KR20180122758A - 히알루론산을 기본으로 하는 조성물의 제조 방법 - Google Patents

히알루론산을 기본으로 하는 조성물의 제조 방법 Download PDF

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Publication number
KR20180122758A
KR20180122758A KR1020187032298A KR20187032298A KR20180122758A KR 20180122758 A KR20180122758 A KR 20180122758A KR 1020187032298 A KR1020187032298 A KR 1020187032298A KR 20187032298 A KR20187032298 A KR 20187032298A KR 20180122758 A KR20180122758 A KR 20180122758A
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South Korea
Prior art keywords
polymer
sieve
composition
product obtained
crosslinked
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KR1020187032298A
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English (en)
Korean (ko)
Inventor
헤이코 바그
조셉 프리드리취
볼프강 리베트로
로버트 쥐. 보익츠
팀 스테픈 릭먼
Original Assignee
메르츠 파마 게엠베하 운트 코. 카가아
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Publication of KR20180122758A publication Critical patent/KR20180122758A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0059—Cosmetic or alloplastic implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C08J3/246—Intercrosslinking of at least two polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
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    • A—HUMAN NECESSITIES
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    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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    • A61L2400/00—Materials characterised by their function or physical properties
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
KR1020187032298A 2012-06-15 2013-06-14 히알루론산을 기본으로 하는 조성물의 제조 방법 Ceased KR20180122758A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261660269P 2012-06-15 2012-06-15
US61/660,269 2012-06-15
EP12004962.2 2012-07-04
EP12004962 2012-07-04
EP13000961 2013-02-26
EP13000961.6 2013-02-26
PCT/EP2013/001782 WO2013185934A1 (en) 2012-06-15 2013-06-14 Method of preparing a composition based on hyaluronic acid

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR20147037159A Division KR20150022934A (ko) 2012-06-15 2013-06-14 히알루론산을 기본으로 하는 조성물의 제조 방법

Publications (1)

Publication Number Publication Date
KR20180122758A true KR20180122758A (ko) 2018-11-13

Family

ID=49757607

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020187032298A Ceased KR20180122758A (ko) 2012-06-15 2013-06-14 히알루론산을 기본으로 하는 조성물의 제조 방법
KR20147037159A Ceased KR20150022934A (ko) 2012-06-15 2013-06-14 히알루론산을 기본으로 하는 조성물의 제조 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR20147037159A Ceased KR20150022934A (ko) 2012-06-15 2013-06-14 히알루론산을 기본으로 하는 조성물의 제조 방법

Country Status (19)

Country Link
US (1) US9822223B2 (enExample)
EP (1) EP2861626B1 (enExample)
JP (1) JP6174690B2 (enExample)
KR (2) KR20180122758A (enExample)
CN (1) CN104395348B (enExample)
AR (1) AR091454A1 (enExample)
AU (1) AU2013276844B2 (enExample)
BR (1) BR112014031412B1 (enExample)
CA (1) CA2876070C (enExample)
IL (1) IL235918B (enExample)
IN (1) IN2014DN10147A (enExample)
LT (1) LT2861626T (enExample)
MX (1) MX354947B (enExample)
PL (1) PL2861626T3 (enExample)
RU (1) RU2640911C2 (enExample)
SG (1) SG11201408312UA (enExample)
TW (1) TWI605834B (enExample)
WO (1) WO2013185934A1 (enExample)
ZA (1) ZA201409155B (enExample)

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FR3029928B1 (fr) * 2014-12-15 2018-03-09 Teoxane Gel reticule
ES2872551T3 (es) 2015-06-30 2021-11-02 Merz Pharma Gmbh & Co Kgaa Método para la producción de ácido hialurónico reticulado
US20180177707A1 (en) * 2015-06-30 2018-06-28 Merz Pharma Gmbh & Co. Kgaa Method of preparing a composition based on hyaluronic acid
EP3320028A1 (en) * 2015-09-01 2018-05-16 Merz Pharma GmbH & Co. KGaA Method of making a cross-linked polymer gel and device for performing the method
TWI727014B (zh) 2016-03-24 2021-05-11 德商梅茲製藥有限兩合公司 修飾透明質酸與其製造方法及其用途
WO2018083195A1 (en) 2016-11-03 2018-05-11 Merz Pharma Gmbh & Co. Kgaa Method for preparing hyaluronic acid dermal fillers, dermal fillers obtained thereby and their use
EP3354258A1 (en) * 2017-01-31 2018-08-01 Teoxane SA Use of a cohesive gel as a matrix material in a periodontal pocket
EP3743079A1 (en) * 2018-02-06 2020-12-02 Regen Lab SA Cross-linked hyaluronic acids and combinations with prp/bmc
ES3040766T3 (en) 2018-06-29 2025-11-04 Merz Pharma Gmbh & Co Kgaa Fatty acid-grafted hyaluronic acid, dermal filler formulations comprising same, process for preparation and use thereof
WO2020030629A1 (en) * 2018-08-07 2020-02-13 Merz Pharma Gmbh & Co. Kgaa Method for dynamic filtration of a cross-linked hydrogel
FR3095206B1 (fr) * 2019-04-17 2021-11-05 Lab Vivacy Procede de reticulation d’un polymere
EP4073148B1 (en) 2019-12-09 2025-02-12 Merz Pharma GmbH & Co. KGaA Process for producing a composition comprising a crosslinked hydrogel
CN112940300B (zh) * 2019-12-10 2023-03-31 爱博诺德(北京)医疗科技股份有限公司 交联透明质酸凝胶的制备方法
WO2021115310A1 (zh) * 2019-12-10 2021-06-17 爱博诺德(北京)医疗科技股份有限公司 交联透明质酸凝胶及其制备方法
FR3109153B1 (fr) * 2020-04-10 2022-07-15 Teoxane SA Compositions à base d’au moins deux glycosaminoglycanes
FR3111903B1 (fr) 2020-06-24 2022-12-02 Lab Vivacy Procede d’incorporation de composes organiques en solution au sein d’un hydrogel
MX2024006615A (es) * 2021-12-03 2024-08-26 Parasight System Inc Método de preparación de muestras fecales para análisis automatizado de imágenes.
JP2025502169A (ja) 2022-01-11 2025-01-24 ワイコ・エセペア 革新的充填剤としての新規なヒアルロン酸誘導体
US12569589B2 (en) * 2023-05-02 2026-03-10 Allure Medical Spa, P.L.L.C. System and methods for delivering a dermal filler
IT202400006892A1 (it) 2024-03-27 2025-09-27 Gpq S R L Riempitivi tissutali polisaccaridici reticolati con resveratrolo

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ZA201409155B (en) 2015-11-25
IL235918A0 (en) 2015-01-29
AR091454A1 (es) 2015-02-04
LT2861626T (lt) 2019-01-25
JP2015526537A (ja) 2015-09-10
CA2876070C (en) 2021-01-26
EP2861626B1 (en) 2018-12-19
CA2876070A1 (en) 2013-12-19
EP2861626A1 (en) 2015-04-22
SG11201408312UA (en) 2015-01-29
IN2014DN10147A (enExample) 2015-08-21
JP6174690B2 (ja) 2017-08-02
MX2014015133A (es) 2015-03-05
MX354947B (es) 2018-03-27
US20150232623A1 (en) 2015-08-20
KR20150022934A (ko) 2015-03-04
US9822223B2 (en) 2017-11-21
RU2015101105A (ru) 2016-08-10
CN104395348B (zh) 2019-07-30
BR112014031412B1 (pt) 2021-01-05
CN104395348A (zh) 2015-03-04
WO2013185934A1 (en) 2013-12-19
BR112014031412A2 (pt) 2017-06-27
HK1205750A1 (en) 2015-12-24
AU2013276844A1 (en) 2014-12-18
PL2861626T3 (pl) 2019-05-31
IL235918B (en) 2018-11-29
AU2013276844B2 (en) 2017-09-28
TW201404409A (zh) 2014-02-01

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