CL2011000967A1 - Forma de dosificacion que comprende tapentadol en una formulacion de liberacion lenta, celulosa microcristalina, alcohol polivinilico, etilcelulosa, dioxido de silicio coloidal, estearil fumarato de sodio, opcionalmente con pregabalina, y un antagonista opioide seleccionado de naloxona, naltrexona o nalmefeno, util como analgesico. - Google Patents
Forma de dosificacion que comprende tapentadol en una formulacion de liberacion lenta, celulosa microcristalina, alcohol polivinilico, etilcelulosa, dioxido de silicio coloidal, estearil fumarato de sodio, opcionalmente con pregabalina, y un antagonista opioide seleccionado de naloxona, naltrexona o nalmefeno, util como analgesico.Info
- Publication number
- CL2011000967A1 CL2011000967A1 CL2011000967A CL2011000967A CL2011000967A1 CL 2011000967 A1 CL2011000967 A1 CL 2011000967A1 CL 2011000967 A CL2011000967 A CL 2011000967A CL 2011000967 A CL2011000967 A CL 2011000967A CL 2011000967 A1 CL2011000967 A1 CL 2011000967A1
- Authority
- CL
- Chile
- Prior art keywords
- tapentadol
- dosage form
- nalmefene
- pregabalin
- naltrexone
- Prior art date
Links
- KWTWDQCKEHXFFR-SMDDNHRTSA-N tapentadol Chemical compound CN(C)C[C@H](C)[C@@H](CC)C1=CC=CC(O)=C1 KWTWDQCKEHXFFR-SMDDNHRTSA-N 0.000 title abstract 3
- 229960005126 tapentadol Drugs 0.000 title abstract 3
- 239000002552 dosage form Substances 0.000 title abstract 2
- 239000003401 opiate antagonist Substances 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title 1
- 239000001856 Ethyl cellulose Substances 0.000 title 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 title 1
- WJBLNOPPDWQMCH-MBPVOVBZSA-N Nalmefene Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 WJBLNOPPDWQMCH-MBPVOVBZSA-N 0.000 title 1
- 239000004372 Polyvinyl alcohol Substances 0.000 title 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title 1
- 230000000202 analgesic effect Effects 0.000 title 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 title 1
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 title 1
- 235000019325 ethyl cellulose Nutrition 0.000 title 1
- 229920001249 ethyl cellulose Polymers 0.000 title 1
- 229960004667 ethyl cellulose Drugs 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 229940016286 microcrystalline cellulose Drugs 0.000 title 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 title 1
- 239000008108 microcrystalline cellulose Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229960005297 nalmefene Drugs 0.000 title 1
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 title 1
- 229960004127 naloxone Drugs 0.000 title 1
- 229960003086 naltrexone Drugs 0.000 title 1
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 title 1
- 229920002451 polyvinyl alcohol Polymers 0.000 title 1
- 229940068984 polyvinyl alcohol Drugs 0.000 title 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 title 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 title 1
- 229960001233 pregabalin Drugs 0.000 title 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 title 1
Classifications
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
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- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Molecular Biology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
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- Neurosurgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
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- Toxicology (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19762508P | 2008-10-30 | 2008-10-30 | |
| US20531209P | 2009-01-21 | 2009-01-21 | |
| US26863009P | 2009-06-15 | 2009-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2011000967A1 true CL2011000967A1 (es) | 2011-09-16 |
Family
ID=42634123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2011000967A CL2011000967A1 (es) | 2008-10-30 | 2011-04-29 | Forma de dosificacion que comprende tapentadol en una formulacion de liberacion lenta, celulosa microcristalina, alcohol polivinilico, etilcelulosa, dioxido de silicio coloidal, estearil fumarato de sodio, opcionalmente con pregabalina, y un antagonista opioide seleccionado de naloxona, naltrexona o nalmefeno, util como analgesico. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9642801B2 (enExample) |
| EP (1) | EP2352494B1 (enExample) |
| JP (2) | JP6216489B2 (enExample) |
| KR (2) | KR101712339B1 (enExample) |
| CN (2) | CN102281876A (enExample) |
| AU (2) | AU2009340504A1 (enExample) |
| BR (1) | BRPI0921725A2 (enExample) |
| CA (1) | CA2741984C (enExample) |
| CL (1) | CL2011000967A1 (enExample) |
| CO (1) | CO6382115A2 (enExample) |
| CY (1) | CY1122269T1 (enExample) |
| DK (1) | DK2352494T3 (enExample) |
| EC (2) | ECSP11011016A (enExample) |
| ES (1) | ES2758831T3 (enExample) |
| HR (1) | HRP20191909T1 (enExample) |
| HU (1) | HUE047438T2 (enExample) |
| IL (2) | IL212523A0 (enExample) |
| LT (1) | LT2352494T (enExample) |
| MX (1) | MX2011004455A (enExample) |
| NZ (1) | NZ592437A (enExample) |
| PE (3) | PE20142368A1 (enExample) |
| PL (1) | PL2352494T3 (enExample) |
| PT (1) | PT2352494T (enExample) |
| RU (2) | RU2673882C1 (enExample) |
| SI (1) | SI2352494T1 (enExample) |
| WO (1) | WO2010096045A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2758831T3 (es) | 2008-10-30 | 2020-05-06 | Gruenenthal Gmbh | Nuevas y potentes formas de dosificación de tapentadol |
| WO2010124856A1 (en) * | 2009-04-30 | 2010-11-04 | Grünenthal GmbH | Use of 1-phenyl-3-dimethylaminopropane compounds for treating rheumatoid pain |
| US10363251B2 (en) | 2009-07-16 | 2019-07-30 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| US20130116333A1 (en) * | 2010-05-05 | 2013-05-09 | Ratiopharm Gmbh | Solid tapentadol in non-crystalline form |
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