RU2609512C2 - Производные ингенола для реактивации латентного вируса вич - Google Patents
Производные ингенола для реактивации латентного вируса вич Download PDFInfo
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- RU2609512C2 RU2609512C2 RU2014139825A RU2014139825A RU2609512C2 RU 2609512 C2 RU2609512 C2 RU 2609512C2 RU 2014139825 A RU2014139825 A RU 2014139825A RU 2014139825 A RU2014139825 A RU 2014139825A RU 2609512 C2 RU2609512 C2 RU 2609512C2
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G8/00—Condensation polymers of aldehydes or ketones with phenols only
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
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| BR102012004739A BR102012004739A2 (pt) | 2012-03-02 | 2012-03-02 | uso de um ou mais derivados de ingenol, associação farmacêutica, composição farmacêutica, adjuvante, método de travamento e método para a reativação do vírus hiv latente |
| BRBR1020120047390 | 2012-03-02 | ||
| BR102012006549A BR102012006549A2 (pt) | 2012-03-23 | 2012-03-23 | uso de um ou mais derivados de ingenol, associação farmacêutica, composição farmacêutica, adjuvante, método de tratamento e método para a reativação do vírus hiv latente |
| BRBR1020120065495 | 2012-03-23 | ||
| PCT/BR2013/000063 WO2013126980A1 (pt) | 2012-03-02 | 2013-03-01 | Derivados de ingenol na reativação de vírus hiv latente |
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| RU2014139825A RU2014139825A (ru) | 2016-04-20 |
| RU2609512C2 true RU2609512C2 (ru) | 2017-02-02 |
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| RU2014139825A RU2609512C2 (ru) | 2012-03-02 | 2013-03-01 | Производные ингенола для реактивации латентного вируса вич |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2662712C2 (ru) * | 2012-11-01 | 2018-07-27 | Амазония Фитомедикаментос Лтда. | Производные ингенола, применяемые для лечения рака |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016022358A1 (en) | 2014-08-08 | 2016-02-11 | The Regents Of The University Of California | Compositions and methods for reactivating latent viral infections |
| WO2016177833A1 (en) | 2015-05-04 | 2016-11-10 | Bionor Immuno As | Dosage regimen for hiv vaccine |
| WO2016191836A1 (pt) * | 2015-06-03 | 2016-12-08 | Amazônia Fitomedicamentos Ltda. | Método de preparação de ingenol-3-dodecanoato, método de preparação de 3-etinil-3-hidroxi-4.7.7-trimetilbiciclo[4.1.0]heptano-2-carbaldeído e método de preparação de 2,2-dimetil-4-etinil-5-trifenilfosforanilideno-1,3-dioxano |
| WO2016191837A1 (pt) * | 2015-06-03 | 2016-12-08 | Amazônia Fitomedicamentos Ltda. | Método de preparação de ingenol-3-hexanoato, método de preparação de 3-etinil-3-hidroxi-4.7.7-trimetilbiciclo[4.1.0]heptano-2-carbaldeído e método de preparação do composto 2,2-dimetil-4-etinil-5-trifenilfosforanilideno-1,3-dioxano |
| CN105079323B (zh) * | 2015-09-15 | 2019-08-23 | 北京工业大学 | 几种中药提取物在hiv潜伏再激活治疗中的应用 |
| CN106928063B (zh) * | 2015-12-31 | 2020-09-01 | 上海鑫昊生物科技有限公司 | 巨大戟二萜醇类化合物及其在抗hiv潜伏治疗上的应用 |
| WO2017130156A1 (en) | 2016-01-27 | 2017-08-03 | Glaxosmithkline Intellectual Property (No.2) Limited | Ingenol analogs, pharmaceutical compositions and methods of use thereof |
| CN109912419A (zh) * | 2017-12-13 | 2019-06-21 | 复旦大学 | 巨大戟烷型二萜及其在制备抗艾滋病毒药物中的用途 |
| CN110251495B (zh) * | 2018-03-12 | 2022-05-31 | 重庆医科大学 | 20-脱氧巨大戟二萜醇在制备抑制hbv复制的药物中的应用 |
| EP3917946A4 (en) * | 2019-01-28 | 2022-10-26 | Xyphos Biosciences Inc. | MODIFIED NKG2D NON-NATURAL LIGANDS THAT DELIVER SELECTIVELY BOUND HETEROLOGOUS MOLECULES TO NON-NATURAL NKG2D RECEPTORS ON CAR CELLS |
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| JPH07165600A (ja) * | 1993-10-18 | 1995-06-27 | Souyaku Gijutsu Kenkyusho:Kk | 抗ウイルス剤 |
| WO2006116897A1 (fr) * | 2005-04-30 | 2006-11-09 | Nihon University | Diterpenes provenant de euphorbia kansui et leur utilisation |
| US20100204318A1 (en) * | 2007-04-30 | 2010-08-12 | Peplin Research Pty Ltd | Treatment of virally induced lesions |
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| RU2013133865A (ru) * | 2010-12-22 | 2015-01-27 | Лео Лэборетериз Лимитед | Ингенол-3-ацелаты i |
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| JP2003171349A (ja) * | 2001-08-06 | 2003-06-20 | Univ Nihon | 新規なジテルペン類、及びこれを用いた組成物、抗炎症剤、抗癌剤 |
| AU2005333828A1 (en) * | 2005-06-28 | 2007-01-04 | Amazonia Fitomedicamentos Ltda | Active fraction of a polar solvent extract from the latex of euphorbiaceae plants |
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| WO2006116897A1 (fr) * | 2005-04-30 | 2006-11-09 | Nihon University | Diterpenes provenant de euphorbia kansui et leur utilisation |
| US20100204318A1 (en) * | 2007-04-30 | 2010-08-12 | Peplin Research Pty Ltd | Treatment of virally induced lesions |
| WO2011086423A1 (en) * | 2010-01-15 | 2011-07-21 | Amazonia Fitomedicamentos Ltda | Pharmaceutical use of multicyclic compounds as anti-aids agents |
| WO2011086424A1 (en) * | 2010-01-15 | 2011-07-21 | Amazonia Fitomedicamentos Ltda | Pharmaceutical use of multicyclic compounds mixtures as concomitant anti-cancer, anti-inflammatory and anti-pain agents |
| RU2013133865A (ru) * | 2010-12-22 | 2015-01-27 | Лео Лэборетериз Лимитед | Ингенол-3-ацелаты i |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2662712C2 (ru) * | 2012-11-01 | 2018-07-27 | Амазония Фитомедикаментос Лтда. | Производные ингенола, применяемые для лечения рака |
Also Published As
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| WO2013126980A1 (pt) | 2013-09-06 |
| JP6280510B2 (ja) | 2018-02-14 |
| EP2821105A1 (en) | 2015-01-07 |
| EP2821105B1 (en) | 2018-05-23 |
| US20150030638A1 (en) | 2015-01-29 |
| AU2013225633B2 (en) | 2017-11-23 |
| IL234404A (en) | 2017-09-28 |
| ES2683726T3 (es) | 2018-09-27 |
| EP2821105A4 (en) | 2015-11-04 |
| MX359300B (es) | 2018-09-21 |
| JP2015508782A (ja) | 2015-03-23 |
| RU2014139825A (ru) | 2016-04-20 |
| IN2014MN01911A (enExample) | 2015-07-10 |
| EP2821105A8 (en) | 2015-04-29 |
| CN104136081B (zh) | 2018-05-15 |
| HK1203872A1 (en) | 2015-11-06 |
| CA2864995C (en) | 2016-12-06 |
| US10105339B2 (en) | 2018-10-23 |
| AU2013225633A1 (en) | 2014-08-28 |
| CN104136081A (zh) | 2014-11-05 |
| NZ628408A (en) | 2017-09-29 |
| MX2014010463A (es) | 2014-10-13 |
| CA2864995A1 (en) | 2013-09-06 |
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