RU2609512C2 - Производные ингенола для реактивации латентного вируса вич - Google Patents
Производные ингенола для реактивации латентного вируса вич Download PDFInfo
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- RU2609512C2 RU2609512C2 RU2014139825A RU2014139825A RU2609512C2 RU 2609512 C2 RU2609512 C2 RU 2609512C2 RU 2014139825 A RU2014139825 A RU 2014139825A RU 2014139825 A RU2014139825 A RU 2014139825A RU 2609512 C2 RU2609512 C2 RU 2609512C2
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G8/00—Condensation polymers of aldehydes or ketones with phenols only
- C08G8/28—Chemically modified polycondensates
- C08G8/30—Chemically modified polycondensates by unsaturated compounds, e.g. terpenes
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| BR102012004739A BR102012004739A2 (pt) | 2012-03-02 | 2012-03-02 | uso de um ou mais derivados de ingenol, associação farmacêutica, composição farmacêutica, adjuvante, método de travamento e método para a reativação do vírus hiv latente |
| BR102012006549A BR102012006549A2 (pt) | 2012-03-23 | 2012-03-23 | uso de um ou mais derivados de ingenol, associação farmacêutica, composição farmacêutica, adjuvante, método de tratamento e método para a reativação do vírus hiv latente |
| BRBR1020120065495 | 2012-03-23 | ||
| PCT/BR2013/000063 WO2013126980A1 (pt) | 2012-03-02 | 2013-03-01 | Derivados de ingenol na reativação de vírus hiv latente |
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| RU2662712C2 (ru) * | 2012-11-01 | 2018-07-27 | Амазония Фитомедикаментос Лтда. | Производные ингенола, применяемые для лечения рака |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016022358A1 (en) | 2014-08-08 | 2016-02-11 | The Regents Of The University Of California | Compositions and methods for reactivating latent viral infections |
| WO2016177833A1 (en) | 2015-05-04 | 2016-11-10 | Bionor Immuno As | Dosage regimen for hiv vaccine |
| WO2016191836A1 (pt) * | 2015-06-03 | 2016-12-08 | Amazônia Fitomedicamentos Ltda. | Método de preparação de ingenol-3-dodecanoato, método de preparação de 3-etinil-3-hidroxi-4.7.7-trimetilbiciclo[4.1.0]heptano-2-carbaldeído e método de preparação de 2,2-dimetil-4-etinil-5-trifenilfosforanilideno-1,3-dioxano |
| WO2016191837A1 (pt) * | 2015-06-03 | 2016-12-08 | Amazônia Fitomedicamentos Ltda. | Método de preparação de ingenol-3-hexanoato, método de preparação de 3-etinil-3-hidroxi-4.7.7-trimetilbiciclo[4.1.0]heptano-2-carbaldeído e método de preparação do composto 2,2-dimetil-4-etinil-5-trifenilfosforanilideno-1,3-dioxano |
| CN105079323B (zh) * | 2015-09-15 | 2019-08-23 | 北京工业大学 | 几种中药提取物在hiv潜伏再激活治疗中的应用 |
| CN106928063B (zh) * | 2015-12-31 | 2020-09-01 | 上海鑫昊生物科技有限公司 | 巨大戟二萜醇类化合物及其在抗hiv潜伏治疗上的应用 |
| WO2017130156A1 (en) | 2016-01-27 | 2017-08-03 | Glaxosmithkline Intellectual Property (No.2) Limited | Ingenol analogs, pharmaceutical compositions and methods of use thereof |
| CN109912419A (zh) * | 2017-12-13 | 2019-06-21 | 复旦大学 | 巨大戟烷型二萜及其在制备抗艾滋病毒药物中的用途 |
| CN110251495B (zh) * | 2018-03-12 | 2022-05-31 | 重庆医科大学 | 20-脱氧巨大戟二萜醇在制备抑制hbv复制的药物中的应用 |
| BR112021014721A2 (pt) * | 2019-01-28 | 2021-12-21 | The J David Gladstone Inst A Testamentary Trust Established Under The Will Of J David Gladstone | Ligantes de nkg2d não naturais modificados que liberam seletivamente moléculas heterólogas ligadas a receptores de nkg2d não naturais em células car |
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| JPH07165600A (ja) * | 1993-10-18 | 1995-06-27 | Souyaku Gijutsu Kenkyusho:Kk | 抗ウイルス剤 |
| WO2006116897A1 (fr) * | 2005-04-30 | 2006-11-09 | Nihon University | Diterpenes provenant de euphorbia kansui et leur utilisation |
| US20100204318A1 (en) * | 2007-04-30 | 2010-08-12 | Peplin Research Pty Ltd | Treatment of virally induced lesions |
| WO2011086423A1 (en) * | 2010-01-15 | 2011-07-21 | Amazonia Fitomedicamentos Ltda | Pharmaceutical use of multicyclic compounds as anti-aids agents |
| WO2011086424A1 (en) * | 2010-01-15 | 2011-07-21 | Amazonia Fitomedicamentos Ltda | Pharmaceutical use of multicyclic compounds mixtures as concomitant anti-cancer, anti-inflammatory and anti-pain agents |
| RU2013133865A (ru) * | 2010-12-22 | 2015-01-27 | Лео Лэборетериз Лимитед | Ингенол-3-ацелаты i |
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|---|---|---|---|---|
| JP2003171349A (ja) * | 2001-08-06 | 2003-06-20 | Univ Nihon | 新規なジテルペン類、及びこれを用いた組成物、抗炎症剤、抗癌剤 |
| BRPI0520394A2 (pt) * | 2005-06-28 | 2009-05-05 | Amazonia Fitomedicamentos Ltda | fração ativa de um extrato de látex de euphorbia tirucalli l. com um solvente polar, uso de um ativo de um extrato de euphorbia tirucalli l. com solvente polar, uso de um ou mais compostos de 3-(2,4,6-dodecatrienoil)-ingenol e 3-(2,4,6,8-tetradecatetranoil)-ingenol, composição , uso da composição e processo para obtenção de uma fração ativa de um extrato de euphorbia tirucalli l. com solvente polar |
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2013
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| JPH07165600A (ja) * | 1993-10-18 | 1995-06-27 | Souyaku Gijutsu Kenkyusho:Kk | 抗ウイルス剤 |
| WO2006116897A1 (fr) * | 2005-04-30 | 2006-11-09 | Nihon University | Diterpenes provenant de euphorbia kansui et leur utilisation |
| US20100204318A1 (en) * | 2007-04-30 | 2010-08-12 | Peplin Research Pty Ltd | Treatment of virally induced lesions |
| WO2011086423A1 (en) * | 2010-01-15 | 2011-07-21 | Amazonia Fitomedicamentos Ltda | Pharmaceutical use of multicyclic compounds as anti-aids agents |
| WO2011086424A1 (en) * | 2010-01-15 | 2011-07-21 | Amazonia Fitomedicamentos Ltda | Pharmaceutical use of multicyclic compounds mixtures as concomitant anti-cancer, anti-inflammatory and anti-pain agents |
| RU2013133865A (ru) * | 2010-12-22 | 2015-01-27 | Лео Лэборетериз Лимитед | Ингенол-3-ацелаты i |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2662712C2 (ru) * | 2012-11-01 | 2018-07-27 | Амазония Фитомедикаментос Лтда. | Производные ингенола, применяемые для лечения рака |
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| HK1203872A1 (en) | 2015-11-06 |
| MX359300B (es) | 2018-09-21 |
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| EP2821105A1 (en) | 2015-01-07 |
| US20150030638A1 (en) | 2015-01-29 |
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| EP2821105B1 (en) | 2018-05-23 |
| AU2013225633B2 (en) | 2017-11-23 |
| RU2014139825A (ru) | 2016-04-20 |
| WO2013126980A1 (pt) | 2013-09-06 |
| ES2683726T3 (es) | 2018-09-27 |
| JP2015508782A (ja) | 2015-03-23 |
| US10105339B2 (en) | 2018-10-23 |
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