RU2599846C2 - Новые и эффективные лекарственые формы тапентадола - Google Patents

Новые и эффективные лекарственые формы тапентадола Download PDF

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RU2599846C2
RU2599846C2 RU2011121513/15A RU2011121513A RU2599846C2 RU 2599846 C2 RU2599846 C2 RU 2599846C2 RU 2011121513/15 A RU2011121513/15 A RU 2011121513/15A RU 2011121513 A RU2011121513 A RU 2011121513A RU 2599846 C2 RU2599846 C2 RU 2599846C2
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Russia
Prior art keywords
tapentadol
naltrexone
pharmaceutically acceptable
combination
acceptable salt
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RU2011121513/15A
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English (en)
Russian (ru)
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RU2011121513A (ru
Inventor
СЕША Рамеш
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Грюненталь Гмбх
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Application filed by Грюненталь Гмбх filed Critical Грюненталь Гмбх
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
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    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
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    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
RU2011121513/15A 2008-10-30 2009-10-29 Новые и эффективные лекарственые формы тапентадола RU2599846C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US19762508P 2008-10-30 2008-10-30
US61/197,625 2008-10-30
US20531209P 2009-01-21 2009-01-21
US61/205,312 2009-01-21
US26863009P 2009-06-15 2009-06-15
US61/268,630 2009-06-15
PCT/US2009/005866 WO2010096045A1 (en) 2008-10-30 2009-10-29 Novel and potent tapentadol dosage forms

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2015154026A Division RU2673882C1 (ru) 2008-10-30 2009-10-29 Новые и эффективные лекарственные формы тапентадола

Publications (2)

Publication Number Publication Date
RU2011121513A RU2011121513A (ru) 2012-12-10
RU2599846C2 true RU2599846C2 (ru) 2016-10-20

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RU2011121513/15A RU2599846C2 (ru) 2008-10-30 2009-10-29 Новые и эффективные лекарственые формы тапентадола
RU2015154026A RU2673882C1 (ru) 2008-10-30 2009-10-29 Новые и эффективные лекарственные формы тапентадола

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US (1) US9642801B2 (enExample)
EP (1) EP2352494B1 (enExample)
JP (2) JP6216489B2 (enExample)
KR (2) KR101712339B1 (enExample)
CN (2) CN104257600A (enExample)
AU (2) AU2009340504A1 (enExample)
BR (1) BRPI0921725A2 (enExample)
CA (1) CA2741984C (enExample)
CL (1) CL2011000967A1 (enExample)
CO (1) CO6382115A2 (enExample)
CY (1) CY1122269T1 (enExample)
DK (1) DK2352494T3 (enExample)
EC (2) ECSP11011016A (enExample)
ES (1) ES2758831T3 (enExample)
HR (1) HRP20191909T1 (enExample)
HU (1) HUE047438T2 (enExample)
IL (2) IL212523A0 (enExample)
LT (1) LT2352494T (enExample)
MX (1) MX2011004455A (enExample)
NZ (1) NZ592437A (enExample)
PE (3) PE20190391A1 (enExample)
PL (1) PL2352494T3 (enExample)
PT (1) PT2352494T (enExample)
RU (2) RU2599846C2 (enExample)
SI (1) SI2352494T1 (enExample)
WO (1) WO2010096045A1 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6216489B2 (ja) 2008-10-30 2017-10-18 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 新規の、効力のあるタペンタドール剤形
PL2424514T3 (pl) * 2009-04-30 2017-08-31 Grünenthal GmbH Tapentadol do leczenia bólu w reumatoidalnym zapaleniu stawów
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
US20130116333A1 (en) * 2010-05-05 2013-05-09 Ratiopharm Gmbh Solid tapentadol in non-crystalline form
WO2011141489A1 (en) 2010-05-10 2011-11-17 Euro-Celtique S.A. Manufacturing of active-free granules and tablets comprising the same
KR101858797B1 (ko) 2010-05-10 2018-05-16 유로-셀티큐 에스.에이. 히드로모르폰 및 날록손을 포함하는 제약 조성물
NZ603170A (en) 2010-05-10 2015-04-24 Euro Celtique Sa Combination of active loaded granules with additional actives
EP2593095B1 (en) 2010-07-16 2019-03-27 Mallinckrodt LLC (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
EP3650439B1 (en) * 2010-07-23 2021-02-24 Grünenthal GmbH Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
WO2012051246A1 (en) * 2010-10-12 2012-04-19 Ratiopharm Gmbh Tapentadol hydrobromide and crystalline forms thereof
SI3287123T1 (sl) * 2011-03-04 2020-07-31 Gruenenthal Gmbh Vodna farmacevtska formulacija tapentadola za peroralno uporabo
KR101911362B1 (ko) 2011-03-04 2018-10-25 그뤼넨탈 게엠베하 타펜타돌을 함유하는 반고체 수성 약제학적 조성물
HUE036567T2 (hu) * 2011-07-29 2018-07-30 Gruenenthal Gmbh 3-[(1S,2S)-3-(dimetilamino)-1-etil-2-metilpropil]fenol intratekális vagy epidurális adagolásra
EP2606879A1 (en) * 2011-12-21 2013-06-26 Hexal AG Multiple unit pellet tablet formulation comprising an opioid
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