CL2011000967A1 - Forma de dosificacion que comprende tapentadol en una formulacion de liberacion lenta, celulosa microcristalina, alcohol polivinilico, etilcelulosa, dioxido de silicio coloidal, estearil fumarato de sodio, opcionalmente con pregabalina, y un antagonista opioide seleccionado de naloxona, naltrexona o nalmefeno, util como analgesico. - Google Patents
Forma de dosificacion que comprende tapentadol en una formulacion de liberacion lenta, celulosa microcristalina, alcohol polivinilico, etilcelulosa, dioxido de silicio coloidal, estearil fumarato de sodio, opcionalmente con pregabalina, y un antagonista opioide seleccionado de naloxona, naltrexona o nalmefeno, util como analgesico.Info
- Publication number
- CL2011000967A1 CL2011000967A1 CL2011000967A CL2011000967A CL2011000967A1 CL 2011000967 A1 CL2011000967 A1 CL 2011000967A1 CL 2011000967 A CL2011000967 A CL 2011000967A CL 2011000967 A CL2011000967 A CL 2011000967A CL 2011000967 A1 CL2011000967 A1 CL 2011000967A1
- Authority
- CL
- Chile
- Prior art keywords
- tapentadol
- dosage form
- nalmefene
- pregabalin
- naltrexone
- Prior art date
Links
- KWTWDQCKEHXFFR-SMDDNHRTSA-N tapentadol Chemical compound CN(C)C[C@H](C)[C@@H](CC)C1=CC=CC(O)=C1 KWTWDQCKEHXFFR-SMDDNHRTSA-N 0.000 title abstract 3
- 229960005126 tapentadol Drugs 0.000 title abstract 3
- 239000002552 dosage form Substances 0.000 title abstract 2
- 239000003401 opiate antagonist Substances 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title 1
- 239000001856 Ethyl cellulose Substances 0.000 title 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 title 1
- WJBLNOPPDWQMCH-MBPVOVBZSA-N Nalmefene Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 WJBLNOPPDWQMCH-MBPVOVBZSA-N 0.000 title 1
- 239000004372 Polyvinyl alcohol Substances 0.000 title 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title 1
- 230000000202 analgesic effect Effects 0.000 title 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 title 1
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 title 1
- 235000019325 ethyl cellulose Nutrition 0.000 title 1
- 229920001249 ethyl cellulose Polymers 0.000 title 1
- 229960004667 ethyl cellulose Drugs 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 229940016286 microcrystalline cellulose Drugs 0.000 title 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 title 1
- 239000008108 microcrystalline cellulose Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229960005297 nalmefene Drugs 0.000 title 1
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 title 1
- 229960004127 naloxone Drugs 0.000 title 1
- 229960003086 naltrexone Drugs 0.000 title 1
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 title 1
- 229920002451 polyvinyl alcohol Polymers 0.000 title 1
- 229940068984 polyvinyl alcohol Drugs 0.000 title 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 title 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 title 1
- 229960001233 pregabalin Drugs 0.000 title 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 title 1
Classifications
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- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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- Emergency Medicine (AREA)
- Molecular Biology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Toxicology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Otolaryngology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19762508P | 2008-10-30 | 2008-10-30 | |
| US20531209P | 2009-01-21 | 2009-01-21 | |
| US26863009P | 2009-06-15 | 2009-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2011000967A1 true CL2011000967A1 (es) | 2011-09-16 |
Family
ID=42634123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2011000967A CL2011000967A1 (es) | 2008-10-30 | 2011-04-29 | Forma de dosificacion que comprende tapentadol en una formulacion de liberacion lenta, celulosa microcristalina, alcohol polivinilico, etilcelulosa, dioxido de silicio coloidal, estearil fumarato de sodio, opcionalmente con pregabalina, y un antagonista opioide seleccionado de naloxona, naltrexona o nalmefeno, util como analgesico. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9642801B2 (enExample) |
| EP (1) | EP2352494B1 (enExample) |
| JP (2) | JP6216489B2 (enExample) |
| KR (2) | KR101712339B1 (enExample) |
| CN (2) | CN102281876A (enExample) |
| AU (2) | AU2009340504A1 (enExample) |
| BR (1) | BRPI0921725A2 (enExample) |
| CA (1) | CA2741984C (enExample) |
| CL (1) | CL2011000967A1 (enExample) |
| CO (1) | CO6382115A2 (enExample) |
| CY (1) | CY1122269T1 (enExample) |
| DK (1) | DK2352494T3 (enExample) |
| EC (2) | ECSP11011016A (enExample) |
| ES (1) | ES2758831T3 (enExample) |
| HR (1) | HRP20191909T1 (enExample) |
| HU (1) | HUE047438T2 (enExample) |
| IL (2) | IL212523A0 (enExample) |
| LT (1) | LT2352494T (enExample) |
| MX (1) | MX2011004455A (enExample) |
| NZ (1) | NZ592437A (enExample) |
| PE (3) | PE20190391A1 (enExample) |
| PL (1) | PL2352494T3 (enExample) |
| PT (1) | PT2352494T (enExample) |
| RU (2) | RU2673882C1 (enExample) |
| SI (1) | SI2352494T1 (enExample) |
| WO (1) | WO2010096045A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2673882C1 (ru) | 2008-10-30 | 2018-12-03 | Грюненталь Гмбх | Новые и эффективные лекарственные формы тапентадола |
| CA2757757C (en) * | 2009-04-30 | 2017-10-24 | Ulrich Jahnel | Use of 1-phenyl-3-dimethylaminopropane compounds for treating rheumatoid pain |
| US10363251B2 (en) | 2009-07-16 | 2019-07-30 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| EP2566461A2 (de) * | 2010-05-05 | 2013-03-13 | Ratiopharm GmbH | Festes tapentadol in nicht-kristalliner form |
| US9700508B2 (en) | 2010-05-10 | 2017-07-11 | Euro-Celtique S.A. | Pharmaceutical compositions comprising hydromorphone and naloxone |
| PH12012502083A1 (en) | 2010-05-10 | 2017-07-26 | Euro Celtique Sa | Manufacturing of active-free granules and tablets comprising the same |
| EP2568965A1 (en) | 2010-05-10 | 2013-03-20 | Euro-Celtique S.A. | Combination of active loaded granules with additional actives |
| AU2010357625B2 (en) | 2010-07-16 | 2015-04-23 | Mallinckrodt Llc | (+)-morphinans as antagonists of Toll-like receptor 9 and therapeutic uses thereof |
| CN110015955A (zh) * | 2010-07-23 | 2019-07-16 | 格吕伦塔尔有限公司 | 3-(3-二甲基氨基-1-乙基-2-甲基-丙基)-苯酚的盐或共晶体 |
| WO2012051246A1 (en) * | 2010-10-12 | 2012-04-19 | Ratiopharm Gmbh | Tapentadol hydrobromide and crystalline forms thereof |
| ES2910085T3 (es) * | 2011-03-04 | 2022-05-11 | Gruenenthal Gmbh | Composición farmacéutica acuosa semisólida que contiene tapentadol |
| MX388963B (es) * | 2011-03-04 | 2025-03-20 | Gruenenthal Gmbh | Formulacion farmaceutica acuosa de tapentadol para administracion oral |
| EP3300726A1 (en) * | 2011-07-29 | 2018-04-04 | Grünenthal GmbH | Intrathecal or epidural administration of 3-[(1s,2s)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol |
| EP2606879A1 (en) * | 2011-12-21 | 2013-06-26 | Hexal AG | Multiple unit pellet tablet formulation comprising an opioid |
| EP2872126B1 (en) * | 2012-07-16 | 2017-12-06 | Grünenthal GmbH | Pharmaceutical patch for transdermal administration of tapentadol |
| CA3042642A1 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| ES2846736T3 (es) * | 2013-08-14 | 2021-07-29 | Evonik Operations Gmbh | Composición de recubrimiento |
| CN103432107A (zh) * | 2013-08-20 | 2013-12-11 | 安徽省先锋制药有限公司 | 一种盐酸他喷他多对乙酰氨基酚口腔崩解片及其制备方法 |
| EP2845625A1 (en) * | 2013-09-04 | 2015-03-11 | Grünenthal GmbH | Tapentadol for use in the treatment of fibromyalgia and chronic fatigue syndrome |
| WO2015071380A1 (en) | 2013-11-13 | 2015-05-21 | Euro-Celtique S.A. | Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| CN103655523A (zh) * | 2013-12-24 | 2014-03-26 | 南京艾德凯腾生物医药有限责任公司 | 他喷他多组合物 |
| CA2955229C (en) | 2014-07-17 | 2020-03-10 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| AU2015336065A1 (en) | 2014-10-20 | 2017-05-04 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
| PE20171651A1 (es) | 2015-03-27 | 2017-11-13 | Gruenenthal Chemie | Formulacion estable para administracion parenteral de tapentadol |
| EP3515412B1 (en) | 2016-09-23 | 2025-04-23 | Grünenthal GmbH | Stable formulation for parenteral administration of tapentadol |
| CN111346078B (zh) * | 2018-12-21 | 2022-06-10 | 宜昌人福药业有限责任公司 | 一种他喷他多或其药学上可接受的盐经鼻粘膜给药的药物组合物及其制备方法和应用 |
| WO2020252384A1 (en) * | 2019-06-14 | 2020-12-17 | Vorsanger Gary | Treatment methods utilizing oxytocin receptor agonists |
| EP3875079A1 (en) | 2020-03-02 | 2021-09-08 | Grünenthal GmbH | Dosage form providing prolonged release of tapentadol phosphoric acid salt |
| PE20230105A1 (es) | 2020-03-02 | 2023-01-25 | Gruenenthal Chemie | Forma de dosificacion que proporciona liberacion prolongada de sal de acido fosforico de tapentadol |
| EP3875077B1 (en) | 2020-03-02 | 2023-12-13 | Grünenthal GmbH | Dosage form providing prolonged release of tapentadol phosphoric acid salt |
| DE202020104285U1 (de) | 2020-07-24 | 2020-12-18 | Grünenthal GmbH | Ethylcellulose-beschichtete Partikel enthaltend ein Salz aus Tapentadol und Phosphorsäure |
| US12303604B1 (en) | 2024-10-16 | 2025-05-20 | Currax Pharmaceuticals Llc | Pharmaceutical formulations comprising naltrexone and/or bupropion |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4034758A (en) | 1975-09-08 | 1977-07-12 | Alza Corporation | Osmotic therapeutic system for administering medicament |
| US4077407A (en) | 1975-11-24 | 1978-03-07 | Alza Corporation | Osmotic devices having composite walls |
| US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| US5071607A (en) | 1990-01-31 | 1991-12-10 | Alza Corporatino | Method and apparatus for forming a hole in a drug dispensing device |
| US5472943A (en) | 1992-09-21 | 1995-12-05 | Albert Einstein College Of Medicine Of Yeshiva University, | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other opioid agonists |
| GB9401894D0 (en) | 1994-02-01 | 1994-03-30 | Rhone Poulenc Rorer Ltd | New compositions of matter |
| DE4426245A1 (de) | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| DE69709646T2 (de) | 1996-03-12 | 2002-08-14 | Alza Corp., Palo Alto | Zusammensetzung und dosisform mit einem opioid-antagonisten |
| US6103258A (en) | 1996-04-12 | 2000-08-15 | Simon; David Lew | Salts and bases of the 17-(Cyclopropylmethyl)-4,5 alpha-epoxy-6-Methylenemorphinan-3,14 diol molecule for optimizing dopamine homeostasis during administration of opioid analgesics |
| JP2001526228A (ja) * | 1997-12-22 | 2001-12-18 | ユーロ−セルティーク，エス．エイ． | オピオイド作動薬／拮抗薬の併用 |
| CA2314896C (en) | 1997-12-22 | 2005-09-13 | Euro-Celtique, S.A. | A method of preventing abuse of opioid dosage forms |
| US6375957B1 (en) | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
| US6765010B2 (en) | 1999-05-06 | 2004-07-20 | Pain Therapeutics, Inc. | Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects |
| HU229705B1 (en) | 2000-02-08 | 2014-05-28 | Euro Celtique Sa | Tamper-resistant oral opioid agonist formulations |
| US6716449B2 (en) | 2000-02-08 | 2004-04-06 | Euro-Celtique S.A. | Controlled-release compositions containing opioid agonist and antagonist |
| US20040024004A1 (en) * | 2001-05-04 | 2004-02-05 | Sherman Barry M. | Novel compositions and methods for enhancing potency or reducing adverse side effects of opioid agonists |
| US6559159B2 (en) | 2001-02-01 | 2003-05-06 | Research Triangle Institute | Kappa opioid receptor ligands |
| ATE431738T1 (de) * | 2001-08-06 | 2009-06-15 | Euro Celtique Sa | Opioid-agonist-formulierungen mit freisetzbarem und sequestriertem antagonist |
| DE10146275A1 (de) | 2001-09-18 | 2003-04-24 | Gruenenthal Gmbh | Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz |
| DE10152469A1 (de) * | 2001-10-24 | 2003-06-26 | Gruenenthal Gmbh | 3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)phenol enthaltendes Arzneimittel mit verzögerter Wirkstofffreisetzung |
| PE20030527A1 (es) | 2001-10-24 | 2003-07-26 | Gruenenthal Chemie | Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen |
| EP1492505B1 (en) | 2002-04-05 | 2015-06-03 | Euro-Celtique S.A. | Pharmaceutical preparation containing oxycodone and naloxone |
| US20050191244A1 (en) | 2002-10-25 | 2005-09-01 | Gruenenthal Gmbh | Abuse-resistant pharmaceutical dosage form |
| DK3241550T3 (da) * | 2002-11-22 | 2020-08-24 | Gruenenthal Gmbh | Anvendelse af (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol til behandling af inflammatoriske smerter |
| CA2524271C (en) | 2003-05-02 | 2012-09-04 | Surmodics, Inc. | Controlled release bioactive agent delivery device |
| US7332142B2 (en) | 2005-06-17 | 2008-02-19 | Emcon Tehnologies Germany (Augsburg) Gmbh | Method and apparatus for bubble injection of agent into exhaust gas for use with emission abatement device |
| US20090082466A1 (en) * | 2006-01-27 | 2009-03-26 | Najib Babul | Abuse Resistant and Extended Release Formulations and Method of Use Thereof |
| WO2008027442A2 (en) * | 2006-08-30 | 2008-03-06 | Theraquest Biosciences, Llc | Abuse deterrent oral pharmaceutical formulations of opioid agonists and method of use |
| EP1985292A1 (en) * | 2007-04-23 | 2008-10-29 | Grünenthal GmbH | Titration of tapentadol |
| DE102007019417A1 (de) * | 2007-04-23 | 2008-11-13 | Grünenthal GmbH | Tapentadol zur Schmerzbehandlung bei Arthrose |
| RU2673882C1 (ru) | 2008-10-30 | 2018-12-03 | Грюненталь Гмбх | Новые и эффективные лекарственные формы тапентадола |
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