NZ628408A - Ingenol derivatives in reactivation of latent hiv virus - Google Patents
Ingenol derivatives in reactivation of latent hiv virusInfo
- Publication number
- NZ628408A NZ628408A NZ628408A NZ62840813A NZ628408A NZ 628408 A NZ628408 A NZ 628408A NZ 628408 A NZ628408 A NZ 628408A NZ 62840813 A NZ62840813 A NZ 62840813A NZ 628408 A NZ628408 A NZ 628408A
- Authority
- NZ
- New Zealand
- Prior art keywords
- reactivation
- latent hiv
- hiv virus
- ingenol derivatives
- ingenol
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 3
- VEBVPUXQAPLADL-POYOOMFHSA-N ingenol Chemical class C1=C(CO)[C@@H](O)[C@]2(O)[C@@H](O)C(C)=C[C@]32[C@H](C)C[C@H]2C(C)(C)[C@H]2[C@H]1C3=O VEBVPUXQAPLADL-POYOOMFHSA-N 0.000 title abstract 2
- 230000007420 reactivation Effects 0.000 title 1
- 229940124522 antiretrovirals Drugs 0.000 abstract 2
- 239000003903 antiretrovirus agent Substances 0.000 abstract 2
- 230000003362 replicative effect Effects 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- -1 ingenol derivative compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G8/00—Condensation polymers of aldehydes or ketones with phenols only
- C08G8/28—Chemically modified polycondensates
- C08G8/30—Chemically modified polycondensates by unsaturated compounds, e.g. terpenes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR102012004739A BR102012004739A2 (pt) | 2012-03-02 | 2012-03-02 | uso de um ou mais derivados de ingenol, associação farmacêutica, composição farmacêutica, adjuvante, método de travamento e método para a reativação do vírus hiv latente |
| BR102012006549A BR102012006549A2 (pt) | 2012-03-23 | 2012-03-23 | uso de um ou mais derivados de ingenol, associação farmacêutica, composição farmacêutica, adjuvante, método de tratamento e método para a reativação do vírus hiv latente |
| PCT/BR2013/000063 WO2013126980A1 (pt) | 2012-03-02 | 2013-03-01 | Derivados de ingenol na reativação de vírus hiv latente |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ628408A true NZ628408A (en) | 2017-09-29 |
Family
ID=49081479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ628408A NZ628408A (en) | 2012-03-02 | 2013-03-01 | Ingenol derivatives in reactivation of latent hiv virus |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10105339B2 (enExample) |
| EP (1) | EP2821105B1 (enExample) |
| JP (1) | JP6280510B2 (enExample) |
| CN (1) | CN104136081B (enExample) |
| AU (1) | AU2013225633B2 (enExample) |
| CA (1) | CA2864995C (enExample) |
| ES (1) | ES2683726T3 (enExample) |
| IL (1) | IL234404A (enExample) |
| IN (1) | IN2014MN01911A (enExample) |
| MX (1) | MX359300B (enExample) |
| NZ (1) | NZ628408A (enExample) |
| RU (1) | RU2609512C2 (enExample) |
| WO (1) | WO2013126980A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR102012028120B8 (pt) * | 2012-11-01 | 2022-08-02 | Amazonia Fitomedicamentos Ltda | Uso de um ou mais derivados de ingenol, composição farmacêutica e medicamento |
| WO2016022358A1 (en) | 2014-08-08 | 2016-02-11 | The Regents Of The University Of California | Compositions and methods for reactivating latent viral infections |
| WO2016177833A1 (en) | 2015-05-04 | 2016-11-10 | Bionor Immuno As | Dosage regimen for hiv vaccine |
| WO2016191836A1 (pt) * | 2015-06-03 | 2016-12-08 | Amazônia Fitomedicamentos Ltda. | Método de preparação de ingenol-3-dodecanoato, método de preparação de 3-etinil-3-hidroxi-4.7.7-trimetilbiciclo[4.1.0]heptano-2-carbaldeído e método de preparação de 2,2-dimetil-4-etinil-5-trifenilfosforanilideno-1,3-dioxano |
| WO2016191837A1 (pt) * | 2015-06-03 | 2016-12-08 | Amazônia Fitomedicamentos Ltda. | Método de preparação de ingenol-3-hexanoato, método de preparação de 3-etinil-3-hidroxi-4.7.7-trimetilbiciclo[4.1.0]heptano-2-carbaldeído e método de preparação do composto 2,2-dimetil-4-etinil-5-trifenilfosforanilideno-1,3-dioxano |
| CN105079323B (zh) * | 2015-09-15 | 2019-08-23 | 北京工业大学 | 几种中药提取物在hiv潜伏再激活治疗中的应用 |
| CN106928063B (zh) * | 2015-12-31 | 2020-09-01 | 上海鑫昊生物科技有限公司 | 巨大戟二萜醇类化合物及其在抗hiv潜伏治疗上的应用 |
| WO2017130156A1 (en) | 2016-01-27 | 2017-08-03 | Glaxosmithkline Intellectual Property (No.2) Limited | Ingenol analogs, pharmaceutical compositions and methods of use thereof |
| CN109912419A (zh) * | 2017-12-13 | 2019-06-21 | 复旦大学 | 巨大戟烷型二萜及其在制备抗艾滋病毒药物中的用途 |
| CN110251495B (zh) * | 2018-03-12 | 2022-05-31 | 重庆医科大学 | 20-脱氧巨大戟二萜醇在制备抑制hbv复制的药物中的应用 |
| BR112021014721A2 (pt) * | 2019-01-28 | 2021-12-21 | The J David Gladstone Inst A Testamentary Trust Established Under The Will Of J David Gladstone | Ligantes de nkg2d não naturais modificados que liberam seletivamente moléculas heterólogas ligadas a receptores de nkg2d não naturais em células car |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07165600A (ja) | 1993-10-18 | 1995-06-27 | Souyaku Gijutsu Kenkyusho:Kk | 抗ウイルス剤 |
| JP2003171349A (ja) * | 2001-08-06 | 2003-06-20 | Univ Nihon | 新規なジテルペン類、及びこれを用いた組成物、抗炎症剤、抗癌剤 |
| WO2006116897A1 (fr) * | 2005-04-30 | 2006-11-09 | Nihon University | Diterpenes provenant de euphorbia kansui et leur utilisation |
| BRPI0520394A2 (pt) * | 2005-06-28 | 2009-05-05 | Amazonia Fitomedicamentos Ltda | fração ativa de um extrato de látex de euphorbia tirucalli l. com um solvente polar, uso de um ativo de um extrato de euphorbia tirucalli l. com solvente polar, uso de um ou mais compostos de 3-(2,4,6-dodecatrienoil)-ingenol e 3-(2,4,6,8-tetradecatetranoil)-ingenol, composição , uso da composição e processo para obtenção de uma fração ativa de um extrato de euphorbia tirucalli l. com solvente polar |
| BRPI0810806A2 (pt) | 2007-04-30 | 2014-10-29 | Peplin Research Pty Ltd | Método para tratar uma lesão cutânea em um indivíduo |
| WO2011086424A1 (en) | 2010-01-15 | 2011-07-21 | Amazonia Fitomedicamentos Ltda | Pharmaceutical use of multicyclic compounds mixtures as concomitant anti-cancer, anti-inflammatory and anti-pain agents |
| US20120289487A1 (en) * | 2010-01-15 | 2012-11-15 | Amazônia Fitomedicamentos Ltda | Pharmaceutical Use of Multicyclic Compounds as Anti-Aids Agents |
-
2013
- 2013-03-01 AU AU2013225633A patent/AU2013225633B2/en not_active Ceased
- 2013-03-01 WO PCT/BR2013/000063 patent/WO2013126980A1/pt not_active Ceased
- 2013-03-01 US US14/382,060 patent/US10105339B2/en not_active Expired - Fee Related
- 2013-03-01 MX MX2014010463A patent/MX359300B/es active IP Right Grant
- 2013-03-01 CN CN201380012133.4A patent/CN104136081B/zh not_active Expired - Fee Related
- 2013-03-01 CA CA2864995A patent/CA2864995C/en not_active Expired - Fee Related
- 2013-03-01 IN IN1911MUN2014 patent/IN2014MN01911A/en unknown
- 2013-03-01 RU RU2014139825A patent/RU2609512C2/ru not_active IP Right Cessation
- 2013-03-01 JP JP2014559040A patent/JP6280510B2/ja not_active Expired - Fee Related
- 2013-03-01 ES ES13754607.3T patent/ES2683726T3/es active Active
- 2013-03-01 EP EP13754607.3A patent/EP2821105B1/en not_active Not-in-force
- 2013-03-01 NZ NZ628408A patent/NZ628408A/en not_active IP Right Cessation
-
2014
- 2014-09-01 IL IL234404A patent/IL234404A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CN104136081A (zh) | 2014-11-05 |
| HK1203872A1 (en) | 2015-11-06 |
| MX359300B (es) | 2018-09-21 |
| CA2864995C (en) | 2016-12-06 |
| IN2014MN01911A (enExample) | 2015-07-10 |
| JP6280510B2 (ja) | 2018-02-14 |
| CN104136081B (zh) | 2018-05-15 |
| EP2821105A4 (en) | 2015-11-04 |
| EP2821105A8 (en) | 2015-04-29 |
| CA2864995A1 (en) | 2013-09-06 |
| AU2013225633A1 (en) | 2014-08-28 |
| IL234404A (en) | 2017-09-28 |
| EP2821105A1 (en) | 2015-01-07 |
| US20150030638A1 (en) | 2015-01-29 |
| MX2014010463A (es) | 2014-10-13 |
| EP2821105B1 (en) | 2018-05-23 |
| RU2609512C2 (ru) | 2017-02-02 |
| AU2013225633B2 (en) | 2017-11-23 |
| RU2014139825A (ru) | 2016-04-20 |
| WO2013126980A1 (pt) | 2013-09-06 |
| ES2683726T3 (es) | 2018-09-27 |
| JP2015508782A (ja) | 2015-03-23 |
| US10105339B2 (en) | 2018-10-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ628408A (en) | Ingenol derivatives in reactivation of latent hiv virus | |
| NZ724503A (en) | Macrocyclic inhibitors of flaviviridae viruses | |
| EA201690687A1 (ru) | Ингибиторы репликации вируса иммунодефицита | |
| PH12014502739A1 (en) | Macrocyclic inhibitors of flaviviridae viruses | |
| NZ631762A (en) | 5-membered heteroaryls and their use as antiviral agents | |
| EA201492205A1 (ru) | Макроциклические ингибиторы вирусов flaviviridae | |
| EA201590450A1 (ru) | Сульфамоил-ариламиды и их применение в качестве лекарственных препаратов для лечения гепатита b | |
| MD4841B1 (ro) | Compuşi policiclici de carbamoilpiridonă şi utilizarea lor farmaceutică | |
| NZ727792A (en) | Therapeutic compounds | |
| EA201391127A1 (ru) | C-17 и c-3 модифицированные тритерпеноиды с ингибиторной активностью созревания вич | |
| EA201490419A1 (ru) | Соединения для лечения и профилактики респираторного синцитиального вирусного заболевания | |
| EA201790661A3 (ru) | Ингибиторы вируса гепатита c | |
| PH12015502539B1 (en) | Cenicriviroc compositions and methods of making and using the same | |
| MX2015010354A (es) | Derivados de acido betulinico modificados con aquilo c-3 y alquenilo utiles en el tratamiento de virus de inmunodeficiencia humana (vih). | |
| PH12014501967B1 (en) | Benzodioxanes in combination with other actives for inhibiting leukotriene production | |
| EA201490643A1 (ru) | Новые производные бетулиновой кислоты с противовирусной активностью | |
| PH12015500746A1 (en) | Benzamides | |
| EA201400822A1 (ru) | Производные гетероциклических амидов в качестве антагонистов p2xрецептора | |
| MX2014014308A (es) | Pirrolidino heterociclos. | |
| WO2014116772A3 (en) | Squaric derivatives for the treatment of hepatitis c | |
| UA109804C2 (xx) | 2-метоксипіридин-4-ільні похідні | |
| UY35390A (es) | Compuestos con actividad anti-hcv y composiciones farmacéuticas que los contienen | |
| NZ702073A (en) | Methanethione compounds having antiviral activity | |
| NZ622558A (en) | Hiv replication inhibitors | |
| UA78174U (en) | 2-(4,6-bis-ethylamino-[1,3,5]triazine-2-ylsulfanyl)-n-(2,4,6-trichlorophenyl)acetamide exhibiting antiviral activity against h1n1 virus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 01 MAR 2020 BY PIPERS Effective date: 20180201 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 MAR 2021 BY PIPERS Effective date: 20200227 |
|
| LAPS | Patent lapsed |