RU2692775C2 - Производные нафтиридина в качестве антагонистов альфа v бета 6 интегрина для лечения, в частности, фиброзных заболеваний - Google Patents

Производные нафтиридина в качестве антагонистов альфа v бета 6 интегрина для лечения, в частности, фиброзных заболеваний Download PDF

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RU2692775C2
RU2692775C2 RU2017114355A RU2017114355A RU2692775C2 RU 2692775 C2 RU2692775 C2 RU 2692775C2 RU 2017114355 A RU2017114355 A RU 2017114355A RU 2017114355 A RU2017114355 A RU 2017114355A RU 2692775 C2 RU2692775 C2 RU 2692775C2
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methyl
pyrazol
pharmaceutically acceptable
acceptable salt
mmol
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RU2017114355A
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RU2017114355A (ru
RU2017114355A3 (OSRAM
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Нилл Эндрю АНДЕРСОН
Ян Бакстер КЭМПБЕЛЛ
Мэттью Говард Джеймс КЭМПБЕЛЛ-КРОУФОРД
Эшли Пол ХЭНКОК
Сибл ЛЕММА
Саймон Джон Фосетт Макдоналд
Джон Мартин Притчард
Панайетис Александроу ПРОКОПИОУ
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Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002Heterocyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU2017114355A 2014-09-26 2015-09-22 Производные нафтиридина в качестве антагонистов альфа v бета 6 интегрина для лечения, в частности, фиброзных заболеваний RU2692775C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1417094.8A GB201417094D0 (en) 2014-09-26 2014-09-26 Novel compounds
GB1417094.8 2014-09-26
PCT/EP2015/071782 WO2016046230A1 (en) 2014-09-26 2015-09-22 Naphthyridine derivatives as alpha v beta 6 integrin antagonists for the treatment of e.g. fibrotic diseases

Publications (3)

Publication Number Publication Date
RU2017114355A RU2017114355A (ru) 2018-10-29
RU2017114355A3 RU2017114355A3 (OSRAM) 2019-01-14
RU2692775C2 true RU2692775C2 (ru) 2019-06-27

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RU2017114355A RU2692775C2 (ru) 2014-09-26 2015-09-22 Производные нафтиридина в качестве антагонистов альфа v бета 6 интегрина для лечения, в частности, фиброзных заболеваний

Country Status (12)

Country Link
US (2) US10144733B2 (OSRAM)
EP (1) EP3197894B1 (OSRAM)
JP (1) JP6657196B2 (OSRAM)
KR (1) KR20170053638A (OSRAM)
CN (1) CN107074851B (OSRAM)
AU (1) AU2015320863B2 (OSRAM)
BR (1) BR112017006242A2 (OSRAM)
CA (1) CA2962321A1 (OSRAM)
ES (1) ES2811119T3 (OSRAM)
GB (1) GB201417094D0 (OSRAM)
RU (1) RU2692775C2 (OSRAM)
WO (1) WO2016046230A1 (OSRAM)

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GB201417002D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compound
GB201417011D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
US20190144547A1 (en) * 2015-11-23 2019-05-16 Merck Patent Gmbh Anti-alpha-v integrin antibody for the treatment of fibrosis and/or fibrotic disorders
JP2019510020A (ja) 2016-03-15 2019-04-11 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 害虫を防除するための置換スルホニルアミド類
GB201604680D0 (en) 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds
BR112019009245A2 (pt) 2016-11-08 2019-07-16 Bristol-Myers Squibb Company azol amidas e aminas como inibidores de alfav integrina
PL3538525T3 (pl) 2016-11-08 2022-09-12 Bristol-Myers Squibb Company 3-podstawione kwasy propionowe jako inhibitory integryny alfa v
MA46745A (fr) 2016-11-08 2021-03-31 Bristol Myers Squibb Co Dérivés d'indazole en tant qu'antagonistes de l'intégrine alpha v
BR112019009129A2 (pt) 2016-11-08 2019-07-16 Bristol-Myers Squibb Company compostos mono e espirocíclicos contendo ciclobutano e azetidina como inibidores de alfa v integrina
JP7220653B2 (ja) * 2016-11-08 2023-02-10 ブリストル-マイヤーズ スクイブ カンパニー アルファvインテグリン阻害剤としてのピロールアミド
US10696672B2 (en) 2016-12-23 2020-06-30 Pliant Therapeutics, Inc. Amino acid compounds and methods of use
EP3589285A4 (en) 2017-02-28 2020-08-12 Morphic Therapeutic, Inc. INHIBITORS OF INTEGRIN (ALPHA-V) (BETA-6)
CN116283977A (zh) 2017-02-28 2023-06-23 莫菲克医疗股份有限公司 αvβ6整合蛋白的抑制剂
AU2018365793A1 (en) 2017-11-07 2020-06-18 Bristol-Myers Squibb Company Pyrrolopyrazine derivatives as alpha V integrin inhibitors
TWI857918B (zh) * 2018-08-29 2024-10-01 美商莫菲克醫療股份有限公司 αvβ6整合素之抑制劑
SG11202101913PA (en) 2018-08-29 2021-03-30 Morphic Therapeutic Inc INHIBITING aV ß6 INTEGRIN
GB202010626D0 (en) 2020-07-10 2020-08-26 Univ Nottingham Compound
EP4490042A1 (en) 2022-03-08 2025-01-15 Equashield Medical Ltd. Fluid transfer station in a robotic pharmaceutical preparation system
CN120731091A (zh) 2022-12-14 2025-09-30 阿尔尼拉姆医药品有限公司 用于肝外递送的α-Vβ-6(αvβ6)整合素配体

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RU2296764C2 (ru) * 2001-11-05 2007-04-10 Новартис Аг Производные нафтиридина, способ их получения и применение
RU2481347C2 (ru) * 2007-08-01 2013-05-10 Валеант Фармасьютикалс Интернэшнл Производные нафтиридина в качестве модуляторов калиевых каналов

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WO2001024797A1 (en) * 1999-10-04 2001-04-12 Merck & Co., Inc. Integrin receptor antagonists
RU2296764C2 (ru) * 2001-11-05 2007-04-10 Новартис Аг Производные нафтиридина, способ их получения и применение
WO2005082889A1 (en) * 2004-02-18 2005-09-09 Janssen Pharmaceutica N.V. Piperidinyl targeting compounds that selectively bind integrins
RU2481347C2 (ru) * 2007-08-01 2013-05-10 Валеант Фармасьютикалс Интернэшнл Производные нафтиридина в качестве модуляторов калиевых каналов

Also Published As

Publication number Publication date
US10513517B2 (en) 2019-12-24
US20190048005A1 (en) 2019-02-14
ES2811119T3 (es) 2021-03-10
WO2016046230A1 (en) 2016-03-31
KR20170053638A (ko) 2017-05-16
AU2015320863A1 (en) 2017-03-09
GB201417094D0 (en) 2014-11-12
RU2017114355A (ru) 2018-10-29
US10144733B2 (en) 2018-12-04
EP3197894A1 (en) 2017-08-02
EP3197894B1 (en) 2020-06-03
AU2015320863B2 (en) 2018-09-06
RU2017114355A3 (OSRAM) 2019-01-14
CA2962321A1 (en) 2016-03-31
CN107074851A (zh) 2017-08-18
JP6657196B2 (ja) 2020-03-04
BR112017006242A2 (pt) 2017-12-12
JP2017528504A (ja) 2017-09-28
US20170291899A1 (en) 2017-10-12
CN107074851B (zh) 2020-01-10

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Effective date: 20200923