RU2564445C2 - Ингибиторы репликации вич - Google Patents
Ингибиторы репликации вич Download PDFInfo
- Publication number
- RU2564445C2 RU2564445C2 RU2013121788/04A RU2013121788A RU2564445C2 RU 2564445 C2 RU2564445 C2 RU 2564445C2 RU 2013121788/04 A RU2013121788/04 A RU 2013121788/04A RU 2013121788 A RU2013121788 A RU 2013121788A RU 2564445 C2 RU2564445 C2 RU 2564445C2
- Authority
- RU
- Russia
- Prior art keywords
- methyl
- mmol
- compound
- pyridin
- added
- Prior art date
Links
- 0 CC(C)(C)OC(C(O)=O)c1c(C)nc2[s]c(CCCC3)c3c2c1-c1c[n](C(*)*)nc1 Chemical compound CC(C)(C)OC(C(O)=O)c1c(C)nc2[s]c(CCCC3)c3c2c1-c1c[n](C(*)*)nc1 0.000 description 5
- KSTKFZCVICUCSS-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c(c(C)n1)c(-c2n[nH]cc2)c2c1[s]c1c2CCCC1 Chemical compound CC(C)(C)OC(C(O)=O)c(c(C)n1)c(-c2n[nH]cc2)c2c1[s]c1c2CCCC1 KSTKFZCVICUCSS-UHFFFAOYSA-N 0.000 description 1
- MFYZBXPPBSSWCQ-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c(ccc(C)c1)c1O Chemical compound CC(C)(C)OC(C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c(ccc(C)c1)c1O MFYZBXPPBSSWCQ-UHFFFAOYSA-N 0.000 description 1
- LJAJKOXCBCPBAK-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c1cc(OC)ncc1 Chemical compound CC(C)(C)OC(C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c1cc(OC)ncc1 LJAJKOXCBCPBAK-UHFFFAOYSA-N 0.000 description 1
- UVBGKMHQFWPVMK-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c1ccc2[s]c(C)nc2c1 Chemical compound CC(C)(C)OC(C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c1ccc2[s]c(C)nc2c1 UVBGKMHQFWPVMK-UHFFFAOYSA-N 0.000 description 1
- HTAGYEBKWGSDIQ-UHFFFAOYSA-N CC(C)(C)OC(C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2C1=CNC2=NC=CC2=C1 Chemical compound CC(C)(C)OC(C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2C1=CNC2=NC=CC2=C1 HTAGYEBKWGSDIQ-UHFFFAOYSA-N 0.000 description 1
- IJAYOSXMNWDRPN-HSZRJFAPSA-N CC(C)(C)O[C@@H](C(O)=O)c(c(C)nc1c2c(C(CCC3)=C)c3[s]1)c2-c(ccc(C)c1)c1O Chemical compound CC(C)(C)O[C@@H](C(O)=O)c(c(C)nc1c2c(C(CCC3)=C)c3[s]1)c2-c(ccc(C)c1)c1O IJAYOSXMNWDRPN-HSZRJFAPSA-N 0.000 description 1
- MNAQPGCEPHVVRF-OGDGHAERSA-N CC(C)(C)O[C@H](C(O)=O)c(c(C)n1)c2-c(ccc(Cl)c3)c3OCC(CCC3)c4c3[s]c1c24 Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(C)n1)c2-c(ccc(Cl)c3)c3OCC(CCC3)c4c3[s]c1c24 MNAQPGCEPHVVRF-OGDGHAERSA-N 0.000 description 1
- HXXYHUUEZMENOP-NRFANRHFSA-N CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c(cc1)ccc1Cl Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c(cc1)ccc1Cl HXXYHUUEZMENOP-NRFANRHFSA-N 0.000 description 1
- RXKUZMGPMATVJK-QFIPXVFZSA-N CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c(ccc(C)c1)c1F Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c(ccc(C)c1)c1F RXKUZMGPMATVJK-QFIPXVFZSA-N 0.000 description 1
- MFYZBXPPBSSWCQ-QFIPXVFZSA-N CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c(ccc(C)c1)c1O Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c(ccc(C)c1)c1O MFYZBXPPBSSWCQ-QFIPXVFZSA-N 0.000 description 1
- YDNFRXQQXLZQGV-NRFANRHFSA-N CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c(cccc1)c1O Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c(cccc1)c1O YDNFRXQQXLZQGV-NRFANRHFSA-N 0.000 description 1
- FTQISHKCVRYCHE-NRFANRHFSA-N CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c1ccc(C(F)(F)F)cc1 Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c1ccc(C(F)(F)F)cc1 FTQISHKCVRYCHE-NRFANRHFSA-N 0.000 description 1
- NJNANSPFHGTFSE-IBGZPJMESA-N CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c1cncnc1 Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c1cncnc1 NJNANSPFHGTFSE-IBGZPJMESA-N 0.000 description 1
- VRNIORWEWKHCCR-WFHLNLCJSA-N CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2C1=CC2SC(C)=NC2C=C1 Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2C1=CC2SC(C)=NC2C=C1 VRNIORWEWKHCCR-WFHLNLCJSA-N 0.000 description 1
- GBZIZRJYQYIXMU-XLDIYJRPSA-N CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2C1=C[NH+]2[N-]C=CC2C=C1 Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2C1=C[NH+]2[N-]C=CC2C=C1 GBZIZRJYQYIXMU-XLDIYJRPSA-N 0.000 description 1
- NXUFMBBZIOWMGR-UHFFFAOYSA-N CC(C)(C)[O-2]C(C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c(cc1)ccc1Br Chemical compound CC(C)(C)[O-2]C(C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c(cc1)ccc1Br NXUFMBBZIOWMGR-UHFFFAOYSA-N 0.000 description 1
- YVRCVPCCDBGTBR-UHFFFAOYSA-N CC(C)(C)[O-2]c1cc(C#N)ncc1-c1c(CC(O)=O)c(C)nc2c1c(CCCC1)c1[s]2 Chemical compound CC(C)(C)[O-2]c1cc(C#N)ncc1-c1c(CC(O)=O)c(C)nc2c1c(CCCC1)c1[s]2 YVRCVPCCDBGTBR-UHFFFAOYSA-N 0.000 description 1
- XRALHHGMTITDCU-UHFFFAOYSA-N CC(C)(C)[O-2]c1nc(OC)ncc1-c1c(CC(O)=O)c(C)nc2c1c(CCCC1)c1[s]2 Chemical compound CC(C)(C)[O-2]c1nc(OC)ncc1-c1c(CC(O)=O)c(C)nc2c1c(CCCC1)c1[s]2 XRALHHGMTITDCU-UHFFFAOYSA-N 0.000 description 1
- FPUUWMIOQNYGMP-UHFFFAOYSA-N CC(C)(C)[O-]C(C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c(ccc(Cl)c1)c1F Chemical compound CC(C)(C)[O-]C(C(O)=O)c(c(C)nc1c2c(CCCC3)c3[s]1)c2-c(ccc(Cl)c1)c1F FPUUWMIOQNYGMP-UHFFFAOYSA-N 0.000 description 1
- AQGQGZICGWHKGX-UHFFFAOYSA-N CC(C)([O-4])OC(Cc(c(C)n1)c2-c(ccc(C)c3)c3OCC(CCC3)c4c3[s]c1c24)=O Chemical compound CC(C)([O-4])OC(Cc(c(C)n1)c2-c(ccc(C)c3)c3OCC(CCC3)c4c3[s]c1c24)=O AQGQGZICGWHKGX-UHFFFAOYSA-N 0.000 description 1
- DSPKIWRTNYJDMH-QVCARPALSA-N CC/C(/C=C/O)=C/C=C/c1c([C@@H](C(O)=O)OC(C)(C)C)c(C)nc2c1c(CCCC1)c1[s]2 Chemical compound CC/C(/C=C/O)=C/C=C/c1c([C@@H](C(O)=O)OC(C)(C)C)c(C)nc2c1c(CCCC1)c1[s]2 DSPKIWRTNYJDMH-QVCARPALSA-N 0.000 description 1
- BISXMNULWGKNJK-NRFANRHFSA-N CCO[C@H](C(O)=O)c1c(C)nc2[s]c(CCCC3)c3c2c1-c1c(CO)cccc1 Chemical compound CCO[C@H](C(O)=O)c1c(C)nc2[s]c(CCCC3)c3c2c1-c1c(CO)cccc1 BISXMNULWGKNJK-NRFANRHFSA-N 0.000 description 1
- SLYVDHVWFXCFGB-UHFFFAOYSA-N Cc(cc1)ccc1-c1c(CC(O)=O)c(C)nc2c1c(CCOC1)c1[s]2 Chemical compound Cc(cc1)ccc1-c1c(CC(O)=O)c(C)nc2c1c(CCOC1)c1[s]2 SLYVDHVWFXCFGB-UHFFFAOYSA-N 0.000 description 1
- MXXQOTRKRPIVPL-UHFFFAOYSA-N Cc1nc([s]c2c3CCCC2)c3c(-c2ccc(C(F)F)cc2)c1CC(O)=O Chemical compound Cc1nc([s]c2c3CCCC2)c3c(-c2ccc(C(F)F)cc2)c1CC(O)=O MXXQOTRKRPIVPL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41361810P | 2010-11-15 | 2010-11-15 | |
US61/413,618 | 2010-11-15 | ||
US201161485355P | 2011-05-12 | 2011-05-12 | |
US61/485,355 | 2011-05-12 | ||
PCT/IB2011/054852 WO2012066442A1 (en) | 2010-11-15 | 2011-11-01 | Inhibitors of hiv replication |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2013121788A RU2013121788A (ru) | 2014-12-27 |
RU2564445C2 true RU2564445C2 (ru) | 2015-10-10 |
Family
ID=44999830
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2013121788/04A RU2564445C2 (ru) | 2010-11-15 | 2011-11-01 | Ингибиторы репликации вич |
Country Status (15)
Country | Link |
---|---|
US (3) | US8809363B2 (pt-PT) |
EP (1) | EP2640729B1 (pt-PT) |
JP (2) | JP5902704B2 (pt-PT) |
CN (2) | CN103429595B (pt-PT) |
AR (1) | AR083870A1 (pt-PT) |
AU (2) | AU2011330850B2 (pt-PT) |
BR (1) | BR112013011991A2 (pt-PT) |
CA (1) | CA2817896A1 (pt-PT) |
CL (1) | CL2013001338A1 (pt-PT) |
MX (1) | MX343274B (pt-PT) |
RU (1) | RU2564445C2 (pt-PT) |
TW (1) | TWI445709B (pt-PT) |
UY (1) | UY33729A (pt-PT) |
WO (1) | WO2012066442A1 (pt-PT) |
ZA (1) | ZA201303433B (pt-PT) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0908394D0 (en) | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
JP5984218B2 (ja) | 2010-07-02 | 2016-09-06 | ギリアード サイエンシーズ, インコーポレイテッド | Aidsを処置するためのナフト−2−イル酢酸誘導体 |
WO2012003498A1 (en) | 2010-07-02 | 2012-01-05 | Gilead Sciences, Inc. | 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds |
BR112013011991A2 (pt) * | 2010-11-15 | 2016-08-30 | Viiv Healthcare Uk Ltd | composto, composição farmacêutica, uso de um composto, método de tratamento, produto, e kit. |
WO2012065963A2 (en) | 2010-11-15 | 2012-05-24 | Katholieke Universiteit Leuven | Novel antiviral compounds |
KR20140027295A (ko) | 2011-04-21 | 2014-03-06 | 길리애드 사이언시즈, 인코포레이티드 | 벤조티아졸 화합물 및 이들의 약학적 용도 |
JP6099149B2 (ja) | 2011-10-25 | 2017-03-22 | 塩野義製薬株式会社 | Hiv複製阻害剤 |
WO2013103724A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids |
US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
PE20141558A1 (es) | 2012-04-20 | 2014-11-06 | Gilead Sciences Inc | Derivados de acido benzotiazol-6-il acetico y su uso para tratar una infeccion por vih |
US8906929B2 (en) | 2012-08-16 | 2014-12-09 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
TW201441197A (zh) | 2013-01-31 | 2014-11-01 | Shionogi & Co | Hiv複製抑制劑 |
JP2016512507A (ja) | 2013-03-13 | 2016-04-28 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | ヒト免疫不全ウイルス複製の阻害剤 |
WO2014164428A1 (en) | 2013-03-13 | 2014-10-09 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
WO2014164467A1 (en) | 2013-03-13 | 2014-10-09 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
CN105189503B (zh) | 2013-03-14 | 2017-03-22 | 百时美施贵宝公司 | 人免疫缺陷病毒复制的抑制剂 |
WO2014159076A1 (en) | 2013-03-14 | 2014-10-02 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
KR102345381B1 (ko) | 2013-06-25 | 2021-12-29 | 브리스톨-마이어스 스큅 컴퍼니 | 키나제 억제제로서 유용한 카르바졸 카르복스아미드 화합물 |
TWI648272B (zh) | 2013-06-25 | 2019-01-21 | 美商必治妥美雅史谷比公司 | 經取代之四氫咔唑及咔唑甲醯胺化合物 |
EP2821082A1 (en) | 2013-07-05 | 2015-01-07 | Laboratoire Biodim | Method of producing an inactivated lentivirus, especially HIV, vaccine, kit and method of use |
ES2654242T3 (es) | 2014-02-12 | 2018-02-12 | Viiv Healthcare (No.5) Limited | Macrociclos de benzotiazol como inhibidores de la réplica del virus de la inmunodeficiencia humana |
WO2015126758A1 (en) | 2014-02-18 | 2015-08-27 | Bristol-Myers Squibb Company | Imidazopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
EP3152215A1 (en) | 2014-02-18 | 2017-04-12 | ViiV Healthcare UK (No.5) Limited | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
US9409922B2 (en) | 2014-02-18 | 2016-08-09 | Bristol-Myers Squibb Company | Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication |
ES2687322T3 (es) | 2014-02-19 | 2018-10-24 | VIIV Healthcare UK (No.5) Limited | Inhibidores de la replicación del virus de inmunodeficiencia humana |
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AU2011330850B2 (en) | 2016-01-28 |
CN103429595B (zh) | 2015-10-21 |
JP2016164163A (ja) | 2016-09-08 |
ZA201303433B (en) | 2014-12-23 |
EP2640729A1 (en) | 2013-09-25 |
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BR112013011991A2 (pt) | 2016-08-30 |
US9447116B2 (en) | 2016-09-20 |
MX2013005486A (es) | 2013-12-12 |
MX343274B (es) | 2016-10-31 |
US20160355528A1 (en) | 2016-12-08 |
US8809363B2 (en) | 2014-08-19 |
CN105330675A (zh) | 2016-02-17 |
UY33729A (es) | 2012-06-29 |
CN103429595A (zh) | 2013-12-04 |
JP2013542247A (ja) | 2013-11-21 |
WO2012066442A1 (en) | 2012-05-24 |
AU2011330850A1 (en) | 2013-06-27 |
CA2817896A1 (en) | 2012-05-24 |
RU2013121788A (ru) | 2014-12-27 |
EP2640729B1 (en) | 2016-12-21 |
TW201300395A (zh) | 2013-01-01 |
AR083870A1 (es) | 2013-03-27 |
TWI445709B (zh) | 2014-07-21 |
AU2016202565A1 (en) | 2016-05-19 |
JP5902704B2 (ja) | 2016-04-13 |
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