RU2627354C2 - Устойчивые кристаллические модификации хлорида dotap - Google Patents
Устойчивые кристаллические модификации хлорида dotap Download PDFInfo
- Publication number
- RU2627354C2 RU2627354C2 RU2013156477A RU2013156477A RU2627354C2 RU 2627354 C2 RU2627354 C2 RU 2627354C2 RU 2013156477 A RU2013156477 A RU 2013156477A RU 2013156477 A RU2013156477 A RU 2013156477A RU 2627354 C2 RU2627354 C2 RU 2627354C2
- Authority
- RU
- Russia
- Prior art keywords
- chloride
- dotap
- crystalline
- values
- theta
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C07B43/06—Formation or introduction of functional groups containing nitrogen of amide groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/08—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of an acyclic unsaturated carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161488428P | 2011-05-20 | 2011-05-20 | |
| US61/488,428 | 2011-05-20 | ||
| PCT/EP2012/001882 WO2012159704A1 (en) | 2011-05-20 | 2012-05-02 | Stable crystal modifications of dotap chloride |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2013156477A RU2013156477A (ru) | 2015-06-27 |
| RU2627354C2 true RU2627354C2 (ru) | 2017-08-07 |
Family
ID=46044632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013156477A RU2627354C2 (ru) | 2011-05-20 | 2012-05-02 | Устойчивые кристаллические модификации хлорида dotap |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10000445B2 (enExample) |
| EP (1) | EP2709981B1 (enExample) |
| JP (3) | JP6290076B2 (enExample) |
| KR (1) | KR101974231B1 (enExample) |
| CN (2) | CN108285422A (enExample) |
| AU (1) | AU2012261276B2 (enExample) |
| BR (2) | BR122021007641B8 (enExample) |
| CA (1) | CA2836499C (enExample) |
| ES (1) | ES2726526T3 (enExample) |
| HK (1) | HK1251217A1 (enExample) |
| HU (1) | HUE042949T2 (enExample) |
| IL (1) | IL229146B (enExample) |
| MX (1) | MX361369B (enExample) |
| NO (1) | NO344225B1 (enExample) |
| PL (1) | PL2709981T3 (enExample) |
| PT (1) | PT2709981T (enExample) |
| RU (1) | RU2627354C2 (enExample) |
| SG (2) | SG194957A1 (enExample) |
| TR (1) | TR201906107T4 (enExample) |
| WO (1) | WO2012159704A1 (enExample) |
| ZA (1) | ZA201309638B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108285422A (zh) * | 2011-05-20 | 2018-07-17 | 默克专利股份有限公司 | 稳定的dotap氯化物晶体变体 |
| WO2016093205A1 (ja) * | 2014-12-08 | 2016-06-16 | 日油株式会社 | カチオン性脂質の製造方法 |
| CN107827762B (zh) * | 2017-11-14 | 2020-10-02 | 苏州东南药业股份有限公司 | 一种(2,3-二油酰基-丙基)三甲基氯化铵及其制备方法和用途 |
| CN119371322B (zh) * | 2023-07-27 | 2026-08-11 | 上海医药工业研究院有限公司 | 一种1,2-二油酰氧基-3-(二甲氨基)丙烷的制备和纯化方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| RU2179549C2 (ru) * | 1995-06-14 | 2002-02-20 | Роше Диагностикс Гмбх | Новые катионные и поликатионные амфифильные соединения, содержащие их реагенты и их применение |
| WO2005049549A1 (en) * | 2003-11-12 | 2005-06-02 | Chemi Spa | Process for the synthesis of cationic lipids |
| WO2006056312A1 (de) * | 2004-11-26 | 2006-06-01 | Merck Patent Gmbh | Stabile kristallmodifikationen von dotap chlorid |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4013632A1 (de) | 1990-04-27 | 1991-10-31 | Max Planck Gesellschaft | Liposomen mit positiver ueberschussladung |
| US5869715A (en) | 1995-09-27 | 1999-02-09 | The Reagents Of The University Of California | Polyfunctional cationic cytofectins |
| US20030129223A1 (en) | 2000-10-11 | 2003-07-10 | Targesome, Inc. | Targeted multivalent macromolecules |
| AU2002953285A0 (en) * | 2002-12-12 | 2003-01-02 | Protech Research Pty Ltd | Yeast treatment |
| CN108285422A (zh) * | 2011-05-20 | 2018-07-17 | 默克专利股份有限公司 | 稳定的dotap氯化物晶体变体 |
-
2012
- 2012-05-02 CN CN201810169562.7A patent/CN108285422A/zh active Pending
- 2012-05-02 HU HUE12719274A patent/HUE042949T2/hu unknown
- 2012-05-02 RU RU2013156477A patent/RU2627354C2/ru active
- 2012-05-02 PT PT12719274T patent/PT2709981T/pt unknown
- 2012-05-02 TR TR2019/06107T patent/TR201906107T4/tr unknown
- 2012-05-02 SG SG2013084363A patent/SG194957A1/en unknown
- 2012-05-02 BR BR122021007641A patent/BR122021007641B8/pt active Search and Examination
- 2012-05-02 US US14/118,571 patent/US10000445B2/en active Active
- 2012-05-02 MX MX2013013403A patent/MX361369B/es active IP Right Grant
- 2012-05-02 CN CN201280024160.9A patent/CN103547560A/zh active Pending
- 2012-05-02 EP EP12719274.8A patent/EP2709981B1/en active Active
- 2012-05-02 WO PCT/EP2012/001882 patent/WO2012159704A1/en not_active Ceased
- 2012-05-02 BR BR112013029588-0A patent/BR112013029588B1/pt active IP Right Grant
- 2012-05-02 AU AU2012261276A patent/AU2012261276B2/en active Active
- 2012-05-02 JP JP2014511756A patent/JP6290076B2/ja active Active
- 2012-05-02 CA CA2836499A patent/CA2836499C/en active Active
- 2012-05-02 PL PL12719274T patent/PL2709981T3/pl unknown
- 2012-05-02 ES ES12719274T patent/ES2726526T3/es active Active
- 2012-05-02 SG SG10201706859QA patent/SG10201706859QA/en unknown
- 2012-05-02 KR KR1020137034017A patent/KR101974231B1/ko active Active
-
2013
- 2013-10-30 IL IL229146A patent/IL229146B/en active IP Right Grant
- 2013-12-18 NO NO20131703A patent/NO344225B1/no unknown
- 2013-12-19 ZA ZA2013/09638A patent/ZA201309638B/en unknown
-
2016
- 2016-12-02 JP JP2016234716A patent/JP2017075166A/ja active Pending
-
2018
- 2018-08-22 HK HK18110787.6A patent/HK1251217A1/zh unknown
- 2018-09-25 JP JP2018178658A patent/JP2018203776A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| RU2179549C2 (ru) * | 1995-06-14 | 2002-02-20 | Роше Диагностикс Гмбх | Новые катионные и поликатионные амфифильные соединения, содержащие их реагенты и их применение |
| WO2005049549A1 (en) * | 2003-11-12 | 2005-06-02 | Chemi Spa | Process for the synthesis of cationic lipids |
| WO2006056312A1 (de) * | 2004-11-26 | 2006-06-01 | Merck Patent Gmbh | Stabile kristallmodifikationen von dotap chlorid |
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