PH12013502219A1 - Humanization of rabbit antibodies using a universal antibody framework - Google Patents

Humanization of rabbit antibodies using a universal antibody framework

Info

Publication number
PH12013502219A1
PH12013502219A1 PH12013502219A PH12013502219A PH12013502219A1 PH 12013502219 A1 PH12013502219 A1 PH 12013502219A1 PH 12013502219 A PH12013502219 A PH 12013502219A PH 12013502219 A PH12013502219 A PH 12013502219A PH 12013502219 A1 PH12013502219 A1 PH 12013502219A1
Authority
PH
Philippines
Prior art keywords
universal antibody
humanization
rabbit antibodies
antibody framework
antibodies
Prior art date
Application number
PH12013502219A
Other languages
English (en)
Inventor
Borras Leonardo
Urech David
Original Assignee
Esbatech Alcon Biomed Res Unit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CH2009/000222 external-priority patent/WO2009155726A2/en
Application filed by Esbatech Alcon Biomed Res Unit filed Critical Esbatech Alcon Biomed Res Unit
Publication of PH12013502219A1 publication Critical patent/PH12013502219A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PH12013502219A 2008-06-25 2013-10-25 Humanization of rabbit antibodies using a universal antibody framework PH12013502219A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US7569208P 2008-06-25 2008-06-25
US7569708P 2008-06-25 2008-06-25
US15504109P 2009-02-24 2009-02-24
US15510509P 2009-02-24 2009-02-24
CH8322009 2009-06-02
PCT/CH2009/000222 WO2009155726A2 (en) 2008-06-25 2009-06-25 Humanization of rabbit antibodies using a universal antibody framework

Publications (1)

Publication Number Publication Date
PH12013502219A1 true PH12013502219A1 (en) 2016-01-25

Family

ID=53532693

Family Applications (2)

Application Number Title Priority Date Filing Date
PH12013502219A PH12013502219A1 (en) 2008-06-25 2013-10-25 Humanization of rabbit antibodies using a universal antibody framework
PH12018501715A PH12018501715A1 (en) 2008-06-25 2018-08-13 Humanization of rabbit antibodies using a universal antibody framework

Family Applications After (1)

Application Number Title Priority Date Filing Date
PH12018501715A PH12018501715A1 (en) 2008-06-25 2018-08-13 Humanization of rabbit antibodies using a universal antibody framework

Country Status (9)

Country Link
JP (5) JP2015120746A (ja)
KR (2) KR102284435B1 (ja)
CL (1) CL2010001539A1 (ja)
ES (1) ES2771150T3 (ja)
HU (1) HUE047678T2 (ja)
PH (2) PH12013502219A1 (ja)
PT (2) PT2307458T (ja)
RU (2) RU2696202C1 (ja)
ZA (3) ZA201008592B (ja)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998002462A1 (en) * 1996-07-16 1998-01-22 Morphosys Gesellschaft Für Proteinoptimierung Mbh Immunoglobulin superfamily domains and fragments with increased solubility
EA013564B1 (ru) * 2000-08-03 2010-06-30 Терапеутик Хьюман Поликлоналз Инк. Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция
CA2445627A1 (en) * 2001-04-25 2002-10-31 Paul H. Weigel Methods of using a hyaluronan receptor
WO2003074679A2 (en) * 2002-03-01 2003-09-12 Xencor Antibody optimization
WO2003097697A2 (en) * 2002-05-22 2003-11-27 Esbatech Ag Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same
WO2004016740A2 (en) * 2002-08-15 2004-02-26 Epitomics, Inc. Humanized rabbit antibodies
EP1651659A4 (en) * 2003-08-07 2008-09-17 Epitomics Inc METHOD FOR HUMANIZATION OF MONOCLONAL RABBIT ANTIBODIES
US20050042664A1 (en) * 2003-08-22 2005-02-24 Medimmune, Inc. Humanization of antibodies
US7431927B2 (en) * 2005-03-24 2008-10-07 Epitomics, Inc. TNFα-neutralizing antibodies
DK2390267T3 (da) * 2005-06-07 2013-08-26 Esbatech A Novartis Co Llc Stabile og opløselige antistoffer, der hæmmer TNF(alfa)
CA2611778C (en) * 2005-06-20 2012-11-27 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
GB0520436D0 (en) * 2005-10-07 2005-11-16 Photobiotics Ltd Biological materials and uses thereof
WO2008004834A1 (en) * 2006-07-06 2008-01-10 Isu Abxis Co., Ltd Humanized monoclonal antibody highly binding to epidermal growth factor receptor, egf receptor
GEP20146112B (en) * 2007-03-22 2014-06-25 Ucb Pharma Sa Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and usage thereof

Also Published As

Publication number Publication date
RU2696202C1 (ru) 2019-07-31
ZA201503267B (en) 2016-07-27
ZA201008592B (en) 2014-02-26
RU2019119412A (ru) 2020-12-21
JP2020114260A (ja) 2020-07-30
JP2015120746A (ja) 2015-07-02
PH12018501715A1 (en) 2019-08-19
KR20210097819A (ko) 2021-08-09
KR20190091578A (ko) 2019-08-06
JP2019065050A (ja) 2019-04-25
ZA201308755B (en) 2015-08-26
PT2307458T (pt) 2018-07-18
JP2016135815A (ja) 2016-07-28
JP2017190352A (ja) 2017-10-19
JP6568557B2 (ja) 2019-08-28
JP6903083B2 (ja) 2021-07-14
KR102284435B1 (ko) 2021-08-02
CL2010001539A1 (es) 2012-02-03
ES2771150T3 (es) 2020-07-06
PT2752428T (pt) 2020-02-14
HUE047678T2 (hu) 2020-05-28

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