RU2696492C2 - Дейтрированные гетероциклические соединения и их применение в качестве средств визуализации - Google Patents
Дейтрированные гетероциклические соединения и их применение в качестве средств визуализации Download PDFInfo
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- RU2696492C2 RU2696492C2 RU2016147742A RU2016147742A RU2696492C2 RU 2696492 C2 RU2696492 C2 RU 2696492C2 RU 2016147742 A RU2016147742 A RU 2016147742A RU 2016147742 A RU2016147742 A RU 2016147742A RU 2696492 C2 RU2696492 C2 RU 2696492C2
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| WO2019145291A1 (en) | 2018-01-24 | 2019-08-01 | Ac Immune Sa | Gamma-carboline compounds for the detection of tau aggregates |
| WO2019169111A1 (en) | 2018-03-02 | 2019-09-06 | The Trustees Of The University Of Pennsylvania | [1,2,4]triazolo[1,5-a]pyrimidine compounds and use in stabilizing microtubules |
| CN112513036B (zh) | 2018-05-17 | 2024-05-24 | 福马治疗有限公司 | 用作泛素特异性肽酶30抑制剂的稠合双环化合物 |
| JP7297053B2 (ja) | 2018-08-20 | 2023-06-23 | アルビナス・オペレーションズ・インコーポレイテッド | 神経変性疾患を治療するためのｅ３ユビキチンリガーゼ結合活性を有するキメラ（ｐｒｏｔａｃ）化合物を標的とし、アルファ－シヌクレインタンパク質を標的とするタンパク質分解 |
| EP3853234B1 (en) | 2018-09-18 | 2025-04-23 | Nikang Therapeutics, Inc. | Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors |
| CA3110113A1 (en) | 2018-10-05 | 2020-04-09 | Forma Therapeutics, Inc. | Fused pyrrolines which act as ubiquitin-specific protease 30 (usp30) inhibitors |
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| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| JP7119978B2 (ja) * | 2018-12-20 | 2022-08-17 | オムロン株式会社 | 制御装置およびプログラム |
| TWI751548B (zh) * | 2019-05-09 | 2022-01-01 | 瑞士商赫孚孟拉羅股份公司 | 經標記之咪唑并[1,2-a]嘧啶之合成 |
| CN114867727B (zh) | 2019-07-17 | 2025-02-21 | 阿尔维纳斯运营股份有限公司 | Tau蛋白靶向化合物及相关使用方法 |
| CN113526526A (zh) * | 2021-07-12 | 2021-10-22 | 苏州大学 | 氘代氨制备方法及以其作为氘源参与的氘代反应 |
| IL310382A (en) | 2021-08-27 | 2024-03-01 | Genentech Inc | Methods for treating tau pathologies |
| CN120187452A (zh) | 2022-06-13 | 2025-06-20 | 基因泰克公司 | 使用克瑞尼珠单抗延迟或预防阿尔茨海默病的发作的方法 |
| WO2025155625A1 (en) * | 2024-01-16 | 2025-07-24 | Eli Lilly And Company | Novel compounds for tau imaging |
| CN118957609B (zh) * | 2024-07-23 | 2025-09-09 | 无锡绿能电合科技有限公司 | 一种氟代芳环的氘代方法 |
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| CN101522624B (zh) * | 2006-03-30 | 2013-11-06 | 宾夕法尼亚大学理事会 | 苯乙烯基吡啶衍生物及其用于结合和成像淀粉样蛋白斑的用途 |
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| LT2247558T (lt) | 2008-02-14 | 2022-04-11 | Eli Lilly And Company | Nauji vizualizavimo agentai neurologinės disfunkcijos aptikimui |
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| ES2797523T3 (es) | 2009-03-23 | 2020-12-02 | Lilly Co Eli | Agentes de obtención de imagen para detectar trastornos neurológicos |
| EP2450332A1 (en) * | 2010-10-22 | 2012-05-09 | Bayer Pharma Aktiengesellschaft | Compounds for use in Imaging, diagnosing and/or treatment of diseases of the central nervous system (F-D2-Deprenyl) |
| NZ610315A (en) * | 2010-11-15 | 2015-08-28 | Univ Leuven Kath | Antiviral condensed heterocyclic compounds |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2847846C1 (ru) * | 2024-12-20 | 2025-10-15 | Федеральное государственное бюджетное учреждение "Российский научный центр радиологии и хирургических технологий имени академика А.М. Гранова" Министерства здравоохранения Российской Федерации | Соли 2,4-бис(4-(диметиламино)стирил)бензо[4,5]азоло[3,2-а]пиримидин-5-ия, обладающие цитотоксическим действием |
| RU2851432C1 (ru) * | 2024-12-20 | 2025-11-24 | Федеральное государственное бюджетное учреждение "Российский научный центр радиологии и хирургических технологий имени академика А.М. Гранова" Министерства здравоохранения Российской Федерации | Соли (E)-4-(4-(диметиламино)стирил)-2-метилбензо[4,5]азоло[3,2-a]пиримидин-5-ия, обладающие цитотоксическим действием |
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