511249A2 (es) 2012-08-31
US8569271B2 (en) 2013-10-29
TWI466668B (zh) 2015-01-01
BR112012005044B8 (pt) 2021-05-25
WO2011045075A1 (en) 2011-04-21
CY1114960T1 (el) 2016-12-14
EP2488170B1 (en) 2014-01-22
RU2016125895A3 (hr) 2018-12-05
AU2010306114A1 (en) 2012-03-15
RU2016125895A (ru) 2018-12-05
PL2488170T3 (pl) 2014-05-30
ZA201202151B (en) 2012-11-28
MA33743B1 (fr) 2012-11-01
US20150150889A1 (en) 2015-06-04
EP2737898A1 (en) 2014-06-04
CA2771651A1 (en) 2011-04-11
PT2488170E (pt) 2014-03-11
RS53202B (en) 2014-06-30
SG178833A1 (en) 2012-05-30
CN102573824A (zh) 2012-07-11
ECSP12011735A (es) 2012-05-30
KR20120089287A (ko) 2012-08-09
TN2012000059A1 (en) 2013-09-19
JP5579858B2 (ja) 2014-08-27
AU2010306114B2 (en) 2015-07-23
TW201114418A (en) 2011-05-01
BR112012005044B1 (pt) 2020-12-15
BR112012005044A2 (pt) 2016-05-03
JP2013507408A (ja) 2013-03-04
CN107050006A (zh) 2017-08-18
AR078653A1 (es) 2011-11-23
US20120172341A1 (en) 2012-07-05
US20140024622A1 (en) 2014-01-23
SMT201400035B (it) 2014-05-07
EP2311446A1 (en) 2011-04-20
RU2707752C2 (ru) 2019-11-29
KR101688996B1 (ko) 2016-12-22
HK1173379A1 (en) 2013-05-16
EP2488170A1 (en) 2012-08-22
JP2014221797A (ja) 2014-11-27
IL218096A (en) 2015-02-26
RU2012120087A (ru) 2013-11-27
MY156275A (en) 2016-01-29
DK2488170T3 (en) 2014-03-03
IN2012DN01434A (hr) 2015-06-05
ES2450615T3 (es) 2014-03-25
UA108213C2 (uk) 2015-04-10
MX2012003051A (es) 2012-05-29
SI2488170T1 (sl) 2014-04-30
NZ598361A (en) 2014-01-31

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