RU2582937C2 - Способы лечения ревматоидного артрита с применением антагонистов il-17 - Google Patents

Способы лечения ревматоидного артрита с применением антагонистов il-17 Download PDF

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RU2582937C2
RU2582937C2 RU2013125775/15A RU2013125775A RU2582937C2 RU 2582937 C2 RU2582937 C2 RU 2582937C2 RU 2013125775/15 A RU2013125775/15 A RU 2013125775/15A RU 2013125775 A RU2013125775 A RU 2013125775A RU 2582937 C2 RU2582937 C2 RU 2582937C2
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patient
seq
antibody
secukinumab
antagonist
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RU2013125775A (ru
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Шефард МПОФУ
Ханно РИЧАРДС
Картхинатхан ТХАНГАВЕЛУ
Маттиас МАШАСЕК
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Новартис Аг
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    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
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    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
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    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
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    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Endocrinology (AREA)
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  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
RU2013125775/15A 2010-11-05 2011-11-04 Способы лечения ревматоидного артрита с применением антагонистов il-17 RU2582937C2 (ru)

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Application Number Priority Date Filing Date Title
US41053310P 2010-11-05 2010-11-05
US61/410,533 2010-11-05
PCT/EP2011/069476 WO2012059598A2 (en) 2010-11-05 2011-11-04 Methods of treating rheumatoid arthritis using il-17 antagonists

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RU2013125775A RU2013125775A (ru) 2014-12-10
RU2582937C2 true RU2582937C2 (ru) 2016-04-27

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US (10) US9744234B2 (OSRAM)
EP (6) EP3912640B1 (OSRAM)
JP (8) JP2014503482A (OSRAM)
KR (5) KR20180129991A (OSRAM)
CN (2) CN103189074A (OSRAM)
AU (1) AU2011325134B2 (OSRAM)
BR (1) BR112013011176A2 (OSRAM)
CA (2) CA3116725C (OSRAM)
CL (1) CL2013001213A1 (OSRAM)
CY (1) CY1121802T1 (OSRAM)
DE (1) DE20187001T1 (OSRAM)
DK (2) DK3111954T3 (OSRAM)
ES (3) ES2733712T3 (OSRAM)
FI (1) FI3757126T3 (OSRAM)
HR (2) HRP20251174T1 (OSRAM)
HU (1) HUE044038T2 (OSRAM)
IL (4) IL311014A (OSRAM)
LT (2) LT3757126T (OSRAM)
MA (1) MA34647B1 (OSRAM)
MX (1) MX362591B (OSRAM)
PH (1) PH12013500890A1 (OSRAM)
PL (1) PL3111954T3 (OSRAM)
PT (2) PT3111954T (OSRAM)
RS (1) RS67377B1 (OSRAM)
RU (1) RU2582937C2 (OSRAM)
SG (2) SG10201505624VA (OSRAM)
SI (1) SI3111954T1 (OSRAM)
TR (1) TR201909531T4 (OSRAM)
TW (3) TWI616204B (OSRAM)
WO (1) WO2012059598A2 (OSRAM)

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RU2852738C1 (ru) * 2019-09-20 2025-12-15 Новартис Аг Способы лечения аутоиммунных заболеваний с применением антагонистов интерлейкина-17 (il-17)

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