RU2673944C2 - Дигидроптеридиноновые производные и их применения - Google Patents

Дигидроптеридиноновые производные и их применения Download PDF

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RU2673944C2
RU2673944C2 RU2016133196A RU2016133196A RU2673944C2 RU 2673944 C2 RU2673944 C2 RU 2673944C2 RU 2016133196 A RU2016133196 A RU 2016133196A RU 2016133196 A RU2016133196 A RU 2016133196A RU 2673944 C2 RU2673944 C2 RU 2673944C2
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substituted
unsubstituted
compound
alkyl
protecting group
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RU2016133196A
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RU2016133196A (ru
RU2016133196A3 (enExample
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Джеймс Е. БРАДНЕР
Натанаэль ГРЕЙ
Джун Ки
Майкл Р. МАККЕУН
Деннис БАКЛИ
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Дана-Фарбер Кансер Институт, Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • AIDS & HIV (AREA)
  • Gynecology & Obstetrics (AREA)
RU2016133196A 2014-01-31 2015-02-02 Дигидроптеридиноновые производные и их применения RU2673944C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461934624P 2014-01-31 2014-01-31
US61/934,624 2014-01-31
PCT/US2015/014044 WO2015117055A1 (en) 2014-01-31 2015-02-02 Dihydropteridinone derivatives and uses thereof

Publications (3)

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RU2016133196A RU2016133196A (ru) 2018-03-01
RU2016133196A3 RU2016133196A3 (enExample) 2018-06-07
RU2673944C2 true RU2673944C2 (ru) 2018-12-03

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US (1) US20160347750A1 (enExample)
EP (1) EP3099171A4 (enExample)
JP (1) JP2017512186A (enExample)
KR (1) KR20160111520A (enExample)
CN (1) CN105939607A (enExample)
CA (1) CA2936871A1 (enExample)
MX (1) MX2016009975A (enExample)
RU (1) RU2673944C2 (enExample)
WO (1) WO2015117055A1 (enExample)

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WO2015164614A1 (en) 2014-04-23 2015-10-29 Dana-Farber Cancer Institute, Inc. Janus kinase inhibitors and uses thereof
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RU2017104897A (ru) 2014-08-08 2018-09-10 Дана-Фарбер Кэнсер Инститьют, Инк. Производные диазепана и их применения
US10870651B2 (en) 2014-12-23 2020-12-22 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
CN107427521B (zh) 2015-03-27 2021-08-03 达纳-法伯癌症研究所股份有限公司 细胞周期蛋白依赖性激酶的抑制剂
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CN105412931B (zh) * 2016-01-07 2017-05-10 国家卫生计生委科学技术研究所 一种小分子抑制剂在抗生育中的用途
CN105412107B (zh) * 2016-01-07 2017-05-03 国家卫生计生委科学技术研究所 蛋白抑制剂t323在抗生育中的应用
CN105640962B (zh) * 2016-01-07 2017-07-07 国家卫生计生委科学技术研究所 一种蛋白抑制剂在抗生育中的应用
CN105801582A (zh) * 2016-04-12 2016-07-27 合肥工业大学 一类新型二氢蝶啶酮类衍生物及其制备方法和在医药上的用途
DE102017005091A1 (de) 2016-05-30 2017-11-30 Bayer Pharma Aktiengesellschaft Substituierte 3,4-Dihydropyrido[2,3-b]pyrazin-2(1H)-one
CN107586315B (zh) * 2016-07-08 2020-03-31 成都海创药业有限公司 一种嵌合分子
WO2019154329A1 (zh) * 2018-02-06 2019-08-15 上海海和药物研究开发有限公司 具有bet抑制活性的化合物及其制备方法和用途
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CN105939607A (zh) 2016-09-14
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EP3099171A4 (en) 2017-08-09
EP3099171A1 (en) 2016-12-07
JP2017512186A (ja) 2017-05-18
CA2936871A1 (en) 2015-08-06
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