RU2640911C2 - Способ получения композиции на основе гиалуроновой кислоты - Google Patents
Способ получения композиции на основе гиалуроновой кислоты Download PDFInfo
- Publication number
- RU2640911C2 RU2640911C2 RU2015101105A RU2015101105A RU2640911C2 RU 2640911 C2 RU2640911 C2 RU 2640911C2 RU 2015101105 A RU2015101105 A RU 2015101105A RU 2015101105 A RU2015101105 A RU 2015101105A RU 2640911 C2 RU2640911 C2 RU 2640911C2
- Authority
- RU
- Russia
- Prior art keywords
- sieve
- stage
- polymer
- composition
- product obtained
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 169
- 238000000034 method Methods 0.000 title claims abstract description 76
- 229920002674 hyaluronan Polymers 0.000 title claims description 60
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims description 56
- 229960003160 hyaluronic acid Drugs 0.000 title claims description 56
- 229920000642 polymer Polymers 0.000 claims abstract description 132
- 238000004132 cross linking Methods 0.000 claims abstract description 77
- 238000001125 extrusion Methods 0.000 claims abstract description 73
- 238000000502 dialysis Methods 0.000 claims abstract description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 41
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 35
- 239000005017 polysaccharide Substances 0.000 claims abstract description 35
- 150000004676 glycans Chemical class 0.000 claims abstract description 34
- 239000012528 membrane Substances 0.000 claims abstract description 28
- 239000002537 cosmetic Substances 0.000 claims abstract description 12
- 239000000385 dialysis solution Substances 0.000 claims abstract description 11
- 238000002156 mixing Methods 0.000 claims description 52
- 229960004194 lidocaine Drugs 0.000 claims description 20
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 19
- 230000003444 anaesthetic effect Effects 0.000 claims description 14
- 239000003416 antiarrhythmic agent Substances 0.000 claims description 14
- 239000000945 filler Substances 0.000 claims description 14
- 238000011049 filling Methods 0.000 claims description 13
- 230000001954 sterilising effect Effects 0.000 claims description 12
- 229960002372 tetracaine Drugs 0.000 claims description 10
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims description 10
- 239000003193 general anesthetic agent Substances 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 7
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 claims description 7
- 159000000000 sodium salts Chemical class 0.000 claims description 7
- 229960004393 lidocaine hydrochloride Drugs 0.000 claims description 5
- LWNPNOFGINFGGV-UHFFFAOYSA-N 2-(diethylamino)-n-(2,6-dimethylphenyl)acetamide;2-(dimethylamino)ethyl 4-(butylamino)benzoate Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C.CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 LWNPNOFGINFGGV-UHFFFAOYSA-N 0.000 claims description 4
- IYBQHJMYDGVZRY-UHFFFAOYSA-N lidocaine hydrochloride Chemical compound [Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C IYBQHJMYDGVZRY-UHFFFAOYSA-N 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 abstract description 7
- 239000000126 substance Substances 0.000 abstract description 7
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 2
- 239000000499 gel Substances 0.000 description 103
- 210000001519 tissue Anatomy 0.000 description 45
- 238000006243 chemical reaction Methods 0.000 description 31
- 239000007853 buffer solution Substances 0.000 description 24
- 150000001875 compounds Chemical class 0.000 description 21
- 238000004519 manufacturing process Methods 0.000 description 18
- 239000000243 solution Substances 0.000 description 16
- SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical compound C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 description 14
- 239000000872 buffer Substances 0.000 description 13
- 239000002245 particle Substances 0.000 description 13
- 230000037303 wrinkles Effects 0.000 description 13
- 230000001815 facial effect Effects 0.000 description 12
- 239000007943 implant Substances 0.000 description 12
- 238000002347 injection Methods 0.000 description 11
- 239000007924 injection Substances 0.000 description 11
- 238000003756 stirring Methods 0.000 description 11
- 239000003431 cross linking reagent Substances 0.000 description 10
- 150000003839 salts Chemical class 0.000 description 10
- 239000012670 alkaline solution Substances 0.000 description 9
- -1 hyaluronic acid Chemical class 0.000 description 9
- 230000008961 swelling Effects 0.000 description 9
- 239000003814 drug Substances 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000002411 adverse Effects 0.000 description 6
- 239000011859 microparticle Substances 0.000 description 6
- 238000004659 sterilization and disinfection Methods 0.000 description 6
- 238000001914 filtration Methods 0.000 description 5
- 239000000017 hydrogel Substances 0.000 description 5
- 238000010791 quenching Methods 0.000 description 5
- 230000000171 quenching effect Effects 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 239000003589 local anesthetic agent Substances 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- 239000004593 Epoxy Substances 0.000 description 3
- 238000010306 acid treatment Methods 0.000 description 3
- 229920000249 biocompatible polymer Polymers 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 229920006037 cross link polymer Polymers 0.000 description 3
- 229920001477 hydrophilic polymer Polymers 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- GYZLOYUZLJXAJU-UHFFFAOYSA-N diglycidyl ether Chemical compound C1OC1COCC1CO1 GYZLOYUZLJXAJU-UHFFFAOYSA-N 0.000 description 2
- 150000002016 disaccharides Chemical class 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 150000004677 hydrates Chemical class 0.000 description 2
- 229910052500 inorganic mineral Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011707 mineral Chemical class 0.000 description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 2
- 235000019799 monosodium phosphate Nutrition 0.000 description 2
- 239000008055 phosphate buffer solution Substances 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 239000012455 biphasic mixture Substances 0.000 description 1
- 238000011095 buffer preparation Methods 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 229940061607 dibasic sodium phosphate Drugs 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- LVXHNCUCBXIIPE-UHFFFAOYSA-L disodium;hydrogen phosphate;hydrate Chemical compound O.[Na+].[Na+].OP([O-])([O-])=O LVXHNCUCBXIIPE-UHFFFAOYSA-L 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 150000002118 epoxides Chemical class 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000007863 gel particle Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 1
- 229940099552 hyaluronan Drugs 0.000 description 1
- 229940014041 hyaluronate Drugs 0.000 description 1
- 230000000887 hydrating effect Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 229940045641 monobasic sodium phosphate Drugs 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 229940075562 sodium phosphate dihydrate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0059—Cosmetic or alloplastic implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
- C08J3/246—Intercrosslinking of at least two polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/594—Mixtures of polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Birds (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261660269P | 2012-06-15 | 2012-06-15 | |
| US61/660,269 | 2012-06-15 | ||
| EP12004962 | 2012-07-04 | ||
| EP12004962.2 | 2012-07-04 | ||
| EP13000961 | 2013-02-26 | ||
| EP13000961.6 | 2013-02-26 | ||
| PCT/EP2013/001782 WO2013185934A1 (en) | 2012-06-15 | 2013-06-14 | Method of preparing a composition based on hyaluronic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015101105A RU2015101105A (ru) | 2016-08-10 |
| RU2640911C2 true RU2640911C2 (ru) | 2018-01-12 |
Family
ID=49757607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015101105A RU2640911C2 (ru) | 2012-06-15 | 2013-06-14 | Способ получения композиции на основе гиалуроновой кислоты |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9822223B2 (enExample) |
| EP (1) | EP2861626B1 (enExample) |
| JP (1) | JP6174690B2 (enExample) |
| KR (2) | KR20150022934A (enExample) |
| CN (1) | CN104395348B (enExample) |
| AR (1) | AR091454A1 (enExample) |
| AU (1) | AU2013276844B2 (enExample) |
| BR (1) | BR112014031412B1 (enExample) |
| CA (1) | CA2876070C (enExample) |
| IL (1) | IL235918B (enExample) |
| IN (1) | IN2014DN10147A (enExample) |
| LT (1) | LT2861626T (enExample) |
| MX (1) | MX354947B (enExample) |
| PL (1) | PL2861626T3 (enExample) |
| RU (1) | RU2640911C2 (enExample) |
| SG (1) | SG11201408312UA (enExample) |
| TW (1) | TWI605834B (enExample) |
| WO (1) | WO2013185934A1 (enExample) |
| ZA (1) | ZA201409155B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2841139C1 (ru) * | 2020-04-10 | 2025-06-03 | Теоксан Са | Композиции на основе по меньшей мере двух гликозаминогликанов |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR099900A1 (es) | 2014-04-01 | 2016-08-24 | Merz Pharma Gmbh & Co Kgaa | Rellenos para tejidos blandos con polisacáridos con persistencia mejorada, kit, procedimiento, uso |
| FR3029928B1 (fr) * | 2014-12-15 | 2018-03-09 | Teoxane | Gel reticule |
| ES2872551T3 (es) * | 2015-06-30 | 2021-11-02 | Merz Pharma Gmbh & Co Kgaa | Método para la producción de ácido hialurónico reticulado |
| WO2017001057A1 (en) * | 2015-06-30 | 2017-01-05 | Merz Pharma Gmbh & Co. Kgaa | Method of preparing a composition based on hyaluronic acid |
| EP3320028A1 (en) * | 2015-09-01 | 2018-05-16 | Merz Pharma GmbH & Co. KGaA | Method of making a cross-linked polymer gel and device for performing the method |
| TWI727014B (zh) | 2016-03-24 | 2021-05-11 | 德商梅茲製藥有限兩合公司 | 修飾透明質酸與其製造方法及其用途 |
| WO2018083195A1 (en) | 2016-11-03 | 2018-05-11 | Merz Pharma Gmbh & Co. Kgaa | Method for preparing hyaluronic acid dermal fillers, dermal fillers obtained thereby and their use |
| EP3354258A1 (en) * | 2017-01-31 | 2018-08-01 | Teoxane SA | Use of a cohesive gel as a matrix material in a periodontal pocket |
| KR20200130685A (ko) * | 2018-02-06 | 2020-11-19 | 리젠 랩 에스에이 | 가교된 히알루론산 및 prp/bmc와의 조합물 |
| EP3813895B1 (en) | 2018-06-29 | 2025-07-30 | Merz Pharma GmbH & Co. KGaA | Fatty acid-grafted hyaluronic acid, dermal filler formulations comprising same, process for preparation and use thereof |
| JP7474239B2 (ja) * | 2018-08-07 | 2024-04-24 | メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー | 架橋ヒドロゲルの動的濾過の方法 |
| FR3095206B1 (fr) * | 2019-04-17 | 2021-11-05 | Lab Vivacy | Procede de reticulation d’un polymere |
| ES3020558T3 (en) | 2019-12-09 | 2025-05-23 | Merz Pharma Gmbh & Co Kgaa | Process for producing a composition comprising a crosslinked hydrogel |
| CN112940300B (zh) * | 2019-12-10 | 2023-03-31 | 爱博诺德(北京)医疗科技股份有限公司 | 交联透明质酸凝胶的制备方法 |
| WO2021115310A1 (zh) * | 2019-12-10 | 2021-06-17 | 爱博诺德(北京)医疗科技股份有限公司 | 交联透明质酸凝胶及其制备方法 |
| FR3109153B1 (fr) * | 2020-04-10 | 2022-07-15 | Teoxane SA | Compositions à base d’au moins deux glycosaminoglycanes |
| FR3111903B1 (fr) | 2020-06-24 | 2022-12-02 | Lab Vivacy | Procede d’incorporation de composes organiques en solution au sein d’un hydrogel |
| MX2024006615A (es) * | 2021-12-03 | 2024-08-26 | Parasight System Inc | Método de preparación de muestras fecales para análisis automatizado de imágenes. |
| US20250340675A1 (en) | 2022-01-11 | 2025-11-06 | WiQo S.P.A. | New hyaluronic acid derivatives as innovative fillers |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2351367C2 (ru) * | 2003-12-22 | 2009-04-10 | Аника Терапьютикс, Инк. | Композиция со сшитой гиалуроновой кислотой для наращивания тканей |
| RU2363496C2 (ru) * | 2004-04-08 | 2009-08-10 | Ку-Мед Аб | Способ увеличения объема мягких тканей |
| WO2010115081A2 (en) * | 2009-04-02 | 2010-10-07 | Allergan, Inc. | Hair-like shaped hydrogels for soft tissue augmentation |
| US20110118206A1 (en) * | 2008-08-04 | 2011-05-19 | Allergan Industrie, Sas | Hyaluronic acid based formulations |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713448A (en) | 1985-03-12 | 1987-12-15 | Biomatrix, Inc. | Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues |
| DE3636590A1 (de) | 1986-10-28 | 1988-05-26 | Braun Melsungen Ag | Blutersatzmittel |
| US5143724A (en) * | 1990-07-09 | 1992-09-01 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
| US5248772A (en) * | 1992-01-29 | 1993-09-28 | Coulter Corporation | Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents |
| US5827937A (en) | 1995-07-17 | 1998-10-27 | Q Med Ab | Polysaccharide gel composition |
| FR2861734B1 (fr) * | 2003-04-10 | 2006-04-14 | Corneal Ind | Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus |
| AU2004312532B2 (en) | 2003-12-30 | 2010-05-20 | Genzyme Corporation | Cohesive gels form cross-linked hyaluronan and/or hylan, their preparation and use |
| FR2865737B1 (fr) | 2004-02-03 | 2006-03-31 | Anteis Sa | Gel reticule biocompatible |
| WO2006051950A1 (ja) | 2004-11-15 | 2006-05-18 | Shiseido Co., Ltd. | 架橋ヒアルロン酸ゲルの製造方法 |
| EP1891941A1 (en) | 2006-08-11 | 2008-02-27 | OctoPlus Technologies B.V. | Aqueous gels comprising microspheres |
| FR2909560B1 (fr) | 2006-12-06 | 2012-12-28 | Fabre Pierre Dermo Cosmetique | Gel d'acide hyaluronique pour injection intradermique |
| EP2155212A2 (fr) | 2007-05-11 | 2010-02-24 | Galderma Research & Development | Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations |
| WO2009021526A1 (de) | 2007-07-25 | 2009-02-19 | S & V Technologies Ag | Hyaluronsäuredispersion, herstellung und anwendung |
| US8318695B2 (en) | 2007-07-30 | 2012-11-27 | Allergan, Inc. | Tunably crosslinked polysaccharide compositions |
| FR2919999B1 (fr) | 2007-08-13 | 2010-01-29 | Oreal | Compositions d'acide hyaluronique |
| US8394782B2 (en) * | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having increased longevity |
| FR2924615B1 (fr) * | 2007-12-07 | 2010-01-22 | Vivacy Lab | Hydrogel cohesif biodegradable. |
| FR2927255B1 (fr) | 2008-02-07 | 2011-08-12 | Keysan Consulting | Produits injectables biocompatibles a liberation de zinc et/ou de sel de saccharide sous forme de zinc et leurs utilisations. |
| WO2010105900A1 (en) | 2009-03-16 | 2010-09-23 | Thomson Licensing | Exponentiation method resistant against side-channel and safe-error attacks |
| IT1395392B1 (it) * | 2009-08-27 | 2012-09-14 | Fidia Farmaceutici | Geli viscoelastici come nuovi filler |
| WO2011119468A1 (en) | 2010-03-22 | 2011-09-29 | Allergan, Inc. | Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation |
| HUE034824T2 (en) | 2010-11-08 | 2018-03-28 | Allergan Ind Sas | Hyaluronic acid-based preparations |
-
2013
- 2013-06-14 IN IN10147DEN2014 patent/IN2014DN10147A/en unknown
- 2013-06-14 RU RU2015101105A patent/RU2640911C2/ru active
- 2013-06-14 US US14/407,231 patent/US9822223B2/en active Active
- 2013-06-14 CA CA2876070A patent/CA2876070C/en active Active
- 2013-06-14 LT LTEP13731292.2T patent/LT2861626T/lt unknown
- 2013-06-14 MX MX2014015133A patent/MX354947B/es active IP Right Grant
- 2013-06-14 AU AU2013276844A patent/AU2013276844B2/en active Active
- 2013-06-14 CN CN201380031602.7A patent/CN104395348B/zh active Active
- 2013-06-14 PL PL13731292T patent/PL2861626T3/pl unknown
- 2013-06-14 WO PCT/EP2013/001782 patent/WO2013185934A1/en not_active Ceased
- 2013-06-14 KR KR20147037159A patent/KR20150022934A/ko not_active Ceased
- 2013-06-14 AR ARP130102107 patent/AR091454A1/es active IP Right Grant
- 2013-06-14 SG SG11201408312UA patent/SG11201408312UA/en unknown
- 2013-06-14 KR KR1020187032298A patent/KR20180122758A/ko not_active Ceased
- 2013-06-14 JP JP2015516514A patent/JP6174690B2/ja active Active
- 2013-06-14 EP EP13731292.2A patent/EP2861626B1/en active Active
- 2013-06-14 BR BR112014031412-8A patent/BR112014031412B1/pt active IP Right Grant
- 2013-06-17 TW TW102121431A patent/TWI605834B/zh active
-
2014
- 2014-11-26 IL IL235918A patent/IL235918B/en active IP Right Grant
- 2014-12-12 ZA ZA2014/09155A patent/ZA201409155B/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2351367C2 (ru) * | 2003-12-22 | 2009-04-10 | Аника Терапьютикс, Инк. | Композиция со сшитой гиалуроновой кислотой для наращивания тканей |
| RU2363496C2 (ru) * | 2004-04-08 | 2009-08-10 | Ку-Мед Аб | Способ увеличения объема мягких тканей |
| US20110118206A1 (en) * | 2008-08-04 | 2011-05-19 | Allergan Industrie, Sas | Hyaluronic acid based formulations |
| WO2010115081A2 (en) * | 2009-04-02 | 2010-10-07 | Allergan, Inc. | Hair-like shaped hydrogels for soft tissue augmentation |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2841139C1 (ru) * | 2020-04-10 | 2025-06-03 | Теоксан Са | Композиции на основе по меньшей мере двух гликозаминогликанов |
| RU2842966C1 (ru) * | 2024-11-21 | 2025-07-04 | Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" | Способ получения биосовместимых и биоразлагаемых гидрогелей методом поэтапной замены растворителя |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013276844A1 (en) | 2014-12-18 |
| IN2014DN10147A (enExample) | 2015-08-21 |
| TW201404409A (zh) | 2014-02-01 |
| RU2015101105A (ru) | 2016-08-10 |
| US9822223B2 (en) | 2017-11-21 |
| IL235918A0 (en) | 2015-01-29 |
| BR112014031412A2 (pt) | 2017-06-27 |
| WO2013185934A1 (en) | 2013-12-19 |
| ZA201409155B (en) | 2015-11-25 |
| MX354947B (es) | 2018-03-27 |
| EP2861626A1 (en) | 2015-04-22 |
| AR091454A1 (es) | 2015-02-04 |
| EP2861626B1 (en) | 2018-12-19 |
| JP2015526537A (ja) | 2015-09-10 |
| CA2876070A1 (en) | 2013-12-19 |
| KR20150022934A (ko) | 2015-03-04 |
| MX2014015133A (es) | 2015-03-05 |
| KR20180122758A (ko) | 2018-11-13 |
| JP6174690B2 (ja) | 2017-08-02 |
| CA2876070C (en) | 2021-01-26 |
| IL235918B (en) | 2018-11-29 |
| PL2861626T3 (pl) | 2019-05-31 |
| LT2861626T (lt) | 2019-01-25 |
| CN104395348B (zh) | 2019-07-30 |
| US20150232623A1 (en) | 2015-08-20 |
| TWI605834B (zh) | 2017-11-21 |
| SG11201408312UA (en) | 2015-01-29 |
| HK1205750A1 (en) | 2015-12-24 |
| AU2013276844B2 (en) | 2017-09-28 |
| CN104395348A (zh) | 2015-03-04 |
| BR112014031412B1 (pt) | 2021-01-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2640911C2 (ru) | Способ получения композиции на основе гиалуроновой кислоты | |
| RU2683286C2 (ru) | Способ поперечного сшивания гиалуроновой кислоты, способ приготовления инъекционного гидрогеля, гидрогель и его применение | |
| KR102076337B1 (ko) | 히알루론산 유도체 및 dna 분획물이 포함된 히알루론산 주사용 조성물 및 이의 이용 | |
| RU2496473C2 (ru) | Гели на основе гиалуроновой кислоты, включающие обезболивающие агенты | |
| CN105473623B (zh) | 用于制备交联的透明质酸产物的方法 | |
| JP7368940B2 (ja) | ｉｎ ｓｉｔｕ架橋性多糖類組成物及びその使用 | |
| TWI641393B (zh) | 用於美容用途之含有交聯玻尿酸及羥磷灰石的無菌可注射水性調配物 | |
| CN105705137B (zh) | 获得基于含有以粉末形式添加的利多卡因和碱剂的透明质酸且热灭菌的可注射水凝胶的方法 | |
| KR20100118102A (ko) | 생분해성 단일-상 점착성 히드로겔 | |
| EP3316911B1 (en) | Method of preparing a composition based on hyaluronic acid | |
| JP2022512363A (ja) | アルデヒド変性ヒアルロン酸、それを調製するための方法およびその用途 | |
| EP3851130B1 (en) | Injection formulation containing poly-l-lactic acid filler and hyaluronic acid filler conjugate, and method for preparing same | |
| ES2705231T3 (es) | Método para preparar una composición basada en ácido hialurónico | |
| RU2778332C2 (ru) | Рассасывающиеся имплантируемые устройства на основе сшитых гликозаминогликанов и способ их получения | |
| HK1205750B (zh) | 制备基於透明质酸的组合物的方法 | |
| WO2025068242A1 (en) | Dexamethasone delivery system | |
| HK1156883B (en) | Hyaluronic acid-based gels including anesthetic agents |