RU2662326C2 - Биомиметический коллаген-гидроксиапатитный композитный материал - Google Patents

Биомиметический коллаген-гидроксиапатитный композитный материал Download PDF

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RU2662326C2
RU2662326C2 RU2016105556A RU2016105556A RU2662326C2 RU 2662326 C2 RU2662326 C2 RU 2662326C2 RU 2016105556 A RU2016105556 A RU 2016105556A RU 2016105556 A RU2016105556 A RU 2016105556A RU 2662326 C2 RU2662326 C2 RU 2662326C2
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Prior art keywords
collagen
bone
hydroxyapatite
composite material
biomimetic
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RU2016105556A
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English (en)
Russian (ru)
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RU2016105556A (ru
RU2016105556A3 (cg-RX-API-DMAC10.html
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Михаэль БУФЛЕР
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Гайстлих Фарма Аг
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B1/00—Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/02—Methods for coating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Nanotechnology (AREA)
  • Composite Materials (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
RU2016105556A 2013-07-19 2014-07-18 Биомиметический коллаген-гидроксиапатитный композитный материал RU2662326C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13003647.8A EP2826495A1 (en) 2013-07-19 2013-07-19 Biomimetic collagen-hydroxyapatite composite material
EP13003647.8 2013-07-19
PCT/EP2014/001966 WO2015007393A1 (en) 2013-07-19 2014-07-18 Biomimetic collagen-hydroxyapatite composite material

Publications (3)

Publication Number Publication Date
RU2016105556A RU2016105556A (ru) 2017-08-24
RU2016105556A3 RU2016105556A3 (cg-RX-API-DMAC10.html) 2018-02-12
RU2662326C2 true RU2662326C2 (ru) 2018-07-25

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Country Link
US (1) US10029028B2 (cg-RX-API-DMAC10.html)
EP (2) EP2826495A1 (cg-RX-API-DMAC10.html)
JP (1) JP6478993B2 (cg-RX-API-DMAC10.html)
KR (1) KR101944163B1 (cg-RX-API-DMAC10.html)
CN (1) CN105358189B (cg-RX-API-DMAC10.html)
AU (1) AU2014292503B2 (cg-RX-API-DMAC10.html)
BR (1) BR112016001093B1 (cg-RX-API-DMAC10.html)
CA (1) CA2917997C (cg-RX-API-DMAC10.html)
DK (1) DK3021883T3 (cg-RX-API-DMAC10.html)
ES (1) ES2611202T3 (cg-RX-API-DMAC10.html)
HU (1) HUE031178T2 (cg-RX-API-DMAC10.html)
PL (1) PL3021883T3 (cg-RX-API-DMAC10.html)
PT (1) PT3021883T (cg-RX-API-DMAC10.html)
RU (1) RU2662326C2 (cg-RX-API-DMAC10.html)
SG (1) SG11201600364VA (cg-RX-API-DMAC10.html)
WO (1) WO2015007393A1 (cg-RX-API-DMAC10.html)

Cited By (1)

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RU2808448C1 (ru) * 2019-12-04 2023-11-28 Датум Дентал Лтд. Устройство на основе коллагена-гидроксиапатита для нехирургического лечения пародонта

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US10238507B2 (en) 2015-01-12 2019-03-26 Surgentec, Llc Bone graft delivery system and method for using same
WO2016179089A1 (en) 2015-05-01 2016-11-10 Rensselaer Polytechnic Institute Biomimetic nano-composite scaffold for enhanced bone healing and fracture repair
DE102016110622A1 (de) 2016-06-09 2017-12-14 Michael Gahlert Knochenersatzmaterial aus Zirkondioxidkeramik
DE202016103296U1 (de) 2016-06-09 2017-09-18 Michael Gahlert Knochenersatzmaterial aus Zirkondioxidkeramik
WO2019115795A1 (en) * 2017-12-14 2019-06-20 Geistlich Pharma Ag Dried implant composition and injectable aqueous implant formulation
CA3083852A1 (en) 2017-12-14 2019-06-20 Geistlich Pharma Ag Biphasic calcium phosphate/hydroxyapatite bone substitute material
JP6813716B1 (ja) * 2017-12-14 2021-01-13 ガイストリッヒ ファーマ アーゲー 骨代替材料
US10687828B2 (en) 2018-04-13 2020-06-23 Surgentec, Llc Bone graft delivery system and method for using same
US11116647B2 (en) 2018-04-13 2021-09-14 Surgentec, Llc Bone graft delivery system and method for using same
EP3695856A1 (en) * 2019-02-13 2020-08-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Biomaterials comprising a scaffold containing a mineral compound, and uses thereof as bone substitutes
WO2020249714A1 (en) * 2019-06-14 2020-12-17 Geistlich Pharma Ag Collagen matrix or granulate blend of bone substitute material
CN114761048B (zh) * 2019-06-14 2023-05-02 盖斯特里希医药公司 骨替代材料的胶原基质或颗粒共混物
FR3101773B1 (fr) 2019-10-10 2023-04-21 Regeska Procede de mineralisation d’une membrane de biopolymere
CN114209880B (zh) * 2021-11-25 2022-11-08 浙江大学 一种有序矿化多肽的生物复合材料的制备方法及其产品和应用
CN114732957B (zh) * 2022-03-16 2022-12-23 武汉理工大学 一种具有预应力的矿化肌腱复合材料及其制备方法与应用
CN114890400B (zh) * 2022-06-15 2023-12-01 杭州彗搏科技有限公司 纳米晶体羟基磷灰石骨修复颗粒、制备方法及应用
CN116271232B (zh) * 2022-09-06 2025-11-07 浙江大学 一种基于原位矿化类骨羟基磷灰石的复合凝胶的合成方法及其产品和应用
CN119857939B (zh) * 2025-03-05 2025-10-03 中南大学 一种种植体表面处理技术
CN121059889B (zh) * 2025-11-06 2026-04-03 北京信智达医疗技术服务有限公司 羟基磷灰石注射剂及其制备方法

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US20090216336A1 (en) * 2004-11-23 2009-08-27 Marco Springer Bioresorbable, mineralised material for filling osseous defects
US20100021520A1 (en) * 2006-04-13 2010-01-28 Jonathan Baskin Biomaterial implants

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US6201039B1 (en) * 1993-09-21 2001-03-13 The Penn State Research Foundation Bone substitute composition comprising hydroxyapatite and a method of production therefor
US20090216336A1 (en) * 2004-11-23 2009-08-27 Marco Springer Bioresorbable, mineralised material for filling osseous defects
US20100021520A1 (en) * 2006-04-13 2010-01-28 Jonathan Baskin Biomaterial implants

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2822395C2 (ru) * 2019-06-14 2024-07-04 Гайстлих Фарма Аг Коллагеновый матрикс или гранулированная смесь костнозамещающего материала
RU2808448C1 (ru) * 2019-12-04 2023-11-28 Датум Дентал Лтд. Устройство на основе коллагена-гидроксиапатита для нехирургического лечения пародонта

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RU2016105556A (ru) 2017-08-24
US10029028B2 (en) 2018-07-24
SG11201600364VA (en) 2016-02-26
PL3021883T3 (pl) 2017-03-31
EP3021883B1 (en) 2016-11-09
KR20160032116A (ko) 2016-03-23
CN105358189A (zh) 2016-02-24
HUE031178T2 (en) 2017-06-28
DK3021883T3 (en) 2017-01-16
US20160144071A1 (en) 2016-05-26
BR112016001093B1 (pt) 2020-07-28
EP2826495A1 (en) 2015-01-21
CA2917997A1 (en) 2015-01-22
EP3021883A1 (en) 2016-05-25
KR101944163B1 (ko) 2019-01-30
WO2015007393A1 (en) 2015-01-22
ES2611202T3 (es) 2017-05-05
CN105358189B (zh) 2018-03-16
HK1218083A1 (en) 2017-02-03
JP6478993B2 (ja) 2019-03-06
PT3021883T (pt) 2016-12-23
CA2917997C (en) 2019-08-20
AU2014292503B2 (en) 2017-06-15
JP2016524964A (ja) 2016-08-22
AU2014292503A1 (en) 2016-02-11

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