RU2706693C2 - Вирусная вакцина и способы ее производства - Google Patents

Вирусная вакцина и способы ее производства Download PDF

Info

Publication number
RU2706693C2
RU2706693C2 RU2016114285A RU2016114285A RU2706693C2 RU 2706693 C2 RU2706693 C2 RU 2706693C2 RU 2016114285 A RU2016114285 A RU 2016114285A RU 2016114285 A RU2016114285 A RU 2016114285A RU 2706693 C2 RU2706693 C2 RU 2706693C2
Authority
RU
Russia
Prior art keywords
virus
mass
purified
japanese encephalitis
membrane
Prior art date
Application number
RU2016114285A
Other languages
English (en)
Russian (ru)
Other versions
RU2016114285A (ru
RU2016114285A3 (fr
Inventor
Кришна Мохан ВАДРЕВУ
Венкатесан РАМАСАМИ
Прасанна Кумар ДУВВУРУ
Original Assignee
Бхарат Байотек Интернэшнл Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бхарат Байотек Интернэшнл Лимитед filed Critical Бхарат Байотек Интернэшнл Лимитед
Publication of RU2016114285A publication Critical patent/RU2016114285A/ru
Publication of RU2016114285A3 publication Critical patent/RU2016114285A3/ru
Application granted granted Critical
Publication of RU2706693C2 publication Critical patent/RU2706693C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24151—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
RU2016114285A 2013-09-14 2014-09-08 Вирусная вакцина и способы ее производства RU2706693C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN4135/CHE/2013 2013-09-14
IN4135CH2013 IN2013CH04135A (fr) 2013-09-14 2014-09-08
PCT/IN2014/000585 WO2015059714A1 (fr) 2013-09-14 2014-09-08 Mode d'urgence dans un véhicule hybride

Publications (3)

Publication Number Publication Date
RU2016114285A RU2016114285A (ru) 2017-10-19
RU2016114285A3 RU2016114285A3 (fr) 2018-07-16
RU2706693C2 true RU2706693C2 (ru) 2019-11-20

Family

ID=52997726

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2016114285A RU2706693C2 (ru) 2013-09-14 2014-09-08 Вирусная вакцина и способы ее производства

Country Status (6)

Country Link
CN (1) CN105744952A (fr)
AU (1) AU2014338520B2 (fr)
IN (1) IN2013CH04135A (fr)
PH (1) PH12016500500A1 (fr)
RU (1) RU2706693C2 (fr)
WO (1) WO2015059714A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015148704A1 (fr) 2014-03-25 2015-10-01 Terumo Bct, Inc. Remplacement passif de milieu
WO2017004592A1 (fr) 2015-07-02 2017-01-05 Terumo Bct, Inc. Croissance cellulaire à l'aide de stimuli mécaniques
WO2017083286A1 (fr) 2015-11-09 2017-05-18 University Of Notre Dame Procédé et dispositifs de purification de taille de particule
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
WO2018184028A2 (fr) 2017-03-31 2018-10-04 Terumo Bct, Inc. Expansion cellulaire
CN111511395B (zh) 2017-11-03 2024-10-15 武田疫苗股份有限公司 用于将寨卡病毒灭活和用于确定灭活完全性的方法
JP2021505549A (ja) 2017-11-30 2021-02-18 タケダ ワクチン, インコーポレイテッドTakeda Vaccines, Inc. ジカワクチン及び免疫原性組成物、ならびにその使用方法
EP3581646A1 (fr) * 2018-06-15 2019-12-18 Themis Bioscience GmbH Système chromatographique et de fabrication intégré pour la production de virus
CN111394321A (zh) * 2020-03-30 2020-07-10 无锡加莱克色谱科技有限公司 病毒颗粒纯化用超大孔径层析介质及其应用方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999011762A1 (fr) * 1997-08-28 1999-03-11 Cheil Jedang Corporation Virus de l'encephalite japonaise attenue, adapte a des cellules vero et vaccin contre l'encephalite japonaise
WO2010137036A2 (fr) * 2009-05-25 2010-12-02 Panacea Biotec Ltd Nouveau vaccin contre l'encéphalite japonaise et procédé de fabrication correspondant
WO2012073257A2 (fr) * 2010-11-30 2012-06-07 Bharat Biotech International Limited Formulations vaccinales pour la prophylaxie et le traitement d'infections par le virus chandipura chez les mammifères
WO2013130001A1 (fr) * 2012-02-29 2013-09-06 Ge Healthcare Bio-Sciences Ab Procédé pour l'élimination des endotoxines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102100910B (zh) * 2009-12-21 2013-01-23 北京清大天一科技有限公司 一种生产病毒疫苗的方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999011762A1 (fr) * 1997-08-28 1999-03-11 Cheil Jedang Corporation Virus de l'encephalite japonaise attenue, adapte a des cellules vero et vaccin contre l'encephalite japonaise
WO2010137036A2 (fr) * 2009-05-25 2010-12-02 Panacea Biotec Ltd Nouveau vaccin contre l'encéphalite japonaise et procédé de fabrication correspondant
WO2012073257A2 (fr) * 2010-11-30 2012-06-07 Bharat Biotech International Limited Formulations vaccinales pour la prophylaxie et le traitement d'infections par le virus chandipura chez les mammifères
WO2013130001A1 (fr) * 2012-02-29 2013-09-06 Ge Healthcare Bio-Sciences Ab Procédé pour l'élimination des endotoxines

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BADAM L., In vitro antiviral activity of indigenous glycyrrhizin, licorice and glycyrrhizic acid (Sigma) on Japanese encephalitis virus.J Commun Dis. 1997 Jun; 29(2):91-9. *
CHEN WR., et al., Genetic variation of Japanese encephalitis virus in nature.J Gen Virol. 1990 Dec;71 ( Pt 12):2915-22. *
SAKODA Y., et al., Purification of human and avian influenza viruses using cellulose sulfate ester (Cellufine Sulfate) *
SAKODA Y., et al., Purification of human and avian influenza viruses using cellulose sulfate ester (Cellufine Sulfate) in the process of vaccine production.Microbiol Immunol. 2012 Jul; 56(7):490-5. doi: 10.1111/j.1348-0421.2012.00468.x. *

Also Published As

Publication number Publication date
AU2014338520B2 (en) 2019-12-05
PH12016500500A1 (en) 2016-06-13
CN105744952A (zh) 2016-07-06
IN2013CH04135A (fr) 2015-08-14
RU2016114285A (ru) 2017-10-19
WO2015059714A1 (fr) 2015-04-30
RU2016114285A3 (fr) 2018-07-16
WO2015059714A8 (fr) 2015-06-18
AU2014338520A1 (en) 2016-03-31

Similar Documents

Publication Publication Date Title
RU2706693C2 (ru) Вирусная вакцина и способы ее производства
EP1427817B1 (fr) Multiplication de virus dans une culture cellulaire
EP1427815B1 (fr) Procedes pour la production industrielle de vaccins
ES2653197T3 (es) Procedimiento para producir antígeno ortomixoviral y vacunas
CN107267466B (zh) 一种大规模生产猪伪狂犬病灭活疫苗的方法
US6149917A (en) Industrial production process for a vaccine against Japanese encephalitis virus and vaccine produced
DE19612966A1 (de) Tierische Zellen und Verfahren zur Vermehrung von Influenzaviren
WO2013154928A1 (fr) Systèmes et procédés de propagation de virus dans une culture cellulaire pour la fabrication de vaccins
CN107567496A (zh) 有关病毒的无菌纯化方法
CN101352570B (zh) 二倍体细胞狂犬疫苗及纯化狂犬疫苗的制备方法
EA010057B1 (ru) Инактивированная полиомиелитная вакцина, полученная из штамма сейбина вируса полиомиелита
US20210268405A1 (en) Method for producing recombinant adenovirus
CN103223163A (zh) Ipv-dpt疫苗
US9932562B2 (en) Drain down and re-feed of microcarrier bioreactor
CN116656628A (zh) 一种痘病毒载体疫苗的制备方法
KR20120027381A (ko) 일본뇌염 백신 및 그것의 제조 방법
KR102245547B1 (ko) 고밀도의 미정제 세포 배양 수거물의 정화를 위한 방법
CN105296438A (zh) 一种制备森林脑炎灭活疫苗的生产方法
US8426124B2 (en) Two-step temperature profile for the propagation of viruses
CN102343087A (zh) 麻疹长-47株制备二倍体细胞减毒活疫苗及制备工艺
CN1513553B (zh) Vero细胞森林脑炎灭活疫苗
RU2683508C1 (ru) Штамм вируса для изготовления вакцинных препаратов против геморрагической лихорадки с почечным синдромом (варианты)
Yashaswini Effect of ionic liquid buffered excipients on inactivation kinetics and storage stability of foot-and-mouth disease vaccine antigen
CN114272366A (zh) 一种制备人用乙型脑炎灭活疫苗的方法及疫苗
CN115305276A (zh) 一种去除病毒样本中支原体污染的方法