MX2013005486A - Inhibidores de la replicacion del vih. - Google Patents

Inhibidores de la replicacion del vih.

Info

Publication number
MX2013005486A
MX2013005486A MX2013005486A MX2013005486A MX2013005486A MX 2013005486 A MX2013005486 A MX 2013005486A MX 2013005486 A MX2013005486 A MX 2013005486A MX 2013005486 A MX2013005486 A MX 2013005486A MX 2013005486 A MX2013005486 A MX 2013005486A
Authority
MX
Mexico
Prior art keywords
inhibitors
hiv replication
compounds
benzothieno
tetrahydro
Prior art date
Application number
MX2013005486A
Other languages
English (en)
Other versions
MX343274B (es
Inventor
David Cameron Pryde
Andrew Simon Bell
Iain Brian Gardner
Florian Michel Wakenhut
Karl Richard Gibson
Original Assignee
Viiv Healthcare Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viiv Healthcare Uk Ltd filed Critical Viiv Healthcare Uk Ltd
Publication of MX2013005486A publication Critical patent/MX2013005486A/es
Publication of MX343274B publication Critical patent/MX343274B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

La presente invención se refiere a novedosos compuestos de 5, 6, 7, 8-tetrahidro-[1]-benzotieno-[2,3-b]-piridina 2, 3, 4-sustituida, y a las sales farmacéuticamente aceptables de los mismos, a composiciones que contenían tales compuestos, y al uso de estos compuestos como inhibidores de la replicación del virus de inmunodeficiencia humana (VIH).
MX2013005486A 2010-11-15 2011-11-01 Inhibidores de la replicacion del vih. MX343274B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41361810P 2010-11-15 2010-11-15
US201161485355P 2011-05-12 2011-05-12
PCT/IB2011/054852 WO2012066442A1 (en) 2010-11-15 2011-11-01 Inhibitors of hiv replication

Publications (2)

Publication Number Publication Date
MX2013005486A true MX2013005486A (es) 2013-12-12
MX343274B MX343274B (es) 2016-10-31

Family

ID=44999830

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005486A MX343274B (es) 2010-11-15 2011-11-01 Inhibidores de la replicacion del vih.

Country Status (15)

Country Link
US (3) US8809363B2 (es)
EP (1) EP2640729B1 (es)
JP (2) JP5902704B2 (es)
CN (2) CN105330675A (es)
AR (1) AR083870A1 (es)
AU (2) AU2011330850B2 (es)
BR (1) BR112013011991A2 (es)
CA (1) CA2817896A1 (es)
CL (1) CL2013001338A1 (es)
MX (1) MX343274B (es)
RU (1) RU2564445C2 (es)
TW (1) TWI445709B (es)
UY (1) UY33729A (es)
WO (1) WO2012066442A1 (es)
ZA (1) ZA201303433B (es)

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US9284323B2 (en) 2012-01-04 2016-03-15 Gilead Sciences, Inc. Naphthalene acetic acid derivatives against HIV infection
MD20140063A2 (ro) 2012-04-20 2014-12-31 Gilead Sciences, Inc. Derivaţi de acid benzotiazol-6-il acetic şi utilizarea acestora pentru tratarea unei infecţii HIV
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WO2015126743A1 (en) 2014-02-18 2015-08-27 Bristol-Myers Squibb Company Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
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WO2015126765A1 (en) 2014-02-19 2015-08-27 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
JP6579549B2 (ja) 2014-05-16 2019-09-25 塩野義製薬株式会社 Ｈｉｖ複製阻害作用を有する３環性複素環誘導体
KR102514914B1 (ko) 2014-10-24 2023-03-27 브리스톨-마이어스 스큅 컴퍼니 카르바졸 유도체
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Also Published As

Publication number Publication date
AU2011330850A1 (en) 2013-06-27
RU2564445C2 (ru) 2015-10-10
JP2013542247A (ja) 2013-11-21
EP2640729B1 (en) 2016-12-21
AU2011330850B2 (en) 2016-01-28
US20160355528A1 (en) 2016-12-08
CN105330675A (zh) 2016-02-17
CN103429595A (zh) 2013-12-04
AR083870A1 (es) 2013-03-27
BR112013011991A2 (pt) 2016-08-30
US8809363B2 (en) 2014-08-19
ZA201303433B (en) 2014-12-23
TW201300395A (zh) 2013-01-01
US20140315927A1 (en) 2014-10-23
MX343274B (es) 2016-10-31
JP5902704B2 (ja) 2016-04-13
RU2013121788A (ru) 2014-12-27
US20120136023A1 (en) 2012-05-31
WO2012066442A1 (en) 2012-05-24
TWI445709B (zh) 2014-07-21
US9447116B2 (en) 2016-09-20
CN103429595B (zh) 2015-10-21
JP2016164163A (ja) 2016-09-08
CA2817896A1 (en) 2012-05-24
CL2013001338A1 (es) 2014-03-28
UY33729A (es) 2012-06-29
AU2016202565A1 (en) 2016-05-19
EP2640729A1 (en) 2013-09-25

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