RU2569733C2 - Агонисты 5-нт4-рецепторов для лечения деменции - Google Patents
Агонисты 5-нт4-рецепторов для лечения деменции Download PDFInfo
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- RU2569733C2 RU2569733C2 RU2012139034/15A RU2012139034A RU2569733C2 RU 2569733 C2 RU2569733 C2 RU 2569733C2 RU 2012139034/15 A RU2012139034/15 A RU 2012139034/15A RU 2012139034 A RU2012139034 A RU 2012139034A RU 2569733 C2 RU2569733 C2 RU 2569733C2
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- Prior art keywords
- methyl
- group
- piperidin
- carboxamide
- dementia
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- 0 CC(C)*1C(O)=C(*)C=C(*)C1=O Chemical compound CC(C)*1C(O)=C(*)C=C(*)C1=O 0.000 description 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28243210P | 2010-02-12 | 2010-02-12 | |
US61/282,432 | 2010-02-12 | ||
PCT/JP2011/000793 WO2011099305A1 (en) | 2010-02-12 | 2011-02-14 | 5-ht4 receptor agonists for the treatment of dementia |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2012139034A RU2012139034A (ru) | 2014-03-20 |
RU2569733C2 true RU2569733C2 (ru) | 2015-11-27 |
Family
ID=44367591
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2012139034/15A RU2569733C2 (ru) | 2010-02-12 | 2011-02-14 | Агонисты 5-нт4-рецепторов для лечения деменции |
Country Status (11)
Country | Link |
---|---|
US (1) | US8980922B2 (ko) |
EP (1) | EP2533780B1 (ko) |
JP (1) | JP6023926B2 (ko) |
KR (1) | KR101737388B1 (ko) |
CN (2) | CN102753172A (ko) |
BR (1) | BR112012020060B8 (ko) |
CA (1) | CA2789663C (ko) |
ES (1) | ES2640752T3 (ko) |
MX (1) | MX343165B (ko) |
RU (1) | RU2569733C2 (ko) |
WO (1) | WO2011099305A1 (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9775843B2 (en) | 2012-10-11 | 2017-10-03 | Grünenthal GmbH | Treatment and/or prophylaxis of TSPO mediated diseases and/or disorders |
US9790211B2 (en) | 2013-03-20 | 2017-10-17 | Suven Life Sciences Limited | 5-amino-quinoline-8-carboxamide derivatives as 5-HT4 receptor agonists |
FR3006686A1 (fr) * | 2013-06-05 | 2014-12-12 | Univ Caen | Composes inhibiteurs de l'acetylcholinesterase et agonistes des recepteurs serotoninergiques 5ht4, a effet promnesiant, leurs procedes de preparation et compositions pharmaceutiques les contenant |
JP6161823B2 (ja) | 2013-12-16 | 2017-07-12 | スヴェン・ライフ・サイエンシズ・リミテッド | 5−ht4受容体アゴニストとしてのインダゾール化合物 |
ES2734734T3 (es) | 2015-02-13 | 2019-12-11 | Suven Life Sciences Ltd | Compuestos de amida como agonistas del receptor 5-HT4 |
JP6900028B2 (ja) * | 2017-03-29 | 2021-07-07 | 国立大学法人帯広畜産大学 | パーキンソン病に併発した認知障害の治療剤 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005092882A1 (en) * | 2004-03-01 | 2005-10-06 | Pfizer Japan, Inc. | 4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders |
WO2007096352A1 (en) * | 2006-02-22 | 2007-08-30 | Glaxo Group Limited | 5-amino-6-bromo-n-{ [1- (tetrahydr0-2h-pyran-4-ylmethyl) -4-piperidinyl] methyl}-3, 4 -dihydro-2h-chromene-8-carboxamide as 5-ht4 receptor agonist |
RU2006133320A (ru) * | 2004-02-18 | 2008-03-27 | Тереванс | Соединения индазолкарбоксамида в качестве агонистов 5-нт4 рецепторов |
RU2008129615A (ru) * | 2005-12-22 | 2010-01-27 | Новартис АГ (CH) | Комбинация агониста 5-ht4 и ингибитора холинэстеразы |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5864039A (en) | 1994-03-30 | 1999-01-26 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzoic acid compounds and use thereof as medicaments |
EP0873990A1 (en) * | 1995-09-22 | 1998-10-28 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzoic acid compounds and medicinal use thereof |
MY134008A (en) | 1999-12-22 | 2007-11-30 | Merck Frosst Canada Inc | Subtituted 8-arylquinoline phospohodiestrase-4 inhibitors |
JP4223287B2 (ja) | 2001-01-22 | 2009-02-12 | メモリー・ファーマスーティカルズ・コーポレーション | 新規な化合物及び製薬上許容し得るそれらの塩並びにそれらを用いた薬剤組成物 |
BR0207302A (pt) | 2001-02-08 | 2004-02-10 | Memory Pharm Corp | Trifluorometilpurinas como inibidores da fosfodiesterase 4 |
JO2311B1 (en) | 2001-08-29 | 2005-09-12 | ميرك فروست كندا ليمتد | Alkyl inhibitors Ariel phosphodiesterase-4 |
MXPA03000145A (es) | 2002-01-07 | 2003-07-15 | Pfizer | Compuestos de oxo u oxi-piridina como moduladores de receptores 5-ht4. |
BR0314584A (pt) * | 2002-09-20 | 2005-08-09 | Pfizer | Compostos piperidinil-imidazopiridina n-substituìda como moduladores e receptores 5-ht4 |
GB0313772D0 (en) | 2003-06-13 | 2003-07-23 | Merck Sharp & Dohme | Therapeutic treatment |
ES2377484T3 (es) * | 2003-09-03 | 2012-03-28 | Pfizer, Inc. | Compuestos de bencimidazolona que tiene actividad agonista del receptor 5-HT |
US7964727B2 (en) | 2003-11-24 | 2011-06-21 | Pfizer Inc. | Quinolonecarboxylic acid compounds having 5-HT4 receptor agonistic activity |
BRPI0507180A (pt) | 2004-01-29 | 2007-06-26 | Pfizer | derivados de 1-isopropil-2-oxo-1,2-diidropiridina-3-carboxamida tendo atividade agonìstica de receptor 5-ht4 |
AU2005254800B2 (en) | 2004-06-15 | 2010-12-09 | Pfizer Inc. | Benzimidazolone carboxylic acid derivatives |
JP4129445B2 (ja) * | 2004-06-15 | 2008-08-06 | ファイザー・インク | ベンズイミダゾロンカルボン酸誘導体 |
JP2008509088A (ja) * | 2004-09-02 | 2008-03-27 | ファイザー株式会社 | ベンズイミダゾロンカルボン酸誘導体 |
ATE513827T1 (de) | 2005-02-22 | 2011-07-15 | Pfizer | Oxyindol-derivate als 5ht4-rezeptor-agonisten |
-
2011
- 2011-02-14 RU RU2012139034/15A patent/RU2569733C2/ru active
- 2011-02-14 CA CA2789663A patent/CA2789663C/en active Active
- 2011-02-14 CN CN2011800090958A patent/CN102753172A/zh active Pending
- 2011-02-14 MX MX2012009211A patent/MX343165B/es active IP Right Grant
- 2011-02-14 JP JP2012536636A patent/JP6023926B2/ja active Active
- 2011-02-14 US US13/578,127 patent/US8980922B2/en active Active
- 2011-02-14 ES ES11742054.7T patent/ES2640752T3/es active Active
- 2011-02-14 BR BR112012020060A patent/BR112012020060B8/pt active IP Right Grant
- 2011-02-14 KR KR1020127023644A patent/KR101737388B1/ko active IP Right Grant
- 2011-02-14 EP EP11742054.7A patent/EP2533780B1/en active Active
- 2011-02-14 CN CN201710271972.8A patent/CN107260736A/zh active Pending
- 2011-02-14 WO PCT/JP2011/000793 patent/WO2011099305A1/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2006133320A (ru) * | 2004-02-18 | 2008-03-27 | Тереванс | Соединения индазолкарбоксамида в качестве агонистов 5-нт4 рецепторов |
WO2005092882A1 (en) * | 2004-03-01 | 2005-10-06 | Pfizer Japan, Inc. | 4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders |
RU2008129615A (ru) * | 2005-12-22 | 2010-01-27 | Новартис АГ (CH) | Комбинация агониста 5-ht4 и ингибитора холинэстеразы |
WO2007096352A1 (en) * | 2006-02-22 | 2007-08-30 | Glaxo Group Limited | 5-amino-6-bromo-n-{ [1- (tetrahydr0-2h-pyran-4-ylmethyl) -4-piperidinyl] methyl}-3, 4 -dihydro-2h-chromene-8-carboxamide as 5-ht4 receptor agonist |
Non-Patent Citations (1)
Title |
---|
RUSSO O. et al. "Design, synthesis and biological evaluation of new 5-HT4 receptor agonists: application as amiloid cascade modulators and potential therapeutic utility in alzheimer’s disease". J Med Chem 2009, 52, 2214-2225, найдено 13.02.2015, найдено из Интернет: http://libgen.asia/e9192df50bc84ffa6d24be4d7e4425ed/russo2009.pdf. * |
Also Published As
Publication number | Publication date |
---|---|
CN107260736A (zh) | 2017-10-20 |
EP2533780A1 (en) | 2012-12-19 |
EP2533780A4 (en) | 2015-04-08 |
KR101737388B1 (ko) | 2017-05-18 |
US8980922B2 (en) | 2015-03-17 |
MX2012009211A (es) | 2012-09-07 |
CA2789663A1 (en) | 2011-08-18 |
BR112012020060B8 (pt) | 2021-05-25 |
CA2789663C (en) | 2018-10-02 |
BR112012020060B1 (pt) | 2021-05-11 |
WO2011099305A1 (en) | 2011-08-18 |
JP2013519630A (ja) | 2013-05-30 |
EP2533780B1 (en) | 2017-08-23 |
US20120322826A1 (en) | 2012-12-20 |
JP6023926B2 (ja) | 2016-11-09 |
BR112012020060A2 (pt) | 2016-05-10 |
ES2640752T3 (es) | 2017-11-06 |
CN102753172A (zh) | 2012-10-24 |
KR20130035999A (ko) | 2013-04-09 |
MX343165B (es) | 2016-10-26 |
RU2012139034A (ru) | 2014-03-20 |
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PC41 | Official registration of the transfer of exclusive right |
Effective date: 20170706 |