JP6478993B2 - バイオミメティックなコラーゲン−ヒドロキシアパタイト複合材料 - Google Patents

バイオミメティックなコラーゲン−ヒドロキシアパタイト複合材料 Download PDF

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Publication number
JP6478993B2
JP6478993B2 JP2016526468A JP2016526468A JP6478993B2 JP 6478993 B2 JP6478993 B2 JP 6478993B2 JP 2016526468 A JP2016526468 A JP 2016526468A JP 2016526468 A JP2016526468 A JP 2016526468A JP 6478993 B2 JP6478993 B2 JP 6478993B2
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Prior art keywords
collagen
hydroxyapatite
bone
biomimetic
composite material
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Expired - Fee Related
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JP2016526468A
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English (en)
Japanese (ja)
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JP2016524964A5 (cg-RX-API-DMAC10.html
JP2016524964A (ja
Inventor
ブフラー，ミヒャエル
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Geistlich Pharma AG
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Geistlich Pharma AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B1/00—Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/02—Methods for coating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Nanotechnology (AREA)
  • Composite Materials (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
JP2016526468A 2013-07-19 2014-07-18 バイオミメティックなコラーゲン−ヒドロキシアパタイト複合材料 Expired - Fee Related JP6478993B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13003647.8A EP2826495A1 (en) 2013-07-19 2013-07-19 Biomimetic collagen-hydroxyapatite composite material
EP13003647.8 2013-07-19
PCT/EP2014/001966 WO2015007393A1 (en) 2013-07-19 2014-07-18 Biomimetic collagen-hydroxyapatite composite material

Publications (3)

Publication Number Publication Date
JP2016524964A JP2016524964A (ja) 2016-08-22
JP2016524964A5 JP2016524964A5 (cg-RX-API-DMAC10.html) 2017-08-03
JP6478993B2 true JP6478993B2 (ja) 2019-03-06

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Country Status (16)

Country Link
US (1) US10029028B2 (cg-RX-API-DMAC10.html)
EP (2) EP2826495A1 (cg-RX-API-DMAC10.html)
JP (1) JP6478993B2 (cg-RX-API-DMAC10.html)
KR (1) KR101944163B1 (cg-RX-API-DMAC10.html)
CN (1) CN105358189B (cg-RX-API-DMAC10.html)
AU (1) AU2014292503B2 (cg-RX-API-DMAC10.html)
BR (1) BR112016001093B1 (cg-RX-API-DMAC10.html)
CA (1) CA2917997C (cg-RX-API-DMAC10.html)
DK (1) DK3021883T3 (cg-RX-API-DMAC10.html)
ES (1) ES2611202T3 (cg-RX-API-DMAC10.html)
HU (1) HUE031178T2 (cg-RX-API-DMAC10.html)
PL (1) PL3021883T3 (cg-RX-API-DMAC10.html)
PT (1) PT3021883T (cg-RX-API-DMAC10.html)
RU (1) RU2662326C2 (cg-RX-API-DMAC10.html)
SG (1) SG11201600364VA (cg-RX-API-DMAC10.html)
WO (1) WO2015007393A1 (cg-RX-API-DMAC10.html)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
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US10238507B2 (en) 2015-01-12 2019-03-26 Surgentec, Llc Bone graft delivery system and method for using same
WO2016179089A1 (en) 2015-05-01 2016-11-10 Rensselaer Polytechnic Institute Biomimetic nano-composite scaffold for enhanced bone healing and fracture repair
DE102016110622A1 (de) 2016-06-09 2017-12-14 Michael Gahlert Knochenersatzmaterial aus Zirkondioxidkeramik
DE202016103296U1 (de) 2016-06-09 2017-09-18 Michael Gahlert Knochenersatzmaterial aus Zirkondioxidkeramik
WO2019115795A1 (en) * 2017-12-14 2019-06-20 Geistlich Pharma Ag Dried implant composition and injectable aqueous implant formulation
CA3083852A1 (en) 2017-12-14 2019-06-20 Geistlich Pharma Ag Biphasic calcium phosphate/hydroxyapatite bone substitute material
JP6813716B1 (ja) * 2017-12-14 2021-01-13 ガイストリッヒ ファーマ アーゲー 骨代替材料
US10687828B2 (en) 2018-04-13 2020-06-23 Surgentec, Llc Bone graft delivery system and method for using same
US11116647B2 (en) 2018-04-13 2021-09-14 Surgentec, Llc Bone graft delivery system and method for using same
EP3695856A1 (en) * 2019-02-13 2020-08-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Biomaterials comprising a scaffold containing a mineral compound, and uses thereof as bone substitutes
WO2020249714A1 (en) * 2019-06-14 2020-12-17 Geistlich Pharma Ag Collagen matrix or granulate blend of bone substitute material
CN114761048B (zh) * 2019-06-14 2023-05-02 盖斯特里希医药公司 骨替代材料的胶原基质或颗粒共混物
FR3101773B1 (fr) 2019-10-10 2023-04-21 Regeska Procede de mineralisation d’une membrane de biopolymere
CN114209880B (zh) * 2021-11-25 2022-11-08 浙江大学 一种有序矿化多肽的生物复合材料的制备方法及其产品和应用
CN114732957B (zh) * 2022-03-16 2022-12-23 武汉理工大学 一种具有预应力的矿化肌腱复合材料及其制备方法与应用
CN114890400B (zh) * 2022-06-15 2023-12-01 杭州彗搏科技有限公司 纳米晶体羟基磷灰石骨修复颗粒、制备方法及应用
CN116271232B (zh) * 2022-09-06 2025-11-07 浙江大学 一种基于原位矿化类骨羟基磷灰石的复合凝胶的合成方法及其产品和应用
CN119857939B (zh) * 2025-03-05 2025-10-03 中南大学 一种种植体表面处理技术
CN121059889B (zh) * 2025-11-06 2026-04-03 北京信智达医疗技术服务有限公司 羟基磷灰石注射剂及其制备方法

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US5532217A (en) 1992-04-24 1996-07-02 Silver; Frederick H. Process for the mineralization of collagen fibers, product produced thereby and use thereof to repair bone
WO1995008304A1 (en) * 1993-09-21 1995-03-30 The Penn State Research Foundation Bone substitute composition comprising hydroxyapatite and a method of production therefor
GB9400163D0 (en) 1994-01-06 1994-03-02 Geistlich Soehne Ag Membrane
JP2754348B2 (ja) * 1994-10-20 1998-05-20 バイオマップ有限会社 アパタイト被覆基材とその製造法
GB9503492D0 (en) 1995-02-22 1995-04-12 Ed Geistlich S Hne A G F R Che Chemical product
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US7514249B2 (en) 2002-04-18 2009-04-07 The University Of Florida Research Foundation, Inc. Biomimetic organic/inorganic composites
WO2006056391A2 (de) * 2004-11-23 2006-06-01 Ossacur Ag Bioresorbierbares und oberflächen-mineralisiertes material zur füllung von knochendefekten
ITMI20050343A1 (it) * 2005-03-04 2006-09-05 Fin Ceramica Faenza S R L Sostituto cartilagineo e osteocindrale comprendente una struttura multistrato e relativo impiego
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WO2012084214A1 (en) * 2010-12-22 2012-06-28 Geistlich Pharma Ag Bone substitute material

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Publication number Publication date
RU2016105556A (ru) 2017-08-24
US10029028B2 (en) 2018-07-24
RU2662326C2 (ru) 2018-07-25
SG11201600364VA (en) 2016-02-26
PL3021883T3 (pl) 2017-03-31
EP3021883B1 (en) 2016-11-09
KR20160032116A (ko) 2016-03-23
CN105358189A (zh) 2016-02-24
HUE031178T2 (en) 2017-06-28
DK3021883T3 (en) 2017-01-16
US20160144071A1 (en) 2016-05-26
BR112016001093B1 (pt) 2020-07-28
EP2826495A1 (en) 2015-01-21
CA2917997A1 (en) 2015-01-22
EP3021883A1 (en) 2016-05-25
KR101944163B1 (ko) 2019-01-30
WO2015007393A1 (en) 2015-01-22
ES2611202T3 (es) 2017-05-05
CN105358189B (zh) 2018-03-16
HK1218083A1 (en) 2017-02-03
PT3021883T (pt) 2016-12-23
CA2917997C (en) 2019-08-20
AU2014292503B2 (en) 2017-06-15
JP2016524964A (ja) 2016-08-22
AU2014292503A1 (en) 2016-02-11

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