JP6657196B2 - 線維性疾患などの治療のためのαｖβ６インテグリンアンタゴニストとしてのナフチリジン誘導体 - Google Patents

線維性疾患などの治療のためのαｖβ６インテグリンアンタゴニストとしてのナフチリジン誘導体 Download PDF

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Publication number
JP6657196B2
JP6657196B2 JP2017516367A JP2017516367A JP6657196B2 JP 6657196 B2 JP6657196 B2 JP 6657196B2 JP 2017516367 A JP2017516367 A JP 2017516367A JP 2017516367 A JP2017516367 A JP 2017516367A JP 6657196 B2 JP6657196 B2 JP 6657196B2
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methyl
pyrazol
mmol
ethyl
acid
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JP2017516367A
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Japanese (ja)
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JP2017528504A (ja
JP2017528504A5 (OSRAM
Inventor
ニール、アンドリュー、アンダーソン
イアン、バクスター、キャンベル
マシュー、ハワード、ジェームズ、キャンベル−クロフォード
アシュリー、ポール、ハンコック
セーブル、レンマ
サイモン、ジョン、フォーセット、マクドナルド
ジョン、マーティン、プリチャード
パナヨティス、アレクサンドル、プロコピウ
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GlaxoSmithKline Intellectual Property Development Ltd
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GlaxoSmithKline Intellectual Property Development Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2017516367A 2014-09-26 2015-09-22 線維性疾患などの治療のためのαｖβ６インテグリンアンタゴニストとしてのナフチリジン誘導体 Expired - Fee Related JP6657196B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1417094.8A GB201417094D0 (en) 2014-09-26 2014-09-26 Novel compounds
GB1417094.8 2014-09-26
PCT/EP2015/071782 WO2016046230A1 (en) 2014-09-26 2015-09-22 Naphthyridine derivatives as alpha v beta 6 integrin antagonists for the treatment of e.g. fibrotic diseases

Publications (3)

Publication Number Publication Date
JP2017528504A JP2017528504A (ja) 2017-09-28
JP2017528504A5 JP2017528504A5 (OSRAM) 2018-10-25
JP6657196B2 true JP6657196B2 (ja) 2020-03-04

Family

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JP2017516367A Expired - Fee Related JP6657196B2 (ja) 2014-09-26 2015-09-22 線維性疾患などの治療のためのαｖβ６インテグリンアンタゴニストとしてのナフチリジン誘導体

Country Status (12)

Country Link
US (2) US10144733B2 (OSRAM)
EP (1) EP3197894B1 (OSRAM)
JP (1) JP6657196B2 (OSRAM)
KR (1) KR20170053638A (OSRAM)
CN (1) CN107074851B (OSRAM)
AU (1) AU2015320863B2 (OSRAM)
BR (1) BR112017006242A2 (OSRAM)
CA (1) CA2962321A1 (OSRAM)
ES (1) ES2811119T3 (OSRAM)
GB (1) GB201417094D0 (OSRAM)
RU (1) RU2692775C2 (OSRAM)
WO (1) WO2016046230A1 (OSRAM)

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HK1254295A1 (zh) * 2015-11-23 2019-07-19 默克专利股份有限公司 用於治疗纤维化和/或纤维化病症的抗-αＶ整合素抗体
AU2017233739A1 (en) 2016-03-15 2018-09-20 Bayer Cropscience Aktiengesellschaft Substituted sulfonyl amides for controlling animal pests
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WO2018089357A1 (en) 2016-11-08 2018-05-17 Bristol-Myers Squibb Company INDAZOLE DERIVATIVES AS αV INTEGRIN ANTAGONISTS
CA3042693A1 (en) * 2016-11-08 2018-05-17 Bristol-Myers Squibb Company Pyrrole amides as .alpha.v integrin inhibitors
JP7128811B2 (ja) 2016-11-08 2022-08-31 ブリストル－マイヤーズ スクイブ カンパニー アルファｖインテグリン阻害剤としてのアゾールアミドおよびアミン
KR102506324B1 (ko) 2016-11-08 2023-03-03 브리스톨-마이어스 스큅 컴퍼니 알파 v 인테그린 억제제로서의 시클로부탄- 및 아제티딘-함유 모노 및 스피로시클릭 화합물
HRP20220990T1 (hr) 2016-11-08 2022-11-11 Bristol-Myers Squibb Company 3-supstituirane propionske kiseline kao inhibitori alfa v integrina
US10696672B2 (en) 2016-12-23 2020-06-30 Pliant Therapeutics, Inc. Amino acid compounds and methods of use
EP3589627A4 (en) 2017-02-28 2020-08-05 Morphic Therapeutic, Inc. (ALPHA-V) (BETA-6) INHIBITORS INTEGRIN
EP3760202A1 (en) 2017-02-28 2021-01-06 Morphic Therapeutic, Inc. Inhibitors of (alpha-v)(beta-6) integrin
WO2019094319A1 (en) 2017-11-07 2019-05-16 Bristol-Myers Squibb Company Pyrrolopyrazine derivatives as alpha v integrin inhibitors
PL3844162T3 (pl) 2018-08-29 2025-06-09 Morphic Therapeutic, Inc. Inhibitory integryny alfa v beta 6
EP3617206A1 (en) 2018-08-29 2020-03-04 Morphic Therapeutic, Inc. Integrin inhibitors
GB202010626D0 (en) 2020-07-10 2020-08-26 Univ Nottingham Compound
JP2025509154A (ja) 2022-03-08 2025-04-11 エクアシールド メディカル リミテッド ロボット医薬品調製システムにおける流体移送ステーション
JP2025541280A (ja) 2022-12-14 2025-12-18 アルナイラム ファーマシューティカルズ， インコーポレイテッド 肝外送達のためのアルファ－ｖベータ－６（αｖβ６）インテグリンリガンド
WO2025259747A2 (en) 2024-06-12 2025-12-18 Alnylam Pharmaceuticals, Inc. Dystrophy myotonic protein kinase (dmpk) irna compositions and methods of use thereof
WO2025259743A1 (en) 2024-06-12 2025-12-18 Alnylam Pharmaceuticals, Inc. Dual conjugate compounds for extrahepatic delivery

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JP2002508323A (ja) * 1997-12-17 2002-03-19 メルク エンド カムパニー インコーポレーテッド インテグリン受容体拮抗薬
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GB201417002D0 (en) * 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compound
GB201417011D0 (en) * 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417018D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
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Also Published As

Publication number Publication date
CN107074851A (zh) 2017-08-18
US10144733B2 (en) 2018-12-04
US20170291899A1 (en) 2017-10-12
US10513517B2 (en) 2019-12-24
CN107074851B (zh) 2020-01-10
KR20170053638A (ko) 2017-05-16
JP2017528504A (ja) 2017-09-28
EP3197894B1 (en) 2020-06-03
RU2017114355A (ru) 2018-10-29
AU2015320863B2 (en) 2018-09-06
US20190048005A1 (en) 2019-02-14
RU2692775C2 (ru) 2019-06-27
GB201417094D0 (en) 2014-11-12
ES2811119T3 (es) 2021-03-10
BR112017006242A2 (pt) 2017-12-12
CA2962321A1 (en) 2016-03-31
WO2016046230A1 (en) 2016-03-31
RU2017114355A3 (OSRAM) 2019-01-14
AU2015320863A1 (en) 2017-03-09
EP3197894A1 (en) 2017-08-02

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