CN105939607A - 二氢蝶啶酮衍生物及其用途 - Google Patents

二氢蝶啶酮衍生物及其用途 Download PDF

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Publication number
CN105939607A
CN105939607A CN201580006508.5A CN201580006508A CN105939607A CN 105939607 A CN105939607 A CN 105939607A CN 201580006508 A CN201580006508 A CN 201580006508A CN 105939607 A CN105939607 A CN 105939607A
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substituted
unsubstituted
compound
alkyl
pharmaceutically acceptable
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Chinese (zh)
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J.E.布拉德纳
N.格雷
J.齐
M.R.麦基翁
D.巴克利
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Transplantation (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
CN201580006508.5A 2014-01-31 2015-02-02 二氢蝶啶酮衍生物及其用途 Pending CN105939607A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461934624P 2014-01-31 2014-01-31
US61/934,624 2014-01-31
PCT/US2015/014044 WO2015117055A1 (en) 2014-01-31 2015-02-02 Dihydropteridinone derivatives and uses thereof

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CN105939607A true CN105939607A (zh) 2016-09-14

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US (1) US20160347750A1 (enExample)
EP (1) EP3099171A4 (enExample)
JP (1) JP2017512186A (enExample)
KR (1) KR20160111520A (enExample)
CN (1) CN105939607A (enExample)
CA (1) CA2936871A1 (enExample)
MX (1) MX2016009975A (enExample)
RU (1) RU2673944C2 (enExample)
WO (1) WO2015117055A1 (enExample)

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CN111039944A (zh) * 2018-10-12 2020-04-21 中国科学院合肥物质科学研究院 Mst1激酶抑制剂及其用途
CN111683932A (zh) * 2018-02-06 2020-09-18 上海海和药物研究开发有限公司 具有bet抑制活性的化合物及其制备方法和用途

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JP7028766B2 (ja) 2015-09-09 2022-03-02 ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド サイクリン依存性キナーゼの阻害剤
HK1256417A1 (zh) 2015-09-11 2019-09-20 达纳-法伯癌症研究所股份有限公司 氰基噻吩並三唑並二氮雜環庚三烯及其用途
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CN105412931B (zh) * 2016-01-07 2017-05-10 国家卫生计生委科学技术研究所 一种小分子抑制剂在抗生育中的用途
CN105597100B (zh) * 2016-01-07 2018-08-21 国家卫生计生委科学技术研究所 一种brdt蛋白抑制剂在雄性抗生育中的应用
CN105412107B (zh) * 2016-01-07 2017-05-03 国家卫生计生委科学技术研究所 蛋白抑制剂t323在抗生育中的应用
CN105801582A (zh) * 2016-04-12 2016-07-27 合肥工业大学 一类新型二氢蝶啶酮类衍生物及其制备方法和在医药上的用途
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