IN2014MN01911A - - Google Patents
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- Publication number
- IN2014MN01911A IN2014MN01911A IN1911MUN2014A IN2014MN01911A IN 2014MN01911 A IN2014MN01911 A IN 2014MN01911A IN 1911MUN2014 A IN1911MUN2014 A IN 1911MUN2014A IN 2014MN01911 A IN2014MN01911 A IN 2014MN01911A
- Authority
- IN
- India
- Prior art keywords
- present
- relates
- ingenol derivatives
- reactivators
- terms
- Prior art date
Links
- VEBVPUXQAPLADL-POYOOMFHSA-N ingenol Chemical class C1=C(CO)[C@@H](O)[C@]2(O)[C@@H](O)C(C)=C[C@]32[C@H](C)C[C@H]2C(C)(C)[C@H]2[C@H]1C3=O VEBVPUXQAPLADL-POYOOMFHSA-N 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 1
- 229940124522 antiretrovirals Drugs 0.000 abstract 1
- 239000003903 antiretrovirus agent Substances 0.000 abstract 1
- 230000003362 replicative effect Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G8/00—Condensation polymers of aldehydes or ketones with phenols only
- C08G8/28—Chemically modified polycondensates
- C08G8/30—Chemically modified polycondensates by unsaturated compounds, e.g. terpenes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Polymers & Plastics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR102012004739A BR102012004739A2 (pt) | 2012-03-02 | 2012-03-02 | uso de um ou mais derivados de ingenol, associação farmacêutica, composição farmacêutica, adjuvante, método de travamento e método para a reativação do vírus hiv latente |
| BR102012006549A BR102012006549A2 (pt) | 2012-03-23 | 2012-03-23 | uso de um ou mais derivados de ingenol, associação farmacêutica, composição farmacêutica, adjuvante, método de tratamento e método para a reativação do vírus hiv latente |
| PCT/BR2013/000063 WO2013126980A1 (pt) | 2012-03-02 | 2013-03-01 | Derivados de ingenol na reativação de vírus hiv latente |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014MN01911A true IN2014MN01911A (enExample) | 2015-07-10 |
Family
ID=49081479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1911MUN2014 IN2014MN01911A (enExample) | 2012-03-02 | 2013-03-01 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10105339B2 (enExample) |
| EP (1) | EP2821105B1 (enExample) |
| JP (1) | JP6280510B2 (enExample) |
| CN (1) | CN104136081B (enExample) |
| AU (1) | AU2013225633B2 (enExample) |
| CA (1) | CA2864995C (enExample) |
| ES (1) | ES2683726T3 (enExample) |
| IL (1) | IL234404A (enExample) |
| IN (1) | IN2014MN01911A (enExample) |
| MX (1) | MX359300B (enExample) |
| NZ (1) | NZ628408A (enExample) |
| RU (1) | RU2609512C2 (enExample) |
| WO (1) | WO2013126980A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR102012028120B8 (pt) * | 2012-11-01 | 2022-08-02 | Amazonia Fitomedicamentos Ltda | Uso de um ou mais derivados de ingenol, composição farmacêutica e medicamento |
| WO2016022358A1 (en) | 2014-08-08 | 2016-02-11 | The Regents Of The University Of California | Compositions and methods for reactivating latent viral infections |
| WO2016177833A1 (en) | 2015-05-04 | 2016-11-10 | Bionor Immuno As | Dosage regimen for hiv vaccine |
| WO2016191836A1 (pt) * | 2015-06-03 | 2016-12-08 | Amazônia Fitomedicamentos Ltda. | Método de preparação de ingenol-3-dodecanoato, método de preparação de 3-etinil-3-hidroxi-4.7.7-trimetilbiciclo[4.1.0]heptano-2-carbaldeído e método de preparação de 2,2-dimetil-4-etinil-5-trifenilfosforanilideno-1,3-dioxano |
| WO2016191837A1 (pt) * | 2015-06-03 | 2016-12-08 | Amazônia Fitomedicamentos Ltda. | Método de preparação de ingenol-3-hexanoato, método de preparação de 3-etinil-3-hidroxi-4.7.7-trimetilbiciclo[4.1.0]heptano-2-carbaldeído e método de preparação do composto 2,2-dimetil-4-etinil-5-trifenilfosforanilideno-1,3-dioxano |
| CN105079323B (zh) * | 2015-09-15 | 2019-08-23 | 北京工业大学 | 几种中药提取物在hiv潜伏再激活治疗中的应用 |
| CN106928063B (zh) * | 2015-12-31 | 2020-09-01 | 上海鑫昊生物科技有限公司 | 巨大戟二萜醇类化合物及其在抗hiv潜伏治疗上的应用 |
| WO2017130156A1 (en) | 2016-01-27 | 2017-08-03 | Glaxosmithkline Intellectual Property (No.2) Limited | Ingenol analogs, pharmaceutical compositions and methods of use thereof |
| CN109912419A (zh) * | 2017-12-13 | 2019-06-21 | 复旦大学 | 巨大戟烷型二萜及其在制备抗艾滋病毒药物中的用途 |
| CN110251495B (zh) * | 2018-03-12 | 2022-05-31 | 重庆医科大学 | 20-脱氧巨大戟二萜醇在制备抑制hbv复制的药物中的应用 |
| EP3917946A4 (en) * | 2019-01-28 | 2022-10-26 | Xyphos Biosciences Inc. | MODIFIED NKG2D NON-NATURAL LIGANDS THAT DELIVER SELECTIVELY BOUND HETEROLOGOUS MOLECULES TO NON-NATURAL NKG2D RECEPTORS ON CAR CELLS |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07165600A (ja) | 1993-10-18 | 1995-06-27 | Souyaku Gijutsu Kenkyusho:Kk | 抗ウイルス剤 |
| JP2003171349A (ja) * | 2001-08-06 | 2003-06-20 | Univ Nihon | 新規なジテルペン類、及びこれを用いた組成物、抗炎症剤、抗癌剤 |
| WO2006116897A1 (fr) * | 2005-04-30 | 2006-11-09 | Nihon University | Diterpenes provenant de euphorbia kansui et leur utilisation |
| AU2005333828A1 (en) * | 2005-06-28 | 2007-01-04 | Amazonia Fitomedicamentos Ltda | Active fraction of a polar solvent extract from the latex of euphorbiaceae plants |
| US9895334B2 (en) * | 2007-04-30 | 2018-02-20 | Leo Laboratories Limited | Treatment of virally induced lesions |
| WO2011086424A1 (en) * | 2010-01-15 | 2011-07-21 | Amazonia Fitomedicamentos Ltda | Pharmaceutical use of multicyclic compounds mixtures as concomitant anti-cancer, anti-inflammatory and anti-pain agents |
| JP2013517262A (ja) * | 2010-01-15 | 2013-05-16 | アマゾニア・フイートメデイカメントス・リミタダ | 抗エイズ剤としての多環式化合物の医薬的使用 |
-
2013
- 2013-03-01 CN CN201380012133.4A patent/CN104136081B/zh not_active Expired - Fee Related
- 2013-03-01 JP JP2014559040A patent/JP6280510B2/ja not_active Expired - Fee Related
- 2013-03-01 RU RU2014139825A patent/RU2609512C2/ru not_active IP Right Cessation
- 2013-03-01 NZ NZ628408A patent/NZ628408A/en not_active IP Right Cessation
- 2013-03-01 CA CA2864995A patent/CA2864995C/en not_active Expired - Fee Related
- 2013-03-01 ES ES13754607.3T patent/ES2683726T3/es active Active
- 2013-03-01 MX MX2014010463A patent/MX359300B/es active IP Right Grant
- 2013-03-01 US US14/382,060 patent/US10105339B2/en not_active Expired - Fee Related
- 2013-03-01 AU AU2013225633A patent/AU2013225633B2/en not_active Ceased
- 2013-03-01 WO PCT/BR2013/000063 patent/WO2013126980A1/pt not_active Ceased
- 2013-03-01 IN IN1911MUN2014 patent/IN2014MN01911A/en unknown
- 2013-03-01 EP EP13754607.3A patent/EP2821105B1/en not_active Not-in-force
-
2014
- 2014-09-01 IL IL234404A patent/IL234404A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013126980A1 (pt) | 2013-09-06 |
| JP6280510B2 (ja) | 2018-02-14 |
| EP2821105A1 (en) | 2015-01-07 |
| EP2821105B1 (en) | 2018-05-23 |
| US20150030638A1 (en) | 2015-01-29 |
| AU2013225633B2 (en) | 2017-11-23 |
| IL234404A (en) | 2017-09-28 |
| ES2683726T3 (es) | 2018-09-27 |
| EP2821105A4 (en) | 2015-11-04 |
| RU2609512C2 (ru) | 2017-02-02 |
| MX359300B (es) | 2018-09-21 |
| JP2015508782A (ja) | 2015-03-23 |
| RU2014139825A (ru) | 2016-04-20 |
| EP2821105A8 (en) | 2015-04-29 |
| CN104136081B (zh) | 2018-05-15 |
| HK1203872A1 (en) | 2015-11-06 |
| CA2864995C (en) | 2016-12-06 |
| US10105339B2 (en) | 2018-10-23 |
| AU2013225633A1 (en) | 2014-08-28 |
| CN104136081A (zh) | 2014-11-05 |
| NZ628408A (en) | 2017-09-29 |
| MX2014010463A (es) | 2014-10-13 |
| CA2864995A1 (en) | 2013-09-06 |
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