RU2685416C2 - Устройство для диагностики in vitro и его применения - Google Patents
Устройство для диагностики in vitro и его применения Download PDFInfo
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- RU2685416C2 RU2685416C2 RU2015100233A RU2015100233A RU2685416C2 RU 2685416 C2 RU2685416 C2 RU 2685416C2 RU 2015100233 A RU2015100233 A RU 2015100233A RU 2015100233 A RU2015100233 A RU 2015100233A RU 2685416 C2 RU2685416 C2 RU 2685416C2
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Immunology (AREA)
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- Hematology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1255452 | 2012-06-11 | ||
| FR1255452A FR2991689B1 (fr) | 2012-06-11 | 2012-06-11 | Dispositif de diagnostic immuno-hematologique et utilisations |
| PCT/FR2013/051358 WO2013186482A1 (fr) | 2012-06-11 | 2013-06-11 | Dispositif de diagnostic in vitro et utilisations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015100233A RU2015100233A (ru) | 2016-08-10 |
| RU2685416C2 true RU2685416C2 (ru) | 2019-04-18 |
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Family Applications (1)
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Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3245516B1 (en) * | 2015-01-14 | 2019-10-16 | Bio-Rad Laboratories, Inc. | Blood analysis systems and methods |
| WO2018176262A1 (zh) * | 2017-03-27 | 2018-10-04 | 武汉优视科技有限公司 | 一种免疫印迹的自动检测系统 |
| CN107045066A (zh) * | 2017-03-27 | 2017-08-15 | 武汉优视科技有限公司 | 一种免疫印迹卷轴 |
| CN106932596A (zh) * | 2017-03-27 | 2017-07-07 | 武汉优视科技有限公司 | 一种免疫印迹薄膜及其制备方法 |
| WO2019150189A1 (en) | 2018-02-05 | 2019-08-08 | Bio-Rad Europe Gmbh | Microfluidic probe head with aspiration posts |
| CN111936237B (zh) | 2018-02-05 | 2022-10-28 | 生物辐射实验室股份有限公司 | 具有屏障突出部的微流体探针头 |
| CN112204398B (zh) * | 2018-02-16 | 2025-01-28 | 迪亚加斯特公司 | 包括珠的体外诊断装置及其用途 |
| CN108333033B (zh) * | 2018-05-07 | 2024-09-24 | 皖南医学院第一附属医院（皖南医学院弋矶山医院） | 血型鉴定和交叉配血用防红细胞冷凝集热湿化装置 |
| CN110286238B (zh) * | 2019-07-25 | 2023-01-06 | 深圳市爱康试剂有限公司 | ABO/Rh（D/C/E）血型检测卡及其制备方法 |
| CN112345773A (zh) * | 2020-09-24 | 2021-02-09 | 北京健乃喜生物技术有限公司 | 体外即时测定人ABO和/或Rh血型的免疫测定装置 |
| EP4392786A4 (en) * | 2021-08-25 | 2024-12-18 | Dia Pro Tibbi Urunler Sanayi Ve Ticaret A.s. | Blood grouping test |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0367468A1 (en) * | 1988-11-04 | 1990-05-09 | Immucor, Inc. | Method for drying mammalian cells for use in solid phase immunoassays and articles incorporating same |
| EP0408378A2 (en) * | 1989-07-12 | 1991-01-16 | W.L. GORE & ASSOCIATES (UK) LTD | Hydrophilic semi-permeable PTFE membranes and their manufacture |
| WO2009007649A2 (fr) * | 2007-07-02 | 2009-01-15 | Abo Diag | Dispositif et procede d'identification et de determination de groupes sanguins |
| RU2398235C2 (ru) * | 2005-08-31 | 2010-08-27 | Эгомедикаль Технологиз Аг | Тест-система с использованием элементов неэнзиматического распознавания анализируемого вещества |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61152700A (ja) * | 1984-12-26 | 1986-07-11 | Susumu Kogyo Kk | タンパク質固定用膜担体およびその製造法 |
| US4797259A (en) * | 1986-12-15 | 1989-01-10 | Pall Corporation | Well-type diagnostic plate device |
| JPH079087Y2 (ja) * | 1987-04-13 | 1995-03-06 | 大日本印刷株式会社 | 検査シ−ト |
| US4902481A (en) * | 1987-12-11 | 1990-02-20 | Millipore Corporation | Multi-well filtration test apparatus |
| ATE105634T1 (de) | 1988-03-23 | 1994-05-15 | Becton Dickinson Co | Vorrichtung zur abgabe einer fluessigen probe auf ein diagnostisches geraet in reguliertem ausmass. |
| US5185127A (en) * | 1989-09-21 | 1993-02-09 | Becton, Dickinson And Company | Test device including flow control means |
| IE903118A1 (en) * | 1989-09-21 | 1991-03-27 | Becton Dickinson Co | Test device including flow control means |
| JP3097768B2 (ja) * | 1991-04-19 | 2000-10-10 | 株式会社ニッショー | 診断用容器 |
| CN2169850Y (zh) * | 1993-06-17 | 1994-06-22 | 朱烨峰 | A、b、o血型系统诊断试剂卡 |
| JPH0954091A (ja) * | 1995-08-09 | 1997-02-25 | Nippon Zoki Pharmaceut Co Ltd | 抗赤血球抗体の測定法 |
| JPH09257794A (ja) * | 1996-03-26 | 1997-10-03 | Kikkoman Corp | 多重測定法 |
| WO1998020348A1 (en) * | 1996-11-08 | 1998-05-14 | Mercury Diagnostics, Inc. | Opaque reaction matrix for the analysis of whole blood |
| AU4101697A (en) * | 1996-11-22 | 1998-05-28 | Robert A. Levine | Process for enhancing the aggregation and/or agglutination of erythrocytes prior to centrifugation |
| US6045899A (en) * | 1996-12-12 | 2000-04-04 | Usf Filtration & Separations Group, Inc. | Highly assymetric, hydrophilic, microfiltration membranes having large pore diameters |
| JP3808304B2 (ja) * | 2000-10-30 | 2006-08-09 | 三菱電機株式会社 | 自動変速機 |
| DE60130919T2 (de) | 2000-12-22 | 2008-10-16 | Bio A.R.T. Sa | Durchflussvorrichtung, diese enthaltender diagnostischer kit und verwendung zum nachweis von analyten in einer probe |
| AU2002330899B2 (en) * | 2001-07-18 | 2008-03-06 | Relia Diagnostic Systems, Inc. | Test strip for a lateral flow assay |
| CA2457930C (en) * | 2001-08-20 | 2012-06-19 | Proteome Systems Intellectual Property Pty Ltd. | Diagnostic testing process and apparatus |
| WO2003016902A1 (en) | 2001-08-20 | 2003-02-27 | Proteome Systems Intellectual Property Pty Ltd | Diagnostic testing process and apparatus |
| CN100510747C (zh) * | 2001-12-12 | 2009-07-08 | 普罗托姆系统有限公司 | 诊断试验方法 |
| US7781172B2 (en) | 2003-11-21 | 2010-08-24 | Kimberly-Clark Worldwide, Inc. | Method for extending the dynamic detection range of assay devices |
| EP1766392A1 (en) | 2004-06-04 | 2007-03-28 | Proteome Systems Intellectual Property Pty Ltd. | Diagnostic testing process and apparatus incorporating controlled sample flow |
| CA2588071A1 (en) * | 2004-11-15 | 2006-05-18 | Inverness Medical Switzerland Gmbh | Blood type method system and device |
| ATE499607T1 (de) | 2005-08-31 | 2011-03-15 | Egomedical Technologies Ag | Analytentestsystem unter verwendung nichtenzymatischer analytenerkennungselemente |
| CN100425990C (zh) * | 2005-10-17 | 2008-10-15 | 中国人民解放军第三军医大学第一附属医院 | 血液检测微阵列制备方法 |
| FR2892820B1 (fr) * | 2005-11-03 | 2008-02-01 | Diagast Soc Par Actions Simpli | Procede magnetique d'immunodiagnostic pour la mise en evidence de complexe anticorps/antigene, en particulier de groupe sanguin |
| US9658224B2 (en) * | 2005-11-29 | 2017-05-23 | The Trustees Of The University Of Pennsylvania | Phage particle diagnostic reagents |
| JP2010515877A (ja) * | 2006-10-18 | 2010-05-13 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | パターン化多孔質媒体に基づくラテラルフロー式及びフロースルー式バイオアッセイ装置、該装置の製造方法、及び該装置の使用方法 |
| WO2008133880A1 (en) | 2007-04-23 | 2008-11-06 | Clavina Diagnostics, Inc. | Method of detecting red cell antigen-antibody reactions |
| FR2917174B1 (fr) * | 2007-06-08 | 2021-02-12 | Bio Rad Pasteur | Analyse multiple d'echantillons sanguins |
| DE202008017854U1 (de) * | 2007-08-14 | 2010-08-19 | Millipore Corp., Billerica | Mittel zur Ionenaustausch-Membranchromatographie auf der Basis von primären polymerischen Aminen, Sorptionsvorrichtung mit diesem Mittel, Chromatographieverfahren und Reinigungsverfahren unter dessen Verwendung |
| CN101603967B (zh) | 2008-06-10 | 2015-02-18 | 英科新创(厦门)科技有限公司 | 快速检测人ABO/Rh/MN血型的方法及试剂盒 |
| WO2010056889A2 (en) * | 2008-11-12 | 2010-05-20 | The Trustees Of The University Of Pennsylvania | Use of an antibody and a rare-earth based crystal |
| FR2963108B1 (fr) * | 2010-07-21 | 2017-06-23 | Diagast | Procede magnetique d'immunodiagnostic et kit pour la mise en evidence de complexe anticorps/antigene de groupe/phenotype sanguin |
-
2012
- 2012-06-11 FR FR1255452A patent/FR2991689B1/fr active Active
-
2013
- 2013-06-11 KR KR1020157000619A patent/KR102034915B1/ko active Active
- 2013-06-11 MA MA37744A patent/MA37744B1/fr unknown
- 2013-06-11 BR BR112014030953A patent/BR112014030953B8/pt not_active IP Right Cessation
- 2013-06-11 IN IN170DEN2015 patent/IN2015DN00170A/en unknown
- 2013-06-11 CN CN201380042301.4A patent/CN104769429B/zh active Active
- 2013-06-11 EP EP13744587.0A patent/EP2859344B1/fr active Active
- 2013-06-11 US US14/406,539 patent/US10591494B2/en active Active
- 2013-06-11 JP JP2015515577A patent/JP6339562B2/ja active Active
- 2013-06-11 ES ES13744587.0T patent/ES2681972T3/es active Active
- 2013-06-11 RU RU2015100233A patent/RU2685416C2/ru active
- 2013-06-11 WO PCT/FR2013/051358 patent/WO2013186482A1/fr not_active Ceased
- 2013-06-11 PL PL13744587T patent/PL2859344T3/pl unknown
-
2014
- 2014-12-04 IL IL236062A patent/IL236062A0/en active IP Right Grant
-
2019
- 2019-08-21 US US16/546,493 patent/US20190376986A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0367468A1 (en) * | 1988-11-04 | 1990-05-09 | Immucor, Inc. | Method for drying mammalian cells for use in solid phase immunoassays and articles incorporating same |
| EP0408378A2 (en) * | 1989-07-12 | 1991-01-16 | W.L. GORE & ASSOCIATES (UK) LTD | Hydrophilic semi-permeable PTFE membranes and their manufacture |
| RU2398235C2 (ru) * | 2005-08-31 | 2010-08-27 | Эгомедикаль Технологиз Аг | Тест-система с использованием элементов неэнзиматического распознавания анализируемого вещества |
| WO2009007649A2 (fr) * | 2007-07-02 | 2009-01-15 | Abo Diag | Dispositif et procede d'identification et de determination de groupes sanguins |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150040269A (ko) | 2015-04-14 |
| BR112014030953B1 (pt) | 2021-01-19 |
| EP2859344B1 (fr) | 2018-05-02 |
| IN2015DN00170A (cg-RX-API-DMAC7.html) | 2015-06-12 |
| BR112014030953B8 (pt) | 2021-02-17 |
| WO2013186482A1 (fr) | 2013-12-19 |
| JP6339562B2 (ja) | 2018-06-06 |
| ES2681972T3 (es) | 2018-09-17 |
| KR102034915B1 (ko) | 2019-10-21 |
| CN104769429A (zh) | 2015-07-08 |
| BR112014030953A2 (pt) | 2017-06-27 |
| US20150140579A1 (en) | 2015-05-21 |
| MA37744A1 (fr) | 2016-05-31 |
| IL236062A0 (en) | 2015-01-29 |
| US20190376986A1 (en) | 2019-12-12 |
| JP2015518969A (ja) | 2015-07-06 |
| FR2991689B1 (fr) | 2018-04-20 |
| FR2991689A1 (fr) | 2013-12-13 |
| US10591494B2 (en) | 2020-03-17 |
| MA37744B1 (fr) | 2017-10-31 |
| RU2015100233A (ru) | 2016-08-10 |
| CN104769429B (zh) | 2018-02-16 |
| PL2859344T3 (pl) | 2018-10-31 |
| EP2859344A1 (fr) | 2015-04-15 |
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