CN104136081B - 再活化潜伏hiv病毒的巨大戟二萜醇衍生物 - Google Patents

再活化潜伏hiv病毒的巨大戟二萜醇衍生物 Download PDF

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Publication number
CN104136081B
CN104136081B CN201380012133.4A CN201380012133A CN104136081B CN 104136081 B CN104136081 B CN 104136081B CN 201380012133 A CN201380012133 A CN 201380012133A CN 104136081 B CN104136081 B CN 104136081B
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Prior art keywords
formula
cells
ingenol
derivatives
inhibitors
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Expired - Fee Related
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CN201380012133.4A
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English (en)
Chinese (zh)
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CN104136081A (zh
Inventor
L.F.皮亚诺维斯基
A.塔努里
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Amazonia Fitomedicamentos Ltda
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Amazonia Fitomedicamentos Ltda
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Priority claimed from BR102012004739A external-priority patent/BR102012004739A2/pt
Priority claimed from BR102012006549A external-priority patent/BR102012006549A2/pt
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Publication of CN104136081A publication Critical patent/CN104136081A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G8/00—Condensation polymers of aldehydes or ketones with phenols only
    • C08G8/28—Chemically modified polycondensates
    • C08G8/30—Chemically modified polycondensates by unsaturated compounds, e.g. terpenes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201380012133.4A 2012-03-02 2013-03-01 再活化潜伏hiv病毒的巨大戟二萜醇衍生物 Expired - Fee Related CN104136081B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
BR1020120047390 2012-03-02
BRBR1020120047390 2012-03-02
BR102012004739A BR102012004739A2 (pt) 2012-03-02 2012-03-02 uso de um ou mais derivados de ingenol, associação farmacêutica, composição farmacêutica, adjuvante, método de travamento e método para a reativação do vírus hiv latente
BR1020120065495 2012-03-23
BRBR1020120065495 2012-03-23
BR102012006549A BR102012006549A2 (pt) 2012-03-23 2012-03-23 uso de um ou mais derivados de ingenol, associação farmacêutica, composição farmacêutica, adjuvante, método de tratamento e método para a reativação do vírus hiv latente
PCT/BR2013/000063 WO2013126980A1 (pt) 2012-03-02 2013-03-01 Derivados de ingenol na reativação de vírus hiv latente

Publications (2)

Publication Number Publication Date
CN104136081A CN104136081A (zh) 2014-11-05
CN104136081B true CN104136081B (zh) 2018-05-15

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CN201380012133.4A Expired - Fee Related CN104136081B (zh) 2012-03-02 2013-03-01 再活化潜伏hiv病毒的巨大戟二萜醇衍生物

Country Status (13)

Country Link
US (1) US10105339B2 (enExample)
EP (1) EP2821105B1 (enExample)
JP (1) JP6280510B2 (enExample)
CN (1) CN104136081B (enExample)
AU (1) AU2013225633B2 (enExample)
CA (1) CA2864995C (enExample)
ES (1) ES2683726T3 (enExample)
IL (1) IL234404A (enExample)
IN (1) IN2014MN01911A (enExample)
MX (1) MX359300B (enExample)
NZ (1) NZ628408A (enExample)
RU (1) RU2609512C2 (enExample)
WO (1) WO2013126980A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR102012028120B8 (pt) * 2012-11-01 2022-08-02 Amazonia Fitomedicamentos Ltda Uso de um ou mais derivados de ingenol, composição farmacêutica e medicamento
WO2016022358A1 (en) 2014-08-08 2016-02-11 The Regents Of The University Of California Compositions and methods for reactivating latent viral infections
JP2018515603A (ja) 2015-05-04 2018-06-14 ビオノル・イムノ・アクシェセルスカプＢｉｏｎｏｒ Ｉｍｍｕｎｏ ＡＳ Ｈｉｖワクチン用の投薬レジメン
WO2016191836A1 (pt) * 2015-06-03 2016-12-08 Amazônia Fitomedicamentos Ltda. Método de preparação de ingenol-3-dodecanoato, método de preparação de 3-etinil-3-hidroxi-4.7.7-trimetilbiciclo[4.1.0]heptano-2-carbaldeído e método de preparação de 2,2-dimetil-4-etinil-5-trifenilfosforanilideno-1,3-dioxano
WO2016191837A1 (pt) * 2015-06-03 2016-12-08 Amazônia Fitomedicamentos Ltda. Método de preparação de ingenol-3-hexanoato, método de preparação de 3-etinil-3-hidroxi-4.7.7-trimetilbiciclo[4.1.0]heptano-2-carbaldeído e método de preparação do composto 2,2-dimetil-4-etinil-5-trifenilfosforanilideno-1,3-dioxano
CN105079323B (zh) * 2015-09-15 2019-08-23 北京工业大学 几种中药提取物在hiv潜伏再激活治疗中的应用
CN106928063B (zh) * 2015-12-31 2020-09-01 上海鑫昊生物科技有限公司 巨大戟二萜醇类化合物及其在抗hiv潜伏治疗上的应用
US10583140B2 (en) * 2016-01-27 2020-03-10 Glaxosmithkline Intellectual Property Development Limited Ingenol analogs, pharmaceutical compositions and methods of use thereof
CN109912419A (zh) * 2017-12-13 2019-06-21 复旦大学 巨大戟烷型二萜及其在制备抗艾滋病毒药物中的用途
CN110251495B (zh) * 2018-03-12 2022-05-31 重庆医科大学 20-脱氧巨大戟二萜醇在制备抑制hbv复制的药物中的应用
CN113710689B (zh) * 2019-01-28 2025-05-06 修普霍斯生物科学有限公司 选择性地将附着的异源分子递送至car细胞上的非天然nkg2d受体的修饰的非天然nkg2d配体

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006116897A1 (fr) * 2005-04-30 2006-11-09 Nihon University Diterpenes provenant de euphorbia kansui et leur utilisation
WO2011086423A1 (en) * 2010-01-15 2011-07-21 Amazonia Fitomedicamentos Ltda Pharmaceutical use of multicyclic compounds as anti-aids agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07165600A (ja) * 1993-10-18 1995-06-27 Souyaku Gijutsu Kenkyusho:Kk 抗ウイルス剤
JP2003171349A (ja) * 2001-08-06 2003-06-20 Univ Nihon 新規なジテルペン類、及びこれを用いた組成物、抗炎症剤、抗癌剤
CA2610889C (en) * 2005-06-28 2016-12-06 Amazonia Fitomedicamentos Ltda. Active fraction of a polar solvent extract from the latex of euphorbiaceae plants
SI2152261T1 (sl) 2007-04-30 2016-05-31 Leo Laboratories Limited Zdravljenje viralno induciranih lezij
WO2011086424A1 (en) 2010-01-15 2011-07-21 Amazonia Fitomedicamentos Ltda Pharmaceutical use of multicyclic compounds mixtures as concomitant anti-cancer, anti-inflammatory and anti-pain agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006116897A1 (fr) * 2005-04-30 2006-11-09 Nihon University Diterpenes provenant de euphorbia kansui et leur utilisation
WO2011086423A1 (en) * 2010-01-15 2011-07-21 Amazonia Fitomedicamentos Ltda Pharmaceutical use of multicyclic compounds as anti-aids agents

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Publication number Publication date
HK1203872A1 (en) 2015-11-06
JP2015508782A (ja) 2015-03-23
IN2014MN01911A (enExample) 2015-07-10
ES2683726T3 (es) 2018-09-27
EP2821105A1 (en) 2015-01-07
EP2821105B1 (en) 2018-05-23
US20150030638A1 (en) 2015-01-29
AU2013225633B2 (en) 2017-11-23
AU2013225633A1 (en) 2014-08-28
US10105339B2 (en) 2018-10-23
CN104136081A (zh) 2014-11-05
NZ628408A (en) 2017-09-29
RU2609512C2 (ru) 2017-02-02
IL234404A (en) 2017-09-28
RU2014139825A (ru) 2016-04-20
WO2013126980A1 (pt) 2013-09-06
MX359300B (es) 2018-09-21
JP6280510B2 (ja) 2018-02-14
MX2014010463A (es) 2014-10-13
CA2864995C (en) 2016-12-06
CA2864995A1 (en) 2013-09-06
EP2821105A8 (en) 2015-04-29
EP2821105A4 (en) 2015-11-04

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Granted publication date: 20180515

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