RU2628537C2 - Лечение нарушений свертываемости крови путем введения рекомбинантного фв - Google Patents

Лечение нарушений свертываемости крови путем введения рекомбинантного фв Download PDF

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RU2628537C2
RU2628537C2 RU2014100107A RU2014100107A RU2628537C2 RU 2628537 C2 RU2628537 C2 RU 2628537C2 RU 2014100107 A RU2014100107 A RU 2014100107A RU 2014100107 A RU2014100107 A RU 2014100107A RU 2628537 C2 RU2628537 C2 RU 2628537C2
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var
fviii
rfv
patient
multimers
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RU2014100107A
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RU2014100107A (ru
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Фридрих ШАЙФЛИНГЕР
Петер Турецек
Брюс ЭВЕНШТАЙН
Винг Йен ВОНГ
Тобиас М. СУИТЕР
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Баксалта Инкорпорейтед
Баксалта Гмбх
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • A61K38/37Factors VIII
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
RU2014100107A 2011-06-10 2012-06-11 Лечение нарушений свертываемости крови путем введения рекомбинантного фв RU2628537C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161495884P 2011-06-10 2011-06-10
US61/495,884 2011-06-10
US201161511901P 2011-07-26 2011-07-26
US61/511,901 2011-07-26
US201161523790P 2011-08-15 2011-08-15
US61/523,790 2011-08-15
PCT/US2012/041957 WO2012171031A1 (en) 2011-06-10 2012-06-11 Treatment of coagulation disease by administration of recombinant vwf

Related Child Applications (1)

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RU2017102679A Division RU2680402C2 (ru) 2011-06-10 2012-06-11 Лечение нарушений свертываемости крови путем введения рекомбинантного фв

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RU2014100107A RU2014100107A (ru) 2015-07-20
RU2628537C2 true RU2628537C2 (ru) 2017-08-18

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RU2014100107A RU2628537C2 (ru) 2011-06-10 2012-06-11 Лечение нарушений свертываемости крови путем введения рекомбинантного фв
RU2017102679A RU2680402C2 (ru) 2011-06-10 2012-06-11 Лечение нарушений свертываемости крови путем введения рекомбинантного фв

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EP (3) EP3412305B1 (enExample)
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KR (3) KR20190041032A (enExample)
CN (3) CN103732244A (enExample)
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AU (5) AU2012267458A1 (enExample)
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PT (3) PT3412305T (enExample)
RU (2) RU2628537C2 (enExample)
SG (2) SG10201604684WA (enExample)
SI (1) SI2717905T1 (enExample)
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WO (1) WO2012171031A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190041032A (ko) * 2011-06-10 2019-04-19 박스알타 인코퍼레이티드 재조합 vwf의 투여에 의한 응고 질환의 치료
CN102776260B (zh) * 2012-07-26 2015-04-29 上海泰龙生物医药科技有限公司 一种高效表达重组人凝血八因子的方法
DK2796145T3 (da) 2013-04-22 2018-01-29 Csl Ltd Et kovalent kompleks af von Willebrand-faktor og faktor VIII linket af en disulfidbro
NL2013007B1 (en) 2014-06-16 2016-07-05 Ablynx Nv Methods of treating TTP with immunoglobulin single variable domains and uses thereof.
FR3034669B1 (fr) * 2015-04-07 2020-02-14 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Nouvelle utilisation du facteur von willebrand
EP4343774A3 (en) 2016-04-15 2024-06-05 Takeda Pharmaceutical Company Limited Method and apparatus for providing a pharmacokinetic drug dosing regiment
US10896749B2 (en) 2017-01-27 2021-01-19 Shire Human Genetic Therapies, Inc. Drug monitoring tool
RU2766118C2 (ru) * 2017-07-07 2022-02-08 Такеда Фармасьютикал Компани Лимитед Лечение пациентов с тяжелой формой болезни фон виллебранда, подвергающихся плановому хирургическому вмешательству, путем введения рекомбинантного ффв
EP4424366A3 (en) * 2017-07-07 2024-12-04 Takeda Pharmaceutical Company Limited Treatment of gastrointestinal bleeding in patients with severe von willebrand disease by administration of recombinant vwf
SG11202006902QA (en) 2018-02-06 2020-08-28 Ablynx Nv Methods of treating initial episode of ttp with immunoglobulin single variable domains
EP3768697A1 (en) * 2018-03-21 2021-01-27 Baxalta Incorporated Separation of vwf and vwf propeptide by chromatographic methods
MX2021009114A (es) * 2019-02-01 2021-10-13 Takeda Pharmaceuticals Co Métodos de tratamiento profiláctico que usan factor de von willebrand recombinante (rvwf).
JP2022547556A (ja) * 2019-09-11 2022-11-14 武田薬品工業株式会社 フォン・ヴィレブランド因子と補体c1qの複合体に関連する治療法
CN115335074A (zh) 2020-02-04 2022-11-11 武田药品工业株式会社 通过施用重组vwf来治疗患有重度冯维勒布兰德病的患者的月经过多
TW202237149A (zh) * 2020-11-24 2022-10-01 美商邦德治療公司 用於治療出血性障礙之組成物及方法
WO2024124136A1 (en) * 2022-12-09 2024-06-13 Vega Therapeutics, Inc. Von willebrand disease animal models

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US4638028A (en) 1985-04-08 1987-01-20 Goodyear Tire & Rubber Company Rubber polymerases and methods for their production and use
EP0218692A4 (en) 1985-04-11 1988-03-22 Childrens Medical Center VON WILLEBRAND FACTOR.
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
SE504074C2 (sv) * 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
DE4435485C1 (de) * 1994-10-04 1996-03-21 Immuno Ag Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor
AT403764B (de) * 1996-03-15 1998-05-25 Immuno Ag Stabiler faktor viii/vwf-komplex
AT405403B (de) * 1997-02-27 1999-08-25 Immuno Ag Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie
AT406373B (de) * 1997-02-27 2000-04-25 Immuno Ag Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie
US6531577B1 (en) 1997-12-15 2003-03-11 Hemasure Denmark A/S von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations
US6864403B1 (en) 1998-10-15 2005-03-08 E. I. Du Pont De Nemours And Company Plant protein disulfide isomerases
US20040014657A1 (en) * 2001-11-05 2004-01-22 Jan Ohrstrom Use of blood coagulation factor XIII for treating haemophilia A
WO2005012354A1 (en) * 2003-07-31 2005-02-10 Zlb Behring Gmbh Method for extending the half-life of fviii
EP1593388A1 (en) 2004-05-05 2005-11-09 ZLB Behring GmbH Therapeutic plasma protein-concentrates containing von willebrand factor as high molecular weight multimers
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
AU2005322067B8 (en) * 2004-12-27 2012-07-26 Takeda Pharmaceutical Company Limited Polymer-von Willebrand factor-conjugates
DK1974014T3 (en) 2006-01-04 2017-06-19 Baxalta Inc OLIGOPEPTID-FREE CELL CULTURE MEDIA
ES2392569T3 (es) * 2007-06-13 2012-12-11 Csl Behring Gmbh Uso de preparaciones FVIII estabilizadas VWF para administración extravascular en la terapia y el tratamiento profiláctico de trastornos de hemorragias
EP2222329A1 (en) 2007-11-09 2010-09-01 Baxter International Inc. Modified recombinant factor viii and von willebrand factor and methods of use
JP2009127455A (ja) 2007-11-20 2009-06-11 Bando Kiko Co Ltd 往復動エンジン
MX2010007150A (es) * 2007-12-28 2010-09-03 Baxter Int Formulaciones del factor de von-willebrand recombinante.
ES2298096B1 (es) * 2008-01-08 2009-01-01 Grifols, S.A. Procedimiento para la obtencion de un concentrado de factor von willebrand o del complejo de factor viii/factor von willebrand y utilizacionde los mismos.
ES2531464T3 (es) * 2008-06-24 2015-03-16 Csl Behring Gmbh Factor VIII, factor de von Willebrand o sus complejos con semivida in vivo prolongada
KR101772674B1 (ko) 2008-10-21 2017-09-01 박스알타 인코퍼레이티드 동결건조된 재조합 vwf 제제
WO2011017414A2 (en) * 2009-08-04 2011-02-10 Baxter International Inc. Transgenic mouse lacking endogenous fviii and vwf - a model of hemophilia a
HRP20180136T1 (hr) 2010-07-08 2018-04-06 Baxalta GmbH POSTUPAK PROIZVODNJE REKOMBINANTNOG VISOKOMOLEKULSKOG vWF U KULTURI STANICA
US20120006800A1 (en) 2010-07-09 2012-01-12 Illinois Tool Works Inc. Weld bead feature communication systems and devices
KR20190041032A (ko) * 2011-06-10 2019-04-19 박스알타 인코퍼레이티드 재조합 vwf의 투여에 의한 응고 질환의 치료

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FISCHER BE., Recombinant von Willebrand factor: potential therapeutic use.J Thromb Thrombolysis. 1999 Oct;8(3):197-205. MEULIEN P., et al., Processing and characterization of recombinant von Willebrand factor expressed in different cell types using a vaccinia virus vector.Thromb Haemost. 1992 Jan 23;67(1):154-60. FISCHER BE., et al., Structural analysis of recombinant von Willebrand factor produced at industrial scale fermentation of transformed CHO cells co-expressing recombinant furin.FEBS Lett. 1995 Nov 20;375(3):259-62. TURECEK PL., et al., Structure and function of a recombinant von Willebrand factor drug candidate.Semin Thromb Hemost. 2010 Jul;36(5):510-21. doi: 10.1055/s-0030-1255445. Epub 2010 Jul 15. RODEGHIERO F., et al., Treatment of von Willebrand disease.Semin Hematol. 2005 Jan;42(1):29-35. *

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DK2717905T3 (en) 2018-07-02
AU2020200026A1 (en) 2020-01-30
EP3858375A1 (en) 2021-08-04
CA2838845C (en) 2019-08-06
US20120316116A1 (en) 2012-12-13
AU2016202299B2 (en) 2017-07-20
MX2013014543A (es) 2014-06-11
LT2717905T (lt) 2018-10-10
SI2717905T1 (sl) 2018-09-28
BR112013031795A2 (pt) 2016-12-20
DK3858375T3 (da) 2024-04-15
KR20200091476A (ko) 2020-07-30
EP3858375B1 (en) 2024-03-20
US9272021B2 (en) 2016-03-01
JP6347468B2 (ja) 2018-06-27
JP6527114B2 (ja) 2019-06-05
AU2012267458A1 (en) 2014-01-09
CN103732244A (zh) 2014-04-16
CA2838845A1 (en) 2012-12-13
JP2019048892A (ja) 2019-03-28
RU2019103386A3 (enExample) 2022-01-24
JP2014516088A (ja) 2014-07-07
CN108210889A (zh) 2018-06-29
ES2860450T3 (es) 2021-10-05
NZ618790A (en) 2015-07-31
KR102319868B1 (ko) 2021-11-01
KR20190041032A (ko) 2019-04-19
RU2680402C2 (ru) 2019-02-21
ES2682249T3 (es) 2018-09-19
PL3412305T3 (pl) 2021-05-31
HRP20180962T1 (hr) 2018-10-19
EP3412305B1 (en) 2021-01-06
HK1257436A1 (zh) 2019-10-18
MX2020000083A (es) 2020-08-06
ES2976169T3 (es) 2024-07-24
EP3412305A1 (en) 2018-12-12
RU2014100107A (ru) 2015-07-20
US20250387455A1 (en) 2025-12-25
AU2016202299A1 (en) 2016-05-05
AU2022201518B2 (en) 2025-07-03
EP2717905A1 (en) 2014-04-16
AR086904A1 (es) 2014-01-29
KR101969515B1 (ko) 2019-04-16
PL3858375T3 (pl) 2024-05-20
FI3858375T3 (fi) 2024-04-17
AU2022201518A1 (en) 2022-03-24
PT2717905T (pt) 2018-07-02
TR201808823T4 (tr) 2018-07-23
DK3412305T3 (da) 2021-03-01
HUE039317T2 (hu) 2018-12-28
JP2017019788A (ja) 2017-01-26
PL2717905T3 (pl) 2018-10-31
WO2012171031A1 (en) 2012-12-13
MX350582B (es) 2017-09-11
EP2717905B1 (en) 2018-05-23
PT3858375T (pt) 2024-04-18
RU2019103386A (ru) 2020-08-07
CN107412743A (zh) 2017-12-01
SG10202002591QA (en) 2020-05-28
RU2017102679A3 (enExample) 2018-12-19
AU2017206235A1 (en) 2017-08-03
US20160184403A1 (en) 2016-06-30
CN107412743B (zh) 2021-07-02
SG10201604684WA (en) 2016-07-28
RU2017102679A (ru) 2018-12-19
KR20140039285A (ko) 2014-04-01
AU2017206235B2 (en) 2019-10-17
PT3412305T (pt) 2021-01-29

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