BR122021007641B8 - Cloreto de (2r,s)-, (2s)- ou (2r)-dotap cristalino, e composição farmacêutica - Google Patents

Cloreto de (2r,s)-, (2s)- ou (2r)-dotap cristalino, e composição farmacêutica

Info

Publication number
BR122021007641B8
BR122021007641B8 BR122021007641A BR122021007641A BR122021007641B8 BR 122021007641 B8 BR122021007641 B8 BR 122021007641B8 BR 122021007641 A BR122021007641 A BR 122021007641A BR 122021007641 A BR122021007641 A BR 122021007641A BR 122021007641 B8 BR122021007641 B8 BR 122021007641B8
Authority
BR
Brazil
Prior art keywords
crystalline
pharmaceutical composition
dotap chloride
preparation
dotap
Prior art date
Application number
BR122021007641A
Other languages
English (en)
Other versions
BR122021007641B1 (pt
Inventor
Alfred Hedinger
Michael Platscher
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR122021007641B1 publication Critical patent/BR122021007641B1/pt
Publication of BR122021007641B8 publication Critical patent/BR122021007641B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/06—Formation or introduction of functional groups containing nitrogen of amide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/08—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of an acyclic unsaturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Liquid Crystal Substances (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

a presente invenção se refere a modificações de cristal de cloreto de dotap racêmico (2r,s) e enanciomericamente puros (2r)- ou (2s), a processos para sua preparação e ao seu uso para a preparação de composições farmacêuticas.
BR122021007641A 2011-05-20 2012-05-02 Cloreto de (2r,s)-, (2s)- ou (2r)-dotap cristalino, e composição farmacêutica BR122021007641B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161488428P 2011-05-20 2011-05-20
US61/488,428 2011-05-20
PCT/EP2012/001882 WO2012159704A1 (en) 2011-05-20 2012-05-02 Stable crystal modifications of dotap chloride
BR112013029588-0A BR112013029588B1 (pt) 2011-05-20 2012-05-02 Processo para preparação de uma forma cristalina de cloreto de (2r,s)-, (2s)- ou (2r)- dotap, e composição farmacêutica

Publications (2)

Publication Number Publication Date
BR122021007641B1 BR122021007641B1 (pt) 2021-11-09
BR122021007641B8 true BR122021007641B8 (pt) 2021-12-07

Family

ID=46044632

Family Applications (2)

Application Number Title Priority Date Filing Date
BR122021007641A BR122021007641B8 (pt) 2011-05-20 2012-05-02 Cloreto de (2r,s)-, (2s)- ou (2r)-dotap cristalino, e composição farmacêutica
BR112013029588-0A BR112013029588B1 (pt) 2011-05-20 2012-05-02 Processo para preparação de uma forma cristalina de cloreto de (2r,s)-, (2s)- ou (2r)- dotap, e composição farmacêutica

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112013029588-0A BR112013029588B1 (pt) 2011-05-20 2012-05-02 Processo para preparação de uma forma cristalina de cloreto de (2r,s)-, (2s)- ou (2r)- dotap, e composição farmacêutica

Country Status (21)

Country Link
US (1) US10000445B2 (pt)
EP (1) EP2709981B1 (pt)
JP (3) JP6290076B2 (pt)
KR (1) KR101974231B1 (pt)
CN (2) CN108285422A (pt)
AU (1) AU2012261276B2 (pt)
BR (2) BR122021007641B8 (pt)
CA (1) CA2836499C (pt)
ES (1) ES2726526T3 (pt)
HK (1) HK1251217A1 (pt)
HU (1) HUE042949T2 (pt)
IL (1) IL229146B (pt)
MX (1) MX361369B (pt)
NO (1) NO344225B1 (pt)
PL (1) PL2709981T3 (pt)
PT (1) PT2709981T (pt)
RU (1) RU2627354C2 (pt)
SG (2) SG194957A1 (pt)
TR (1) TR201906107T4 (pt)
WO (1) WO2012159704A1 (pt)
ZA (1) ZA201309638B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2627354C2 (ru) * 2011-05-20 2017-08-07 Мерк Патент Гмбх Устойчивые кристаллические модификации хлорида dotap
KR102583917B1 (ko) * 2014-12-08 2023-10-04 니치유 가부시키가이샤 양이온성 지질을 제조하는 방법
CN107827762B (zh) * 2017-11-14 2020-10-02 苏州东南药业股份有限公司 一种(2,3-二油酰基-丙基)三甲基氯化铵及其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
DE4013632A1 (de) 1990-04-27 1991-10-31 Max Planck Gesellschaft Liposomen mit positiver ueberschussladung
DE19521412A1 (de) * 1995-06-14 1996-12-19 Boehringer Mannheim Gmbh Neue kationische und polykationische Amphiphile, diese enthaltende Reagenzien und deren Verwendung
US5869715A (en) 1995-09-27 1999-02-09 The Reagents Of The University Of California Polyfunctional cationic cytofectins
US20030129223A1 (en) 2000-10-11 2003-07-10 Targesome, Inc. Targeted multivalent macromolecules
AU2002953285A0 (en) * 2002-12-12 2003-01-02 Protech Research Pty Ltd Yeast treatment
ITMI20032185A1 (it) 2003-11-12 2005-05-13 Chemi Spa Processo per la sintesi di lipidi cationici.
DE102004057303A1 (de) * 2004-11-26 2006-06-01 Merck Patent Gmbh Stabile Kristallmodifikationen von DOTAP Chlorid
RU2627354C2 (ru) * 2011-05-20 2017-08-07 Мерк Патент Гмбх Устойчивые кристаллические модификации хлорида dotap

Also Published As

Publication number Publication date
US20140093558A1 (en) 2014-04-03
MX361369B (es) 2018-12-05
MX2013013403A (es) 2013-12-10
AU2012261276B2 (en) 2017-05-25
HUE042949T2 (hu) 2019-07-29
RU2013156477A (ru) 2015-06-27
IL229146A0 (en) 2013-12-31
JP2017075166A (ja) 2017-04-20
SG194957A1 (en) 2013-12-30
US10000445B2 (en) 2018-06-19
BR122021007641B1 (pt) 2021-11-09
NZ619175A (en) 2015-08-28
AU2012261276A1 (en) 2014-01-09
ZA201309638B (en) 2015-04-29
SG10201706859QA (en) 2017-09-28
EP2709981B1 (en) 2019-02-13
EP2709981A1 (en) 2014-03-26
JP2018203776A (ja) 2018-12-27
CA2836499C (en) 2019-01-15
IL229146B (en) 2019-08-29
CN103547560A (zh) 2014-01-29
WO2012159704A1 (en) 2012-11-29
BR112013029588B1 (pt) 2021-10-26
JP6290076B2 (ja) 2018-03-07
RU2627354C2 (ru) 2017-08-07
HK1251217A1 (zh) 2019-01-25
TR201906107T4 (tr) 2019-05-21
JP2014520085A (ja) 2014-08-21
WO2012159704A8 (en) 2013-09-12
PL2709981T3 (pl) 2019-07-31
NO20131703A1 (no) 2013-12-18
ES2726526T3 (es) 2019-10-07
PT2709981T (pt) 2019-05-30
KR20140032451A (ko) 2014-03-14
BR112013029588A2 (pt) 2020-11-17
CA2836499A1 (en) 2012-11-29
NO344225B1 (no) 2019-10-14
KR101974231B1 (ko) 2019-04-30
CN108285422A (zh) 2018-07-17

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Legal Events

Date Code Title Description
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/05/2012, OBSERVADAS AS CONDICOES LEGAIS.

B09W Correction of the decision to grant [chapter 9.1.4 patent gazette]

Free format text: RETIFIQUE-SE PARA CORRECAO DE ERRO MATERIAL NAS REIVINDICACOES

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: REFERENTE AO DESPACHO 16.1 PUBLICADO NA RPI 2653 DE 09.11.2021, QUANTO AS REIVINDICACOES