RU2696202C1 - Гуманизация антител кролика с использованием универсального каркаса антитела - Google Patents

Гуманизация антител кролика с использованием универсального каркаса антитела Download PDF

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RU2696202C1
RU2696202C1 RU2018109506A RU2018109506A RU2696202C1 RU 2696202 C1 RU2696202 C1 RU 2696202C1 RU 2018109506 A RU2018109506 A RU 2018109506A RU 2018109506 A RU2018109506 A RU 2018109506A RU 2696202 C1 RU2696202 C1 RU 2696202C1
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Russia
Prior art keywords
framework
molecule
antibody
immunobinding
rabbit
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RU2018109506A
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English (en)
Russian (ru)
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Леонардо БОРРАС
Дэвид УРЕХ
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ИЭсБиЭйТЕК, ЭН АЛЬКОН БАЙОМЕДИКАЛ РИСЕРЧ ЮНИТ ЭлЭлСи
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
RU2018109506A 2008-06-25 2018-03-19 Гуманизация антител кролика с использованием универсального каркаса антитела RU2696202C1 (ru)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US7569208P 2008-06-25 2008-06-25
US7569708P 2008-06-25 2008-06-25
US61/075,697 2008-06-25
US61/075,692 2008-06-25
US15510509P 2009-02-24 2009-02-24
US15504109P 2009-02-24 2009-02-24
US61/155,041 2009-02-24
US61/155,105 2009-02-24
CH832/09 2009-06-02
CH8322009 2009-06-02

Related Parent Applications (1)

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RU2014111173A Division RU2652907C2 (ru) 2008-06-25 2014-03-24 Гуманизация антител кролика с использованием универсального каркаса антитела

Related Child Applications (1)

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RU2019119412A Division RU2019119412A (ru) 2008-06-25 2019-06-21 Гуманизация антител кролика с использованием универсального каркаса антитела

Publications (1)

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RU2696202C1 true RU2696202C1 (ru) 2019-07-31

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RU2018109506A RU2696202C1 (ru) 2008-06-25 2018-03-19 Гуманизация антител кролика с использованием универсального каркаса антитела
RU2019119412A RU2019119412A (ru) 2008-06-25 2019-06-21 Гуманизация антител кролика с использованием универсального каркаса антитела

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Country Status (9)

Country Link
JP (5) JP2015120746A (ja)
KR (2) KR20210097819A (ja)
CL (1) CL2010001539A1 (ja)
ES (1) ES2771150T3 (ja)
HU (1) HUE047678T2 (ja)
PH (2) PH12013502219A1 (ja)
PT (2) PT2307458T (ja)
RU (2) RU2696202C1 (ja)
ZA (3) ZA201008592B (ja)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002086093A2 (en) * 2001-04-25 2002-10-31 Weigel Paul H Methods of using a hyaluronan receptor
EA007958B1 (ru) * 2000-08-03 2007-02-27 Терапеутик Хьюман Поликлоналз Инк. ТРАНСГЕННЫЙ ВЕКТОР, СОДЕРЖАЩИЙ ГУМАНИЗИРОВАННЫЙ ЛОКУС Ig, И ЕГО ПРИМЕНЕНИЕ ДЛЯ ПОЛУЧЕНИЯ ТРАНСГЕННЫХ ЖИВОТНЫХ

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000516452A (ja) * 1996-07-16 2000-12-12 プリュックテュン，アンドレアス 可溶性が増大した免疫グロブリンスーパーファミリードメインおよびフラグメント
AU2003217912A1 (en) * 2002-03-01 2003-09-16 Xencor Antibody optimization
NZ536412A (en) * 2002-05-22 2008-10-31 Esbatech Ag Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same
EP1539947A4 (en) * 2002-08-15 2006-09-06 Epitomics Inc HUMANIZED RABBIT ANTIBODIES
JP2007520991A (ja) * 2003-08-07 2007-08-02 エピトミクス インコーポレーティッド ウサギ単クローン抗体をヒト型化する方法
JP2007528723A (ja) * 2003-08-22 2007-10-18 メディミューン，インコーポレーテッド 抗体のヒト化
US7431927B2 (en) * 2005-03-24 2008-10-07 Epitomics, Inc. TNFα-neutralizing antibodies
CA2609999C (en) * 2005-06-07 2017-05-30 Esbatech Ag Stable and soluble antibodies inhibiting tnf.alpha.
ATE523525T1 (de) * 2005-06-20 2011-09-15 Genentech Inc Anti-tumorassoziiertes antigen tat10772 zum nachweis und behandlung von krebs
GB0520436D0 (en) * 2005-10-07 2005-11-16 Photobiotics Ltd Biological materials and uses thereof
WO2008004834A1 (en) * 2006-07-06 2008-01-10 Isu Abxis Co., Ltd Humanized monoclonal antibody highly binding to epidermal growth factor receptor, egf receptor
MX2009010120A (es) * 2007-03-22 2009-10-19 Ucb Pharma Sa Proteinas de union, incluyendo anticuerpos, derivados de anticuerpo y fragmentos de anticuerpo, que se unen especificamente cd154 y sus usos.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA007958B1 (ru) * 2000-08-03 2007-02-27 Терапеутик Хьюман Поликлоналз Инк. ТРАНСГЕННЫЙ ВЕКТОР, СОДЕРЖАЩИЙ ГУМАНИЗИРОВАННЫЙ ЛОКУС Ig, И ЕГО ПРИМЕНЕНИЕ ДЛЯ ПОЛУЧЕНИЯ ТРАНСГЕННЫХ ЖИВОТНЫХ
WO2002086093A2 (en) * 2001-04-25 2002-10-31 Weigel Paul H Methods of using a hyaluronan receptor

Also Published As

Publication number Publication date
PT2307458T (pt) 2018-07-18
HUE047678T2 (hu) 2020-05-28
KR102284435B1 (ko) 2021-08-02
PH12018501715A1 (en) 2019-08-19
JP2016135815A (ja) 2016-07-28
ZA201008592B (en) 2014-02-26
JP6903083B2 (ja) 2021-07-14
ES2771150T3 (es) 2020-07-06
JP2015120746A (ja) 2015-07-02
KR20210097819A (ko) 2021-08-09
JP2019065050A (ja) 2019-04-25
CL2010001539A1 (es) 2012-02-03
ZA201308755B (en) 2015-08-26
RU2019119412A (ru) 2020-12-21
KR20190091578A (ko) 2019-08-06
ZA201503267B (en) 2016-07-27
JP2017190352A (ja) 2017-10-19
PT2752428T (pt) 2020-02-14
JP6568557B2 (ja) 2019-08-28
PH12013502219A1 (en) 2016-01-25
JP2020114260A (ja) 2020-07-30

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Effective date: 20200310